Lipid biochemistry: Functions of glycerolipids and sphingolipids in cellular signaling

FASEB Journal

Volumn 11, Issue 1, 1997, Pages 45-50

  Ghosh, Sujoy ^a   Strum, Jay C ^a   Bell, Robert M ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

cell cycle; lipid; PKC; Raf; second messenger

Indexed keywords

CERAMIDE; DIACYLGLYCEROL; GLYCEROLIPID; PHOSPHATIDIC ACID; PROGESTERONE; PROTEIN KINASE C; SPHINGOLIPID; SPHINGOMYELIN;

LIPID METABOLISM; METABOLIC REGULATION; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SECOND MESSENGER;

EID: 0031057288     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.11.1.9034165     Document Type: Review

References (55)

1. Gorter, E., and Grendell, F. (1925) On biomolecular layers of lipids on the chromocyles of the blood. J. Exp. Med. 41, 439-443
2. Singer, S. J., and Nicholson, G. L. (1972) The fluid mosaic model of the structure of cell membranes. Science 175, 720-731
3. Vance, D. E. (1990) Phosphatidylcholine metabolism: masochistic enzymology, metabolic regulation and lipoprotein assembly. Biochem Cell Biol. 68, 1151-1165
4. McGovern, U.B., Jones, K. T., and Sharpe, G. R. (1995) Intracellular calcium as a second messenger following growth stimulation of human keratinocytes. Br. J. Dermatol. 132, 892-896
5. Choi, E. J., Xia, Z., Villacres, E. C., and Storm, D. R. (1993) The regulatory diversity of the mammalian adenylyl cyclases. Curr. Opin. Cell Biol. 5, 269-273
6. Bell, R. M., and Coleman, R. A. (1980) Enzymes of glycerolipid synthesis in eukaryotes. Annu. Rev. Biochem. 49, 459-487
7. Hawthorne, J. N. (1982) Inositol phospholipids. In Phospholipids. (Hawthorne, J. N., and Ansell, G. B., eds) pp. 263-278, Elsevier, Amsterdam
8. Takai, Y., Kishimoto, A., Iwasa, Y., Kawahari, Y., Mori, T., and Nishizuka, Y. (1979) A role of membranes in the activation of a new multifunctional protein kinase system. J. Biochem. 86, 575-578
9. Kaibuchi, K., Takai, Y., and Nishizuka, Y. (1981) Cooperative roles of various membrane phospholipids on the activation of calcium-activated, phospholipid-dependent protein kinase. J. Biol. Chem. 256, 7146-7149
10. Kishimoto, A., Takai, Y., Mori, T., Kikkawa, U., and Nishizuka, Y. (1980) Activation of calcium and phospholipid dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover. J. Biol. Chem. 255, 2273-2276
11. Nishizuka, Y. (1984) The role of protein kinase C in cell surface signal transduction and tumor promotion. Nature (London) 308, 693-695
12. Bell, R. M. (1986) Protein kinase C activation by diacylglycerol second messengers. Cell 45, 631-632
13. Castagna, M., Takai, Y., Kaibuchi, K., Sano, K., Kikkawa, U., and Nishizuka, Y. (1982) Direct activation of calcium activated, phospholipid dependent protein kinase by tumor promoting phorbol ester. J. Biol. Chem. 257, 7847-7851
14. Ganong, B. R., Loomis, C. R., Hannun, Y. A., and Bell, R. M. (1987) Regulation of protein kinase C by lipid cofactors. In Cell Membranes: Methods and Reviews. (Elson, E., Frazier, W., and Glaser, L., eds) pp. 183-214, Plenum, New York
15. Ganong, B. R., Loomis, C. R., and Bell, R. M. (1986) Specificity and mechanism of protein kinase C activation by sn-1,2-diacylglycerols. Proc. Natl. Acad. Sci. USA 83, 1184-1188
16. Davis, R. J., Ganong, B. R., Bell, R. M., and Czech, M. P. (1985) Dioclanoylglycerol: A cell permeable diacylglycerol that mimicks phorbol diester action on the epidermal growth factor receptor and mitogenesis. J. Biol. Chem. 260, 1562-1566
17. Bell, R. M., Hannun, Y. A., and Loomis, C. R. (1986) Mixed micelle assay of protein kinase C. In Methods in Enzymology. (Conn. M., ed) pp. 353-358, Academic Press, New York
