Novel benzofuroxan derivatives against multidrug-resistant Staphylococcus aureus strains: Design using Topliss' decision tree, synthesis and biological assay

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 16, 2011, Pages 5031-5038

  Jorge, Salomão Dória ^a   Palace Berl, Fanny ^a   Masunari, Andrea ^b   Cechinel, Cléber André ^c   Ishii, Marina ^a   Pasqualoto, Kerly Fernanda Mesquita ^a   Tavares, Leoberto Costa ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Faculdade de Farmacia   (Brazil)

^c Diretoria de Pesquisa e Pós Graduaão   (Brazil)

Author keywords

Benzofuroxan derivatives; MIC; Multidrug resistant Staphylococcus aureus; Topliss' approach

Indexed keywords

2,4 DICHLORO [N' (BENZOFUROXAN 5 YL)METHYLENE]BENZHYDRAZIDE; 3,4 DICHLORO [N' (BENZOFUROXAN 5 YL)METHYLENE]BENZHYDRAZIDE; 4 NITRO 3 (TRIFLUOROMETHYL) [N' (BENZOFUROXAN 5 YL)METHYLENE]BENZHYDRAZIDE; 4 NITRO 3 (TRIFLUOROMETHYL)BENZHYDRAZIDE; 4 NITRO 3 (TRIFLUOROMETHYL)BENZOIC ACID METHYL ESTER; 4 NITRO [N' (BENZOFUROXAN 5 YL)METHYLENE]BENZHYDRAZIDE; ANTIINFECTIVE AGENT; BENZOFUROXAN DERIVATIVE; UNCLASSIFIED DRUG;

AMMONOLYSIS; ARTICLE; BACTERIAL STRAIN; BROTH DILUTION; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CRYSTALLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; ESTERIFICATION; HYDROPHOBICITY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHYSICAL CHEMISTRY; PROTON NUCLEAR MAGNETIC RESONANCE; STAPHYLOCOCCUS AUREUS; TAXONOMY;

ANTI-BACTERIAL AGENTS; BENZOXAZOLES; DECISION TREES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; SENSITIVITY AND SPECIFICITY; SOFTWARE; STAPHYLOCOCCAL INFECTIONS; STRUCTURE-ACTIVITY RELATIONSHIP;

STAPHYLOCOCCUS AUREUS;

EID: 79961167724     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.06.034     Document Type: Article

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