Neonatal UVB exposure accelerates melanoma growth and enhances distant metastases in Hgf-Cdk4 R24C C57BL/6 mice

International Journal of Cancer

Volumn 129, Issue 2, 2011, Pages 285-294

  Gaffal, Evelyn ^a   Gaffal, Jennifer ^a   Bald, Tobias ^a   Sporleder, Alexander ^a   Kohlmeyer, Judith ^a   Tüting, Thomas ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Genetically engineered mouse tumor model; Melanoma; Nevus; Tumor microenvironment; UVB irradiation

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CANCER GROWTH; CANCER INVASION; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; DISTANT METASTASIS; HISTOPATHOLOGY; LUNG METASTASIS; MELANOCYTIC NEVUS; MELANOMA; MOUSE; NEWBORN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RADIATION CARCINOGENESIS; RADIATION EXPOSURE; TUMOR VASCULARIZATION; ULTRAVIOLET B RADIATION; ANIMAL; C57BL MOUSE; ENVIRONMENTAL EXPOSURE; EXPERIMENTAL MELANOMA; FEMALE; GENETICS; LUNG TUMOR; MALE; METASTASIS; MUTATION; NEVUS; PATHOLOGY; RADIATION INDUCED NEOPLASM; TRANSGENIC ANIMAL; ULTRAVIOLET RADIATION;

CDK4 PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE 4; HGF PROTEIN, MOUSE; SCATTER FACTOR;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANIMALS, NEWBORN; CYCLIN-DEPENDENT KINASE 4; ENVIRONMENTAL EXPOSURE; FEMALE; GERM-LINE MUTATION; HEPATOCYTE GROWTH FACTOR; LUNG NEOPLASMS; MALE; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; NEOPLASMS, RADIATION-INDUCED; NEVUS; ULTRAVIOLET RAYS;

EID: 79961111402     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25913     Document Type: Article

References (33)

