Single nucleotide polymorphisms in the growth hormone-insulin-like growth factor axis in straightbred and crossbred Angus, Brahman, and Romosinuano heifers: Population genetic analyses and association of genotypes with reproductive phenotypes

Journal of Animal Science

Volumn 89, Issue 4, 2011, Pages 926-934

  Luna Nevarez, P ^a,e   Rincon, G ^b   Medrano, J F ^b   Riley, D G ^c,f   Chase Jr , C C ^c   Coleman, S W ^c   van Leeuwen, D M ^d   de Atley, K L ^a   Islas Trejo, A ^b   Silver, G A ^a   Thomas, M G ^a  

^a NEW MEXICO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c USDA ARS SubTropical Agricultural Research Station   (United States)

^d NEW MEXICO STATE UNIVERSITY   (United States)

^e INSTITUTO TECNOLÓGICO DE SONORA   (Mexico)

^f TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Breed; Cattle; Fertility; Genotype; Single nucleotide polymorphism

Indexed keywords

ANIMALIA; BOS; BOS INDICUS; BOS TAURUS;

GROWTH HORMONE; PREGNANCY ASSOCIATED PLASMA PROTEIN A; SOMATOMEDIN;

ANIMAL; ARTICLE; CATTLE; CHROMOSOME; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETICS; GENOTYPE; PEDIGREE; PHYLOGENY; PREGNANCY; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; CATTLE; CHROMOSOMES, MAMMALIAN; FEMALE; GENE FREQUENCY; GENOTYPE; GROWTH HORMONE; LINKAGE DISEQUILIBRIUM; PEDIGREE; PHYLOGENY; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY; PREGNANCY-ASSOCIATED PLASMA PROTEIN-A; SOMATOMEDINS;

EID: 79960987720     PISSN: 00218812     EISSN: 15253163     Source Type: Journal    
DOI: 10.2527/jas.2010-3483     Document Type: Article

References (54)

