Enhanced oral bioavailability of vinpocetine through mechanochemical salt formation: Physico-chemical characterization and in vivo studies

Pharmaceutical Research

Volumn 28, Issue 8, 2011, Pages 1870-1883

  Hasa, Dritan ^a   Voinovich, Dario ^a   Perissutti, Beatrice ^a   Grassi, Mario ^a   Bonifacio, Alois ^a   Sergo, Valter ^a   Cepek, Cinzia ^b   Chierotti, Michele R ^c   Gobetto, Roberto ^c   Dall'Acqua, Stefano ^d   Invernizzi, Sergio ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

^b LABORATORIO TASC   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

^d UNIVERSITY OF PADOVA   (Italy)

Author keywords

mechanochemical reaction activation; oral absorption; physico chemical characterization; solvent free process; vinpocetine citrate

Indexed keywords

CITRATE SODIUM; CITRIC ACID; CROSPOVIDONE; OXOPOCETINE; UNCLASSIFIED DRUG; VINPOCETINE; VINPOCETINE CITRATE SALT;

ANALYTIC METHOD; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; EXPERIMENTAL DESIGN; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; MECHANOTRANSDUCTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSICAL CHEMISTRY; POROSIMETRY; PRIORITY JOURNAL; RAMAN SPECTROMETRY; RAT; SOLID STATE; SOLUBILIZATION; TIME TO MAXIMUM PLASMA CONCENTRATION; X RAY DIFFRACTION; X RAY PHOTOELECTRON SPECTROSCOPY;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CITRIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; PARTICLE SIZE; PHOTOELECTRON SPECTROSCOPY; POVIDONE; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SPECTRUM ANALYSIS, RAMAN; VINCA ALKALOIDS; X-RAY DIFFRACTION;

EID: 79961173955     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0415-8     Document Type: Article

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