Missense mutation in APOC3 within the C-terminal lipid binding domain of human ApoC-III results in impaired assembly and secretion of triacylglycerol-rich very low density lipoproteins: Evidence that ApoC-III plays a major role in the formation of lipid precursors within the microsomal lumen

Journal of Biological Chemistry

Volumn 286, Issue 31, 2011, Pages 27769-27780

  Qin, Wen ^a   Sundaram, Meenakshi ^b   Wang, Yuwei ^b   Zhou, Hu ^b   Zhong, Shumei ^b   Chang, Chia Ching ^e,f   Manhas, Sanjay ^b   Yao, Erik F ^b   Parks, Robin J ^c   McFie, Pamela J ^d   Stone, Scot J ^d   Jiang, Zhenghui G ^g   Wang, Congrong ^a   Figeys, Daniel ^b   Jia, Weiping ^a   Yao, Zemin ^b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b UNIVERSITY OF OTTAWA   (Canada)

^c OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^d UNIVERSITY OF SASKATCHEWAN   (Canada)

^e NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

^f INSTITUTE OF PHYSICS   (Taiwan)

^g BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEINS; LIPID BINDING; LIPID DROPLETS; METABOLIC LABELING; MUTANT PROTEINS; POSITIVE CHARGES; TRIACYLGLYCEROLS; VERY LOW DENSITY LIPOPROTEINS;

DROPS; GLYCEROL; LIPIDS; MAMMALS;

PHYSIOLOGY;

APOLIPOPROTEIN B100; APOLIPOPROTEIN C3; FAT DROPLET; GLUTAMINE; LYSINE; MUTANT PROTEIN; RECOMBINANT APOLIPOPROTEIN C3; RECOMBINANT PROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL STIMULATION; CONTROLLED STUDY; GENE MUTATION; GENETIC TRANSFECTION; LIPID BINDING DOMAIN; LIPID METABOLISM; LIPID STORAGE; LIPOPROTEIN SECRETION; LOSS OF FUNCTION MUTATION; MALE; MICROSOME; MISSENSE MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LIPID INTERACTION; PROTEIN MODIFICATION; WESTERN BLOTTING;

APOLIPOPROTEIN C-III; CHROMATOGRAPHY, GEL; HUMANS; LIPOPROTEINS, LDL; MICROSOMES, LIVER; MUTATION, MISSENSE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUBCELLULAR FRACTIONS; TANDEM MASS SPECTROMETRY; TRIGLYCERIDES;

MUS;

EID: 79960989620     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.203679     Document Type: Article

References (34)

