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Volumn 27, Issue 9, 2011, Pages 609-614

Evaluation of asymmetric dimethylarginine, nitric oxide levels and associated independent variables in obese and lean patients with polycystic ovarian syndrome

Author keywords

asymmetric dimethylarginine; cardiovascular; insulin resistance; nitric oxide; obesity; PCOS

Indexed keywords

FOLLITROPIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LUTEINIZING HORMONE; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE; PRASTERONE SULFATE; TESTOSTERONE; THYROTROPIN; TRIACYLGLYCEROL;

EID: 80051478473     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.3109/09513590.2010.507291     Document Type: Article
Times cited : (8)

References (47)
  • 5
    • 0032948363 scopus 로고    scopus 로고
    • Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: A prospective, controlled study in 254 affected women
    • DOI 10.1210/jc.84.1.165
    • Legro RS, Kunselman AR, Dodson WC, Dunaif A. Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women. J Clin Endocrinol Metab 1999;84:165-169. (Pubitemid 29036695)
    • (1999) Journal of Clinical Endocrinology and Metabolism , vol.84 , Issue.1 , pp. 165-169
    • Legro, R.S.1    Kunselman, A.R.2    Dodson, W.C.3    Dunaif, A.4
  • 7
    • 0030047162 scopus 로고    scopus 로고
    • Elevated ambulatory day-time blood pressure in women with polycystic ovary syndrome: A sign of a pre-hypertensive state?
    • Holte J, Gennarelli G, Berne C, Bergh T, Lithell H. Elevated ambulatory day-time blood pressure in women with polycystic ovary syndrome: a sign of a pre-hypertensive state? Hum Reprod 1996;11:23-28. (Pubitemid 26047667)
    • (1996) Human Reproduction , vol.11 , Issue.1 , pp. 23-28
    • Holte, J.1    Gennarelli, G.2    Berne, C.3    Bergh, T.4    Lithell, H.5
  • 8
    • 0042628161 scopus 로고    scopus 로고
    • Incidence and treatment of metabolic syndrome in newly referred women with confirmed polycystic ovarian syndrome
    • DOI 10.1016/S0026-0495(03)00104-5
    • Glueck CJ, Papanna R, Wang P, Goldenberg N, Sieve-Smith L. Incidence and treatment of metabolic syndrome in newly referred women with confirmed polycystic ovarian syndrome. Metabolism 2003;52:908-915. (Pubitemid 36957780)
    • (2003) Metabolism: Clinical and Experimental , vol.52 , Issue.7 , pp. 908-915
    • Glueck, C.J.1    Papanna, R.2    Wang, P.3    Goldenberg, N.4    Sieve-Smith, L.5
  • 9
    • 77952109594 scopus 로고    scopus 로고
    • Insulin resistance and adolescent girls with polycystic ovary syndrome
    • Bhattacharya SM, Ghosh M. Insulin resistance and adolescent girls with polycystic ovary syndrome. J Pediatr Adolesc Gynecol 2010;23:158-161.
    • (2010) J. Pediatr. Adolesc. Gynecol. , vol.23 , pp. 158-161
    • Bhattacharya, S.M.1    Ghosh, M.2
  • 11
    • 33747397670 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine is an independent risk factor for coronary heart disease: Results from the multicenter coronary artery risk determination investigating the influence of adma concentration cardiac study
    • Schulze F, Lenzen H, Hanefeld C, Bartling A, Osterziel KJ, Goudeva L, Schmidt-Lucke C, Kusus M, Maas R, Schwedhelm E, et al. Asymmetric dimethylarginine is an independent risk factor for coronary heart disease: results from the multicenter Coronary Artery Risk Determination investigating the Influence of ADMA Concentration (CARDIAC) study. Am Heart J 2006;152:493 e1-493 e8.
