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Volumn 47, Issue 5, 2010, Pages 408-414

Expressing thiopurine S-methyltransferase activity as units per litre of whole-blood overcomes misleading high results in patients with anaemia

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; THIOPURINE METHYLTRANSFERASE;

EID: 77957673685     PISSN: 00045632     EISSN: 00045632     Source Type: Journal    
DOI: 10.1258/acb.2010.010058     Document Type: Article
Times cited : (5)

References (41)
  • 1
    • 0037237923 scopus 로고    scopus 로고
    • Clinical use and practical application of TPMT enzyme and 6-mercaptopurine metabolite monitoring in IBD
    • Seidman EG. Clinical use and practical application of TPMT enzyme and 6-mercaptopurine metabolite monitoring in IBD. Rev Gastroenterol Dis 2003;3:S30-8
    • (2003) Rev Gastroenterol Dis , vol.3
    • Seidman, E.G.1
  • 2
    • 11144340253 scopus 로고    scopus 로고
    • Guidelines for prescribing azathioprine in dermatology
    • Anstey AV, Wakelin S, Reynolds NJ. Guidelines for prescribing azathioprine in dermatology. Br J Dermatol 2004;151:1123-32
    • (2004) Br J Dermatol , vol.151 , pp. 1123-1132
    • Anstey, A.V.1    Wakelin, S.2    Reynolds, N.J.3
  • 3
    • 33749515604 scopus 로고    scopus 로고
    • Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia: A randomised trial
    • DOI 10.1016/S0140-6736(06)69558-5, PII S0140673606695585
    • Vora A, Mitchell CD, Lennard L, et al. Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia: a randomised trial. Lancet 2006;368:1339-48 (Pubitemid 44528747)
    • (2006) Lancet , vol.368 , Issue.9544 , pp. 1339-1348
    • Vora, A.1    Mitchell, C.D.2    Lennard, L.3    Eden, T.4    Kinsey, S.E.5    Lilleyman, J.6    Richards, S.M.7
  • 5
    • 4444224484 scopus 로고    scopus 로고
    • Azathioprine, 6-mercaptopurine in inflammatory bowel disease: Pharmacology, efficacy, and safety
    • Dubinsky MC. Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety. Clin Gastroenterol Hepatol 2004;2:731-43
    • (2004) Clin Gastroenterol Hepatol , vol.2 , pp. 731-743
    • Dubinsky, M.C.1
  • 6
    • 0026443183 scopus 로고
    • Pancytopenia related to azathioprine - An enzyme deficiency caused by a common genetic polymorphism
    • Anstey A, Lennard L, Mayou SC, Kirby JD. Pancytopenia related to azathioprine - an enzyme deficiency caused by a common genetic polymorphism. J R Soc Med 1992;85:752-6
    • (1992) J R Soc Med , vol.85 , pp. 752-756
    • Anstey, A.1    Lennard, L.2    Mayou, S.C.3    Kirby, J.D.4
  • 8
    • 0020512528 scopus 로고
    • Childhood leukaemia: A relationship between intracellular 6-mercaptopurine metabolites and neutropenia
    • Lennard L, Rees CA, Lilleyman JS, Maddocks JL. Childhood leukaemia: a relationship between intracellular 6-mercaptopurine metabolites and neutropenia. Br J Clin Pharmacol 1983;16:359-63 (Pubitemid 13015758)
    • (1983) British Journal of Clinical Pharmacology , vol.16 , Issue.4 , pp. 359-363
    • Lennard, L.1    Rees, C.A.2    Lilleyman, J.S.3    Maddocks, J.L.4
  • 9
    • 0018822866 scopus 로고
    • Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity
    • Weinshilboum RM, Sladek SL. Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet 1980;32:651-62
    • (1980) Am J Hum Genet , vol.32 , pp. 651-662
    • Weinshilboum, R.M.1    Sladek, S.L.2
  • 11
    • 77950387206 scopus 로고    scopus 로고
    • Thiopurine s-methyltransferase (TPMT) assessment prior to starting thiopurine drug treatment; a pharmacogenomic test whose time has come
    • Ford L, Berg JD. Thiopurine s-methyltransferase (TPMT) assessment prior to starting thiopurine drug treatment; a pharmacogenomic test whose time has come. J Clin Pathol 2010;63:288-95
    • (2010) J Clin Pathol , vol.63 , pp. 288-295
    • Ford, L.1    Berg, J.D.2
  • 13
    • 34547523374 scopus 로고    scopus 로고
    • Should we test TPMT enzyme levels before starting azathioprine?
    • Richard VS, Al-Ismail D, Salamat A. Should we test TPMT enzyme levels before starting azathioprine? Hematology 2007;12:359-60
    • (2007) Hematology , vol.12 , pp. 359-360
    • Richard, V.S.1    Al-Ismail, D.2    Salamat, A.3
  • 14
    • 66749086530 scopus 로고    scopus 로고
    • Editorial: TPMT testing before azathioprine therapy?