1. Allan, M. F., L. A. Kuehn, R. A. Cusham, W. M. Snelling, and S. E. Echternkamp, and R. M. Thallman. 2009. Confirmation of QTL using a low density SNP map for twinning and ovulation rate on bovine chromosome 5. J. Anim. Sci. 87:46-56.
2. Balding, D. J. 2006. A tutorial on statistical methods for population association studies. Natl. Rev. Genet. 7:781-791.
3. Boldt, H. B., and C. A. Conover. 2007. Pregnancy-associated plasma protein-A (PAPP-A): A local regulator of IGF bioavailability through cleavage of IGFBPs. Growth Horm. IGF Res. 17:10-18.
4. Brenneman, R. A., C. C. Chase Jr., T. A. Olson, D. G. Riley, and S. W. Coleman. 2007. Genetic diversity among Angus, American Brahman, Senepol and Romosinuano cattle breeds. Anim. Genet. 38:50-53.
5. Casellas, J., and J. F. Medrano. 2008. Lack of Socs2 expression reduces lifespan in high-growth mice. Age (Dordr.) 30:245-249.
6. CattleQTLdb. 2009. Release 11. Accessed Jan. 15, 2009. http://www.animalgenome.org/cgi-bin/QTLdb/BT/index.
7. Chagas, L. M., J. J. Bass, D. Blache, C. R. Burke, J. K. Kay, D. R. Lindsay, M. C. Lucy, G. B. Martin, S. Meier, F. M. Rhodes, J. R. Roche, W. W. Thatcher, and R. Webb. 2007. Invited review: New perspectives on the roles of nutrition and metabolic priorities in the subfertility of high-producing dairy cows. J. Dairy Sci. 90:4022-4032.
8. Conover, C. A., L. K. Bale, M. T. Overgaard, E. W. Johnstone, U. H. Laursen, E. M. Fuchtbauer, C. Oxvig, and J. van Deursen. 2004. Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development. Development 131:1187-1194.
9. Corva, P. M., N. C. Mucci, K. Evans, and J. F. Medrano. 2004. Diet effects on female reproduction in high growth (hg/hg) mice that are deficient in the Socs-2 gene. Reprod. Nutr. Dev. 44:303-312.
10. DeAtley, K. L. 2009. Genetic distance, population stratification, and association of microsatellite ETH10 genotypes to performance trait levels in Angus and Brahman-influenced cattle. MS Thesis. New Mexico State Univ., Las Cruces.
11. Etherton, T. D. 2004. Somatotropic function: The somatomedin hypothesis revisited. J. Anim. Sci. 82(E-Suppl.):239-244.
12. Falconer, D. S., and T. C. F. McKay. 1996. Introduction to Quantitative Genetics. 4th ed. Longman Scientific and Technical, New York, NY.
13. Falush, D., M. Stephens, and J. K. Pritchard. 2007. Technical article: Inference of population structure using multilocus genotype data: Dominant markers and null alleles. Mol. Ecol. Notes 7:574-578.
14. Farber, C. R., P. M. Corva, and J. F. Medrano. 2006. Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains. BMC Genomics 7:102.
15. Frago, L. M., and J. A. Chowen. 2005. Basic physiology of the growth hormone/insulin-like growth factor axis. Adv. Exp. Med. Biol. 567:1-25.
16. Fruhbeck, G. 2006. Intracellular signaling pathways activated by leptin. Biochem. J. 393:7-20.
17. Garrett, A. J., G. Rincon, J. F. Medrano, M. A. Elzo, G. A. Silver, and M. G. Thomas. 2008. Promoter region of the bovine growth hormone receptor gene: Single nucleotide polymorphism discovery in cattle and association with performance in Brangus bulls. J. Anim. Sci. 86:3315-3323.
18. Hubisz, M. J., D. Falush, M. Stephens, and J. K. Pritchard. 2009. Technical advances: Inferring weak population structure with the assistance of sample group information. Mol. Ecol. Res. 9:1322-1332.
19. Kim, E. S., X. Shi, O. Cobanoglu, K. Weigel, P. J. Berger, and B. W. Kirkpatrick. 2009. Refined mapping of twinning-rate quantitative trait loci on bovine chromosome 5 and analysis of insulinlike growth factor-1 as a positional candidate gene. J. Anim. Sci. 87:835-843.
20. Kwintkiewicz, J., and L. C. Guidice. 2009. The interplay of insulinlike growth factors, gonadotropins, and endocrine disruptors in ovarian follicular development and function. Semin. Reprod. Med. 27:43-51.
21. Lucy, M. C. 2008. Functional differences in the growth hormone and insulin-like growth factor axis in cattle and pigs: Implications for post-partum nutrition and reproduction. Reprod. Domest. Anim. 43(Suppl 2):31-39.
