Solid state mechanochemical activation of Silybum marianum dry extract with betacyclodextrins: Characterization and bioavailability of the coground systems

Journal of Pharmaceutical Sciences

Volumn 98, Issue 11, 2009, Pages 4119-4129

  Voinovich, D ^a   Perissutti, B ^a   Grassi, M ^a   Passerini, N ^b   Bigotto, A ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Betacyclodextrins; Bioavailability; Mechanical activation; Oral absorption; Physical characterization; Planetary mill; Process optimization; Silybum marianum extract; Solid state

Indexed keywords

BETACYCLODEXTRINS; DRUG CARRIER; SILIREX; SILYBUM MARIANUM EXTRACT; SILYMARIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG MIXTURE; DRUG SOLUBILITY; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MALE; MECHANOTRANSDUCTION; NONHUMAN; PHYSICAL CHEMISTRY; POROSITY; PROCESS OPTIMIZATION; RAMAN SPECTROMETRY; RAT; SINGLE DRUG DOSE; SOLID STATE; X RAY POWDER DIFFRACTION;

EID: 70349637460     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21704     Document Type: Article

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