Disruption of a novel krüppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus

Journal of Biological Chemistry

Volumn 286, Issue 32, 2011, Pages 28414-28424

  Bonnefond, Amélie ^a   Lomberk, Gwen ^b   Buttar, Navtej ^b   Busiah, Kanetee ^c   Vaillant, Emmanuel ^a   Lobbens, Stéphane ^a   Yengo, Loïc ^a   Dechaume, Aurélie ^a   Mignot, Brigitte ^d   Simon, Albane ^c   Scharfmann, Raphaël ^c   Neve, Bernadette ^a   Tanyolaç, Sinan ^e   Hodoglugil, Ugur ^f   Pattou, François ^a   Cavé, Hélène ^g   Iovanna, Juan ^c   Stein, Roland ^h   Polak, Michel ^c   Vaxillaire, Martine ^a   Froguel, Philippe ^a,i,j   Urrutia, Raul ^b   more..

^a UNIV LILLE   (France)

^b MAYO CLINIC   (United States)

^c INSERM   (France)

^d UNIVERSITY HOSPITAL OF BESANÇON   (France)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^h VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁱ IMPERIAL COLLEGE LONDON   (United Kingdom)

^j HAMMERSMITH HOSPITAL   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; BIOSYNTHESIS; DIAGNOSIS; INSULIN; MAMMALS; PROTEINS; SODIUM SULFATE; TRANSCRIPTION FACTORS;

BIOCHEMICAL MECHANISMS; BIOCHEMICAL PATHWAY; CELLULAR CONTEXTS; CHROMATIN IMMUNOPRECIPITATION; DIABETES MELLITUS; ELECTROMOBILITY; EXPRESSION PROFILING; INSULIN SECRETION;

TRANSCRIPTION;

INSULIN; KRUPPEL LIKE FACTOR; KRUPPEL LIKE FACTOR 11; PROTEIN P300; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; KLF11 PROTEIN, HUMAN; KLF11 PROTEIN, MOUSE; REPRESSOR PROTEIN; TIEG2 PROTEIN, RAT; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; GENE; GENE MUTATION; HOMOZYGOSITY; HUMAN; HUMAN CELL; INS GENE; INSULIN BLOOD LEVEL; INSULIN SYNTHESIS; MOLECULAR MECHANICS; MOUSE; NEWBORN DIABETES MELLITUS; NEWBORN DISEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; REGULATORY MECHANISM; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; ADULT; ANIMAL; BIOSYNTHESIS; CELL LINE; DNA RESPONSIVE ELEMENT; FEMALE; GENE EXPRESSION REGULATION; GENETICS; INFANT; MALE; METABOLISM; MOUSE MUTANT; NEWBORN; PANCREAS ISLET BETA CELL; PATHOLOGY; PRESCHOOL CHILD; RAT;

MUS;

ADULT; ANIMALS; CELL CYCLE PROTEINS; CELL LINE; CHILD, PRESCHOOL; DIABETES MELLITUS; DNA-BINDING PROTEINS; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; INFANT, NEWBORN, DISEASES; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE; MICE, KNOCKOUT; MUTAGENESIS, INSERTIONAL; RATS; REPRESSOR PROTEINS; RESPONSE ELEMENTS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 80051527724     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.215822     Document Type: Article

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