The effect of the potential phoq histidine kinase inhibitors on shigella flexneri virulence

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Cai, Xia ^a   Zhang, Jian ^b   Chen, Mingliang ^c   Wu, Yang ^a   Wang, Xueqing ^a   Chen, Jiayu ^a   Zhang, Junqin ^a   Shen, Xu ^b   Qu, Di ^a   Jiang, Hualiang ^b  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c SHANGHAI MUNICIPAL CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

[No Author keywords available]

Indexed keywords

PHOQ INHIBITOR; PROTEIN HISTIDINE KINASE; PROTEIN KINASE INHIBITOR; PROTEIN PHOQ; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; BACTERIAL PROTEIN; PHOQ PROTEIN, BACTERIA; PROTEIN KINASE; PROTEIN-HISTIDINE KINASE; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL VIRULENCE; BINDING AFFINITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HEMOLYSIS; HUMAN; HUMAN CELL; KERATOCONJUNCTIVITIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; SHIGELLA FLEXNERI; SHIGELLOSIS; TOXICITY TESTING; ANIMAL; BINDING SITE; BIOLOGY; CELL DEATH; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; ERYTHROCYTE; HELA CELL; METABOLISM; MICROBIOLOGICAL EXAMINATION; MICROBIOLOGY; PATHOGENICITY; PATHOLOGY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SALMONELLA TYPHIMURIUM; SEQUENCE ANALYSIS; VIRULENCE;

MUS; SHIGELLA; SHIGELLA FLEXNERI;

ADENOSINE TRIPHOSPHATE; ANIMALS; BACTERIAL PROTEINS; BINDING SITES; CELL DEATH; COMPUTATIONAL BIOLOGY; ERYTHROCYTES; HELA CELLS; HEMOLYSIS; HUMANS; KERATOCONJUNCTIVITIS; MICE; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SALMONELLA TYPHIMURIUM; SEQUENCE ANALYSIS, PROTEIN; SHIGELLA FLEXNERI; VIRULENCE;

EID: 80051498472     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023100     Document Type: Article

References (50)

