Demonstration of the use of windows of operation to visualize the effects of fouling on the performance of a chromatographic step

Biotechnology Progress

Volumn 27, Issue 4, 2011, Pages 1009-1017

  Boushaba, Rihab ^a,b   Baldascini, Helen ^a   Gerontas, Spyridon ^a   Titchener Hooker, Nigel J ^a   Bracewell, Daniel G ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b Universite Mentouri Constantine   (Algeria)

Author keywords

Antibody fragment; Chromatography; Fouling; General rate model; Windows of operation

Indexed keywords

ADSORPTION KINETICS; ANTIBODY FRAGMENT; BIOPROCESS DEVELOPMENT; CATION EXCHANGES; DOWNSTREAM-PROCESSING; FEED STREAMS; FOULING PROCESS; GENERAL RATE MODEL; HIGH RESOLUTION; LABORATORY COLUMNS; PACKED BED CHROMATOGRAPHY; PROCESS MATERIALS; TARGET PROTEINS; THERAPEUTIC MOLECULES;

ADSORPTION; CHROMATOGRAPHY; ESCHERICHIA COLI; PACKED BEDS;

FOULING;

ARTICLE; CENTRIFUGATION; CHROMATOGRAPHY; ESCHERICHIA COLI; THEORETICAL MODEL;

CENTRIFUGATION; CHROMATOGRAPHY; ESCHERICHIA COLI; MODELS, THEORETICAL;

ESCHERICHIA COLI;

EID: 79961022043     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.617     Document Type: Article

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