18. Hannun, Y. A. and Bell, R. M. (1986) Phorbol ester binding and activation of protein kinase C in Triton X-100 mixed micelles containing phosphatidylserine. J. Biol. Chem. 261, 9341-9347
19. König, B., DiNitto, P. A., and Blumberg, P. M. (1985) Stoichiometric binding of diacylglycerol to the phorbol ester receptor. J. Cell. Biochem. 29, 37-44
20. Lee, M. Y., and Bell, R. M. (1989) Phospholipid functional groups involved in protein kinase C activation, phorbol ester binding and binding to mixed micelles. J. Biol. Chem. 264, 14797-14805
21. Lee, M. Y., and Bell, R. M. (1986) The lipid-binding regulatory domain of protein kinase C. J. Biol. Chem. 261, 14867-14870
22. Burns, D. J., and Bell, R. M. (1991) Protein kinase C contains two phorbol ester binding domains. J. Biol. Chem. 266, 18330-18338
23. Quest, A. F. G., and Bell, R. M. (1994) The molecular mechanism of protein kinase C regulation by lipids. In Protein kinase C. (Kuo, J. F., ed) pp. 64-95, Oxford University Press, New York
24. Ono, Y., Fujii, T., Igarashi, K., Kuno, T., Tanaka, C., Kikkawa, U., and Nishizuka, Y. (1989) Phorbol ester binding to protein kinase C requires a cysteine-rich zinc finger like sequence. Proc. Natl. Acad. Sci. USA 86, 4868-4871
25. Sharkey, N. A., Leech, K. L., and Blumberg, P. M. (1984) Competitive inhibition by diacylglycerol of specific phorbol ester binding. Proc. Natl. Acad. Sci. USA 81, 697-610
26. Quest, A. F. G., Bardes, E. S. G., and Bell, R. M. (1994) A phorbol ester binding domain of protein kinase Cγ: Deletion analysis of the Cys2 domain defines a minimal 43 amino acid peptide. J. Biol. Chem. 269, 2961-2970
27. Quest, A. F. G., Bardes, E. S. G., and Bell, R. M. (1994) A phorbol ester binding domain of protein kinase Cγ: High affinity binding to glutathione-S-transferase/Cys2 fusion protein. J. Biol. Chem. 269, 2953-2960
28. Quest, A. F. G., and Bell, R. M. (1994) The regulatory region of protein kinase C: Studies of phorbol ester binding to individual and combined functional segments expressed as glutathione-S-transferase fusion proteins indicate a complex mechanism of regulation by phospholipids, phorbol esters and divalent cations. J. Biol. Chem. 269, 20000-20012
29. Ahmed, S., Kozma, R., Lee, J., Monfries, C., Harden, N., and Lim, L. (1991) The cysteine-rich domain of human proteins, neuronal chimerin, protein kinase C and diacylglycerol kinase binds zinc. Biochem. J. 280, 233-241
30. Quest, A. F. G., Bloomenthal, J., Bardes, E. S. G., and Bell, R. M. (1992) The regulatory domain of protein kinase C coordinates four atoms of zinc. J. Biol. Chem. 267, 10193-10197
31. Zhang, G., Kazanietz, M. G., Blumberg, P. M., and Hurley, J. H. (1995) Crystal structure of the Cys2 activator binding domain of protein kinase C delta in complex with phorbol ester. Cell 81, 917-924
32. Hommel, U., Zurini, M., and Luyten, M. (1994) Solution structure of a cysteine-rich domain of rat protein kinase C. Nature (Struct. Biol.) 1, 383-387
33. Moelling, K., Heimann, B., Beimling, P., Rapp, U. R., and Sander, T., (1984) Serine and threonine specific protein kinase activities of purified gag-mil and gag-raf proteins. Nature (London) 312, 558-561
34. Moodie, S. A., Willumsen, B. M., Weber, M. J., and Wolfman, A. (1993) Complexes of Ras · GTP with Raf-1 and mitogen-activated protein kinase kinase. Science 260, 1658-1661
35. Ghosh, S., and Bell, R. M. (1994) Identification of discrete segments of human Raf-1 kinase critical for high affinity binding to Ha-Ras. J. Biol. Chem. 269, 30785-30788
36. Willumsen, B. M., Christensen, A., Hubbert, N. L., Papageorge, A. G., and Lowry, D. W. (1984) The p21-ras C-terminus is required for transformation and membrane association. Nature (London) 310, 583-586