    • Editorial: TPMT testing before azathioprine therapy? Drug Ther Bull 2009;47:9-12
    • (2009) Drug Ther Bull , vol.47 , pp. 9-12
  • 15
    • 0033486029 scopus 로고    scopus 로고
    • Mercaptopurine therapy intolerance and heterozygosity at the thiopurine s-methyltransferase gene locus
    • Relling MV, Hancock ML, Rivera GK, et al. Mercaptopurine therapy intolerance and heterozygosity at the thiopurine s-methyltransferase gene locus. J Natl Cancer Inst 1999;91:2002-8
    • (1999) J Natl Cancer Inst , vol.91 , pp. 2002-2008
    • Relling, M.V.1    Hancock, M.L.2    Rivera, G.K.3
  • 16
    • 0346463205 scopus 로고    scopus 로고
    • Relevance of thiopurine methyltransferase status in rheumatology patients receiving azathioprine
    • DOI 10.1093/rheumatology/keg442
    • Clunie G, Lennard L. Relevance of thiopurine methyltransferase status in rheumatology patients receiving azathioprine. Rheumatology 2004;43:13-18 (Pubitemid 38088361)
    • (2004) Rheumatology , vol.43 , Issue.1 , pp. 13-18
    • Clunie, G.P.R.1    Lennard, L.2
  • 17
    • 3242704015 scopus 로고    scopus 로고
    • Thiopurine methyltransferase: Should it be measured before commencing thiopurine drug therapy?
    • Sanderson J, Ansari A, Marinaki T, Duley J. Thiopurine methyltransferase: should it be measured before commencing thiopurine drug therapy? Ann Clin Biochem 2004;41:294-302
    • (2004) Ann Clin Biochem , vol.41 , pp. 294-302
    • Sanderson, J.1    Ansari, A.2    Marinaki, T.3    Duley, J.4
  • 18
    • 0030934850 scopus 로고    scopus 로고
    • Molecular diagnosis of thiopurine S-methyl transferase deficiency. Genetic basis for azathioprine and mercaptopurine intolerance
    • Yates CR, Krynetski EY, Loennechen T, et al. Molecular diagnosis of thiopurine S-methyl transferase deficiency. Genetic basis for azathioprine and mercaptopurine intolerance. Ann Intern Med 1997;126:608-14
    • (1997) Ann Intern Med , vol.126 , pp. 608-614
    • Yates, C.R.1    Krynetski, E.Y.2    Loennechen, T.3
  • 19
    • 33748756416 scopus 로고    scopus 로고
    • Two cases of thiopurine methyltransferase (TPMT) deficiency - A lucky save and a near miss with azathioprine
    • Gardiner SJ, Gearry RB, Barclay ML, Begg EJ. Two cases of thiopurine methyltransferase (TPMT) deficiency - a lucky save and a near miss with azathioprine. Br J Clin Pharmacol 2006;62:473-6
    • (2006) Br J Clin Pharmacol , vol.62 , pp. 473-476
    • Gardiner, S.J.1    Gearry, R.B.2    Barclay, M.L.3    Begg, E.J.4
  • 21
    • 0030802914 scopus 로고    scopus 로고
    • Thiopurine methyltransferase deficiency in childhood lymphoblastic leukaemia: 6-mercaptopurine dosage strategies
    • DOI 10.1002/(SICI)1096-911X(199710)29:4<252::AID-MPO3>3.0.CO;2-L
    • Lennard L, Lewis IJ, Michelagnoli M, Lilleyman JS. Thiopurine methyltransferase deficiency in childhood lymphoblastic leukaemia: 6-mercaptopurine dosage strategies. Med Pediatr Oncol 1997;29:252-5 (Pubitemid 27329123)
    • (1997) Medical and Pediatric Oncology , vol.29 , Issue.4 , pp. 252-255
    • Lennard, L.1    Lewis, I.J.2    Michelagnoli, M.3    Lilleyman, J.S.4
  • 22
    • 0036790212 scopus 로고    scopus 로고
    • Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease
    • Ansari A, Hassan C, Duley J, et al. Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease. Aliment Pharmacol Ther 2002;16:1743-50
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 1743-1750
    • Ansari, A.1    Hassan, C.2    Duley, J.3
  • 23
    • 2342420871 scopus 로고    scopus 로고
    • Thiopurine methyltransferase activity influences clinical response to azathioprine in inflammatory bowel disease
    • DOI 10.1016/S1542-3565(04)00127-2, PII S1542356504001272
    • Cuffari C, Dassopoulos T, Turnbough L, Thompson RE, Bayless TM. Thiopurine methyltransferase activity influences clinical response to azathioprine in inflammatory bowel disease. Clin Gastroenterol Hepatol 2004;2:410-7 (Pubitemid 38561239)