1. Whiteman D, Green A. The pathogenesis of melanoma induced by ultraviolet radiation. N Engl J Med 1999;341:766-7. (Pubitemid 29407385)
2. Gilchrest BA, Eller MS, Geller AC, Yaar M. The pathogenesis of melanoma induced by ultraviolet radiation. N Engl J Med 1999; 340:1341-8. (Pubitemid 29196597)
3. Oliveria SA, Saraiya M, Geller AC,Heneghan MK, Jorgensen C. Sun exposure and risk of melanoma. Arch Dis Child 2006;91:131-8. (Pubitemid 43362517)
4. von Thaler AK, Kamenisch Y, Berneburg M. The role of ultraviolet radiation in melanomagenesis. ExpDermatol 2010;19: 81-8.
5. van SA, Jongsma MJ, Bisschop R, van Venrooij GM, Rebel H, de Gruijl FR. Single UVB overexposure stimulates melanocyte proliferation in murine skin, in contrast to fractionated or UVA-1 exposure. J Invest Dermatol 2005;124: 241-7. (Pubitemid 40100975)
6. Zaidi MR, Day CP, Merlino G. From UVs to metastases: Modeling melanoma initiation and progression in the mouse. J Invest Dermatol 2008;128: 2381-91.
7. Otsuka T, Takayama H, Sharp R, Celli G, LaRochelle WJ, Bottaro DP, Ellmore N, Vieira W, Owens JW, Anver M, Merlino G. c-Met autocrine activation induces development of malignant melanoma and acquisition of the metastatic phenotype. Cancer Res 1998;58:5157-67. (Pubitemid 28521177)
8. Noonan FP, Recio JA, Takayama H, Duray P, Anver MR, Rush WL, De Fabo EC, Merlino G. Neonatal sunburn and melanoma in mice. Nature 2001;413:271-2. (Pubitemid 32905840)
9. Recio JA, Noonan FP, Takayama H, Anver MR, Duray P, Rush WL, Lindner G, De Fabo EC, DePinho RA, Merlino G. Ink4a/ arf deficiency promotes ultraviolet radiation-induced melanomagenesis. Cancer Res 2002;62:6724-30. (Pubitemid 35364144)
10. Bishop DT, Demenais F, Goldstein AM, Bergman W, Bishop JN, Bressac-de Paillerets B, Chompret A, Ghiorzo P, Gruis N, Hansson J, Harland M, Hayward N, Holland EA, Mann GJ, Mantelli M, Nancarrow D, Platz A, Tucker MA. Melanoma Genetics Consortium. Geographical variation in the penetrance of CDKN2A mutations for melanoma. J Natl Cancer Inst 2002;94:894-903. (Pubitemid 34778088)
11. Tormo D, Ferrer A, Gaffal E, Wenzel J, Basner-Tschakarjan E, Steitz J, Heukamp LC, Gütgemann I, Buettner R, Malumbres M, Barbacid M, Merlino G, Tüting T. Rapid growth of invasive metastatic melanoma in carcinogen-treated hepatocyte growth factor/scatter factor-transgenic mice carrying an oncogenic CDK4 mutation. Am J Pathol 2006;169:665-672. (Pubitemid 44156322)
12. Wölfel T, Hauer M, Schneider J, Serrano M, Wolfel C, Klehmann-Hieb E, De PE, Hankeln T, Meyer zum Buschenfelde KH, Beach D. A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science 1995;269: 1281-4.
13. Zuo L, Weger J, Yang Q, Goldstein AM, Tucker MA, Walker GJ, Hayward N, Dracopoli NC. Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma. Nat Genet 1996;12: 97-9. (Pubitemid 26013159)
14. Michaloglou C, Vredeveld LC, Soengas MS, Denoyelle C, Kuilman T, van der Horst CM, Majoor DM, Shay JW, Mooi WJ, Peeper DS. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 2005;436:720-4. (Pubitemid 41117276)
15. Sotillo R, Garcia JF, Ortega S, Martin J, Dubus P, Barbacid M, Malumbres M. Invasive melanoma in Cdk4-targeted mice. Proc Natl Acad Sci USA 2001;98:13312-7. (Pubitemid 33051359)
16. Steitz J, Büchs S, Tormo D, Ferrer A, Wenzel J, Huber C, Wolfel T, Barbacid M, Malumbres M, Tüting T. Evaluation of genetic melanoma vaccines in cdk4-mutant mice provides evidence for immunological tolerance against authochthonous melanomas in the skin. Int J Cancer 2006; 118:373-80. (Pubitemid 41779077)
17. Landsberg J, Gaffal E, Cron M, Kohlmeyer J, Renn M, Tüting T. Autochthonous primary and metastatic melanomas in Hgf-Cdk4 R24C mice evade T-cell-mediated immune surveillance. Pigment Cell Melanoma Res 2010;23:649-60.
18. Kohlmeyer J, Cron M, Landsberg J, Bald T, Renn M, Mikus S, Bondong S, Wikasari D, Gaffal E, Hartmann G, Tüting T. Complete regression of advanced primary and metastatic mouse melanomas following combination chemoimmunotherapy. Cancer Res 2009;69:6265-74.
