Self-complementary AAV2.5-BMP2-coated femoral allografts mediated superior bone healing versus live autografts in mice with equivalent biomechanics to unfractured femur

Molecular Therapy

Volumn 19, Issue 8, 2011, Pages 1416-1425

  Yazici, Cemal ^a   Takahata, Masahiko ^a   Reynolds, David G ^a,b   Xie, Chao ^a   Samulski, R Jude ^c,d   Samulski, Jade ^d   Beecham, E Jeffrey ^c,d   Gertzman, Arthur A ^e   Spilker, Mark ^e   Zhang, Xinping ^a   O'Keefe, Regis J ^a   Awad, Hani A ^a,b   Schwarz, Edward M ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b University of Rochester   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d ASKLEPIOS BIOPHARMACEUTICAL INC   (United States)

^e Musculoskeletal Transplant Foundation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; PARVOVIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ADENO ASSOCIATED VIRUS 2.5; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE ALLOGRAFT; BONE DEFECT; BONE GRAFT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORTICAL BONE; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG TREATMENT FAILURE; ENZYME ACTIVITY; FEMALE; FEMUR; FRACTURE HEALING; IN VITRO STUDY; IN VIVO GENE TRANSFER; MOUSE; NONHUMAN; OSTEOLYSIS; PROTEIN EXPRESSION; RIGIDITY; SEROTYPE; SIGNAL TRANSDUCTION;

ADENO-ASSOCIATED VIRUS; MURINAE; MUS;

EID: 79961029073     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2010.294     Document Type: Article

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