    • (2006) Am. Heart J. , vol.152
    • Schulze, F.1    Lenzen, H.2    Hanefeld, C.3    Bartling, A.4    Osterziel, K.J.5    Goudeva, L.6    Schmidt-Lucke, C.7    Kusus, M.8    Maas, R.9    Schwedhelm, E.10
  • 12
    • 0034698038 scopus 로고    scopus 로고
    • LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: Involvement of S-adenosylmethionine-dependent methyltransferases
    • Boger RH, Sydow K, Borlak J, Thum T, Lenzen H, Schubert B, Tsikas D, Bode-Boger SM. LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S- adenosylmethionine-dependent methyltransferases. Circ Res 2000;87:99-105. (Pubitemid 30616904)
    • (2000) Circulation Research , vol.87 , Issue.2 , pp. 99-105
    • Boger, R.H.1    Sydow, K.2    Borlak, J.3    Thum, T.4    Lenzen, H.5    Schubert, B.6    Tsikas, D.7    Bode-Boger, S.M.8
  • 13
    • 0028818990 scopus 로고
    • Response of cerebral blood vessels to an endogenous inhibitor of nitric oxide synthase
    • Faraci FM, Brian JE Jr, Heistad DD. Response of cerebral blood vessels to an endogenous inhibitor of nitric oxide synthase. Am J Physiol 1995;269:H1522-H1527. (Pubitemid 3005958)
    • (1995) The American journal of physiology , vol.269 , Issue.52
    • Faraci, F.M.1    Brian, J.E.2    Heistad, D.D.3
  • 14
    • 0041733065 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase
    • DOI 10.1161/01.ATV.0000081742.92006.59
    • Achan V, Broadhead M, Malaki M, Whitley G, Leiper J, MacAllister R, Vallance P. Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase. Arterioscler Thromb Vasc Biol 2003;23:1455-1459. (Pubitemid 36994536)
    • (2003) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.23 , Issue.8 , pp. 1455-1459
    • Achan, V.1    Broadhead, M.2    Malaki, M.3    Whitley, G.4    Leiper, J.5    MacAllister, R.6    Vallance, P.7
  • 15
    • 0027256181 scopus 로고
    • Effect of local intra-arterial asymmetric dimethylarginine (ADMA) on the forearm arteriolar bed of healthy volunteers
    • Calver A, Collier J, Leone A, Moncada S, Vallance P. Effect of local intra-arterial asymmetric dimethylarginine (ADMA) on the forearm arteriolar bed of healthy volunteers. J Hum Hypertens 1993;7:193-194. (Pubitemid 23138200)
    • (1993) Journal of Human Hypertension , vol.7 , Issue.2 , pp. 193-194
    • Calver, A.1    Collier, J.2    Leone, A.3    Moncada, S.4    Vallance, P.5
  • 17
    • 0035109723 scopus 로고    scopus 로고
    • Elevation of asymmetrical dimethylarginine may mediate endothelial dysfunction during experimental hyperhomocyst(e)inaemia in humans
    • DOI 10.1042/CS20000173
    • Boger RH, Lentz SR, Bode-Boger SM, Knapp HR, Haynes WG. Elevation of asymmetrical dimethylarginine may mediate endothelial dysfunction during experimental hyperhomocyst( e)inaemia in humans. Clin Sci (Lond) 2001;100:161-167. (Pubitemid 32165360)
    • (2001) Clinical Science , vol.100 , Issue.2 , pp. 161-167
    • Boger, R.H.1    Lentz, S.R.2    Bode-Boger, S.M.3    Knapp, H.R.4    Haynes, W.G.5
  • 18
    • 27744500087 scopus 로고    scopus 로고
    • ADMA and hyperhomocysteinemia
    • DOI 10.1191/1358863x05vm599oa
    • Dayal S, Lentz SR. ADMA and hyperhomocysteinemia. Vasc Med 2005;10 (Suppl 1):S27-S33. (Pubitemid 43137265)
    • (2005) Vascular Medicine , vol.10 , Issue.SUPPL. 1
    • Dayal, S.1    Lentz, S.R.2
  • 19
    • 0026548912 scopus 로고
    • Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure
    • Vallance P, Leone A, Calver A, Collier J, Moncada S. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 1992;339:572-575.
    • (1992) Lancet , vol.339 , pp. 572-575
    • Vallance, P.1    Leone, A.2    Calver, A.3    Collier, J.4    Moncada, S.5
  • 20
    • 77952430963 scopus 로고    scopus 로고
    • Relation of baseline plasma ADMA levels to cardiovascular morbidity and mortality at two years in men with diabetes mellitus referred for coronary angiography
    • Cavusoglu E, Ruwende C, Chopra V, Poludasu S, Yanamadala S, Frishman WH, Eng C, Pinsky DJ, Marmur JD. Relation of baseline plasma ADMA levels to cardiovascular morbidity and mortality at two years in men with diabetes mellitus referred for coronary angiography. Atherosclerosis 2010;210:226-231.
