Transglutaminase 2, a novel regulator of eicosanoid production in asthma revealed by genome-wide expression profiling of distinct asthma phenotypes

PLoS ONE

Volumn 5, Issue 1, 2010, Pages

  Hallstrand, Teal S ^a   Wurfel, Mark M ^a   Lai, Ying ^a   Ni, Zhanglin ^a   Gelb, Michael H ^a   Altemeier, William A ^a   Beyer, Richard P ^a   Aitken, Moira L ^a   Henderson Jr , William R ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CARBOXYPEPTIDASE A; CARBOXYPEPTIDASE A3; ICOSANOID; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 GROUP X; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2; RECOMBINANT ENZYME; TRYPTASE; UNCLASSIFIED DRUG; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE;

ADULT; ARTICLE; ASTHMA; BIOLOGY; BRONCHUS BIOPSY; CELL INFILTRATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; EPITHELIUM CELL; EXERCISE INDUCED ASTHMA; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LEUKOCYTE; MALE; MAST CELL; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PHENOTYPE; RESPIRATORY FUNCTION; SPUTUM EXAMINATION; UPREGULATION; BIOSYNTHESIS; COHORT ANALYSIS; ENZYME ACTIVATION; ENZYMOLOGY; GENETIC ASSOCIATION; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; MIDDLE AGED; POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADULT; ASTHMA; BLOTTING, WESTERN; COHORT STUDIES; EICOSANOIDS; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION PROFILING; GENOME-WIDE ASSOCIATION STUDY; GTP-BINDING PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PHENOTYPE; PHOSPHOLIPASES A2; POLYMERASE CHAIN REACTION; TRANSGLUTAMINASES;

EID: 77649169695     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0008583     Document Type: Article

References (42)

