Bone marrow cell therapy ameliorates and reverses chagasic cardiomyopathy in a mouse model

Journal of Infectious Diseases

Volumn 197, Issue 4, 2008, Pages 544-547

  Goldenberg, Regina C S ^a   Jelicks, Linda A ^c   Fortes, Fabio S A ^a   Weiss, Louis M ^c   Rocha, Leonardo L ^b   Zhao, Dazhi ^c   De Carvalho, Antonio Campos ^a,c   Spray, David C ^c   Tanowitz, Herbert B ^c  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CARDIOMYOPATHY; CELL THERAPY; CHAGAS DISEASE; FEMALE; HEART MUSCLE FIBROSIS; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; TRYPANOSOMA CRUZI;

ANIMALS; BONE MARROW TRANSPLANTATION; CHAGAS CARDIOMYOPATHY; DISEASE MODELS, ANIMAL; FEMALE; HYPERTROPHY, RIGHT VENTRICULAR; MAGNETIC RESONANCE IMAGING; MICE; MICE, INBRED STRAINS;

EID: 40049097812     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/526793     Document Type: Article

References (15)

1. Orlic D, Kajstura J, Chimenti S, et al. Bone marrow cells regenerate infarcted myocardium. Nature 2001; 410:701-5.
2. Orlic D, Hill JM, Arai AE. Stem cells for myocardial regeneration. Circ Res 2002; 91:1092-102.
3. Min JY, Yang Y, Converso KL, et al. Transplantation of embryonic stem cells improves cardiac function in postinfarcted rats. J Appl Physiol 2002; 92:288-96.
4. Saito T, Kuang JQ, Bittira B, Al-Khaldi A, Chiu RC. Xenotransplant cardiac chimera: immune tolerance of adult stem cells. Ann Thorac Surg 2002; 74:19-24.
5. Orlic D, Kajstura J, Chimenti S, et al. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci USA 2001; 98:10344-9.
6. Jackson KA, Majka SM, Wang H, et al. Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest 2001; 107:1395-402.
7. Soares MB, Lima RS, Rocha LL, et al. Transplanted bone marrow cells repair heart tissue and reduce myocarditis in chronic chagasic mice. Am J Pathol 2004; 164:441-7.
8. Huang H, Chan J, Wittner M, et al. Expression of cardiac cytokines and inducible form of nitric oxide synthase (NOS2) in Trypanosoma cruzi-infected mice. J Mol Cell Cardiol 1999; 31:75-88.
9. de Souza AP, Tang B, Tanowitz HB, Araujo-Jorge TC, Jelicks LA. Magnetic resonance imaging in experimental Chagas disease: a brief review of the utility of the method for monitoring right ventricular chamber dilatation. Parasitol Res 2005; 97:87-90.
10. Guarita-Souza LC, Carvalho KA, Woitowicz V, et al. Simultaneous autologous transplantation of cocultured mesenchymal stem cells and skeletal myoblasts improves ventricular function in a murine model of Chagas disease. Circulation 2006; 114:I120-4.
11. Nunes MD, Rocha MO, Ribeiro AL, et al. Right ventricular dysfunction is an independent predictor of survival in patients with dilated chronic Chagas' cardiomyopathy. Int J Cardiol 2007; 7 August (electronically published ahead of print).
12. Wall ST, Walker JC, Healy KE, Ratcliffe MB, Guccione JM. Theoretical impact of the injection of material into the myocardium: a finite element model simulation. Circulation 2006; 114:2627-35.
13. Zhang S, Guo J, Zhang P, et al. Long-term effects of bone marrow mononuclear cell transplantation on left ventricular function and remodeling in rats. Life Sci 2004; 74:2853-64.
14. Zhang S, Ge J, Sun A, et al. Comparison of various kinds of bone marrow stem cells for the repair of infracted myocardium: single clonally purified non-hematopoietic mesenchymal stem cells serve as a superior source. J Cell Biochem 2006; 99:1132-47.
15. Vilas-Boas F, Feitosa GS, Soares MB, et al. Early results of bone marrow cell transplantation to the myocardium of patients with heart failure due to Chagas disease. Arq Bras Cardiol 2006; 87:159-66.