    • (2004) Clinical Gastroenterology and Hepatology , vol.2 , Issue.5 , pp. 410-417
    • Cuffari, C.1    Dassopoulos, T.2    Turnbough, L.3    Thompson, R.E.4    Bayless, T.M.5
  • 24
    • 27644565720 scopus 로고    scopus 로고
    • Thiopurine methyltransferase and 6-thioguanine nucleotide measurement: Early experience of use in clinical practice
    • Gearry RB, Barclay ML, Roberts RL, et al. Thiopurine methyltransferase and 6-thioguanine nucleotide measurement: early experience of use in clinical practice. Intern Med J 2005;35:580-5
    • (2005) Intern Med J , vol.35 , pp. 580-585
    • Gearry, R.B.1    Barclay, M.L.2    Roberts, R.L.3
  • 25
    • 56749185267 scopus 로고    scopus 로고
    • Severe hepatotoxicity with high 6-methylmercaptopurine nucleotide concentrations after thiopurine dose escalation due to low 6-thioguanine nucleotides
    • Gardiner SJ, Gearry RB, Burt MJ, Ding SL, Barclay ML. Severe hepatotoxicity with high 6-methylmercaptopurine nucleotide concentrations after thiopurine dose escalation due to low 6-thioguanine nucleotides. Eur J Gastroenterol Hepatol 2008;20:1238-42
    • (2008) Eur J Gastroenterol Hepatol , vol.20 , pp. 1238-1242
    • Gardiner, S.J.1    Gearry, R.B.2    Burt, M.J.3    Ding, S.L.4    Barclay, M.L.5
  • 26
    • 0019956940 scopus 로고
    • Pharmacogenetics of human thiopurine methyltransferase: Kidney-erythrocyte correlation and immunotitration studies
    • Woodson LC, Dunnette JH, Weinshilboum RM. Pharmacogenetics of human thiopurine methyltransferase: kidney-erythrocyte correlation and immunotitration studies. J Pharmacol Exp Ther 1982;222:174-81
    • (1982) J Pharmacol Exp Ther , vol.222 , pp. 174-181
    • Woodson, L.C.1    Dunnette, J.H.2    Weinshilboum, R.M.3
  • 27
    • 0026907122 scopus 로고
    • Human liver thiopurine s-methyltransferase pharmacogenetics: Biochemical properties, liver-erthrocyte correlation and presence of isoenzymes
    • Szumlanski CL, Honchel R, Scott MC, et al. Human liver thiopurine s-methyltransferase pharmacogenetics: biochemical properties, liver-erthrocyte correlation and presence of isoenzymes. Pharmacogenetics 1992;2:148-59
    • (1992) Pharmacogenetics , vol.2 , pp. 148-159
    • Szumlanski, C.L.1    Honchel, R.2    Scott, M.C.3
  • 28
    • 3242724021 scopus 로고    scopus 로고
    • Reference intervals for thiopurine S-methyltransferase activity in red blood cells using 6-thioguanine as substrate and a rapid non-extraction liquid chromatographic technique
    • Ford LT, Cooper SC, Lewis MJV, Berg JD. Reference intervals for thiopurine S-methyltransferase activity in red blood cells using 6-thioguanine as substrate and a rapid non-extraction liquid chromatographic technique. Ann Clin Biochem 2004;41:303-8
    • (2004) Ann Clin Biochem , vol.41 , pp. 303-308
    • Ford, L.T.1    Cooper, S.C.2    Lewis, M.J.V.3    Berg, J.D.4
  • 29
    • 20444445901 scopus 로고    scopus 로고
    • Measurement of thiopurine methyl transferase activity guides dose-initiation and prevents toxicity from azathioprine
    • Sies C, Florkowski C, George P, et al. Measurement of thiopurine methyl transferase activity guides dose-initiation and prevents toxicity from azathioprine. N Z Med J 2005;118:1324-8
    • (2005) N Z Med J , vol.118 , pp. 1324-1328
    • Sies, C.1    Florkowski, C.2    George, P.3
  • 30
    • 33749509197 scopus 로고    scopus 로고
    • Whole-blood thiopurine S-methyltransferase activity with genotype concordance: A new, simplified phenotyping assay
    • DOI 10.1258/000456306778520070
    • Ford L, Graham V, Berg J. Whole-blood thiopurine S-methyltransferase activity with genotype concordance: a new, simplified phenotyping assay. Ann Clin Biochem 2006;43:354-60 (Pubitemid 44526533)
    • (2006) Annals of Clinical Biochemistry , vol.43 , Issue.5 , pp. 354-360
    • Ford, L.1    Graham, V.2    Berg, J.3
  • 31
    • 0035515573 scopus 로고    scopus 로고
    • Human thiopurine methyltransferase activity varies with red blood cell age
