Structural mechanisms of DIAP1 auto-inhibition and DIAP1-mediated inhibition of drICE

Nature Communications

Volumn 2, Issue 1, 2011, Pages

  Li, Xiaochun ^a   Wang, Jiawei ^a   Shi, Yigong ^a  

^a TSINGHUA UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; DROSOPHILA PROTEIN; EFFECTOR CASPASE; INHIBITOR OF APOPTOSIS PROTEIN 1; PROTEIN DRICE; UNCLASSIFIED DRUG; CASPASE; ICE PROTEIN, DROSOPHILA; INHIBITOR OF APOPTOSIS PROTEIN; THREAD PROTEIN, DROSOPHILA;

AMINO TERMINAL SEQUENCE; ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME CONFORMATION; ENZYME INHIBITION; NONHUMAN; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; CONFORMATION; CRYSTALLIZATION; DOWN REGULATION; DROSOPHILA MELANOGASTER; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; CASPASES; CRYSTALLIZATION; DOWN-REGULATION; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INHIBITOR OF APOPTOSIS PROTEINS; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 79961196239     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms1418     Document Type: Article

References (40)

1. Thornberry, N. A. & Lazebnik, Y. Caspases: Enemies within. Science 281, 1312-1316 (1998). (Pubitemid 28406817)
2. Yan, N. & Shi, Y. Mechanisms of apoptosis through structural biology. Annu. Rev. Cell Dev. Biol. 21, 35-56 (2005). (Pubitemid 41740626)
3. Pop, C. & Salvesen, G. Human caspases: Activation, specificity, and regulation. J. Biol. Chem. 284, 21777-21781 (2009).
4. Shi, Y. Mechanisms of caspase inhibition and activation during apoptosis. Mol. Cell 9, 459-470 (2002). (Pubitemid 34273778)
5. Riedl, S. J. & Shi, Y. Molecular mechanisms of caspase regulation during apoptosis. Nat. Rev. Mol. Cell. Biol. 5, 897-907 (2004). (Pubitemid 39486541)
6. Gyrd-Hansen, M. & Meier, P. IAPs: From caspase inhibitors to modulators of NF-kappaB, inflammation and cancer. Nat. Rev. Cancer 10, 561-574 (2010).
7. Shiozaki, E. N. et al. Mechanism of XIAP-mediated inhibition of caspase-9. Mol. Cell 11, 519-527 (2003). (Pubitemid 36293842)
8. Chai, J. et al. Structural basis of caspase-7 inhibiton by XIAP. Cell 104, 769-780 (2001). (Pubitemid 32241026)
9. Huang, Y. et al. Structural basis of caspase inhibition by XIAP: Differential roles of the linker versus the BIR domain. Cell 104, 781-790 (2001). (Pubitemid 32241027)
10. Riedl, S. J. et al. Structural basis for the inhibition of caspase-3 by XIAP. Cell 104, 791-800 (2001). (Pubitemid 32241028)
11. Chai, J. et al. Molecular mechanism of Reaper/Grim/Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination. Nat. Struct. Biol. 10, 892-898 (2003). (Pubitemid 37386097)
12. Wilson, R. et al. The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis. Nat. Cell Biol. 4, 445-450 (2002). (Pubitemid 34746163)
13. Shi, Y. A conserved tetrapeptide motif: Potentiating apoptosis through IAP-binding. Cell Death Differ. 9, 93-95 (2002). (Pubitemid 34144766)
14. Wu, G. et al. Structural basis of IAP recognition by Smac/DIABLO. Nature 408, 1008-1012 (2000). (Pubitemid 32101651)
15. Liu, Z. et al. Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain. Nature 408, 1004-1008 (2000). (Pubitemid 32101650)
16. Wu, J.- W., Cocina, A. E., Chai, J., Hay, B. A. & Shi, Y. Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides. Mol. Cell 8, 95-104 (2001). (Pubitemid 32772908)
17. Yan, N. et al. Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid, and Grim. Nature Struct. Mol. Biol. 11, 420-428 (2004). (Pubitemid 38568945)
