Activation of human platelets by 2-arachidonoylglycerol: Role of PKC in NO/cGMP pathway modulation

Current Neurovascular Research

Volumn 8, Issue 3, 2011, Pages 200-209

  Signorello, Maria Grazia ^a   Giacobbe, Enrica ^a   Segantin, Alessia ^a   Avigliano, Luciana ^b   Sinigaglia, Fabiola ^c   Maccarrone, Mauro ^d,e   Leoncini, Giuliana ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^d UNIVERSITY OF TERAMO   (Italy)

^e IRCCS FONDAZIONE SANTA LUCIA   (Italy)

Author keywords

2 Arachidonoylglycerol; Enos phosphorylation dephosphorylation; Human platelets; Nitric oxide; PKC; PP1; PP2A

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 2 ARACHIDONOYLGLYCEROL; 2 MORPHOLINO 8 PHENYLCHROMONE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; ACYLGLYCEROL LIPASE; AMILORIDE; CALCIUM ION; CALYCULIN A; CYCLIC GMP; EGTAZIC ACID; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; FATTY ACID AMIDASE; MK 2206; NIFEDIPINE; NITRATE; NITRIC OXIDE; NITRITE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOLIPASE C; PLECKSTRIN; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; PROTEIN KINASE C; PROTEIN P47; SERINE; THREONINE; THROMBOXANE A2 RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION;

EID: 80051533854     PISSN: 15672026     EISSN: 18755739     Source Type: Journal    
DOI: 10.2174/156720211796558041     Document Type: Article

References (42)

