Ultra scale-down approach to correct dispersive and retentive effects in small-scale columns when predicting larger scale elution profiles

Biotechnology Progress

Volumn 25, Issue 4, 2009, Pages 1103-1110

  Hutchinson, N ^a   Chhatre, S ^a   Baldascini, H ^a   Davies, J L ^b   Bracewell, D G ^a   Hoare, M ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b Lonza Biologics plc   (United Kingdom)

Author keywords

Antibodies; Dispersion; Retention; Transition analysis; Ultra scale down (USD)

Indexed keywords

ACCURATE ESTIMATION; BIOPHARMACEUTICAL SECTORS; CHROMATOGRAPHIC PROFILES; CONDUCTIVITY CHANGES; EFFICIENT DESIGNS; ELUTION PROFILES; EMPIRICAL CORRELATIONS; LABORATORY COLUMNS; PILOT SCALE; PROCESS PERFORMANCE; PRODUCT CONCENTRATION; PROTEIN A CHROMATOGRAPHY; RETENTION; SCALE-DOWN; TRANSITION ANALYSIS; ULTRA SCALE-DOWN; ULTRA SCALE-DOWN (USD);

CHROMATOGRAPHIC ANALYSIS; COLUMN CHROMATOGRAPHY; MONOCLONAL ANTIBODIES;

DISPERSIONS;

ANTIBODY;

ADSORPTION; CHEMICAL MODEL; CHEMISTRY; CHROMATOGRAPHY; CONFERENCE PAPER; EVALUATION; INSTRUMENTATION; ISOLATION AND PURIFICATION; METHODOLOGY;

ADSORPTION; ANTIBODIES; CHROMATOGRAPHY; MODELS, CHEMICAL;

EID: 69149094324     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1002/btpr.172     Document Type: Conference Paper

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