Analysis of the contribution of I to to repolarization in canine ventricular myocardium

British Journal of Pharmacology

Volumn 164, Issue 1, 2011, Pages 93-105

  Virag L ^a   Jost, N ^b   Papp, R ^a   Koncz, I ^a   Kristof A ^b   Kohajda, Z ^b   Harmati, G ^c   Carbonell Pascual, B ^d   Ferrero Jr , J M ^d   Papp, J G ^a   Nanasi P P ^c   Varro A ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c UNIVERSITY OF DEBRECEN   (Hungary)

^d UNIVERSITAT POLITÈCNICA DE VALÈNCIA   (Spain)

Author keywords

action potential duration; arrhythmia; cardiac ventricular muscle; repolarization reserve; transient outward current

Indexed keywords

CHROMANOL 293B; DOFETILIDE; N [3 HYDROXY 2,2 DIMETHYL 6 (4,4,4 TRIFLUOROBUTOXY)CHROMAN 4 YL] N METHYLMETHANESULFONAMIDE;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; COMPUTER SIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOG; FEMALE; HEART MUSCLE CELL; HEART REPOLARIZATION; MALE; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; TRANSIENT OUTWARD POTASSIUM CURRENT; VOLTAGE CLAMP;

ACTION POTENTIALS; ANIMALS; CHROMANS; DOGS; FEMALE; HEART CONDUCTION SYSTEM; HEART VENTRICLES; MALE; MYOCARDIUM; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; PHENETHYLAMINES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; SULFONAMIDES; VENTRICULAR FUNCTION;

EID: 79961245166     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01331.x     Document Type: Article

References (46)

