Constitutive NF-κB activation confers interleukin 6 (IL6) independence and resistance to dexamethasone and Janus kinase inhibitor INCB018424 in murine plasmacytoma cells

Journal of Biological Chemistry

Volumn 286, Issue 32, 2011, Pages 27988-27997

  Yang, Yanqiang ^a   Groshong, Jason S ^a   Matta, Hittu ^a,b   Gopalakrishnan, Ramakrishnan ^b   Yi, Han ^b   Chaudhary, Preet M ^a,b  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIAPOPTOTIC; BCL-2 FAMILY; DEXAMETHASONES; DISEASE PROGRESSION; ECTOPIC EXPRESSIONS; HUMAN T CELL LEUKEMIA VIRUS; IN-VITRO; INDUCED APOPTOSIS; INTERLEUKIN-6; INTRAPERITONEALLY; JANUS KINASE; MOLECULAR TOOLS; MYELOMA CELL; PLASMACYTOMA; PROTECTIVE EFFECTS; TAX PROTEIN;

CELL DEATH; ENZYMES; GENE EXPRESSION; MAMMALS; VIRUSES;

DRUG PRODUCTS;

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; CASPASE 3; DEXAMETHASONE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; K 13; PRISTANE; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; PROTEIN MCL 1; RUXOLITINIB; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; TAX PROTEIN; TUMOR NECROSIS FACTOR ALPHA; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS; MAP2K7 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; PYRAZOLE DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA CONTENT; ENZYME ACTIVATION; GEL MOBILITY SHIFT ASSAY; HUMAN T CELL LEUKEMIA VIRUS 1; IMMUNOBLOTTING; MOUSE; MULTIPLE MYELOMA; MYELOMA CELL; NONHUMAN; PARACRINE SIGNALING; PLASMACYTOMA; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR GROWTH; UPREGULATION; VIRAL GENE DELIVERY SYSTEM; ANIMAL; CANCER TRANSPLANTATION; CELL STRAIN HEK293; DRUG ANTAGONISM; DRUG EFFECT; DRUG RESISTANCE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; ISOGRAFT; METABOLISM; MUTATION; PATHOLOGY; TUMOR CELL LINE;

HUMAN HERPESVIRUS 8; HUMAN T-LYMPHOTROPIC VIRUS 1; MURINAE; MUS;

ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; CELL LINE, TUMOR; DEXAMETHASONE; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HUMANS; INTERLEUKIN-6; MAP KINASE KINASE 7; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 8; MUTATION; NEOPLASM TRANSPLANTATION; NF-KAPPA B; PLASMACYTOMA; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRAZOLES; TRANSPLANTATION, ISOGENEIC;

EID: 80051483056     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.213363     Document Type: Article

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