1. Chu YW, Houang ET, Lyon DJ, Ling JM, Ng TK, et al. (1998) Antimicrobial resistance in Shigella flexneri and Shigella sonnei in Hong Kong, 1986 to 1995. Antimicrob Agents Chemother 42: 440-443.
2. Haukka K, Siitonen A, (2007) Emerging resistance to newer antimicrobial agents among Shigella isolated from Finnish foreign travellers. Epidemiology and Infection 136.
3. Monsalveo JC, Avila GG, Saavedra RR, Azorin AS, (2008) Shigellosis outbreak with 146 cases related to a fair. Gaceta Sanitaria 22: 35-39.
4. Prost LR, Miller SI, (2008) The Salmonellae PhoQ sensor: mechanisms of detection of phagosome signals. Cellular Microbiology 10: 576-582.
5. Vescovi EG, Soncini FC, Groisman EA, (1996) Mg2+ as an extracellular signal: Environmental regulation of Salmonella virulence. Cell 84: 165-174.
6. Groisman EA, (2001) The pleiotropic two-component regulatory system PhoP-PhoQ. Journal of Bacteriology 183: 1835-1842.
7. Moss JE, Fisher PE, Vick B, Groisman EA, Zychlinsky A, (2000) The regulatory protein PhoP controls susceptibility to the host inflammatory response in Shigella flexneri. Cellular Microbiology 2: 443-452.
8. Miller SI, Mekalanos JJ, (1990) Constitutive Expression of the PhoP Regulon Attenuates Salmonella Virulence and Survival within Macrophages. Journal of Bacteriology 172: 6.
9. Miura M, Terajima J, Izumiya H, Mitobe J, Komano T, et al. (2006) OspE2 of Shigella sonnei is required for the maintenance of cell architecture of bacterium-infected cells. Infection and Immunity 74: 2587-2595.
10. Roychoudhury S, Zielinski NA, Ninfa AJ, Allen NE, Jungheim LN, et al. (1993) Inhibitors of two-component signal transduction systems: inhibition of alginate gene activation in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A 90: 965-969.
11. Hentzer M, Wu H, Andersen JB, Riedel K, Rasmussen TB, et al. (2003) Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors. EMBO J 22: 3803-3815.
12. Giacometti A, Cirioni O, Ghiselli R, Dell'Acqua G, Orlando F, et al. (2005) RNAIII-inhibiting peptide improves efficacy of clinically used antibiotics in a murine model of staphylococcal sepsis. Peptides 26: 169-175.
13. Raffa RB, Iannuzzo JR, Levine DR, Saeid KK, Schwartz RC, et al. (2005) Bacterial communication ("quorum sensing") via ligands and receptors: a novel pharmacologic target for the design of antibiotic drugs. J Pharmacol Exp Ther 312: 417-423.
14. Rasmussen TB, Givskov M, (2006) Quorum-sensing inhibitors as anti-pathogenic drugs. International Journal of Medical Microbiology 296: 149-161.
15. Muller S, Feldman MF, Cornelis GR, (2001) The Type III secretion system of Gram-negative bacteria: a potential therapeutic target? Expert Opin Ther Targets 5: 327-339.
16. Costerton JW, Stewart PS, Greenberg EP, (1999) Bacterial biofilms: a common cause of persistent infections. Science 284: 1318-1322.
17. Aberg V, Almqvist F, (2007) Pilicides-small molecules targeting bacterial virulence. Org Biomol Chem 5: 1827-1834.
18. Rasko DA, Moreira CG, Li de R, Reading NC, Ritchie JM, et al. (2008) Targeting QseC signaling and virulence for antibiotic development. Science 321: 1078-1080.
19. Derzelle S, Turlin E, Duchaud E, Pages S, Kunst F, et al. (2004) The PhoP-PhoQ two-component regulatory system of Photorhabdus luminescens is essential for virulence in insects. Journal of Bacteriology 186: 1270-1279.
20. Guo L, Lim KB, Gunn JS, Bainbridge B, Darveau RP, et al. (1997) Regulation of lipid A modifications by Salmonella typhimurium virulence genes phoP-phoQ. Science 276: 250-253.
21. Rebeil R, Ernst RK, Gowen BB, Miller SI, Hinnebusch BJ, (2004) Variation in lipid A structure in the pathogenic yersiniae. Mol Microbiol 52: 1363-1373.
22. Ernst RK, (1999) Specific Lipopolysaccharide Found in Cystic Fibrosis Airway Pseudomonas aeruginosa. Science 286: 1561-1565.
23. Bader MW, Sanowar S, Daley ME, Schneider AR, Cho US, et al. (2005) Recognition of antimicrobial peptides by a bacterial sensor kinase. Cell 122: 461-472.
24. Bader MW, Navarre WW, Shiau W, Nikaido H, Frye JG, et al. (2003) Regulation of Salmonella typhimurium virulence gene expression by cationic antimicrobial peptides. Molecular Microbiology 50: 219-230.
25. Prost LR, Daley ME, Le Sage V, Bader MW, Le Moual H, et al. (2007) Activation of the bacterial sensor kinase PhoQ by acidic pH. Mol Cell 26: 165-174.