1. Petrosino S, Ligresti A, Di Marzo V. Endocannabinoid chemical biology: a tool for the development of novel therapies. Curr Opin Chem Biol 2009; 13(3): 309-20.
2. Salzet M, Breton C, Bisogno T, Di Marzo V. Comparative biology of the endocannabinoid system possible role in the immune response. Eur J Biochem 2000; 267(16): 4917-27. (Pubitemid 30641288)
3. Sugiura T. Waku K. Cannabinoid receptors and their endogenous ligands. J Biochem 2002; 132(1): 7-12. (Pubitemid 34832264)
4. Sugiura T, Kishimoto S, Oka S, Gokoh M. Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. Prog Lipid Res 2006; 45(5): 405-46.
5. Kobayashi Y, Arai S, Waku K, Sugiura T. Activation by 2- arachidonoylglycerol, an endogenous cannabinoid receptor ligand, of p42/44 mitogen-activated protein kinase in HL-60 cells. J Biochem 2001; 129(5): 665-9. (Pubitemid 32499776)
6. Derkinderen P, Ledent C, Parmentier M, Girault JA. Cannabinoids activate p38 mitogen-activated protein kinases through CB1 receptors in hippocampus. J Neurochem 2001; 77(3): 957-60. (Pubitemid 32466793)
7. Sugiura T, Kodaka T, Kondo S, et al. Inhibition by 2- arachidonoylglycerol, a novel type of possible neuromodulator, of the depolarization-induced increase in intracellular free calcium in neuroblastoma x glioma hybrid NG108-15 cells. Biochem Biophys Res Commun 1997; 233(1): 207-10. (Pubitemid 27215937)
8. Kishimoto S, Kobayashi Y, Oka S, Gokoh M, Waku K, Sugiura T, 2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells. J Biochem 2004; 135(4): 517-24. (Pubitemid 38660939)
9. Kishimoto S, Gokoh M, Oka S, et al. 2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism. J Biol Chem 2003; 278(27): 24469-75. (Pubitemid 37548598)
10. Jordà MA, Verbakel SE, Valk PJ, et al. Hematopoietic cells expressing the peripheral cannabinoid receptor migrate in response to the endocannabinoid 2-arachidonoylglycerol. Blood 2002; 99(8): 2786-93. (Pubitemid 34525366)
11. Randall MD. Endocannabinoids and the haematological system. Br J Pharmacol 2007; 152(5): 671-5. (Pubitemid 350034975)
12. Mach F, Montecucco F, Steffens S. Effect of blockage of the endocannabinoid system by CB(1) antagonism on cardiovascular risk. Pharmacol Rep 2009; 61(1): 13-21.
13. Sugiura T, Kodaka T, Nakane S, Kishimoto S, Kondo S, Waku K. Detection of an endogenous cannabimimetic molecule, 2-arachidonoylglycerol, and cannabinoid CB1 receptor mRNA in human vascular cells: is 2-arachidonoylglycerol a possible vasomodulator? Biochem Biophys Res Commun 1998; 243(3): 838-43. (Pubitemid 28414169)
14. Maccarrone M, Bari M, Menichelli A, Giuliani E, Del Principe D, Finazzi-Agrò A. Human platelets bind and degrade 2-arachidonoylglycerol, which activates these cells through a cannabinoid receptor. Eur J Biochem 2001; 268(3): 819-25. (Pubitemid 32862642)
15. Catani MV, Fezza F, Baldassarri S. et al. Expression of the endocannabinoid system in the bi-potential HEL cell line: commitment to the megakaryoblastic lineage by 2-arachidonoylglycerol. J Mol Med 2009; 87(1): 65-74.
16. Catani MV, Gasperi V, Catanzaro G, et al. Human platelets express authentic CB1 and CB2 receptors. Curr Neurovasc Res 2010; 7(4): 311-8.
17. Baldassarri S, Bertoni A, Bagarotti A, et al. The endocannabinoid 2-arachidonoylglycerol activates human platelets through non- CB1/CB2 receptors. J Thromb Haemost 2008; 6(10): 1772-9.
18. Born GVR. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 1962; 194: 927-9.
19. Russo I, Doronzo G, Mattiello L, De Salve A, Trovati M, Anfossi G. The activity of constitutive nitric oxide synthase is increased by the pathway cAMP/cAMP-activated protein kinase in human platelets. New insights into the antiaggregating effects of cAMPelevating agents. Thromb Res 2004; 114(4): 265-73. (Pubitemid 39286012)
20. Kathuria S, Gaetani S, Fegley D, et al. Modulation of anxiety through blockade of anandamide hydrolysis. Nat Med 2003; 9(1): 76-81. (Pubitemid 36098263)
21. Makara JK, Mor M, Fegley D, et al. Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus. Nat Neurosci 2005; 8(9): 1139-41. (Pubitemid 43348129)
22. Tarzia G, Antonietti F, Duranti A, et al. Identification of a bioactive impurity in a commercial sample of 6-methyl-2-p-tolylaminobenzo d][1,3]oxazin-4-one (URB754). Ann Chim 2007; 97(9): 887-94. (Pubitemid 47442122)
23. Randriamboavonjy V, Fleming I. Endothelial nitric oxide synthase (eNOS) in platelets: how is it regulated and what is it doing there? Pharmacol Rep 2005; 57 (Suppl): 59-65.
24. Malorni W, Bari M, Straface E, et al. Morphological evidence that 2-arachidonoyl-glycerol is a true agonist of human platelets. Thromb Haemost 2004; 92(5): 1159-61. (Pubitemid 39545545)
25. Sugiura T, Kobayashi Y, Oka S, Waku K. Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance. Prostaglandins Leukot Essent Fatty Acids 2002; 66(2-3): 173-92. (Pubitemid 34743593)
26. Signorello MG, Segantin A, Leoncini G. The arachidonic acid effect on platelet nitric oxide level. Biochim Biophys Acta 2009; 1791(11): 1084-92.
27. Keown OP, Winterburn TJ, Wainwright CL, et al. 2-arachidonyl glycerol activates platelets via conversion to arachidonic acid and not by direct activation of cannabinoid receptors. Br J Clin Pharmacol 2010; 70(2): 180-8.
28. Signorello MG, Giacobbe E, Passalacqua M, et al. The anandamide effect on NO/cGMP pathway in human platelets. J Cell Biochem 2011; 112(3): 924-32.
29. Michell BJ, Chen ZP, Tiganis T, et al. Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase. J Biol Chem 2001; 276(21): 17625-8.
30. Fleming I. Molecular mechanisms underlying the activation of eNOS. Pflugers Arch 2010; 459(6): 793-806.
31. Partovian C, Zhuang Z, Moodie K, et al. PKCalpha activates eNOS and increases arterial blood flow in vivo. Circ Res 2005; 97(5): 482-7. (Pubitemid 41298179)
32. Nishikawa M, Toyoda H, Saito M, et al. Calyculin A and okadiac acid inhibit human platelet aggregation by blocking protein phosphatases types 1 and 2A. Cell Signal 1994; 6(1): 59-71. (Pubitemid 24110329)
33. Moscardó A, Vallés J, Piñón M, Aznar J, Mart́nez-Sales V, Santos MT. Regulation of cytosolic PlA2 activity by PP1/PP2A serine/ threonine phosphatases in human platelets. Platelets 2006; 17(6): 405-15. (Pubitemid 44410505)
34. Pawlowski M, Ragab A, Rosa JP, Bryckaert M. Selective dephosphorylation of the threonine(183) residue of ERK2 upon (alpha)llb(beta)3 engagement in platelets. FEBS Lett 2002; 521(1- 3): 145-51. (Pubitemid 34628475)
35. Ramirez-Sanchez I, Maya L, Ceballos G, Villareal F. (-)- epicatechin activation of endothelial cell endothelial nitric oxide synthase, nitric oxide, and related signaling pathways. Hypertension 2010; 55(6): 398-405.
36. Harris MB, Ju H, Venema VJ, et al. Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation. J Biol Chem 2001; 276(19): 16587-91.
37. Lin MI, Fulton D, Babbitt R, et al. Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production. J Biol Chem 2003; 278(45): 44719-26. (Pubitemid 37377229)
38. Radomski MW, Palmer RM, Moncada S. Comparative pharmacology of endothelium-derived relaxing factor, nitric oxide and prostacyclin in platelets. Br J Pharmacol 1987; 92(1): 181-7. (Pubitemid 17134934)
39. Radomski MW, Palmer RM, Moncada S. An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc Natl Acad Sci USA 1990; 87(13): 5193-7.
40. Radomski MW, Palmer RM, Moncada, S. Characterization of the L-arginine: nitric oxide pathway in human platelets. Br J Pharmacol 1990; 101(2): 325-8.
41. Stefano GB, Bilfinger TV, Rialas CM, Deutsch DG. 2-arachidonylglycerol stimulates nitric oxide release from human immune and vascular tissues and invertebrate immunocytes by cannabinoid receptor 1. Pharmacol Res 2000; 42(4): 317-22.
42. Liaudet L, Vassalli G, Pacher P. Role of peroxynitrite in the redox regulation of cell signal transduction pathways. Front Biosci 2009; 14: 4809-14.