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Volumn 735, Issue , 2011, Pages 77-96

G-Quadruplex Structures and G-Quadruplex-Interactive Compounds

Author keywords

Anticancer drug targets; G quadruplex structures; G quadruplex interactive compounds; Human telomeres; Structure polymorphism; Telomerase inhibitors

Indexed keywords

GUANINE; GUANINE QUADRUPLEX; ORGANOMETALLIC COMPOUND; POTASSIUM; TELOMERASE;

EID: 79960993486     PISSN: 10643745     EISSN: 19406029     Source Type: Book Series    
DOI: 10.1007/978-1-61779-092-8_8     Document Type: Chapter
Times cited : (24)

References (42)
  • 1
    • 77953381213 scopus 로고    scopus 로고
    • Structural Insights into G-quadruplexes: Towards New Anti-Cancer Drugs
    • In press
    • Yang, D., and Okamoto, K. (2010) Structural Insights into G-quadruplexes: Towards New Anti-Cancer Drugs., Fut. Med. Chem. In press.
    • (2010) Fut. Med. Chem.
    • Yang, D.1    Okamoto, K.2
  • 2
    • 0025269255 scopus 로고
    • A sodiumpotassium switch in the formation of fourstranded G4-DNA
    • Sen, D., and Gilbert, W. (1990) A sodiumpotassium switch in the formation of fourstranded G4-DNA, Nature 344, 410–414.
    • (1990) Nature , vol.344 , pp. 410-414
    • Sen, D.1    Gilbert, W.2
  • 3
    • 34447531353 scopus 로고    scopus 로고
    • The role of cations in determining quadruplex structure and stability
    • Neidle, S., Ed.), Royal Society of Chemistry, RSC Publishing, Cambridge
    • Hud, N. V., and Plavec, J. (2006) The role of cations in determining quadruplex structure and stability, in Quadruplex Nucleic Acids (Neidle, S., Ed.), pp 100–130, Royal Society of Chemistry, RSC Publishing, Cambridge.
    • (2006) Quadruplex Nucleic Acids , pp. 100-130
    • Hud, N.V.1    Plavec, J.2
  • 4
    • 0036562687 scopus 로고    scopus 로고
    • Telomere maintenance as a target for anticancer drug discovery
    • Neidle, S., and Parkinson, G. (2002) Telomere maintenance as a target for anticancer drug discovery, Nature Reviews Drug Discovery 1, 383–393.
    • (2002) Nature Reviews Drug Discovery , vol.1 , pp. 383-393
    • Neidle, S.1    Parkinson, G.2
  • 5
    • 47849105417 scopus 로고    scopus 로고
    • Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions
    • Qin, Y., and Hurley, L. H. (2008) Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions, Biochimie 90, 1149–1171.
    • (2008) Biochimie , vol.90 , pp. 1149-1171
    • Qin, Y.1    Hurley, L.H.2
  • 6
    • 77953367722 scopus 로고    scopus 로고
    • Therapeutic Targets and Drugs-G-quadruplex inhibitors
    • Hiyama, K., Ed.), Springer, NJ, USA
    • Punchihewa, C., and Yang, D. Z. (2009) Therapeutic Targets and Drugs-G-quadruplex inhibitors., in Telomeres and Telomerase in Cancer (Hiyama, K., Ed.), pp 251–280, Springer, NJ, USA.
    • (2009) Telomeres and Telomerase in Cancer , pp. 251-280
    • Punchihewa, C.1    Yang, D.Z.2
  • 7
    • 0023663911 scopus 로고
    • Telomeric DNA oligonucleotides form novel intramolecular structures containing guanineguanine base pairs
    • Henderson, E., Hardin, C. C., Walk, S. K., Tinoco, I., Jr., and Blackburn, E. H. (1987) Telomeric DNA oligonucleotides form novel intramolecular structures containing guanineguanine base pairs, Cell 51, 899–908.
    • (1987) Cell , vol.51 , pp. 899-908
    • Henderson, E.1    Hardin, C.C.2    Walk, S.K.3    Tinoco, I.4    Blackburn, E.H.5
  • 9
    • 0030731928 scopus 로고    scopus 로고
    • Normal human chromosomes have long G-rich telomeric overhangs at one end
    • Wright, W. E., Tesmer, V. M., Huffman, K. E., Levene, S. D., and Shay, J. W. (1997) Normal human chromosomes have long G-rich telomeric overhangs at one end, Genes Dev. 11, 2801–2809.
    • (1997) Genes Dev , vol.11 , pp. 2801-2809
    • Wright, W.E.1    Tesmer, V.M.2    Huffman, K.E.3    Levene, S.D.4    Shay, J.W.5
  • 11
    • 85015833920 scopus 로고    scopus 로고
    • Modulation of the catalytic activity and processivity of human telomerase from HeLa cell
    • Sun, D., Lopez, C., Von Hoff, D. D., and Hurley, L. H. (1998) Modulation of the catalytic activity and processivity of human telomerase from HeLa cell, Proc. Am. Assoc. Cancer Res. 39, 569.
