Chordin knockdown enhances the osteogenic differentiation of human mesenchymal stem cells

Arthritis Research and Therapy

Volumn 10, Issue 3, 2007, Pages

  Kwong, Francois N K ^a   Richardson, Stephen M ^b   Evans, Christopher H ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; CHORDIN;

ARTICLE; BONE DEVELOPMENT; CALCIFICATION; CELL DIFFERENTIATION; CONTROLLED STUDY; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; MESENCHYME CELL; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN TARGETING; RNA INTERFERENCE;

EID: 45749094563     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar2436     Document Type: Article

References (30)

1. Westerhuis RJ van Bezooijen RL Kloen P Use of bone morphogenetic proteins in traumatology Injury 2005, 36:1405-1412 10.1016/ j.injury.2005.02.047 16125704
2. Piccolo S Sasai Y Lu B De Robertis EM Dorsoventral patterning in Xenopus: Inhibition of ventral signals by direct binding of chordin to BMP-4 Cell 1996, 86:589-598 10.1016/S0092-8674(00)80132-4 8752213
3. Sasai Y Lu B Piccolo S De Robertis EM Endoderm induction by the organizer-secreted factors chordin and noggin in Xenopus animal caps Embo J 1996, 15:4547-4555 452184 8887546
4. Larrain J Bachiller D Lu B Agius E Piccolo S De Robertis EM BMP-binding modules in chordin: A model for signalling regulation in the extracellular space Development 2000, 127:821-830 2280033 10648240
5. Aspenberg P Jeppsson C Economides AN The bone morphogenetic proteins antagonist Noggin inhibits membranous ossification J Bone Miner Res 2001, 16:497-500 10.1359/jbmr.2001.16.3.497 11277267
6. Tsuji K Bandyopadhyay A Harfe BD Cox K Kakar S Gerstenfeld L Einhorn T Tabin CJ Rosen V BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing Nat Genet 2006, 38:1424-1429 10.1038/ng1916 17099713
7. Frank O Heim M Jakob M Barbero A Schafer D Bendik I Dick W Heberer M Martin I Real-time quantitative RT-PCR analysis of human bone marrow stromal cells during osteogenic differentiation in vitro J Cell Biochem 2002, 85:737-746 10.1002/jcb.10174 11968014
8. Edgar CM Chakravarthy V Barnes G Kakar S Gerstenfeld LC Einhorn TA Autogenous regulation of a network of bone morphogenetic proteins (BMPs) mediates the osteogenic differentiation in murine marrow stromal cells Bone 2007, 40:1389-1398 10.1016/j.bone.2007.01.001 17303481
9. Bi LX Simmons DJ Mainous E Expression of BMP-2 by rat bone marrow stromal cells in culture Calcif Tissue Int 1999, 64:63-68 10.1007/ s002239900580 9868286
10. Horst van der G van Bezooijen RL Deckers MM Hoogendam J Visser A Lowik CW Karperien M Differentiation of murine preosteoblastic KS483 cells depends on autocrine bone morphogenetic protein signaling during all phases of osteoblast formation Bone 2002, 31:661-669 10.1016/ S8756-3282(02)00903-1 12531559
11. Lecanda F Avioli LV Cheng SL Regulation of bone matrix protein expression and induction of differentiation of human osteoblasts and human bone marrow stromal cells by bone morphogenetic protein-2 J Cell Biochem 1997, 67:386-396 10.1002/ (SICI)1097-4644(19971201)67:3<386::AID-JCB10>3.0.CO;2-B 9361193
12. Jager M Fischer J Dohrn W Li X Ayers DC Czibere A Prall WC Lensing-Hohn S Krauspe R Dexamethasone modulates BMP-2 effects on mesenchymal stem cells in vitro J Orthop Res 2008, 18404732
13. Cook SD Salkeld SL Brinker MR Wolfe MW Rueger DC Use of an osteoinductive biomaterial (rhOP-1) in healing large segmental bone defects J Orthop Trauma 1998, 12:407-412 10.1097/ 00005131-199808000-00007 9715448
14. Gerhart TN Kirker-Head CA Kriz MJ Holtrop ME Hennig GE Hipp J Schelling SH Wang E Healing segmental femoral defects in sheep using recombinant human bone morphogenetic protein Clin Orthop Relat Res 1993, 293:317-326 8339499
