A novel chimeric protein-based HIV-1 fusion inhibitor targeting gp41 glycoprotein with high potency and stability

Journal of Biological Chemistry

Volumn 286, Issue 32, 2011, Pages 28425-28434

  Pan, Chungen ^a,c   Cai, Lifeng ^a,d   Lu, Hong ^a   Lu, Lu ^a,b   Jiang, Shibo ^a,b  

^a NEW YORK BLOOD CENTER   (United States)

^b FUDAN UNIVERSITY   (China)

^c SUN YAT SEN UNIVERSITY   (China)

^d BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRAL DRUGS; CELL-CELL FUSION; CIRCULAR DICHROISM SPECTRA; DRUG-RESISTANT STRAINS; E. COLI; FURTHER DEVELOPMENT; FUSION INHIBITORS; GOOD YIELD; HELICAL CONTENT; HIGH COSTS; HIGH POTENCY; HIV-1 INFECTIONS; HUMAN SERUM; N-TERMINALS; PEPTIDE SYNTHESIS; PERIPHERAL BLOOD MONONUCLEAR CELLS; PRODUCTION COST; SALVAGE THERAPY; STABLE COMPLEXES; THERMALLY STABLE;

ANIMAL CELL CULTURE; DICHROISM; DRUG THERAPY; ESCHERICHIA COLI; PEPTIDES;

DISEASES;

ENFUVIRTIDE; GLYCOPROTEIN GP 41; HUMAN IMMUNODEFICIENCY VIRUS FUSION INHIBITOR; T 1144; TLT 35; UNCLASSIFIED DRUG;

ALPHA HELIX; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ANTIBODY TITER; ANTIVIRAL RESISTANCE; AQUEOUS SOLUTION; ARTICLE; CIRCULAR DICHROISM; CLADISTICS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG POTENCY; DRUG STABILITY; DRUG TARGETING; ESCHERICHIA COLI; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; IMMUNOGENICITY; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; THERMOSTABILITY; VIRUS STRAIN;

CELL LINE; CIRCULAR DICHROISM; DRUG RESISTANCE, VIRAL; ESCHERICHIA COLI; GENE EXPRESSION; HIV ENVELOPE PROTEIN GP41; HIV FUSION INHIBITORS; HIV INFECTIONS; HIV-1; HUMANS; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT FUSION PROTEINS; VIRUS INTERNALIZATION;

ESCHERICHIA COLI; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 80051516345     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.241992     Document Type: Article

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