    • (1998) Proc. Am. Assoc. Cancer Res. , vol.39 , pp. 569
    • Sun, D.1    Lopez, C.2    von Hoff, D.D.3    Hurley, L.H.4
  • 12
    • 0035902465 scopus 로고    scopus 로고
    • In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei
    • Schaffitzel, C., Berger, I., Postberg, J., Hanes, J., Lipps, H. J., and Pluckthun, A. (2001) In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei, Proc. Natl. Acad. Sci. USA 98, 8572–8577.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 8572-8577
    • Schaffitzel, C.1    Berger, I.2    Postberg, J.3    Hanes, J.4    Lipps, H.J.5    Pluckthun, A.6
  • 13
    • 27144451010 scopus 로고    scopus 로고
    • Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo
    • Paeschke, K., Simonsson, T., Postberg, J., Rhodes, D., and Lipps, H. J. (2005) Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo, Nat. Struct. Mol. Biol. 12, 847–854.
    • (2005) Nat. Struct. Mol. Biol. , vol.12 , pp. 847-854
    • Paeschke, K.1    Simonsson, T.2    Postberg, J.3    Rhodes, D.4    Lipps, H.J.5
  • 14
    • 33847372902 scopus 로고    scopus 로고
    • Physiological relevance of telomeric G-quadruplex formation: A potential drug target
    • Oganesian, L., and Bryan, T. M. (2007) Physiological relevance of telomeric G-quadruplex formation: a potential drug target, Bioessays 29, 155–165.
    • (2007) Bioessays , vol.29 , pp. 155-165
    • Oganesian, L.1    Bryan, T.M.2
  • 16
    • 18744369280 scopus 로고    scopus 로고
    • A novel carbazole derivative, BMVC: A potential antitumor agent and fluorescence marker of cancer cells
    • Chang, C. C., Kuo, I. C., Lin, J. J., Lu, Y. C., Chen, C. T., Back, H. T., Lou, P. J., and Chang, T. C. (2004) A novel carbazole derivative, BMVC: A potential antitumor agent and fluorescence marker of cancer cells, Chemistry & Biodiversity 1, 1377–1384.
    • (2004) Chemistry & Biodiversity , vol.1 , pp. 1377-1384
    • Chang, C.C.1    Kuo, I.C.2    Lin, J.J.3    Lu, Y.C.4    Chen, C.T.5    Back, H.T.6    Lou, P.J.7    Chang, T.C.8
  • 17
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley, C. B., Futcher, A. B., and Greider, C. W. (1990) Telomeres shorten during ageing of human fibroblasts, Nature 345, 458–460.
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 18
    • 0022402513 scopus 로고
    • Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
    • Greider, C. W., and Blackburn, E. H. (1985) Identification of a specific telomere terminal transferase activity in Tetrahymena extracts, Cell 43, 405–413.
    • (1985) Cell , vol.43 , pp. 405-413
    • Greider, C.W.1    Blackburn, E.H.2
  • 20
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D., and Weinberg, R. A. (2000) The hallmarks of cancer, Cell. 100, 57–70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 21
    • 0025877846 scopus 로고
    • Inhibition of Telomerase by G-Quartet DNA Structures
    • Zahler, A. M., Williamson, J. R., Cech, T. R., and Prescott, D. M. (1991) Inhibition of Telomerase by G-Quartet DNA Structures, Nature 350, 718–720.
    • (1991) Nature , vol.350 , pp. 718-720
    • Zahler, A.M.1    Williamson, J.R.2    Cech, T.R.3    Prescott, D.M.4
  • 22
    • 0027918585 scopus 로고
    • Solution Structure of the Human Telomeric Repeat D[Ag(3)(T(2)Ag(3))3] G-Tetraplex
    • Wang, Y., and Patel, D. J. (1993) Solution Structure of the Human Telomeric Repeat D[Ag(3)(T(2)Ag(3))3] G-Tetraplex, Structure 1, 263–282.
    • (1993) Structure , vol.1 , pp. 263-282
    • Wang, Y.1    Patel, D.J.2
  • 23
    • 0037142071 scopus 로고    scopus 로고
    • Crystal structure of parallel quadruplexes from human telomeric DNA
    • Parkinson, G. N., Lee, M. P. H., and Neidle, S. (2002) Crystal structure of parallel quadruplexes from human telomeric DNA, Nature 417, 876–880.
    • (2002) Nature , vol.417 , pp. 876-880
    • Parkinson, G.N.1    Lee, M.P.H.2    Neidle, S.3
  • 24
    • 33646943863 scopus 로고    scopus 로고
    • Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution
    • Ambrus, A., Chen, D., Dai, J. X., Bialis, T., Jones, R. A., and Yang, D. Z. (2006) Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution, Nucleic Acids Res. 34, 2723–2735.
    • (2006) Nucleic Acids Res , vol.34 , pp. 2723-2735