    • (2010) Atherosclerosis , vol.210 , pp. 226-231
    • Cavusoglu, E.1    Ruwende, C.2    Chopra, V.3    Poludasu, S.4    Yanamadala, S.5    Frishman, W.H.6    Eng, C.7    Pinsky, D.J.8    Marmur, J.D.9
  • 21
    • 42149132162 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine independently predicts fatal and nonfatal myocardial infarction and stroke in women: 24-Year follow-up of the population study of women in Gothenburg
    • DOI 10.1161/ATVBAHA.107.156596, PII 0004360520080500000028
    • Leong T, Zylberstein D, Graham I, Lissner L, Ward D, Fogarty J, Bengtsson C, Bjorkelund C, Thelle D. Asymmetric dimethylarginine independently predicts fatal and nonfatal myocardial infarction and stroke in women: 24-year follow-upof the population study of women in Gothenburg. Arterioscler Thromb Vasc Biol 2008;28:961-967. (Pubitemid 351544114)
    • (2008) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.28 , Issue.5 , pp. 961-967
    • Leong, T.1    Zylberstein, D.2    Graham, I.3    Lissner, L.4    Ward, D.5    Fogarty, J.6    Bengtsson, C.7    Bjorkelund, C.8    Thelle, D.9
  • 23
    • 0346725827 scopus 로고    scopus 로고
    • Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome
    • Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004;81:19-25.
    • (2004) Fertil. Steril. , vol.81 , pp. 19-25
  • 24
    • 0020448709 scopus 로고
    • 15N]nitrate in biological fluids
    • DOI 10.1016/0003-2697(82)90118-X
    • Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem 1982;126:131-138. (Pubitemid 13203451)
    • (1982) Analytical Biochemistry , vol.126 , Issue.1 , pp. 131-138
    • Green, L.C.1    Wagner, D.A.2    Glogowski, J.3
  • 26
    • 0035655992 scopus 로고    scopus 로고
    • Obesity, rather than menstrual cycle pattern or follicle cohort size, determines hyperinsulinaemia, dyslipidaemia and hypertension in ageing women with polycystic ovary syndrome
    • DOI 10.1046/j.1365-2265.2001.01412.x
    • Elting MW, Korsen TJ, Schoemaker J. Obesity, rather than menstrual cycle pattern or follicle cohort size, determines hyperinsulinaemia, dyslipidaemia and hypertension in ageing women with polycystic ovary syndrome. Clin Endocrinol (Oxf) 2001;55:767-776. (Pubitemid 34008748)
    • (2001) Clinical Endocrinology , vol.55 , Issue.6 , pp. 767-776
    • Elting, M.W.1    Korsen, T.J.M.2    Schoemaker, J.3
  • 27
    • 33644932595 scopus 로고    scopus 로고
    • Obesity free testosterone and cardiovascular risk factors in adolescents with polycystic ovary syndrome and regularly cycling adolescents
    • Glueck CJ, Morrison JA, Friedman LA, Goldenberg N, Stroop DM, Wang P. Obesity, free testosterone, and cardiovascular risk factors in adolescents with polycystic ovary syndrome and regularly cycling adolescents. Metabolism 2006;55:508-514.
    • (2006) Metabolism , vol.55 , pp. 508-514
    • Glueck, C.J.1    Morrison, J.A.2    Friedman, L.A.3    Goldenberg, N.4    Stroop, D.M.5    Wang, P.6
  • 28
    • 38349111105 scopus 로고    scopus 로고
    • The administration of estrogens combined with anti-androgens has beneficial effects on the hormonal features and asymmetric dimethyl-arginine levels in women with the polycystic ovary syndrome
    • Charitidou C, Farmakiotis D, Zournatzi V, Pidonia I, Pegiou T, Karamanis N, Hatzistilianou M, Katsikis I, Panidis D. The administration of estrogens, combined with anti-androgens, has beneficial effects on the hormonal features and asymmetric dimethyl-arginine levels, in women with the polycystic ovary syndrome. Atherosclerosis 2008;196:958-965.
    • (2008) Atherosclerosis , vol.196 , pp. 958-965
    • Charitidou, C.1    Farmakiotis, D.2    Zournatzi, V.3    Pidonia, I.4    Pegiou, T.5    Karamanis, N.6    Hatzistilianou, M.7    Katsikis, I.8    Panidis, D.9
  • 29
    • 52049126456 scopus 로고    scopus 로고
    • Metformin and oral contraceptive treatments reduced circulating asymmetric dimethylarginine ADMA levels in patients with polycystic ovary syndrome PCOS
    • Ozgurtas T, Oktenli C, Dede M, Tapan S, Kenar L, Sanisoglu SY, Yesilova Z, YenenMC, ErbilMK, Baser IY. Metformin and oral contraceptive treatments reduced circulating asymmetric dimethylarginine (ADMA) levels in patients with polycystic ovary syndrome (PCOS). Atherosclerosis 2008;200: 336-344.
