Dual loss of Rb1 and Trp53 in melanocytes perturbs melanocyte homeostasis and genetic stability in vitro but does not cause melanoma or pigmentation defects in vivo

Pigment Cell and Melanoma Research

Volumn 22, Issue 3, 2009, Pages 328-330

  Tonks, Ian D ^a   Mould, Arne ^a   Nurcombe, Victor ^b   Cool, Simon M ^b   Walker, Graeme J ^a   Hacker, Elke ^a   Keith, Patricia ^a   Schroder, Wayne A ^a   Cotterill, Andrew ^c   Hayward, Nicholas K ^a   Kay, Graham F ^a  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^b INSTITUTE OF MEDICAL BIOLOGY   (Singapore)

^c MATER CHILDREN S HOSPITAL   (Australia)

Author keywords

Melanocytes; Melanoma; Mouse model; Rb1; Trp53

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; PROTEIN MDM2; PROTEIN TRP53; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANEUPLOIDY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CANCER SUSCEPTIBILITY; CELL CYCLE PROGRESSION; GENETIC STABILITY; GENOTYPE; LETTER; MELANOCYTE; MELANOMA; MOUSE; NONHUMAN; PIGMENT DISORDER;

ANIMALS; HOMEOSTASIS; MELANOCYTES; MELANOMA; MICE; MICE, TRANSGENIC; PIGMENTATION; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 65549088485     PISSN: None     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1755-148X.2009.00560.x     Document Type: Letter

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