    • Ambrus, A.1    Chen, D.2    Dai, J.X.3    Bialis, T.4    Jones, R.A.5    Yang, D.Z.6
  • 26
    • 34249846802 scopus 로고    scopus 로고
    • Structure of the intramolecular human telomeric G-quadruplex in potassium solution: A novel adenine triple formation
    • Dai, J. X., Punchihewa, C., Ambrus, A., Chen, D., Jones, R. A., and Yang, D. Z. (2007) Structure of the intramolecular human telomeric G-quadruplex in potassium solution: a novel adenine triple formation, Nucleic Acids Res. 35, 2440–2450.
    • (2007) Nucleic Acids Res , vol.35 , pp. 2440-2450
    • Dai, J.X.1    Punchihewa, C.2    Ambrus, A.3    Chen, D.4    Jones, R.A.5    Yang, D.Z.6
  • 31
    • 47249089630 scopus 로고    scopus 로고
    • Polymorphism of human telomeric quadruplex structures
    • Dai, J. X., Carver, M., and Yang, D. Z. (2008) Polymorphism of human telomeric quadruplex structures, Biochimie. 90, 1172–1183.
    • (2008) Biochimie , vol.90 , pp. 1172-1183
    • Dai, J.X.1    Carver, M.2    Yang, D.Z.3
  • 32
    • 13644267721 scopus 로고    scopus 로고
    • Solution structure of the biologically relevant G-quadruplex element in the human c-MYC promoter. Implications for G-quadruplex stabilization
    • Ambrus, A., Chen, D., Dai, J. X., Jones, R. A., and Yang, D. Z. (2005) Solution structure of the biologically relevant G-quadruplex element in the human c-MYC promoter. Implications for G-quadruplex stabilization, Biochemistry 44, 2048–2058.
    • (2005) Biochemistry , vol.44 , pp. 2048-2058
    • Ambrus, A.1    Chen, D.2    Dai, J.X.3    Jones, R.A.4    Yang, D.Z.5
  • 33
    • 33750990787 scopus 로고    scopus 로고
    • NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region
    • Dai, J. X., Chen, D., Jones, R. A., Hurley, L. H., and Yang, D. Z. (2006) NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region, Nucleic Acids Res. 34, 5133–5144.
    • (2006) Nucleic Acids Res , vol.34 , pp. 5133-5144
    • Dai, J.X.1    Chen, D.2    Jones, R.A.3    Hurley, L.H.4    Yang, D.Z.5
  • 35
    • 33846569026 scopus 로고    scopus 로고
    • Structure-specific recognition of quadruplex DNA by organic cations: Influence of shape, substituents and charge
    • White, E. W., Tanious, F., Ismail, M. A., Reszka, A. P., Neidle, S., Boykin, D. W., and Wilson, W. D. (2007) Structure-specific recognition of quadruplex DNA by organic cations: Influence of shape, substituents and charge, Biophys. Chem. 126, 140–153.
    • (2007) Biophys. Chem. , vol.126 , pp. 140-153
    • White, E.W.1    Tanious, F.2    Ismail, M.A.3    Reszka, A.P.4    Neidle, S.5    Boykin, D.W.6    Wilson, W.D.7
  • 36
    • 57549117622 scopus 로고    scopus 로고
    • Controlledfolding of a small molecule modulates DNA G-quadruplex recognition
    • Muller, S., Pantos, G. D., Rodriguez, R., and Balasubramanian, S. (2009) Controlledfolding of a small molecule modulates DNA G-quadruplex recognition, Chem. Commun. 80–82.
    • (2009) Chem. Commun. , pp. 80-82
    • Muller, S.1    Pantos, G.D.2    Rodriguez, R.3    Balasubramanian, S.4
  • 39
    • 85015897759 scopus 로고    scopus 로고
    • The interaction of telomerase inhibitory porphyrines with G-quadruplex DNA
    • Wheelhouse, R. T., Han, F. X., Sun, D., and Hurley, L. H. (1998) The interaction of telomerase inhibitory porphyrines with G-quadruplex DNA., Proc. Am. Assoc. Cancer Res. 39, 430.
    • (1998) Proc. Am. Assoc. Cancer Res. , vol.39 , pp. 430
    • Wheelhouse, R.T.1    Han, F.X.2    Sun, D.3    Hurley, L.H.4
  • 40
    • 8544273289 scopus 로고    scopus 로고
    • Novel DNA Bisintercalation by MLN944, a potent clinical bisphenazine anticancer drug
    • Dai, J. X., Punchihewa, C., Mistry, P., Ooi, A. T., and Yang, D. Z. (2004) Novel DNA Bisintercalation by MLN944, a potent clinical bisphenazine anticancer drug, J. Biol. Chem. 279, 46096–46103.
    • (2004) J. Biol. Chem. , vol.279 , pp. 46096-46103
    • Dai, J.X.1    Punchihewa, C.2    Mistry, P.3    Ooi, A.T.4    Yang, D.Z.5
  • 41
    • 85139055369 scopus 로고    scopus 로고
    • San Francisco
    • Goddard, T. D., and Kneller, D. G. (2004) University of California, San Francisco.
    • (2004)
    • Goddard, T.D.1    Kneller, D.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.