1. Sundaram, M., and Yao, Z. (2010) Nutr. Metab. 7, 35
2. Raabe, M., Véniant, M. M., Sullivan, M. A., Zlot, C. H., Björkegren, J., Nielsen, L. B., Wong, J. S., Hamilton, R. L., and Young, S. G. (1999) J. Clin. Invest. 103, 1287-1298
3. Kulinski, A., Rustaeus, S., and Vance, J. E. (2002) J. Biol. Chem. 277, 31516-31525
4. Wang, Y., Tran, K., and Yao, Z. (1999) J. Biol. Chem. 274, 27793-27800
5. Wang, H., Gilham, D., and Lehner, R. (2007) J. Biol. Chem. 282, 33218-33226
6. Sundaram, M., Zhong, S., Bou, Khalil, M., Zhou, H., Jiang, Z. G., Zhao, Y., Iqbal, J., Hussain, M. M., Figeys, D., Wang, Y., and Yao, Z. (2010) J. Lipid Res. 51, 1524-1534
7. Jong, M. C., Hofker, M. H., and Havekes, L. M. (1999) Arterioscler. Thromb. Vasc. Biol. 19, 472-484
8. Talmud, P. J., Hawe, E., Martin, S., Olivier, M., Miller, G. J., Rubin, E. M., Pennacchio, L. A., and Humphries, S. E. (2002) Hum. Mol. Genet. 11, 3039-3046
9. Pollin, T. I., Damcott, C. M., Shen, H., Ott, S. H., Shelton, J., Horenstein, R. B., Post, W., McLenithan, J. C., Bielak, L. F., Peyser, P. A., Mitchell, B. D., Miller, M., O'Connell, J. R., and Shuldiner, A. R. (2008) Science 322, 1702-1705
10. Ginsberg, H. N., Le, N. A., Goldberg, I. J., Gibson, J. C., Rubinstein, A., Wang-Iverson, P., Norum, R., and Brown, W. V. (1986) J. Clin. Invest. 78, 1287-1295
11. Sehayek, E., and Eisenberg, S. (1991) J. Biol. Chem. 266, 18259-18267
12. Zheng, C., Khoo, C., Ikewaki, K., and Sacks, F. M. (2007) J. Lipid Res. 48, 1190-1203
13. Zheng, C., Khoo, C., Furtado, J., Ikewaki, K., and Sacks, F. M. (2008) Am. J. Clin. Nutr. 88, 272-281
14. Sundaram, M., Zhong, S., Bou, Khalil, M., Links, P. H., Zhao, Y., Iqbal, J., Hussain, M. M., Parks, R. J., Wang, Y., and Yao, Z. (2010) J. Lipid Res. 51, 150-161
15. Sparrow, J. T., Gotto, A. M., Jr., and Morrisett, J. D. (1973) Proc. Natl. Acad. Sci. U.S.A. 70, 2124-2128
16. von Eckardstein, A., Holz, H., Sandkamp, M., Weng, W., Funke, H., and Assmann, G. (1991) J. Clin. Invest. 87, 1724-1731
17. McLeod, R. S., Wang, Y., Wang, S., Rusiñol, A., Links, P., and Yao, Z. (1996) J. Biol. Chem. 271, 18445-18455
18. Vance, D. E., Weinstein, D. B., and Steinberg, D. (1984) Biochim. Biophys. Acta 792, 39-47
19. Rogers, L., Burchat, S., Gage, J., Hasu, M., Thabet, M., Willcox, L., Wilcox, L., Ramsamy, T. A., and Whitman, S. C. (2008) Cardiovasc. Res. 78, 167-174
20. Zhong, S., Magnolo, A. L., Sundaram, M., Zhou, H., Yao, E. F., Di, Leo, E., Loria, P., Wang, S., Bamji-Mirza, M., Wang, L., McKnight, C. J., Figeys, D., Wang, Y., Tarugi, P., and Yao, Z. (2010) J. Biol. Chem. 285, 6453-6464
21. Dowler, S., Kular, G., and Alessi, D. R. (2002) Sci. STKE 2002, l6
22. Cases, S., Stone, S. J., Zhou, P., Yen, E., Tow, B., Lardizabal, K. D., Voelker, T., and Farese, R. V., Jr. (2001) J. Biol. Chem. 276, 38870-38876
23. Athar, H., Iqbal, J., Jiang, X. C., and Hussain, M. M. (2004) J. Lipid Res. 45, 764-772
24. Chang, T. Y., Limanek, J. S., and Chang, C. C. (1981) Anal. Biochem. 116, 298-302
25. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
26. Gangabadage, C. S., Zdunek, J., Tessari, M., Nilsson, S., Olivecrona, G., and Wijmenga, S. S. (2008) J. Biol. Chem. 283, 17416-17427
27. Segrest, J. P., De Loof, H., Dohlman, J. G., Brouillette, C. G., and Anantharamaiah, G. M. (1990) Proteins 8, 103-117
28. Petersen, K. F., Dufour, S., Hariri, A., Nelson-Williams, C., Foo, J. N., Zhang, X. M., Dziura, J., Lifton, R. P., and Shulman, G. I. (2010) N. Engl. J. Med. 362, 1082-1089
29. Samuel, V. T., Liu, Z. X., Wang, A., Beddow, S. A., Geisler, J. G., Kahn, M., Zhang, X. M., Monia, B. P., Bhanot, S., and Shulman, G. I. (2007) J. Clin. Invest. 117, 739-745
30. Liu, H., Talmud, P. J., Lins, L., Brasseur, R., Olivecrona, G., Peelman, F., Vandekerckhove, J., Rosseneu, M., and Labeur, C. (2000) Biochemistry 39, 9201-9212
31. Sparrow, J. T., Pownall, H. J., Hsu, F. J., Blumenthal, L. D., Culwell, A. R., and Gotto, A. M. (1977) Biochemistry 16, 5427-5431
32. Bou Khalil, M., Sundaram, M., Zhang, H. Y., Links, P. H., Raven, J. F., Manmontri, B., Sariahmetoglu, M., Tran, K., Reue, K., Brindley, D. N., and Yao, Z. (2009) J. Lipid Res. 50, 47-58
33. Stone, S. J., Levin, M. C., Zhou, P., Han, J., Walther, T. C., and Farese, R. V., Jr. (2009) J. Biol. Chem. 284, 5352-5361
34. Shannon, P., Markiel, A., Ozier, O., Baliga, N. S., Wang, J. T., Ramage, D., Amin, N., Schwikowski, B., and Ideker, T. (2003) Genome Res. 13, 2498-2504