Dopamine receptor type 5 in the primary cilia has dual chemo-and mechano-sensory roles

Hypertension

Volumn 58, Issue 2, 2011, Pages 325-331

  Abdul Majeed, Shakila ^a   Nauli, Surya M ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

Dopamine receptors; polycystic kidney disease; primary cilia; vascular endothelia

Indexed keywords

ACTIN; COFILIN; DOPAMINE; DOPAMINE 5 RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTERY; ARTICLE; CELL CULTURE; CELL FUNCTION; CELL MUTANT; CELL STRUCTURE; CELLULAR DISTRIBUTION; CHEMOSENSITIVITY; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; ENDOTHELIUM CELL; GENE SILENCING; IN VIVO STUDY; KIDNEY POLYCYSTIC DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN POLYMERIZATION; SENSORY SYSTEM; SHEAR STRESS; VASCULAR ENDOTHELIAL PRIMARY CILIA; VASCULAR ENDOTHELIUM; WILD TYPE;

ACTINS; ANIMALS; CELLS, CULTURED; CHEMORECEPTOR CELLS; CILIA; COFILIN 1; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FEMORAL ARTERY; MECHANORECEPTORS; MICE; PHOSPHORYLATION; RECEPTORS, DOPAMINE D5;

EID: 80051469652     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.111.172080     Document Type: Article

References (37)