    • (2008) Atherosclerosis , vol.200 , pp. 336-344
    • Ozgurtas, T.1    Oktenli, C.2    Dede, M.3    Tapan, S.4    Kenar, L.5    Sanisoglu, S.Y.6    Yesilova, Z.7    Yenen, M.C.8    Erbil, M.K.9    Baser, I.Y.10
  • 31
    • 67649297319 scopus 로고    scopus 로고
    • A comprehensive assessment of endothelial function in overweight women with and without polycystic ovary syndrome
    • Lond
    • Moran LJ, Hutchison SK, Meyer C, Zoungas S, Teede HJ. A comprehensive assessment of endothelial function in overweight women with and without polycystic ovary syndrome. Clin Sci (Lond) 2009;116:761-770.
    • (2009) Clin. Sci. , vol.116 , pp. 761-770
    • Moran, L.J.1    Hutchison, S.K.2    Meyer, C.3    Zoungas, S.4    Teede, H.J.5
  • 33
    • 34250770617 scopus 로고    scopus 로고
    • Serum leptin, oxidized low density lipoprotein and plasma asymmetric dimethylarginine levels and their relationship with dyslipidaemia in adolescent girls with polycystic ovary syndrome
    • DOI 10.1111/j.1365-2265.2007.02849.x
    • Demirel F, Bideci A, Cinaz P, Camurdan MO, Biberoglu G, Yesilkaya E, Hasanoglu A. Serum leptin, oxidized low density lipoprotein and plasma asymmetric dimethylarginine levels and their relationship with dyslipidaemia in adolescent girls with polycystic ovary syndrome. Clin Endocrinol (Oxf) 2007;67:129-134. (Pubitemid 46955452)
    • (2007) Clinical Endocrinology , vol.67 , Issue.1 , pp. 129-134
    • Demirel, F.1    Bideci, A.2    Cinaz, P.3    Camurdan, M.O.4    Biberoglu, G.5    Yesilkaya, E.6    Hasanoglu, A.7
  • 34
    • 77049092981 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine levels and carotid intima-media thickness in obese patients with polycystic ovary syndrome and their relationship to metabolic parameters
    • Pamuk BO, Torun AN, KulaksizogluM, Ertugrul D, Ciftci O, Kulaksizoglu S, Yildirim E, Demirag NG. Asymmetric dimethylarginine levels and carotid intima-media thickness in obese patients with polycystic ovary syndrome and their relationship to metabolic parameters. Fertil Steril 2010;93:1227-1233.
    • (2010) Fertil. Steril. , vol.93 , pp. 1227-1233
    • Pamuk, B.O.1    Torun, A.N.2    Kulaksizoglu, M.3    Ertugrul, D.4    Ciftci, O.5    Kulaksizoglu, S.6    Yildirim, E.7    Demirag, N.G.8
  • 35
    • 77956187425 scopus 로고    scopus 로고
    • Relationship between interleukin-6 levels and ambulatory blood pressure in women with polycystic ovary syndrome
    • in press
    • Kaya C, Pabuccu R, Koca C, Oguz AK, Erkan AF, Korkmaz A, Erbas D. Relationship between interleukin-6 levels and ambulatory blood pressure in women with polycystic ovary syndrome. Fertil Steril, in press.
    • Fertil. Steril.
    • Kaya, C.1    Pabuccu, R.2    Koca, C.3    Oguz, A.K.4    Erkan, A.F.5    Korkmaz, A.6    Erbas, D.7
  • 38
    • 57049117339 scopus 로고    scopus 로고
    • Polymorphisms of the endothelial nitric oxide synthase gene in premenopausal women with polycystic ovary syndrome
    • Walch K, Kolbus A, Hefler-Frischmuth K. Polymorphisms of the endothelial nitric oxide synthase gene in premenopausal women with polycystic ovary syndrome. Maturitas 2008;61: 256-259.