19. de Visser KE, Korets LV, Coussens LM. De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent. Cancer Cell 2005;7:411-23. (Pubitemid 40719125)
20. Hacker E, Muller HK, Irwin N, Gabrielli B, Lincoln D, Pavey S, Powell MB, Malumbres M, Barbacid M, Hayward N, Walker G. Spontaneous and UV radiationinduced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice. Cancer Res 2006;66:2946-52.
21. Kannan K, Sharpless NE, Xu J, O'Hagan RC, Bosenberg M, Chin L. Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model. Proc Natl Acad Sci USA 2003;100:1221-5. (Pubitemid 36183983)
22. Ha L, Ichikawa T, Anver M, Dickins R, Lowe S, Sharpless NE, Krimpenfort P, DePinho RA, Bennett DC, Sviderskaya EV, Merlino G. ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence. Proc Natl Acad Sci USA 2007;104:10968-73. (Pubitemid 47175210)
23. Merlino G. Building the perfect beast: Complex mouse models teach surprisingly simple melanoma lessons. Pigment Cell Melanoma Res 2009;22:246-7.
24. Dhomen N, Reis-Filho JS, Da Rocha DS, Hayward R, Savage K, Delmas V, Larue L, Pritchard C, Marais R. Oncogenic Braf induces melanocyte senescence and melanoma in mice. Cancer Cell 2009;15: 294-303.
25. Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, Davis N, Dicks E, Ewing R, Floyd Y, Gray K, Hall S, Hawes R, Hughes J, Kosmidou V, Menzies A, Mould C, Parker A, Stevens C, Watt S, Hooper S, Wilson R, Jayatilake H, Gusterson BA, Cooper C, Shipley J, Hargrave D, Pritchard-Jones K, Maitland N, Chenevix-Trench G, Riggins GJ, Bigner DD, Palmieri G, Cossu A, Flanagan A, Nicholson A, Ho JW, Leung SY, Yuen ST, Weber BL, Seigler HF, Darrow TL, Paterson H, Marais R, Marshall CJ, Wooster R, Stratton MR, Futreal PA. Mutations of the BRAF gene in human cancer. Nature 2002;417:949-54. (Pubitemid 34716871)
26. van SA, van Venrooij GM, Jongsma MJ, Banus HA, Mullenders LH, van Kranen HJ, de Gruijl FR. Induction of nevi and skin tumors in Ink4a/Arf Xpa knockout mice by neonatal, intermittent, or chronic UVB exposures. Cancer Res 2006;66: 2608-15.
27. Yang G, Curley D, Bosenberg MW, Tsao H. Loss of xeroderma pigmentosum C (Xpc) enhances melanoma photocarcinogenesis in Ink4a-Arf-deficient mice. Cancer Res 2007;67:5649-57. (Pubitemid 46984996)
28. Yamazaki F, Okamoto H, Matsumura Y, Tanaka K, Kunisada T, Horio T. Development of a new mouse model (xeroderma pigmentosum a-deficient, stem cell factor-transgenic) of ultraviolet B-induced melanoma. J Invest Dermatol 2005;125:521-5.
29. Ferguson B, Konrad MH, Handoko HY, Khosrotehrani K, Beermann F, Hacker E, Peter SH, Bosenberg M, Walker GJ. Differential roles of the pRb and Arf/p53 pathways in murine naevus and melanoma genesis. Pigment Cell Melanoma Res 2010; 23:771-80.
30. Terzian T, Torchia EC, Dai D, Robinson SE, Murao K, Stiegmann RA, Gonzalez V, Boyle GM, Powell MB, Pollock PM, Lozano G, Robinson WA, Roop DR, Box NF. p53 Prevents progression of nevi to melanoma predominantly through cell cycle regulation. Pigment Cell Melanoma Res 2010;23:781-94.
31. Tonks ID, Mould A, Nurcombe V, Cool SM, Walker GJ, Hacker E, Keith P, Schroder WA, Cotterill A, Hayward NK, Kay GF. Dual loss of Rb1 and Trp53 in melanocytes perturbs melanocyte homeostasis and genetic stability in vitro but does not cause melanoma or pigmentation defects in vivo. Pigment Cell Melanoma Res 2009;22: 328-30.
32. Barnhill RL and Levy MA. Regressing thin cutaneous malignant melanomas (< or = 1.0 mm) are associated with angiogenesis Am J Pathol 1993 143 99-104 (Pubitemid 24058164)
33. Walker GJ, Kimlin MG, Hacker E, Ravishankar S, Muller HK, Beermann F, Hayward NK. Murine neonatal melanocytes exhibit a heightened proliferative response to ultraviolet radiation and migrate to the epidermal basal layer. J Invest Dermatol 2009;129: 184-93.