    • Lennard L, Chew TS, Lilleyman JS. Human thiopurine methyltransferase activity varies with red blood cell age. Br J Clin Pharmacol 2001;52:539-46
    • (2001) Br J Clin Pharmacol , vol.52 , pp. 539-546
    • Lennard, L.1    Chew, T.S.2    Lilleyman, J.S.3
  • 33
    • 77957683406 scopus 로고    scopus 로고
    • See (last checked 16 October 2009)
    • See http://www.tpmtassay.com/Document/TPMTImmunoassayUserGuidev2.0.pdf (last checked 16 October 2009)
  • 34
    • 0032917646 scopus 로고    scopus 로고
    • The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian populations
    • Collie-Duguid ES, Pritchard SC, Powrie RH, et al. The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian populations. Pharmacogenetics 1999;9:37-42
    • (1999) Pharmacogenetics , vol.9 , pp. 37-42
    • Collie-Duguid, E.S.1    Pritchard, S.C.2    Powrie, R.H.3
  • 35
    • 42449125302 scopus 로고    scopus 로고
    • Ethnic variation of thiopurine S-methyltransferase activity; a large, prospective population study
    • Cooper SC, Ford LT, Berg JD, Lewis MJ. Ethnic variation of thiopurine S-methyltransferase activity; a large, prospective population study. Pharmacogenomics 2008;9:303-9
    • (2008) Pharmacogenomics , vol.9 , pp. 303-309
    • Cooper, S.C.1    Ford, L.T.2    Berg, J.D.3    Lewis, M.J.4
  • 36
    • 1142273254 scopus 로고    scopus 로고
    • A multiplexed allele-specific polymerase chain reaction assay for the detection of common thiopurine s-methyltransferase (TPMT) mutations
    • Roberts RL, Barclay ML, Gearry RB, Kennedy MA. A multiplexed allele-specific polymerase chain reaction assay for the detection of common thiopurine s-methyltransferase (TPMT) mutations. Clin Chim Acta 2004;341:49-53
    • (2004) Clin Chim Acta , vol.341 , pp. 49-53
    • Roberts, R.L.1    Barclay, M.L.2    Gearry, R.B.3    Kennedy, M.A.4
  • 37
    • 0035515573 scopus 로고    scopus 로고
    • Human thiopurine methyltransferase activity varies with red blood cell age
    • Lennard L, Chew TS, Lileyman JS. Human thiopurine methyltransferase activity varies with red blood cell age. Br J Clin Pharmacol 2001;52:539-46
    • (2001) Br J Clin Pharmacol , vol.52 , pp. 539-546
    • Lennard, L.1    Chew, T.S.2    Lileyman, J.S.3
  • 38
    • 64549121174 scopus 로고    scopus 로고
    • Thiopurine S-methyltransferase genotype-phenotype concordance: Used as a quality assurance tool to help control the phenotype assay
    • Ford L, Kampanis P, Berg J. Thiopurine S-methyltransferase genotype-phenotype concordance: used as a quality assurance tool to help control the phenotype assay. Ann Clin Biochem 2009;46:152-4
    • (2009) Ann Clin Biochem , vol.46 , pp. 152-154
    • Ford, L.1    Kampanis, P.2    Berg, J.3
  • 40
    • 46749126229 scopus 로고    scopus 로고
    • Avoiding adverse drug reactions by pharmacogenetic testing: A systematic review of the economic evidence in the case of TPMT and AZA-induced side effects
    • DOI 10.1017/S0266462308080392, PII S0266462308080392
    • Compagni A, Bartoli S, Buehrlen B, Fattore G, Ibarreta D, de Mesa EG. Avoiding adverse drug reactions by pharmacogenetic testing: a systematic review of the economic evidence in the case of TPMT and AZA-induced side effects. Int J Technol Assess Health Care 2008;24:294-302 (Pubitemid 351950165)
    • (2008) International Journal of Technology Assessment in Health Care , vol.24 , Issue.3 , pp. 294-302
    • Compagni, A.1    Bartoli, S.2    Buehrlen, B.3    Fattore, G.4    Ibarreta, D.5    De Mesa, E.G.6
  • 41
    • 67651083364 scopus 로고    scopus 로고
    • TPMT testing in azathioprine: A 'cost-effective use of healthcare resources'?
    • Payne K, Newman WG, Gurwitz D, Ibarreta D, Phillips KA. TPMT testing in azathioprine: a 'cost-effective use of healthcare resources'? Person Med 2009;6:103-13
    • (2009) Person Med , vol.6 , pp. 103-113
    • Payne, K.1    Newman, W.G.2    Gurwitz, D.3    Ibarreta, D.4    Phillips, K.A.5


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