15. Sciadini MF Johnson KD Evaluation of recombinant human bone morphogenetic protein-2 as a bone-graft substitute in a canine segmental defect model J Orthop Res 2000, 18:289-302 10.1002/jor.1100180218 10815831
16. Porter RM Liu FJ Pilapil C Betz OB Harris MB Vrahas M Evans CH Osteogenic potential of reamer irrigator aspirator (RIA) aspirate collected from patients undergoing hip arthroplasty J Orthop Res 2008
17. Hanada K Dennis JE Caplan AI Stimulatory effects of basic fibroblast growth factor and bone morphogenetic protein-2 on osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells J Bone Miner Res 1997, 12:1606-1614 10.1359/jbmr.1997.12.10.1606 9333121
18. Ogasawara T Kawaguchi H Jinno S Hoshi K Itaka K Takato T Nakamura K Okayama H Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6 Mol Cell Biol 2004, 24:6560-6568 444857 15254224 10.1128/MCB.24.15.6560-6568.2004
19. Petryk A Shimmi O Jia X Carlson AE Tervonen L Jarcho MP O'Connor MB Gopalakrishnan R Twisted gastrulation and chordin inhibit differentiation and mineralization in MC3T3-E1 osteoblast-like cells Bone 2005, 36:617-626 10.1016/j.bone.2005.01.018 15780974
20. Devlin RD Du Z Pereira RC Kimble RB Economides AN Jorgetti V Canalis E Skeletal overexpression of noggin results in osteopenia and reduced bone formation Endocrinology 2003, 144:1972-1978 10.1210/en.2002-220918 12697704
21. Gazzerro E Gangji V Canalis E Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts J Clin Invest 1998, 102:2106-2114 509165 9854046 10.1172/ JCI3459
22. Brunet LJ McMahon JA McMahon AP Harland RM Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton Science 1998, 280:1455-1457 10.1126/science.280.5368.1455 9603738
23. Kugimiya F Kawaguchi H Kamekura S Chikuda H Ohba S Yano F Ogata N Katagiri T Harada Y Azuma Y Nakamura K Chung UI Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation J Biol Chem 2005, 280:35704-35712 10.1074/jbc.M505166200 16109715
24. Yoshimura Y Nomura S Kawasaki S Tsutsumimoto T Shimizu T Takaoka K Colocalization of noggin and bone morphogenetic protein-4 during fracture healing J Bone Miner Res 2001, 16:876-884 10.1359/ jbmr.2001.16.5.876 11341332
25. Wan DC Pomerantz JH Brunet LJ Kim JB Chou YF Wu BM Harland R Blau HM Longaker MT Noggin suppression enhances in vitro osteogenesis and accelerates in vivo bone formation J Biol Chem 2007, 282:26450-26459 10.1074/jbc.M703282200 17609215
26. Stein GS Lian JB Molecular mechanisms mediating proliferation/ differentiation interrelationships during progressive development of the osteoblast phenotype Endocr Rev 1993, 14:424-442 10.1210/er.14.4.424 8223340
27. Huang W Rudkin GH Carlsen B Ishida K Ghasri P Anvar B Yamaguchi DT Miller TA Overexpression of BMP-2 modulates morphology, growth, and gene expression in osteoblastic cells Exp Cell Res 2002, 274:226-234 10.1006/ excr.2002.5483 11900483
28. Aybar B Emes Y Atalay B Vural P Kaya AS Eren SN Issever H Bilir A Effects of bone morphogenetic protein on neonatal rat calvarial osteoblast-like cells: An in vitro study J Biomed Mater Res A 2008, 18260142
29. Justesen J Stenderup K Eriksen EF Kassem M Maintenance of osteoblastic and adipocytic differentiation potential with age and osteoporosis in human marrow stromal cell cultures Calcif Tissue Int 2002, 71:36-44 10.1007/s00223-001-2059-x 12200657
30. Abdallah BM Haack-Sorensen M Fink T Kassem M Inhibition of osteoblast differentiation but not adipocyte differentiation of mesenchymal stem cells by sera obtained from aged females Bone 2006, 39:181-188 10.1016/ j.bone.2005.12.082 16530029