    • (2008) Maturitas , vol.61 , pp. 256-259
    • Walch, K.1    Kolbus, A.2    Hefler-Frischmuth, K.3
  • 39
    • 36849013997 scopus 로고    scopus 로고
    • Dimethylarginine dimethylaminohydrolase (DDAH): Expression, regulation, and function in the cardiovascular and renal systems
    • DOI 10.1152/ajpheart.00998.2007
    • Palm F, Onozato ML, Luo Z, Wilcox CS. Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems. Am J Physiol Heart Circ Physiol 2007;293:H3227-H3245. (Pubitemid 350230862)
    • (2007) American Journal of Physiology - Heart and Circulatory Physiology , vol.293 , Issue.6
    • Palm, F.1    Onozato, M.L.2    Luo, Z.3    Wilcox, C.S.4
  • 40
    • 0033594888 scopus 로고    scopus 로고
    • Novel mechanism for endothelial dysfunction: Dysregulation of dimethylarginine dimethylaminohydrolase
    • Ito A, Tsao PS, Adimoolam S, Kimoto M, Ogawa T, Cooke JP. Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. Circulation 1999;99:3092-3095. (Pubitemid 29289071)
    • (1999) Circulation , vol.99 , Issue.24 , pp. 3092-3095
    • Ito, A.1    Tsao, P.S.2    Adimoolam, S.3    Kimoto, M.4    Ogawa, T.5    Cooke, J.P.6
  • 41
    • 0035923560 scopus 로고    scopus 로고
    • Homocysteine impairs the nitric oxide synthase pathway role of asymmetric dimethylarginine
    • Stuhlinger MC, Tsao PS, Her JH, Kimoto M, Balint RF, Cooke JP. Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine. Circulation 2001;104:2569-2575. (Pubitemid 33104795)
    • (2001) Circulation , vol.104 , Issue.21 , pp. 2569-2575
    • Stuhlinger, M.C.1    Tsao, P.S.2    Her, J.-H.3    Kimoto, M.4    Balint, R.F.5    Cooke, J.P.6
  • 42
    • 33748177479 scopus 로고    scopus 로고
    • Adverse effects of cigarette smoke on no bioavailability: Role of arginine metabolism and oxidative stress
    • DOI 10.1161/01.HYP.0000231509.27406.42, PII 0000426820060800000022
    • Zhang WZ, Venardos K, Chin-Dusting J, Kaye DM. Adverse effects of cigarette smoke on NO bioavailability: role of arginine metabolism and oxidative stress. Hypertension 2006;48:278-285. (Pubitemid 44309824)
    • (2006) Hypertension , vol.48 , Issue.2 , pp. 278-285
    • Zhang, W.-Z.1    Venardos, K.2    Chin-Dusting, J.3    Kaye, D.M.4
  • 43
    • 2442643859 scopus 로고    scopus 로고
    • Plasma homocysteine in polycystic ovary syndrome: Does it correlate with insulin resistance and ethnicity?
    • DOI 10.1111/j.1365-2265.2004.02019.x
    • Wijeyaratne CN, Nirantharakumar K, Balen AH, Barth JH, Sheriff R, Belchetz PE. Plasma homocysteine in polycystic ovary syndrome: does it correlate with insulin resistance and ethnicity? Clin Endocrinol (Oxf) 2004;60:560-567. (Pubitemid 38669845)
    • (2004) Clinical Endocrinology , vol.60 , Issue.5 , pp. 560-567
    • Wijeyaratne, C.N.1    Nirantharakumar, K.2    Balen, A.H.3    Barth, J.H.4    Sheriff, R.5    Belchetz, P.E.6
  • 44
    • 0037385778 scopus 로고    scopus 로고
    • Insulin resistance in patients with polcystic ovary syndrome is associated with elevated plasma homocysteine
    • DOI 10.1093/humrep/deg190
    • Schachter M, Raziel A, Friedler S, Strassburger D, Bern O,Ron-El R. Insulin resistance in patients with polycystic ovary syndrome is associated with elevated plasma homocysteine. Hum Reprod 2003;18:721-727. (Pubitemid 36426948)
    • (2003) Human Reproduction , vol.18 , Issue.4 , pp. 721-727
    • Schachter, M.1    Raziel, A.2    Friedler, S.3    Strassburger, D.4    Bern, O.5    Ron-El, R.6
  • 46
    • 18844433823 scopus 로고    scopus 로고
    • Phenotypic variation in hyperandrogenic women influences the findings of abnormal metabolic and cardiovascular risk parameters
    • DOI 10.1210/jc.2004-2279
    • Carmina E, Chu MC, Longo RA, Rini GB, Lobo RA. Phenotypic variation in hyperandrogenic women influences the findings of abnormal metabolic and cardiovascular risk parameters. J Clin Endocrinol Metab 2005;90:2545-2549. (Pubitemid 40686289)
    • (2005) Journal of Clinical Endocrinology and Metabolism , vol.90 , Issue.5 , pp. 2545-2549
    • Carmina, E.1    Chu, M.C.2    Longo, R.A.3    Rini, G.B.4    Lobo, R.A.5


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