Structure-activity relationships and DNA binding properties of apoptosis inducing cytotoxic rhodium(III) polypyridyl complexes containing the cyclic thioether [9]aneS3

Journal of Inorganic Biochemistry

Volumn 103, Issue 5, 2009, Pages 698-708

  Bieda, Ruth ^a   Ott, Ingo ^b   Dobroschke, Mara ^c   Prokop, Aram ^c   Gust, Ronald ^b   Sheldrick, William S ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Antitumor agents; DNA cleavage; Polypyridyl ligands; Rhodium; Thioether complexes

Indexed keywords

1,10 PHENANTHROLINE; 1,4,7 TRITHIACYCLONONANE; 2,2' BIPYRIDINE; 2,2' BIPYRIMIDINE; ALKANE DERIVATIVE; ANTINEOPLASTIC AGENT; DIPYRIDO[2,3 A:2',3' C]PHENAZINE; DIPYRIDO[3,2 D:2',3' F]QUINOXALINE; DNA; ETHER DERIVATIVE; LACTATE DEHYDROGENASE; NITROGEN; NUCLEASE; PHENAZINE DERIVATIVE; PYRAZINO[2,3 F]QUINOXALINE; PYRIDINE DERIVATIVE; QUINOXALINE DERIVATIVE; RHODIUM POLYPYRIDYL COMPLEX; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DEATH; CELL STRAIN HT29; CELL STRAIN MCF 7; CIRCULAR DICHROISM; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DNA FRAGMENTATION; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME RELEASE; GEL ELECTROPHORESIS; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; STRUCTURE ACTIVITY RELATION; ULTRAVIOLET IRRADIATION; ULTRAVIOLET SPECTROSCOPY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DNA; HT29 CELLS; HUMANS; ORGANOMETALLIC COMPOUNDS; RHODIUM; SPECTROPHOTOMETRY, ATOMIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 64449085274     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2009.01.008     Document Type: Article

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