-
1
-
-
0027524983
-
Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia
-
Lennard, L., Gibson, B. E., Nicole, T. & Lilleyman, J. S. Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia. Arch. Dis. Child. 69, 577-579 (1993). (Pubitemid 23355853)
-
(1993)
Archives of Disease in Childhood
, vol.69
, Issue.5
, pp. 577-579
-
-
Lennard, L.1
Gibson, B.E.S.2
Nicole, T.3
Lilleyman, J.S.4
-
2
-
-
79951809968
-
Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing
-
Relling, M. V. et al. Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing. Clin. Pharmacol. Ther. 89, 387-391 (2011).
-
(2011)
Clin. Pharmacol. Ther.
, vol.89
, pp. 387-391
-
-
Relling, M.V.1
-
3
-
-
12644291917
-
Human thiopurine methyltransferase pharmacogenetics: Gene sequence polymorphisms
-
DOI 10.1016/S0009-9236(97)90152-1
-
Otterness, D. et al. Human thiopurine methyltransferase pharmacogenetics: Gene sequence polymorphisms. Clin. Pharmacol. Ther. 62, 60-73 (1997). (Pubitemid 27327100)
-
(1997)
Clinical Pharmacology and Therapeutics
, vol.62
, Issue.1
, pp. 60-73
-
-
Otterness, D.1
Szumlanski, C.2
Lennard, L.3
Klemetsdal, B.4
Aarbakke, J.5
Park-Hah, J.O.6
Iven, H.7
Schmiegelow, K.8
Branum, E.9
O'Brien, J.10
Weinshilboum, R.11
-
4
-
-
0023119219
-
Thiopurine pharmacogenetics in leukemia: Correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations
-
Lennard, L., Van Loon, J. A., Lilleyman, J. S. & Weinshilboum, R. M. Thiopurine pharmacogenetics in leukemia: Correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations. Clin. Pharmacol. Ther. 41, 18-25 (1987). (Pubitemid 17008125)
-
(1987)
Clinical Pharmacology and Therapeutics
, vol.41
, Issue.1
, pp. 18-25
-
-
Lennard, L.1
Van Loon, J.A.2
Lilleyman, J.S.3
Weinshilboum, R.M.4
-
5
-
-
0032874716
-
Lack of effect of intravenous administration on time to respond to azathioprine for steroid-treated Crohn's disease
-
DOI 10.1016/S0016-5085(99)70445-2
-
Sandborn, W. J. et al. Lack of effect of intravenous administration on time to respond to azathioprine for steroid-treated Crohn's disease. North American Azathioprine Study Group. Gastroenterology 117, 527-535 (1999). (Pubitemid 29409238)
-
(1999)
Gastroenterology
, vol.117
, Issue.3
, pp. 527-535
-
-
Sandborn, W.J.1
Tremaine, W.J.2
Wolf, D.C.3
Targan, S.R.4
Sninsky, C.A.5
Sutherland, L.R.6
Hanauer, S.B.7
McDonald, J.W.D.8
Feagan, B.G.9
Fedorak, R.N.10
Isaacs, K.L.11
Pike, M.G.12
Mays, D.C.13
Lipsky, J.J.14
Gordon, S.15
Kleoudis, C.S.16
Murdock Jr., R.H.17
-
6
-
-
0027239758
-
The George Hitchings and Gertrude Elion Lecture. The pharmacology of azathioprine
-
Elion, G. B. The George Hitchings and Gertrude Elion Lecture. The pharmacology of azathioprine. Ann. NY Acad. Sci. 685, 400-407 (1993).
-
(1993)
Ann. NY Acad. Sci.