1. to. Am J Physiol Heart Circ Physiol 286: H602-H609. (Pubitemid 38140340)
2. Antzelevitch C, (2006). Brugada syndrome. Pacing Clin Electrophysiol 29: 1130-1159. (Pubitemid 44581402)
3. Antzelevitch C, Sicouri S, Litovsky SH, Lukas A, Krishnan SC, Di Diego JM, et al,. (1991). Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial, and M cells. Circ Res 69: 1427-1449.
4. + currents in isolated human ventricular myocytes from patients with terminal heart failure. Circ Res 73: 379-385. (Pubitemid 23212118)
5. + current, on repolarization in human and guinea pig ventricular myocytes. Cardiovasc Res 38: 441-450. (Pubitemid 28294162)
6. Burashnikov A, Antzelevitch C, (2002). Prominent I(Ks) in epicardium and endocardium contributes to development of transmural dispersion of repolarization but protects against development of early afterdepolarizations. J Cardiovasc Electrophysiol 13: 172-177. (Pubitemid 34211922)
7. Campbell DL, Rasmusson RL, Qu Y, Strauss HC, (1993). The calcium-independent transient outward potassium current in isolated ferret right ventricular myocytes. I. Basic characterization and kinetic analysis. J Gen Physiol 101: 571-601. (Pubitemid 23123422)
8. Decker KF, Heijman J, Silva JR, Hund TJ, Rudy Y, (2009). Properties and ionic mechanisms of action potential adaptation, restitution, and accommodation in canine epicardium. Am J Physiol Heart Circ Physiol 296: H1017-H1026.
9. Diochot S, Drici MD, Moinier D, Fink M, Lazdunski M, (1999). Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis. Br J Pharmacol 126: 251-263. (Pubitemid 29041765)
10. El-Atat FA, McFarlane SI, Sowers JR, Bigger JT, (2004). Sudden cardiac death in patients with diabetes. Curr Diab Rep 4: 187-193. (Pubitemid 38899148)
11. Frank-Hansen R, Larsen LA, Andersen P, Jespersgaard C, Christiansen M, (2005). Mutations in the genes KCND2 and KCND3 encoding the ion channels Kv4.2 and Kv4.3, conducting the cardiac fast transient outward current (ITO,f), are not a frequent cause of long QT syndrome. Clin Chim Acta 351: 95-100. (Pubitemid 39563561)
12. Gebauer M, Isbrandt D, Sauter K, Callsen B, Nolting A, Pongs O, et al,. (2004). N-type inactivation features of Kv4.2 channel gating. Biophys J 86: 210-223. (Pubitemid 38067449)
13. Greenstein JL, Wu R, Po S, Tomaselli GF, Winslow RL, (2000). Role of the calcium-independent transient outward current I(to1) in shaping action potential morphology and duration. Circ Res 87: 1026-1033.
14. Han W, Wang Z, Nattel S, (2000). A comparison of transient outward currents in canine cardiac Purkinje cells and ventricular myocytes. Am J Physiol 279: H466-H474.
15. Hiraoka M, Kawano S, (1989). Calcium-sensitive and insensitive transient outward current in rabbit ventricular myocytes. J Physiol 410: 187-212. (Pubitemid 19075139)
16. Hoppe UC, Marban E, Johns DC, (2000). Molecular dissection of cardiac repolarization by in vivo Kv4.3 gene transfer. J Clin Invest 105: 1077-1084. (Pubitemid 30217692)
17. Iost N, Virág L, Varró A, Papp JG, (2003). Comparison of the effect of class IA antiarrhythmic drugs on transmembrane potassium currents in rabbit ventricular myocytes. J Cardiovasc Pharmacol Ther 8: 31-41. (Pubitemid 36363209)
18. Ks in human ventricular muscle. Circulation 112: 1392-1399. (Pubitemid 41291763)
19. Kaab S, Nuss HB, Chiamvimonvat N, O'Rourke B, Pak PH, Kass DA, et al,. (1996). Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure. Circ Res 78: 262-273. (Pubitemid 26040856)
20. Lengyel C, Virág L, Bíró T, Jost N, Magyar J, Biliczki P, et al,. (2007). Diabetes mellitus attenuates the repolarization reserve in mammalian heart. Cardiovasc Res 73: 512-520. (Pubitemid 46073948)
21. Li GR, Du XL, Siow YL, O K, Tse HF, Lau CP, (2003). Calcium-activated transient outward chloride current and phase 1 repolarization of swine ventricular action potential. Cardiovasc Res 58: 89-98. (Pubitemid 36351625)
22. to1 in myocytes isolated from the human right ventricle. Am J Physiol 275: H369-H377.
23. Litovsky SH, Antzelevitch C, (1989). Rate dependence of action potential duration and refractoriness in canine ventricular endocardium differs from that of epicardium: role of the transient outward current. J Am Coll Cardiol 14: 1053-1066. (Pubitemid 19250598)
24. Magyar J, Rusznák Z, Szentesi P, Szucs G, Kovács L, (1992). Action potentials and potassium currents in rat ventricular muscle during experimental diabetes. J Mol Cell Cardiol 24: 841-853.
25. Näbauer M, Beuckelmann DJ, Erdmann E, (1993). Characteristics of transient outward current in human ventricular myocytes from patients with terminal heart failure. Circ Res 73: 386-394. (Pubitemid 23212119)
26. Näbauer M, Beuckelmann DJ, Uberfuhr P, Steinbeck G, (1996). Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle. Circulation 93: 168-177. (Pubitemid 26006581)
27. to', phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms. J Physiol 569: 7-39. (Pubitemid 41701374)
28. Priebe L, Beuckelmann DJ, (1998). Simulation study of cellular electric properties in heart failure. Circ Res 82: 1206-1223. (Pubitemid 28311128)
29. Radicke S, Cotella D, Graf EM, Ravens U, Wettwer E, (2005). Expression and function of dipeptidyl-aminopeptidase-like protein 6 as a putative beta-subunit of human cardiac transient outward current encoded by Kv4.3. J Physiol 565: 751-756. (Pubitemid 40903290)
30. + current and prolongation of the guinea-pig ventricular action potential by 4-aminopyridine. J Physiol 549: 667-672. (Pubitemid 36889760)
31. Sah R, Ramirez RJ, Oudit GY, Gidrewicz D, Trivieri MG, Zobel C, et al,. (2003). Regulation of cardiac excitation-contraction coupling by action potential repolarization: role of the transient outward potassium current (I(to)). J Physiol 546: 5-18. (Pubitemid 36104968)
32. Sanguinetti MC, Johnson JH, Hammerland LG, Kelbaugh PR, Volkmann RA, Saccomano NA, et al,. (1997). Heteropodatoxins: peptides isolated from spider venom that block Kv4.2 potassium channels. Mol Pharmacol 51: 491-498. (Pubitemid 27118486)
33. + currents in rat ventricular myocytes. Circ Res 74: 620-628. (Pubitemid 24088522)
34. i-dependent chloride current in single Purkinje cells from rabbit heart. J Physiol 468: 641-667. (Pubitemid 23254467)
35. i-dependent membrane currents in guinea-pig ventricular cells in the absence of Na/Ca exchange. Pflugers Arch 430: 871-878.
36. Sun ZQ, Thomas GP, Antzelevitch C, (2001). Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes. J Cardiovasc Electrophysiol 12: 472-478. (Pubitemid 32324664)
37. to) in shaping canine ventricular action potential-a dynamic clamp study. J Physiol 564: 411-419. (Pubitemid 40585042)
38. Tomaselli GF, Zipes DP, (2004). What causes sudden death in heart failure? Circ Res 95: 754-763. (Pubitemid 39390577)
39. Tseng GN, Hoffman BF, (1989). Two components of transient outward current in canine ventricular myocytes. Circ Res 64: 633-647. (Pubitemid 19105300)
40. Van Bogaert PP, Snyders DJ, (1982). Effects of 4-aminopyridine on inward rectifying and pacemaker currents of cardiac Purkinje fibres. Pflugers Arch 394: 230-238. (Pubitemid 12009833)
41. Ks in dog ventricular muscle and Purkinje fibre repolarization. J Physiol 523: 67-81. (Pubitemid 30135822)
42. Virág L, Varró A, Papp JG, (1998). Effect of disopyramide on potassium currents in rabbit ventricular myocytes. Naunyn Schmiedebergs Arch Pharmacol 357: 268-275. (Pubitemid 28112576)
43. Wettwer E, Amos GJ, Posival H, Ravens U, (1994). Transient outward current in human ventricular myocytes of subepicardial and subendocardial origin. Circ Res 75: 473-482. (Pubitemid 24256408)
44. Zicha S, Xiao L, Stafford S, Cha TJ, Han W, Varro A, et al,. (2004). Transmural expression of transient outward potassium current subunits in normal and failing canine and human hearts. J Physiol 561: 735-748. (Pubitemid 40074931)
45. Zygmunt AC, (1994). Intracellular calcium activates a chloride current in canine ventricular myocytes. Am J Physiol 267: H1984-H1995.
46. Zygmunt AC, Robitelle DC, Eddlestone GT, (1997). Ito1 dictates behavior of ICl(Ca) during early repolarization of canine ventricle. Am J Physiol 273: H1096-H1106.