1. Nauli SM, Haymour HS, AbouAlaiwi WA, Lo ST, Nauli AM. Primary cilia are mechanosensory organelles in vestibular tissues. Mechanosensitiv Mechanotransduct. 2011;4:317-350.
2. Nauli SM, Rossetti S, Kolb RJ, Alenghat FJ, Consugar MB, Harris PC, Ingber DE, Loghman-Adham M, Zhou J. Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction. J Am Soc Nephrol. 2006;17:1015-1025.
3. Xu C, Rossetti S, Jiang L, Harris PC, Brown-Glaberman U, Wandinger-Ness A, Bacallao R, Alper SL. Human ADPKD primary cyst epithelial cells with a novel, single codon deletion in the PKD1 gene exhibit defective ciliary polycystin localization and loss of flow-induced Ca2 signaling. Am J Physiol. 2007;292:F930-F945. (Pubitemid 46393419)
4. Xu C, Shmukler BE, Nishimura K, Kaczmarek E, Rossetti S, Harris PC, Wandinger-Ness A, Bacallao RL, Alper SL. Attenuated, flow-induced ATP release contributes to absence of flow-sensitive, purinergic Cai2 signaling in human ADPKD cyst epithelial cells. Am J Physiol. 2009; 296:F1464-F1476.
5. Ecder T, Schrier RW. Cardiovascular abnormalities in autosomaldominant polycystic kidney disease. Nat Rev. 2009;5:221-228.
6. Harris PC, Torres VE. Polycystic kidney disease. Ann Rev Med. 2009; 60:321-337.
7. AbouAlaiwi WA, Takahashi M, Mell BR, Jones TJ, Ratnam S, Kolb RJ, Nauli SM. Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades. Circ Res. 2009;104:860-869.
8. Nauli SM, Kawanabe Y, Kaminski JJ, Pearce WJ, Ingber DE, Zhou J. Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1. Circulation. 2008;117: 1161-1171. (Pubitemid 351544064)
9. Zeng C, Armando I, Luo Y, Eisner GM, Felder RA, Jose PA. Dysregulation of dopamine-dependent mechanisms as a determinant of hypertension: studies in dopamine receptor knockout mice. Am J Physiol Heart Circ Physiol. 2008;294:H551-H569. (Pubitemid 351253262)
10. Johns DW, Ayers CR, Carey RM. The dopamine agonist bromocriptine induces hypotension by venous and arteriolar dilation. J Cardiovasc Pharmacol. 1984;6:582-587. (Pubitemid 14089224)
11. Yamauchi M, Kobayashi Y, Shimoura K, Hattori K, Nakase A. Endothelium-dependent and-independent relaxation by dopamine in the rabbit pulmonary artery. Clin Exper Pharmacol Physiol. 1992;19:401-410.
12. Ohlstein EH, Zabko-Potapovich B, Berkowitz BA. Studies on vascular dopamine receptors with the dopamine receptor agonist: SK&F 82526. J Pharmacol Exp Ther. 1984;229:433-439. (Pubitemid 14149032)
13. Sato M, Soma M, Nakayama T, Kanmatsuse K. Dopamine D1 receptor gene polymorphism is associated with essential hypertension. Hypertension. 2000; 36:183-186. (Pubitemid 30626986)
14. Sowers JR, Nyby M, Jasberg K. Dopaminergic control of prolactin and blood pressure: altered control in essential hypertension. Hypertension. 1982;4:431-437.
15. Thomas GN, Tomlinson B, Critchley JA. Modulation of blood pressure and obesity with the dopamine D2 receptor gene TaqI polymorphism. Hypertension. 2000;36:177-182. (Pubitemid 30626985)
16. Albrecht FE, Drago J, Felder RA, Printz MP, Eisner GM, Robillard JE, Sibley DR, Westphal HJ, Jose PA. Role of the D1A dopamine receptor in the pathogenesis of genetic hypertension. J Clin Investig. 1996;97: 2283-2288.
17. Asico L, Zhang X, Jiang J, Cabrera D, Escano CS, Sibley DR, Wang X, Yang Y, Mannon R, Jones JE, Armando I, Jose PA. Lack of renal dopamine D5 receptors promotes hypertension. J Am Soc Nephrol. 2010; 22:82-89.
18. Hollon TR, Bek MJ, Lachowicz JE, Ariano MA, Mezey E, Ramachandran R, Wersinger SR, Soares-da-Silva P, Liu ZF, Grinberg A, Drago J, Young WS III, Westphal H, Jose PA, Sibley DR. Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive. J Neurosci. 2002;22:10801-10810. (Pubitemid 36005154)
19. Barendregt JN, Florijn KW, Muizert Y, Chang PC. Borderline hypertensive autosomal dominant polycystic kidney disease patients have enhanced production of renal dopamine: normalization of renal haemodynamics by DOPA infusion. Nephrol Dial Transplant. 1995;10: 1332-1341.
20. Lu CJ, Du H, Wu J, Jansen DA, Jordan KL, Xu N, Sieck GC, Qian Q. Non-random distribution and sensory functions of primary cilia in vascular smooth muscle cells. Kidney Blood Press Res. 2008;31:171-184. (Pubitemid 351915044)
21. Wu J, Du H, Wang X, Mei C, Sieck GC, Qian Q. Characterization of primary cilia in human airway smooth muscle cells. Chest. 2009;136: 561-570.
22. Kim J, Lee JE, Heynen-Genel S, Suyama E, Ono K, Lee K, Ideker T, Aza-Blanc P, Gleeson JG. Functional genomic screen for modulators of ciliogenesis and cilium length. Nature. 2010;464:1048-1051.
23. Pitaval A, Tseng Q, Bornens M, Thery M. Cell shape and contractility regulate ciliogenesis in cell cycle-arrested cells. J Cell Biol. 2010;191: 303-312.
24. Sharma N, Kosan ZA, Stallworth JE, Berbari NF, Yoder BK. Soluble levels of cytosolic tubulin regulate ciliary length control. Mol Biol Cell. 2011;22:806-816.
25. Moriyama K, Iida K, Yahara I. Phosphorylation of Ser-3 of cofilin regulates its essential function on actin. Genes Cells. 1996;1:73-86. (Pubitemid 126673108)
26. Nebl G, Meuer SC, Samstag Y. Dephosphorylation of serine 3 regulates nuclear translocation of cofilin. J Biol Chem. 1996;271:26276-26280. (Pubitemid 26347477)
27. Duan Y, Gotoh N, Yan Q, Du Z, Weinstein AM, Wang T, Weinbaum S. Shear-induced reorganization of renal proximal tubule cell actin cytoskeleton and apical junctional complexes. Proc Natl Acad Sci USA. 2008;105:11418-11423.
28. AbouAlaiwi WA, Ratnam S, Booth RL, Shah JV, Nauli SM. Endothelial cells from humans and mice with polycystic kidney disease are characterized by polyploidy and chromosome segregation defects through survivin down-regulation. Hum Mol Genet. 2011;20:354-367.
29. Davenport JR, Watts AJ, Roper VC, Croyle MJ, van Groen T, Wyss JM, Nagy TR, Kesterson RA, Yoder BK. Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease. Curr Biol. 2007;17:1586-1594. (Pubitemid 47380400)
30. Masyuk AI, Gradilone SA, Banales JM, Huang BQ, Masyuk TV, Lee SO, Splinter PL, Stroope AJ, Larusso NF. Cholangiocyte primary cilia are chemosensory organelles that detect biliary nucleotides via P2Y12 purinergic receptors. Am J Physiol Gastrointest Liver Physiol. 2008;295: G725-G734.
31. AbouAlaiwi WA, Lo ST, Nauli SM. Primary cilia: highly sophisticated biological sensors. Sensors. 2009;9:7003-7020.
32. Hierck BP, Van der Heiden K, Alkemade FE, Van de Pas S, Van Thienen JV, Groenendijk BC, Bax WH, Van der Laarse A, Deruiter MC, Horrevoets AJ, Poelmann RE. Primary cilia sensitize endothelial cells for fluid shear stress. Dev Dyn. 2008;237:725-735. (Pubitemid 351398038)
33. Du H, Wang X, Wu J, Qian Q. Phenylephrine induces elevated RhoA activation and smooth muscle-actin expression in Pkd2/vascular smooth muscle cells. Hypertens Res. 2010;33:37-42.
34. Yuen EY, Yan Z. Dopamine D4 receptors regulate AMPA receptor trafficking and glutamatergic transmission in GABAergic interneurons of prefrontal cortex. J Neurosci. 2009;29:550-562.
35. Graziane NM, Yuen EY, Yan Z. Dopamine D4 receptors regulate GABAA receptor trafficking via an actin/cofilin/myosin-dependent mechanism. J Biol Chem. 2009;284:8329-8336.
36. Nauli SM, Alenghat FJ, Luo Y, Williams E, Vassilev P, Li X, Elia AE, Lu W, Brown EM, Quinn SJ, Ingber DE, Zhou J. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet. 2003;33:129-137. (Pubitemid 36177063)
37. Siroky BJ, Ferguson WB, Fuson AL, Xie Y, Fintha A, Komlosi P, Yoder BK, Schwiebert EM, Guay-Woodford LM, Bell PD. Loss of primary cilia results in deregulated and unabated apical calcium entry in ARPKD collecting duct cells. Am J Physiol. 2006;290:F1320-F1328. (Pubitemid 43830756)