, vol.685
, pp. 400-407
-
-
Elion, G.B.1
-
7
-
-
27944434836
-
TPMT genotype screening for patients about to begin azathioprine treatment - A look at costs and potential benefits
-
DOI 10.1097/01.MIB.0000186491.43191.0e
-
Provenzale, D. & Onken, J. E. TPMT genotype screening for patients about to begin azathioprine treatment-a look at costs and potential benefits. Inflamm. Bowel Dis. 11, 1119-1120 (2005). (Pubitemid 41682569)
-
(2005)
Inflammatory Bowel Diseases
, vol.11
, Issue.12
, pp. 1119-1120
-
-
Provenzale, D.1
Onken, J.E.2
-
8
-
-
0842288110
-
Mistaken identity: Misclassification of TPMT phenotype following blood transfusion
-
DOI 10.1097/00042737-200311000-00016
-
Cheung, S. T. & Allan, R. N. Mistaken identity: Misclassification of TPMT phenotype following blood transfusion. Eur. J. Gastroenterol. Hepatol. 15, 1245-1247 (2003). (Pubitemid 38174852)
-
(2003)
European Journal of Gastroenterology and Hepatology
, vol.15
, Issue.11
, pp. 1245-1247
-
-
Cheung, S.-T.1
Allan, R.N.2
-
9
-
-
0030934850
-
Molecular diagnosis of thiopurine S-methyltransferase deficiency: Genetic basis for azathioprine and mercaptopurine intolerance
-
Yates, C. R. et al. Molecular diagnosis of thiopurine S-methyltransferase deficiency: Genetic basis for azathioprine and mercaptopurine intolerance. Ann. Intern. Med. 126, 608-614 (1997). (Pubitemid 27172187)
-
(1997)
Annals of Internal Medicine
, vol.126
, Issue.8
, pp. 608-614
-
-
Yates, C.R.1
Krynetski, E.Y.2
Loennechen, T.3
Fessing, M.Y.4
Tai, H.-L.5
Pui, C.-H.6
Relling, M.V.7
Evans, W.E.8
-
10
-
-
3242762099
-
Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-caucasians and identification of novel TPMT variants
-
DOI 10.1097/01.fpc.0000114745.08559.db
-
Schaeffeler, E. et al. Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants. Pharmacogenetics 14, 407-417 (2004). (Pubitemid 38971231)
-
(2004)
Pharmacogenetics
, vol.14
, Issue.7
, pp. 407-417
-
-
Schaeffeler, E.1
Fischer, C.2
Brockmeier, D.3
Wernet, D.4
Moerike, K.5
Eichelbaum, M.6
Zanger, U.M.7
Schwab, M.8
-
11
-
-
0036784123
-
Thiopurine methyltransferase phenotype and genotype in relation to azathioprine therapy in autoimmune hepatitis
-
Langley, P. G., Underhill, J., Tredger, J. M., Norris, S. & McFarlane, I. G. Thiopurine methyltransferase phenotype and genotype in relation to azathioprine therapy in autoimmune hepatitis. J. Hepatol. 37, 441-447 (2002).
-
(2002)
J. Hepatol.
, vol.37
, pp. 441-447
-
-
Langley, P.G.1
Underhill, J.2
Tredger, J.M.3
Norris, S.4
McFarlane, I.G.5
-
12
-
-
0035871560
-
Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine
-
Evans, W. E. et al. Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine. J. Clin. Oncol. 19, 2293-2301 (2001). (Pubitemid 32366982)
-
(2001)
Journal of Clinical Oncology
, vol.19
, Issue.8
, pp. 2293-2301
-
-
Evans, W.E.1
Yuen Yi Hon2
Bomgaars, L.3
Coutre, S.4
Holdsworth, M.5
Janco, R.6
Kalwinsky, D.7
Keller, F.8
Khatib, Z.9
Margolin, J.10
Murray, J.11
Quinn, J.12
Ravindranath, Y.13
Ritchey, K.14
Roberts, W.15
Rogers, Z.R.16
Schiff, D.17
Steuber, C.18
Tucci, F.19
Kornegay, N.20
Krynetski, E.Y.21
Relling, M.V.22
more..
-
13
-
-
77957673685
-
Expressing thiopurine S-methyltransferase activity as units per litre of whole-blood overcomes misleading high results in patients with anaemia
-
Barlow, N. L., Graham, V. & Berg, J. D. Expressing thiopurine S-methyltransferase activity as units per litre of whole-blood overcomes misleading high results in patients with anaemia. Ann. Clin. Biochem. 47, 408-414 (2010).
-
(2010)
Ann. Clin. Biochem.
, vol.47
, pp. 408-414
-
-
Barlow, N.L.1
Graham, V.2
Berg, J.D.3
-
14
-
-
0033837392
-
Thiopurine methyltransferase polymorphic tandem repeat: Genotype-phenotype correlation analysis
-
DOI 10.1067/mcp.2000.108674
-
Yan, L. et al. Thiopurine methyltransferase polymorphic tandem repeat: Genotype-phenotype correlation analysis. Clin. Pharmacol. Ther. 68, 210-219 (2000). (Pubitemid 30659176)
-
(2000)
Clinical Pharmacology and Therapeutics
, vol.68
, Issue.2
, pp. 210-219
-
-
Yan, L.1
Zhang, S.2
Eiff, B.3
Szumlanski, C.L.4
Powers, M.5
O'Brien, J.F.6
Weinshilboum, R.M.7
-
15
-
-
0026717661
-
The importance of thiopurine methyltransferase activity for the use of azathioprine in transplant recipients
-
Chocair, P. R., Duley, J. A., Simmonds, H. A. & Cameron, J. S. The importance of thiopurine methyltransferase activity for the use of azathioprine in transplant recipients. Transplantation 53, 1051-1056 (1992).
