Aberrant methylation of RARβ2and APC genes in voided urine as molecular markers for early detection of bilharzial and nonbilharzial bladder cancer

Cancer Epidemiology Biomarkers and Prevention

Volumn 20, Issue 8, 2011, Pages 1657-1664

  Eissa, Sanaa ^a   Swellam, Menha ^d   El Khouly, Inas M ^a   Kassim, Samar K ^a   Shehata, Hanan ^a   Mansour, Amal ^a   Esmat, Mohamed ^b   Nossier, Ahmed Ibrahim ^f   Hamdy, Mohamed A ^e   Awad, Nahla M ^b   El Ahmady, Omar ^c  

^a Faculty of Computer Science   (Egypt)

^b AIN SHAMS UNIVERSITY   (Egypt)

^c Ain Shams University   (Egypt)

^d CAIRO UNIVERSITY   (Egypt)

^e CAIRO UNIVERSITY   (Egypt)

^f MISR UNIVERSITY FOR SCIENCE AND TECHNOLOGY   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

TUMOR MARKER; DNA; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR, BETA2, HUMAN;

ADULT; AGED; ARTICLE; BLADDER CANCER; CANCER DIAGNOSIS; CANCER GRADING; CANCER PATIENT; CANCER STAGING; CONTROLLED STUDY; DNA METHYLATION; EARLY DIAGNOSIS; EPIGENETICS; FEMALE; GENE; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAR BETA 2 GENE; RETROSPECTIVE STUDY; SCHISTOSOMIASIS; SENSITIVITY AND SPECIFICITY; TUMOR SUPPRESSOR GENE; URINALYSIS; URINE CYTOLOGY; ANIMAL; BLADDER TUMOR; CASE CONTROL STUDY; GENETICS; ISOLATION AND PURIFICATION; MIDDLE AGED; PARASITOLOGY; SCHISTOSOMA HEMATOBIUM; SCHISTOSOMIASIS HAEMATOBIA; URINE;

ADULT; AGED; ANIMALS; CASE-CONTROL STUDIES; DNA METHYLATION; DNA, NEOPLASM; FEMALE; GENES, APC; HUMANS; MALE; MIDDLE AGED; RECEPTORS, RETINOIC ACID; RETROSPECTIVE STUDIES; SCHISTOSOMA HAEMATOBIUM; SCHISTOSOMIASIS HAEMATOBIA; TUMOR MARKERS, BIOLOGICAL; URINARY BLADDER NEOPLASMS; YOUNG ADULT;

EID: 79961238006     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-11-0237     Document Type: Article

References (26)