18. Ditzel, M. et al. Inactivation of effector caspases through nondegradative polyubiquitylation. Mol. Cell 32, 540-553 (2008).
19. Ditzel, M. et al. Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis. Nat. Cell Biol. 5, 467-473 (2003). (Pubitemid 36592271)
20. Zachariou, A. et al. IAP-antagonists exhibit non-redundant modes of action through differential DIAP1 binding. EMBO J. 22, 6642-6652 (2003). (Pubitemid 38009610)
21. Tenev, T., Zachariou, A., Wilson, R., Ditzel, M. & Meier, P. IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms. Nat. Cell Biol. 7, 70-77 (2005). (Pubitemid 40123385)
22. Riedl, S. J. et al. Structural basis for the activation of human procaspase-7. Proc. Natl Acad. Sci. USA 98, 14790-14795 (2001). (Pubitemid 34013923)
23. Chai, J. et al. Crystal structure of a procaspase-7 zymogen: Mechanisms of activation and substrate binding. Cell 107, 399-407 (2001). (Pubitemid 33049982)
24. Goyal, L., McCall, K., Agapite, J., Hartwieg, E. & Steller, H. Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function. EMBO J. 19, 589-597 (2000). (Pubitemid 30093732)
25. Lisi, S., Mazzon, I. & White, K. Diverse domains of THREAD/DIAP1 are required to inhibit apoptosis induced by REAPER and HID in Drosophila. Genetics 154, 669-678 (2000). (Pubitemid 30096589)
26. Xu, D. et al. The effector caspases drICE and dcp-1 have partially overlapping functions in the apoptotic pathways in Drosophila. Cell Death Differ. 13, 1697-1706 (2006). (Pubitemid 44390857)
27. Chai, J. et al. Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature 406, 855-862 (2000). (Pubitemid 30664254)
28. Sun, C. et al. NMR structure and mutagenesis of the inhibitor-of- apoptosis protein XIAP. Nature 401, 818-822 (1999).
29. Riedl, S. J., Renatus, M., Snipas, S. J. & Salvesen, G. S. Mechanism-based inactivation of caspases by the apoptotic suppressor p35. Biochemistry 40, 13274-13280 (2001). (Pubitemid 33043543)
30. Xu, G. et al. Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex. Nature 410, 494-497 (2001). (Pubitemid 32240052)
31. Li, P. et al. Cytochrome c and dATP-dependent formation of Apaf-1/Caspase-9 complex initiates an apoptotic protease cascade. Cell 91, 479-489 (1997). (Pubitemid 27508237)
32. Riedl, S. J., Li, W., Chao, Y., Schwarzenbacher, R. & Shi, Y. Structure of the apoptotic protease activating factor 1 bound to ADP. Nature 434, 926-933 (2005). (Pubitemid 40559008)
33. Kim, H. E., Du, F., Fang, M. & Wang, X. Formation of apoptosome is initiated by cytochrome c-induced dATP hydrolysis and subsequent nucleotide exchange on Apaf-1. Proc. Natl Acad. Sci. USA 102, 17545-17550 (2005). (Pubitemid 41803534)
34. Otwinowski, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307-326 (1997). (Pubitemid 27085611)
35. Collaborative Computational Project, N. The CCP4 suite: Programs for protein crystallography. Acta Crystallogr. D50, 760-763 (1994).
36. McCoy, A. et al. Phaser crystallographic software. J. Appl. Crystallogr. 40, 658-674 (2007). (Pubitemid 47080256)
37. Murshudov, G., Vagin, A. & Dodson, E. Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr. D53, 240-255 (1997). (Pubitemid 27235885)
38. Adams, P. et al. PHENIX: Building new software for automated crystallographic structure determination. Acta Crystallogr. D58, 1948-1954 (2002). (Pubitemid 35337293)
39. Emsley, P. & Cowtan, K. Coot: Model-building tools for molecular graphics. Acta Crystallogr. D Biol. Crystallogr. 60, 2126-2132 (2004). (Pubitemid 41742764)
40. DeLano, W. L. The PyMOL Molecular Graphics System on World Wide Web http://www.pymol.org (2002).