-
(1992)
Transplantation
, vol.53
, pp. 1051-1056
-
-
Chocair, P.R.1
Duley, J.A.2
Simmonds, H.A.3
Cameron, J.S.4
-
16
-
-
58449117037
-
Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia
-
Stocco, G. et al. Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia. Clin. Pharmacol. Ther. 85, 164-172 (2009).
-
(2009)
Clin. Pharmacol. Ther.
, vol.85
, pp. 164-172
-
-
Stocco, G.1
-
17
-
-
67349087340
-
TPMT but not ITPA gene polymorphism influences the risk of azathioprine intolerance in renal transplant recipients
-
Kurzawski, M., Dziewanowski, K., Lener, A. & Drozdzik, M. TPMT but not ITPA gene polymorphism influences the risk of azathioprine intolerance in renal transplant recipients. Eur. J. Clin. Pharmacol. 65, 533-540 (2009).
-
(2009)
Eur. J. Clin. Pharmacol.
, vol.65
, pp. 533-540
-
-
Kurzawski, M.1
Dziewanowski, K.2
Lener, A.3
Drozdzik, M.4
-
18
-
-
0016257264
-
Studies on the mechanism of formation of 5-mercapto-1-methyl-4- nitroimidazole, a metabolite of the immunosuppressive drug azathioprine
-
Chalmers, A. H. Studies on the mechanism of formation of 5-mercapto-1-methyl-4-nitroimidazole, a metabolite of the immunosuppressive drug azathioprine. Biochem. Pharmacol. 23, 1891-1901 (1974).
-
(1974)
Biochem. Pharmacol.
, vol.23
, pp. 1891-1901
-
-
Chalmers, A.H.1
-
19
-
-
30644465348
-
Mechanistic mathematical modelling of mercaptopurine effects on cell cycle of human acute lymphoblastic leukaemia cells
-
DOI 10.1038/sj.bjc.6602893, PII 6602893
-
Panetta, J. C., Evans, W. E. & Cheok, M. H. Mechanistic mathematical modelling of mercaptopurine effets on cell cycle of human acute lymphoblastic leukaemia cells. Br. J. Cancer 94, 93-100 (2006). (Pubitemid 43088547)
-
(2006)
British Journal of Cancer
, vol.94
, Issue.1
, pp. 93-100
-
-
Panetta, J.C.1
Evans, W.E.2
Cheok, M.H.3
-
20
-
-
0015529240
-
Hazard of combining allopurinol and thiopurine
-
Berns, A., Rubenfeld, S., Rymzo, W. T. Jr. & Calabro, J. J. Hazard of combining allopurinol and thiopurine. N. Engl. J. Med. 286, 730-731 (1972).
-
(1972)
N. Engl. J. Med.
, vol.286
, pp. 730-731
-
-
Berns, A.1
Rubenfeld, S.2
Rymzo Jr., W.T.3
Calabro, J.J.4
-
21
-
-
0038638963
-
TPMT in the treatment of inflammatory bowel disease with azathioprine
-
Qasim, A., Seery, J., Buckley, M. & Morain, C. O. TPMT in the treatment of inflammatory bowel disease with azathioprine. Gut 52, 767 (2003).
-
(2003)
Gut
, vol.52
, pp. 767
-
-
Qasim, A.1
Seery, J.2
Buckley, M.3
Morain, C.O.4
-
22
-
-
0034067784
-
Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease
-
Dubinsky, M. C. et al. Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease. Gastroenterology 118, 705-713 (2000). (Pubitemid 30171620)
-
(2000)
Gastroenterology
, vol.118
, Issue.4
, pp. 705-713
-
-
Dubinsky, M.C.1
Lamothe, S.2
Yang, H.Y.3
Targan, S.R.4
Sinnett, D.5
Theoret, Y.6
Seidman, E.G.7
-
23
-
-
33646011261
-
Association of 6-thioguanine nucleotide levels and inflammatory bowel disease activity: A meta-analysis
-
Osterman, M. T., Kundu, R., Lichtenstein, G. R. & Lewis, J. D. Association of 6-thioguanine nucleotide levels and inflammatory bowel disease activity: A meta-analysis. Gastroenterology 130, 1047-1053 (2006).