37. Leevers, S. J., Paterson, H. F., and Marshall, C. J. (1994) Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. Nature (London) 369, 411-414
38. Ghosh, S., Xie, W. Q., Quest, A. F. G., Mabrouk, G. M., Strum, J. C., and Bell, R. M. (1994) The cysteine-rich region of Raf-1 kinase contains zinc, translocates to liposomes, and is adjacent to a segment that binds GTP-Ras. J. Biol. Chem. 269, 10000-10007
39. Mott, H. R., Carpenter, J. W., Zhong, S., Ghosh, S., Bell, R. M., and Campbell, S. (1996) The solution structure of the Raf-1 cysteine-rich domain: a novel Ras and phospliolipid binding site. Proc. Natl. Acad. Sci. USA 93, 8312-8317
40. Ghosh, S., Strum, J. C., Sciorra, V. A., Daniel, L., and Bell, R. M. (1996) Raf-I kinase possesses distinct binding domains for phosphatidylserine and phosphatidic acid: phosphatidic acid regulates the translocation of Raf-1 in 12-O-tetradecanoylphorbol-13-acetate stimulated Madin-Darby canine kidney cells. J. Biol. Chem. 271, 8472-8480
41. Marquardt, B. (1994) Signaling from TPA to MAP kinase requires protein kinase C, raf, and MEK: reconstitution of the signaling pathway in vitro. Oncogene 9, 3213-3218
42. Edwards, Y. S., and Murray, A. W. (1995) Accumulation of phosphatidylalcohol in cultured cells: use of subcellular fractionation to investigate phospholipase D activity during signal transduction. Biochem. J. 308, 473-480
43. English, D., Cui, V., and Siddiqui, R. A. (1996) Messenger functions of phosphatidic acid. Chem. Phys. Lipids 80, 117-132
44. Siddiqui, R. A., and Yang, Y. S. (1995) Interleukin-11 induces phosphatidic acid and activates MAP kinase in mouse 3T3-L1 cells. Cell. Signalling 7, 247-259
45. Okada, T., Masuda, T., Shinkai, M., Kariya, K., and Kataoka, T. (1996) Post-translational modification of H-Ras is required for activation of, but not for association with B-Raf. J. Biol. Chem. 271, 4671-4678
46. Hakomori, S. (1990) Bifunctional rule of glycosphingolipids. J. Biol. Chem. 265, 18713-18716
47. Merrill, A. H., Jr., Hannun, Y. A., and Bell, R. M. (1993) Sphingolipids and their metabolites in cell regulation. In Advances in Lipid Research. (Bell, R. M., Merrill, A. H. Jr., and Hannun, Y. A., eds) pp. 1-24, Academic Press, New York
48. Hannun, Y. A., Loomis, C. R., Merrill, A., and Bell, R. M. (1986) Sphingosine inhibition of protein kinase G activity and of phorbol dibutyrate binding in vitro and in human platelets. J. Biol. Chem. 261, 12604-12609
49. Oishi, K., Raynor, R. L., Charp, P. A., and Kuo, J. F. (1988) Regulation of protein kinase C by lysophospholipids. Potential role in signal transduction. J. Biol. Chem. 263, 6865-6871
50. Hannun, Y. A., and Bell, R. M. (1989) Functions of sphingolipids and sphingolipid breakdown products in cellular regulation. Science 243, 500-507
51. 3 in HL-60 cells. Role in cell differentiation. J. Biol. Chem. 264, 19076-19080
52. Hannun, Y. A., Obeid, L. M., and Dbaibo, G. S. (1996) Ceramide: A novel second messenger and lipid mediator. In Handbook of Lipid Research. (Bell, R. M., Exton, J. H. and Prescott, S. M., eds) pp. 177-204, Plenum, New York
53. Carnero, A., and Lacal, J. C. (1993) Phospholipase-induced maturation of Xenopus laevis oocytes: mitogenic activity of generated metabolites. J. Cell. Biochem. 52, 440-448
54. Varnold, R. L., and Smith, L. D. (1990) Protein kinase C and progesterone-induced maturation in Xenopus oocytes. Development 109, 597-604
55. Strum, J. C., Swenson, K.I., Turner, J. E., and Bell, R. M. (1995) Ceramide triggers meiotic cell cycle progression in Xenopus oocytes. A potential mediator of progesterone induced maturation. J. Biol. Chem. 270, 13541-13547