Synthesis and biochemical characterization of a series of 17α-perfluoroalkylated estradiols as selective ligands for estrogen receptor α

Journal of Medicinal Chemistry

Volumn 53, Issue 19, 2010, Pages 6947-6953

  Eignerová, Barbara ^a,b   Sedlák, David ^c   Dračínský, Martin ^b   Bartůněk, Petr ^c   Kotora, Martin ^a,b  

^a CHARLES UNIVERSITY   (Czech Republic)

^b INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^c INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

1' [17 (4',4',5',5',6',6',6' HEPTAFLUOROHEX 1' EN 1' YL)ESTRA 3,17BETA DIOL]; 1' [17 (5',5',6',6',7',7',8',8',9',9',10',10',10' TRIDETAFLUORONON 1' EN 1' YL)ESTRA 3,17BETA DIOL]; 2' [17 (5' (TRIFLUOROMETHYL) 5',6',6',6' TETRAFLUOROHEX 2' EN 1' YL)ESTRA 3,17BETA DIOL]; 2' [17 (5',5',6',6',7',7',7' HEPTAFLUOROHEPT 2' EN 1' YL)ESTRA 3,17BETA DIOL]; ESTRADIOL DERIVATIVE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GLUCOCORTICOID RECEPTOR; MINERALOCORTICOID RECEPTOR; RUTHENIUM; SELECTIVE ESTROGEN RECEPTOR MODULATOR; UNCLASSIFIED DRUG; ESTRADIOL; LIGAND;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CROSS METATHESIS REACTION; DRUG ANTAGONISM; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; SUBSTITUTION REACTION; AGONISTS; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; HUMAN; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

CELL LINE, TUMOR; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; HUMANS; LIGANDS; SELECTIVE ESTROGEN RECEPTOR MODULATORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTIONAL ACTIVATION;

EID: 77957915688     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100563h     Document Type: Article

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