1. Hallstrand TS, Moody MW, Wurfel MM, Schwartz LB, Henderson WR Jr, et al. (2005) Inflammatory basis of exercise-induced bronchoconstriction. Am J Respir Crit Care Med 172: 679-686.
2. Cabral AL, Conceicao GM, Fonseca-Guedes CH, Martins MA (1999) Exercise-induced bronchospasm in children: effects of asthma severity. Am J Respir Crit Care Med 159: 1819-1823.
3. Hallstrand TS, Curtis JR, Koepsell TD, Martin DP, Schoene RB, et al. (2002) Effectiveness of screening examinations to detect unrecognized exercise-induced bronchoconstriction. J Pediatr 141: 343-348.
4. Henriksen AH, Tveit KH, Holmen TL, Sue-Chu M, Bjermer L (2002) A study of the association between exercise-induced wheeze and exercise versus methacholine-induced bronchoconstriction in adolescents. Pediatr Allergy Immunol 13: 203-208.
5. Vianna EO, Boaventura LC, Terra-Filho J, Nakama GY, Martinez JA, et al. (2002) Morning-to-evening variation in exercise-induced bronchospasm. J Allergy Clin Immunol 110: 236-240.
6. Holzer K, Anderson SD, Douglass J (2002) Exercise in elite summer athletes: Challenges for diagnosis. J Allergy Clin Immunol 110: 374-380.
7. Joos GF, O'Connor B, Anderson SD, Chung F, Cockcroft DW, et al. (2003) Indirect airway challenges. Eur Respir J 21: 1050-1068.
8. Hallstrand TS, Moody MW, Aitken ML, Henderson WR Jr (2005) Airway immunopathology of asthma with exercise-induced bronchoconstriction. J Allergy Clin Immunol 116: 586-593.
9. Carraro S, Corradi M, Zanconato S, Alinovi R, Pasquale MF, et al. (2005) Exhaled breath condensate cysteinyl leukotrienes are increased in children with exercise-induced bronchoconstriction. J Allergy Clin Immunol 115: 764-770.
10. Hallstrand TS, Debley JS, Farin FM, Henderson WR Jr (2007) Role of MUC5AC in the pathogenesis of exercise-induced bronchoconstriction. J Allergy Clin Immunol 119: 1092-1098.
11. Mickleborough TD, Lindley MR, Ray S (2005) Dietary salt, airway inflammation, and diffusion capacity in exercise-induced asthma. Med Sci Sports Exerc 37: 904-914.
12. Anderson SD, Brannan JD (2002) Exercise-induced asthma: is there still a case for histamine? J Allergy Clin Immunol 109: 771-773.
13. Anderson SD, Daviskas E (2000) The mechanism of exercise-induced asthma is. J Allergy Clin Immunol 106: 453-459.
14. 2 group X overexpression in asthma and bronchial hyperresponsiveness. Am J Respir Crit Care Med 176: 1072-1078.
15. 2 in allergen-induced airway inflammation and remodeling in a mouse asthma model. J Exp Med 204: 865-877.
16. Hallstrand TS, Wurfel MM, Lai Y, Beyer RP, Aitken ML, et al. (2009) Genomewide expression profiling in phenotypically distinct groups of asthmatics identifies overexpression of epithelial and mast cell genes in exercise-induced bronchoconstriction (Aspen Lung Conference Abstract). Proc Am Thorac Soc 6: 325-326.
17. Hallstrand TS, Wurfel MM, Moody MM, Henderson WR Jr, Aitken ML (2004) Identification of differentially expressed genes in human airways contributing to exercise-induced bronchoconstriction (Abstract). Am J Respir Crit Care Med 167: A16.
18. Hallstrand TS, Martin DP, Hummel JP, Williams BL, Logerfo JP (2009) Initial Test of the Seattle Asthma Severity and Control Questionnaire (SASCQ): A Multidimensional Assessment of Asthma Severity and Control. Ann Allergy Asthma Immunol in press.
19. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, et al. (2005) Standardisation of spirometry. Eur Respir J 26: 319-338.
20. Crapo RO, Casaburi R, Coates AL, Enright PL, Hankinson JL, et al. (2000) Guidelines for methacholine and exercise challenge testing-1999. Am J Respir Crit Care Med 161: 309-329.
21. Wurfel MM, Park WY, Radella F, Ruzinski J, Sandstrom A, et al. (2005) Identification of high and low responders to lipopolysaccharide in normal subjects: an unbiased approach to identify modulators of innate immunity. J Immunol 175: 2570-2578.
22. 2. 4-glycerol derivatives of 4,5-dihydro-3-(4-tetradecyloxybenzyl)-1,2,4-4H-oxadiazol-5-one with broad activities. J Med Chem 50: 1618-1626.
23. 2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis. J Biol Chem 277: 5061-5073.
24. Karp CL, Grupe A, Schadt E, Ewart SL, Keane-Moore M, et al. (2000) Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma. Nat Immunol 1: 221-226.
25. Zimmermann N, King NE, Laporte J, Yang M, Mishra A, et al. (2003) Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. J Clin Invest 111: 1863-1874.
26. Lilly CM, Tateno H, Oguma T, Israel E, Sonna LA (2005) Effects of allergen challenge on airway epithelial cell gene expression. Am J Respir Crit Care Med 171: 579-586.
27. Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, et al. (2004) Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 5: R80.
28. Smyth GK (2004) Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3: Article3.
29. Hess A, Iyer H (2007) Fisher's combined p-value for detecting differentially expressed genes using Affymetrix expression arrays. BMC Genomics 8: 96.
30. (2009) http://bioinformatics.mdanderson.org/MicroarraySampleSize/ MicroarraySampleSize.aspx.
31. Tusher VG, Tibshirani R, Chu G (2001) Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A 98: 5116-5121.
32. Efthimiadis A, Spanevello A, Hamid Q, Kelly MM, Linden M, et al. (2002) Methods of sputum processing for cell counts, immunocytochemistry and in situ hybridisation. Eur Respir J Suppl 37: 19s-23s.
33. Antonyak MA, Jansen JM, Miller AM, Ly TK, Endo M, et al. (2006) Two isoforms of tissue transglutaminase mediate opposing cellular fates. Proc Natl Acad Sci U S A 103: 18609-18614.
34. Stern DA, Morgan WJ, Halonen M, Wright AL, Martinez FD (2008) Wheezing and bronchial hyper-responsiveness in early childhood as predictors of newly diagnosed asthma in early adulthood: a longitudinal birth-cohort study. Lancet 372: 1058-1064.
35. Kuperman DA, Lewis CC, Woodruff PG, Rodriguez MW, Yang YH, et al. (2005) Dissecting asthma using focused transgenic modeling and functional genomics. J Allergy Clin Immunol 116: 305-311.
36. Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, et al. (2007) Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci U S A 104: 15858-15863.
37. Laprise C, Sladek R, Ponton A, Bernier MC, Hudson TJ, et al. (2004) Functional classes of bronchial mucosa genes that are differentially expressed in asthma. BMC Genomics 5: 21.
38. Ma Y, Koza-Taylor PH, DiMattia DA, Hames L, Fu H, et al. (2003) Microarray analysis uncovers retinoid targets in human bronchial epithelial cells. Oncogene 22: 4924-4932.
39. Cookson W (2004) The immunogenetics of asthma and eczema: a new focus on the epithelium. Nat Rev Immunol 4: 978-988.
40. Sohn J, Kim TI, Yoon YH, Kim JY, Kim SY (2003) Novel transglutaminase inhibitors reverse the inflammation of allergic conjunctivitis. J Clin Invest 111: 121-128.
41. 2 in inflammatory and allergic diseases: not just enzymes. J Allergy Clin Immunol 116: 1000-1006.
42. Lee J, Kim YS, Choi DH, Bang MS, Han TR, et al. (2004) Transglutaminase 2 induces nuclear factor-kappaB activation via a novel pathway in BV-2 microglia. J Biol Chem 279: 53725-53735.