Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-homologous kinase (CHK) and identification of β-synuclein as a potential CHK physiological substrate

Biochemistry

Volumn 50, Issue 31, 2011, Pages 6667-6677

  Ia, Kim K ^a,b   Jeschke, Grace R ^c   Deng, Yang ^c   Kamaruddin, Mohd Aizuddin ^a,b   Williamson, Nicholas A ^b   Scanlon, Denis B ^b   Culvenor, Janetta G ^a   Hossain, Mohammed Iqbal ^a,b   Purcell, Anthony W ^a,b   Liu, Sheng ^a   Zhu, Hong Jian ^a   Catimel, Bruno ^d   Turk, Benjamin E ^c   Cheng, Heung Chin ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; C-TERMINAL TAIL; CELLULAR PROTEINS; COMBINATORIAL PEPTIDE LIBRARIES; CYTOSOLS; HYDROPHOBIC RESIDUES; KINASE SUBSTRATE TRACKING AND ELUCIDATIONS; PHOSPHORYLATION SITES; PHYSIOLOGICAL SUBSTRATE; PROTEIN SUBSTRATE; RAT BRAIN; SRC-FAMILY KINASE; SUBSTRATE SPECIFICITY; SYNUCLEIN; TUMOR SUPPRESSORS;

AMINO ACIDS; ENZYMES; OPTIMIZATION; PEPTIDES; PHOSPHORYLATION; PHYSIOLOGY;

SUBSTRATES;

BETA SYNUCLEIN; C TERMINAL SRC KINASE HOMOLOGOUS KINASE; CELL PROTEIN; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVE SITE; ENZYME PHOSPHORYLATION; MOLECULAR LIBRARY; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SRC HOMOLOGY DOMAIN;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BETA-SYNUCLEIN; CATALYTIC DOMAIN; CYTOSOL; HEK293 CELLS; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RATS; SRC HOMOLOGY DOMAINS; STRUCTURAL HOMOLOGY, PROTEIN; SUBSTRATE SPECIFICITY;

RATTUS;

EID: 79961084021     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2001938     Document Type: Article

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