Sucrose ester nanodispersions: Microviscosity and viscoelastic properties

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 70, Issue 2, 2008, Pages 550-555

  Ullrich, Sebastian ^a   Metz, Hendrik ^a   Mäder, Karsten ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Electron paramagnetic resonance; EPR; Lipid drug delivery; Microviscosity; Nanodispersion; Sucrose ester; Sugar ester; Viscoelastic behaviour

Indexed keywords

RYOTO; SUCROSE ESTER DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DISPERSION; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; ELECTRON SPIN RESONANCE; FLOW KINETICS; MICELLE; TRANSMISSION ELECTRON MICROSCOPY; VISCOELASTICITY; VISCOSITY;

CALORIMETRY, DIFFERENTIAL SCANNING; DRUG DELIVERY SYSTEMS; ELASTICITY; ELECTRON SPIN RESONANCE SPECTROSCOPY; ESTERS; EXCIPIENTS; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; SUCROSE; VISCOSITY;

EID: 52949105800     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.05.014     Document Type: Article

References (32)

1. Vadas E.B. Sustained release formulations with lipid derived excipients; big pharma perspectives - why and when. Bull. Technol. Gattefosse 97 (2004) 21-27
2. Porter C.J., and Charman W.N. In vitro assessment of oral lipid based formulations. Adv. Drug Deliv. Rev. 50 Suppl. 1 (2001) 127-147
3. Davis S.S. Coming of age of lipid-based drug delivery systems. Adv. Drug Deliv. Rev. 56 (2004) 1241-1242
4. Cannon J.B. Oral solid dosage forms of lipid-based drug delivery systems. Am. Pharm. Rev. 8 (2005) 108-114
5. Craig D.Q.M. Lipid matrices for sustained release - an academic overview. Bull. Technol. Gattefosse 97 (2004) 9-19
6. Pouton C.W. Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system. Eur. J. Pharm. Sci. 29 (2006) 278-287
7. Bunjes H., Koch M.H.J., and Westesen K. Influence of emulsifiers on the crystallization of solid lipid nanoparticles. J. Pharm. Sci. 92 (2003) 1509-1520
8. Mitsubishi Kagaku Foods Corporation, Ryoto(r) Sugar Ester Technical Information, Mitsubishi-Kagaku Foods Corporation, Japan, 2003.
9. Anton R., Barlow S., Boskou D., Castle L., Crebelli C., Dekant W., Engel K.-H., Forsythe S., Grunow W., Heinonen M., Larsen J.C., Leclercq C., Mennes W., Milana M.-R., Pratt I., Rietjens I., Svensson K., Tobback P., and Toldrá F. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on Sucrose esters of fatty acids, E 473 and sucroglycerides, E 474. EFSA J. 106 (2004) 1-24
10. JECFA, Summary of Evaluations Performed by the Joint FAO/WHO Expert Committee on Food Additives, Sucrose Esters of Fatty Acids, JECFA, 11 (2003) 73-79.
11. Mitsubishi Kagaku Foods Corporation, Applications of Sugar esters, 2007. Available from: .
12. J.W. Groenendaal, Homogeneous granulated formulations for dose sipping technology, WO Patent 9834598, August 13, 1998.
13. Fanun M., Wachtel E., Antalek B., Aserin A., and Garti N. A study of the microstructure of four-component sucrose ester microemulsions by SAXS and NMR. Colloids Surf. A: Physicochem. Eng. Asp. 180 (2001) 173-186
14. Garti N., Clement V., Leser M., Aserin A., and Fanun M. Sucrose ester microemulsions. J. Mol. Liq. 80 (1999) 253-296
15. Csoka G., Marton S., Zelko R., Otomo N., and Antal I. Application of sucrose fatty acid esters in transdermal therapeutic systems. Eur. J. Pharm. Biopharm. 65 (2007) 233-237
16. Rentel C.-O., Bouwstra J.A., Naisbett B., and Junginger H.E. Niosomes as a novel peroral vaccine delivery system. Int. J. Pharm. 186 (1999) 161-167
17. Youan B.B., Hussian A., and Nguyen N.T. Evaluation of sucrose esters as alternative surfactants in microencapsulation of proteins by the solvent evaporation method. AAPS PharmSciTech. 5 (2003) 222-230
18. K. Mäder, R.E. Martin, S. Raab, L.C. Scheibler, T. Schindler, M. Schröder, Pharmaceutical composition comprising a lipase inhibitor and a sucrose fatty acid ester, WO Patent 2002098412, 2002.
19. Lehmann L., Keipert S., and Gloor M. Effects of microemulsions on the stratum corneum and hydrocortisone penetration. Eur. J. Pharm. Biopharm. 52 (2001) 129-136
20. Lurie D.J., and Mäder K. Monitoring drug delivery processes by EPR and related techniques-principles and applications. Adv. Drug Deliv. Rev. 57 (2005) 1171-1190
21. Wertz J.E., and Bolton J.R. Electron Spin Resonance: Elementary Theory and Practical Applications (1972), McGraw-Hill Inc., NY 497p
22. Swartz H.M., Borg D.C., and Bolton J.R. Biological Applications of Electron Spin Resonance (1972), Wiley Interscience, NY p. 544
23. Duling D.R. Simulation of multiple isotropic spin-trap EPR spectra. J. Magn. Reson. B 104 (1994) 105-110
24. Katzhendler I., Mäder K., and Friedman M. Correlation between drug release kinetics from protein matrix and matrix structure: EPR and NMR study. J. Pharm. Sci. 89 (2000) 365-381
25. P.L. Nordio, General magnetic resonance theory, in: L.J. Berliner (Ed.), Spin Labeling: Theory and Applications, vol. 2, Academic Press, New York, 1976, pp. 5-52.
26. Köhler K., Förster G., Hauser A., Dobner B., Heiser U.F., Ziethe F., Richter W., Steiniger F., Drechsler M., Stettin H., and Blume A. Temperature-dependent behavior of a symmetric long-chain bolaamphiphile with phosphocholine headgroups in water: from hydrogel to nanoparticles. J. Am. Chem. Soc. 126 (2004) 16804-16813
27. Lippacher A., Müller R.H., and Mäder K. Liquid and semisolid SLN dispersions for topical application: rheological characterization. Eur. J. Pharm. Biopharm. 58 (2004) 561-567
28. O'Neil M., Smith A., and Heckelmann P.E. In: Budavari S. (Ed). The Merck Index: An Enzyclopaedia of Chemicals, Drugs and Biologicals vol. 13 (2001), Merck Research Laboratories, Merck & Co., Inc. 4347
29. Buchachenko A.L., Kovarski A.L., and Vassermann A.M. In: Rogovin Z.A. (Ed). Advances in Polymer Sciences (1974), Wiley Interscience, NY 26-57
30. Berner B., and Kivelson D. The electron spin resonance line width method for measuring diffusion. A critique. J. Phys. Chem. 83 (1979) 1406-1412
31. Kempe S., Metz H., Bastrop M., Hvilsom A., Contri R.V., and Mäder K. Characterization of thermosensitive chitosan-based hydrogels by rheology and electron paramagnetic resonance spectroscopy. Eur. J. Pharm. Biopharm. 68 (2008) 26-33
32. Maestro A., Acharya D.P., Furukawa H., Gutierrez J.M., Lopez-Quintela M.A., Ishitobi M., and Kunieda H. Formation and disruption of viscoelastic wormlike micellar networks in the mixed surfactant systems of sucrose alkanoate and polyoxyethylene alkyl ether. J. Phys. Chem. B 108 (2004) 14009-14016