-
(2006)
Gastroenterology
, vol.130
, pp. 1047-1053
-
-
Osterman, M.T.1
Kundu, R.2
Lichtenstein, G.R.3
Lewis, J.D.4
-
24
-
-
26444447579
-
Thiopurine therapies: Problems, complexities, and progress with monitoring thioguanine nucleotides
-
DOI 10.1097/01.ftd.0000169061.52715.3e
-
Duley, J. A. & Florin, T. H. Thiopurine therapies: Problems, complexities, and progress with monitoring thioguanine nucleotides. Ther. Drug Monit. 27, 647-654 (2005). (Pubitemid 41437645)
-
(2005)
Therapeutic Drug Monitoring
, vol.27
, Issue.5
, pp. 647-654
-
-
Duley, J.A.1
Florin, T.H.J.2
-
25
-
-
0025034447
-
Azathioprine metabolism: Pharmacokinetics of 6-mercaptopurine, 6-thiouric acid and 6-thioguanine nucleotides in renal transplant patients
-
Chan, G. L., Erdmann, G. R., Gruber, S. A., Matas, A. J. & Canafax, D. M. Azathioprine metabolism: Pharmacokinetics of 6-mercaptopurine, 6-thiouric acid and 6-thioguanine nucleotides in renal transplant patients. J. Clin. Pharmacol. 30, 358-363 (1990). (Pubitemid 20274115)
-
(1990)
Journal of Clinical Pharmacology
, vol.30
, Issue.4
, pp. 358-363
-
-
Chan, G.L.1
Erdmann, G.R.2
Gruber, S.A.3
Matas, A.J.4
Canafax, D.M.5
-
26
-
-
0034012136
-
Recombinant human granulocyte colony-stimulating factor after kidney transplantation: A retrospective analysis to evaluate the benefit or risk of immunostimulation
-
Schmaldienst, S. et al. Recombinant human granulocyte colony-stimulating factor after kidney transplantation: A retrospective analysis to evaluate the benefit or risk of immunostimulation. Transplantation 69, 527-531 (2000). (Pubitemid 30129584)
-
(2000)
Transplantation
, vol.69
, Issue.4
, pp. 527-531
-
-
Schmaldienst, S.1
Bekesi, G.2
Deicher, R.3
Franz, M.4
Horl, W.H.5
Pohanka, E.6
-
27
-
-
4644275047
-
Consequences of binding an S-adenosylmethionine analogue on the structure and dynamics of the thiopurine methyltransferase protein backbone
-
DOI 10.1021/bi0492556
-
Scheuermann, T. H., Keeler, C. & Hodsdon, M. E. Consequences of binding an S-adenosylmethionine analogue on the structure and dynamics of the thiopurine methyltransferase protein backbone. Biochemistry 43, 12198-12209 (2004). (Pubitemid 39280563)
-
(2004)
Biochemistry
, vol.43
, Issue.38
, pp. 12198-12209
-
-
Scheuermann, T.H.1
Keeler, C.2
Hodsdon, M.E.3
-
28
-
-
67349097159
-
Heterozygosity at the TPMT gene locus, augmented by mutated MTHFR gene, predisposes to 6-MP related toxicities in childhood ALL patients
-
Karas-Kuzelicki, N., Jazbec, J., Milek, M. & Mlinaric-Rascan, I. Heterozygosity at the TPMT gene locus, augmented by mutated MTHFR gene, predisposes to 6-MP related toxicities in childhood ALL patients. Leukemia 23, 971-974 (2009).
-
(2009)
Leukemia
, vol.23
, pp. 971-974
-
-
Karas-Kuzelicki, N.1
Jazbec, J.2
Milek, M.3
Mlinaric-Rascan, I.4
-
29
-
-
33645885609
-
Prevalence of methylenetetrahydrofolate reductase polymorphisms in young patients with inflammatory bowel disease
-
Stocco, G. et al. Prevalence of methylenetetrahydrofolate reductase polymorphisms in young patients with inflammatory bowel disease. Dig. Dis. Sci. 51, 474-479 (2006).
-
(2006)
Dig. Dis. Sci.
, vol.51
, pp. 474-479
-
-
Stocco, G.1
-
30
-
-
22144482338
-
Pharmacogenetic association with adverse drug reactions to azathioprine immunosuppressive therapy following liver transplantation
-
DOI 10.1002/lt.20377
-
Breen, D. P., Marinaki, A. M., Arenas, M. & Hayes, P. C. Pharmacogenetic association with adverse drug reactions to azathioprine immunosuppressive therapy following liver transplantation. Liver Transpl. 11, 826-833 (2005). (Pubitemid 40975585)
-
(2005)
Liver Transplantation
, vol.11
, Issue.7
, pp. 826-833
-
-
Breen, D.P.1
Marinaki, A.M.2
Arenas, M.3
Hayes, P.C.4
|