1. Gutiérrez M, Siraj A, Khaled H, Koon N, El-Rifai W, Bhatia K. CpG island methylation in Schistosoma- and non-Schistosoma-associated bladder cancer. Mod Pathol 2004;17:1268-74. (Pubitemid 39312953)
2. National Cancer Institute registry. The national cancer registry newsletter, Ministry of Health and Population, Egypt. 2002.
3. Kitamura H, Tsukamoto T. Early bladder cancer: concept, diagnosis, and management. Int J Clin Oncol 2006;11:28-37. (Pubitemid 43320324)
4. Eissa S, Swellam M, Labib RA, Mansour A, El-Malt O, Tash FM. Detection of telomerase in urine by three methods: evaluation of diagnostic accuracy of bladder cancer. J Urol 2007;178:1068-72. (Pubitemid 47211050)
5. Eissa S, Labib RA, Swellam M, Bassiony M, Tash FM, Al-Zayat TM. Noninvasive diagnosis of bladder cancer by detection of matrix metalloproteinases (MMP-2 and MMP-9) and their inhibitor (TIMP-2) in urine. Eur Urol 2007;52:1388-97. (Pubitemid 47445978)
6. Eissa S, Salem AM, Zohny SF, Hegazy MG. The diagnostic efficacy of urinary TGF-beta1 and VEGF in bladder cancer: comparison with voided urine cytology. Cancer Biomarker 2007;3:275-80.
7. Eissa S, Zohny SF, Swellam M, Mahmoud MH, El-Zayat TM, Salem AM. Comparison of CD44 and cytokeratin 20 mRNA in voided urine samples as diagnostic tools for bladder cancer. Clin Biochem 2008;41:1335-41.
8. Eissa S, Swellam M, Labib RA, El-Zayat T, El Ahmady O. A panel of angiogenic factors for early bladder cancer detection: enzyme immunoassay and Western blot. J Urol 2009;181;1353-60.
9. Eissa S, Zohny SF, Zekri AR, El-Zayat TM, Maher AM. Diagnostic value of fibronectin and mutant p53 in the urine of patients with bladder cancer: impact on clinicopathological features and disease recurrence. Med Oncol 2010;27:1286-91.
10. Eissa S, Swellam M, Shehata H, El-Khouly IM, El-Zayat T, El-Ahmady O. Expression of HYAL1 and survivin RNA as diagnostic molecular markers for bladder cancer. J Urol 2010;183:493-8.
11. Eissa S, Shabayek MI, Ismail MF, El-Allawy RM, Hamdy MA. Diagnostic evaluation of apoptosis inhibitory gene and tissue inhibitor matrix metalloproteinase-2 in patients with bladder cancer. IUBMB L ife 2010;62:394-9.
12. Chan MWY, Chan LW, Tang NLS, Tong JHM, Lo KW, Lee TL, et al. Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients. Clin Can Res 2002;8:464-70. (Pubitemid 34193966)
13. Kim YK, Kim WJ. Epigenetic markers as promising prognosticators for bladder cancer. Int J Urol 2009;16:17-22.
14. American Joint Committee on Cancer (AJCC), cancer staging manual, 5th ed. Philadelphia, PA: Lippincott; Pa-Raven Publishers. 1997;241.
15. Sobin LH, Wittkind CH. UICC TNM classification of malignant tumors, 5th ed., New York: Wiley Liss; 1997. p. 187.
16. Papanicolaou GN, Marshall VF. Urine sediment smears as a diagnostic procedure in cancers of the urinary tract. Science 1945;101:519-23.
17. Gui M, Idris MA, Shi YE, Muhling A, Ruppel A. Reactivity of Schistosoma japonicum and S. mansoni antigen preparations in indirect haemagglutination (IHA) with sera of patients with homologous and heterogonous schistosomiasis. Ann Trop Med Parasitol 1991;85:599-604.
18. Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A. 1996;93:9821-6. (Pubitemid 26296693)
19. Esteller M, Sparks A, Toyota M, Sanchez-Cespedes M, Capella G, Peinado MA, et al. Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer. Cancer Res 2000;60:4366-71. (Pubitemid 32103613)
20. Sambrook J, Russell DW. Molecular cloning: a laboratory manual. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press; 2001;5:14.
21. Sackett DL, Haynes RB, Guyatt GH, Tugwell P. Clinical epidemiology. 2nd ed. Boston: Little Brown; 1991.
22. Seifert HH, Schmiemann V, Mueller M, Kazimirek M, Onofre F, Neuhausen A, et al. In situ detection of global DNA hypomethylation in exfoliative urine cytology of patients with suspected bladder cancer. Exp Mol Pathol 2007;82:292-7. (Pubitemid 46686656)
23. Negraes PD, Favaro FP, Camargo JL, Oliveira ML, Goldberg J, Rainho CA, et al. DNA methylation patterns in bladder cancer and washing cell sediments: a perspective for tumor recurrence detection. BMC Cancer 2008;8:238-41.
24. Hirao Y, Kim WJ, Fujimoto K. Environmental factors promoting bladder cancer. Curr Opin Urol 2009;19:494-9.
25. Felix AS, Soliman AS, Khaled H, Zaghloul MS, Banerjee M, El-Baradie M, et al. The changing patterns of bladder cancer in Egypt over the past 26 years. Cancer Causes Control 2008;19:421-9.
26. Konety BR. Molecular markers in bladder cancer: a critical appraisal. Urol Oncol 2006;24:326-37. (Pubitemid 43963409)