26. Murata T, Tseng W, Guina T, Miller SI, Nikaido H, (2007) PhoPQ-mediated regulation produces a more robust permeability barrier in the outer membrane of Salmonella enterica serovar typhimurium. Journal of Bacteriology 189: 7213-7222.
27. Lyon GJ, Muir TW, (2003) Chemical signaling among bacteria and its inhibition. Chem Biol 10: 1007-1021.
28. Hoch JA, (2000) Two-component and phosphorelay signal transduction. Curr Opin Microbiol 3: 165-170.
29. Jun Terajima EM, Kuratab T, Watanabe H, (1999) Preincubation of recombinant Ipa proteins of Shigella sonnei promotes entry of non-invasive Escherichia coli into HeLa cells. Microbial Pathogenesis 26: 223-230.
30. Wanner BL, Wilmes-Riesenberg MR, (1992) Involvement of phosphotransacetylase, acetate kinase, and acetyl phosphate synthesis in control of the phosphate regulon in Escherichia coli. Journal of Bacteriology 174: 2124-2130.
31. Silva JC, Haldimann A, Prahalad MK, Walsh CT, Wanner BL, (1998) In vivo characterization of the type A and B vancomycin-resistant enterococci (VRE) VanRS two-component systems in Escherichia coli: a nonpathogenic model for studying the VRE signal transduction pathways. Proc Natl Acad Sci U S A 95: 11951-11956.
32. Matsubara M, Mizuno T, (1999) EnvZ-independent phosphotransfer signaling pathway of the OmpR-mediated osmoregulatory expression of OmpC and OmpF in Escherichia coli. Biosci Biotechnol Biochem 63: 408-414.
33. Kim SK, Wilmes-Riesenberg MR, Wanner BL, (1996) Involvement of the sensor kinase EnvZ in the in vivo activation of the response-regulator PhoB by acetyl phosphate. Mol Microbiol 22: 135-147.
34. Hung DT, Shakhnovich EA, Pierson E, Mekalanos JJ, (2005) Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization. Science 310: 670-674.
35. Marra A, (2006) Targeting virulence for antibacterial chemotherapy: identifying and characterising virulence factors for lead discovery. Drugs R D 7: 1-16.
36. Cegelski L, Marshall GR, Eldridge GR, Hultgren SJ, (2008) The biology and future prospects of antivirulence therapies. Nat Rev Microbiol 6: 17-27.
37. Hughes DT, Sperandio V, (2008) Inter-kingdom signalling: communication between bacteria and their hosts. Nature Reviews Microbiology 6: 111-120.
38. Ward GE, Carey KL, Westwood NJ, (2002) Using small molecules to study big questions in cellular microbiology. Cellular Microbiology 4: 471-482.
39. Walsh DP, Chang YT, (2006) Chemical genetics. Chem Rev 106: 2476-2530.
40. Gauthier A, Robertson ML, Lowden M, Ibarra JA, Puente JL, et al. (2005) Transcriptional inhibitor of virulence factors in enteropathogenic Escherichia coli. Antimicrob Agents Chemother 49: 4101-4109.
41. Nordfelth R, Kauppi AM, Norberg HA, Wolf-Watz H, Elofsson M, (2005) Small-molecule inhibitors specifically targeting type III secretion. Infection and Immunity 73: 3104-3114.
42. Qin Z, Zhang J, Xu B, Chen L, Wu Y, et al. (2006) Structure-based discovery of inhibitors of the YycG histidine kinase New chemical leads to combat Staphylococcus epidermidis infections. BMC Microbiology 6: 96.
43. Macielag MJ, Goldschmidt R, (2000) Inhibitors of bacterial two-component signalling systems. Expert Opin Investig Drugs 9: 2351-2369.
44. Ewing TJA, Makino S, Skillman AG, Kuntz ID, (2001) DOCK 4.0: Search strategies for automated molecular docking of flexible molecule databases. Journal of Computer-Aided Molecular Design 15: 411-428.
45. Kuntz ID, (1992) Structure-based strategies for drug design and discovery. Science 257: 1078-1082.
46. Rarey M, Kramer B, Lengauer T, Klebe G, (1996) A fast flexible docking method using an incremental construction algorithm. Journal of Molecular Biology 261: 470-489.
47. Hapfelmeier S, Ehrbar K, Stecher B, Barthel M, Kremer M, (2004) Role of the Salmonella Pathogenicity Island 1 Effector Proteins SipA, SopB, SopE, and SopE2 in Salmonella enterica Subspecies 1 Serovar Typhimurium Colitis in Streptomycin-Pretreated Mice. Infection and Immunity 72: 795-809.
48. Murayama SY, Sakai T, Makino S, Kurata T, Sasakawa C, et al. (1986) The Use of Mice in the Sereny Test as a Virulence Assay of Shigellae and Enteroinvasive Escherichia-Coli. Infection and Immunity 51: 696-698.
49. Venkatesan MM, Hartman AB, Newland JW, Ivanova VS, Hale TL, et al. (2002) Construction, characterization, and animal testing of WRSd1, a Shigella dysenteriae 1 vaccine. Infection and Immunity 70: 2950-2958.
50. Miyoshi SI, Sasahara K, Akamatsu S, Rahman MM, Katsu T, et al. (1997) Purification and characterization of a hemolysin produced by Vibrio mimicus. Infection and Immunity 65: 1830-1835.