22. Martin, L. C., J. S. Brinks, R. M. Bourdon, and L. V. Cundiff. 1992. Genetic effects on beef heifer puberty and subsequent reproduction. J. Anim. Sci. 70:4006-4017.
23. Matukumalli, L. K., C. T. Lawley, R. D. Schnabel, J. F. Taylor, M. F. Allan, M. P. Heaton, J. O'Connell, S. S. Moore, T. P. L. Smith, T. S. Sonstegard, and C. P. Van Tassell. 2009. Development and characterization of a high density SNP genotyping assay for cattle. PLoS ONE 4:e5350.
24. Nassir, R., R. Kosoy, C. Tian, P. A. White, L. M. Butler, G. Silva, R. Kittles, M. E. Alarcon-Riquelme, P. K. Gregersen, J. W. Belmont, F. M. De La Vega, and M. F. Seldin. 2009. An ancestry informative marker set for determining continental origin: Validation and extension using human genome diversity panels. BMC Genet. 10:39.
25. Nei, M. 1972. Genetic distance between populations. Am. Nat. 106:283-292.
26. Nishizawa, H., K. Pryor-Koishi, M. Suzuki, T. Kato, H. Kogo, T. Sekiya, H. Kurahashi, and Y. Udagawa. 2008. Increased levels of pregnancy-associated plasma protein-A2 in the serum of preeclamptic patients. Mol. Hum. Reprod. 14:595-602.
27. Nyegaard, M., M. T. Overgaard, Y.-Q. Su, A. E. Hamilton, J. Kwintkiewicz, M. Hsieh, N. R. Nayak, M. Conti, C. A. Conover, and L. C. Guidice. 2010. Lack of functional pregnancyassociated plasma protein-A (PAPPA) compromises mouse ovarian steroidogenesis and female fertility. Biol. Reprod. 82:1129-1138.
28. Ohlsson, C., S. Mohan, K. Sjorgren, A. Tivesten, J. Isgaard, O. Isaksson, J.-O. Jansson, and J. Svensson. 2009. The role of liver-derived insulin-like growth factor-I. Endocr. Rev. 30:494-535.
29. Parmentier, I., D. Portetelle, N. Gengler, A. Prandi, C. Bertozzi, L. Vleurick, R. Gilson, and R. Renaville. 1999. Candidate gene markers associated with somatotropic axis and milk selection. Domest. Anim. Endocrinol. 17:139-148.
30. Pritchard, J. K., M. Stephens, and P. J. Donelly. 2000. Inference of population structure using multilocus genotype data. Genetics 155:945-959.
31. Rawlings, J. S., K. M. Rosler, and D. A. Harrison. 2004. The JAK/ STAT signaling pathway. J. Cell Sci. 117:1281-1283.
32. Riley, D. G., C. C. Chase Jr., S. W. Coleman, and T. A. Olson. 2007. Evaluation of birth and weaning traits of Romosinuano calves as purebreds and crosses with Brahman and Angus. J. Anim. Sci. 85:289-298.
33. Riley, D. G., C. C. Chase, S. W. Coleman, T. A. Olson, and R. D. Randel. 2010. Evaluation of tropically-adapted straightbred and crossbred beef cattle: Heifer age and size at first conception and characteristics of their first calves. J. Anim. Sci. 88:3173-3182.
34. Rincon, G., E. A. Farber, C. R. Farber, J. D. Nkrumah, and J. F. Medrano. 2009. Polymorphisms in the STAT6 gene and their association with carcass traits in feedlot cattle. Anim. Genet. 40:878-882.
35. Rodriguez, S., T. R. Gaunt, and I. N. M. Day. 2007. Molecular genetics of human growth hormone, insulin-like growth factors and their pathways in common disease. Hum. Genet. 122:1-21.
36. Rodriguez-Murillo, L., and D. A. Greenberg. 2008. Genetic association analysis: A primer on how it works, its strengths and its weakness. Int. J. Androl. 31:546-556.
37. Rosas, U., N. H. Barton, L. Copsey, P. Barbier de Reuille, and E. Coen. 2010. Cryptic variation between species and the basis of hybrid performance. PLoS Biol. 8:e1000429.
38. Sahana, G., B. Guldbrandtsen, C. Bendixen, and M. S. Lund. 2010. Genome-wide association mapping for female fertility traits in Danish and Swedish Holstein cattle. Anim. Genet. 41:579-588. doi:10.1111/j.1365-2052.2010.02064.x
39. Saxton, A. M., M. G. Balzarini, A. Cappio-Borlino, W. Czika, J. D. Fry, G. Gibson, J. L. L. Guerra, M. S. Kang, N. P. P. Macciotta, G. Pulina, G. J. M. Rosa, A. M. Saxton, K. J. Stalder, R. J. Tempelman, R. Wolfinger, C. Xu, S. Xu, and X. Yu. 2004. Genetic Analysis of Complex Traits Using SAS. SAS Inst. Inc., Cary, NC.
40. Schindler, C., and C. Plumlee. 2008. Interferons pen the JAK-STAT pathway. Semin. Cell Dev. Biol. 19:311-318.
41. Seldin, M. F., and A. L. Price. 2008. Application of ancestry informative markers to association studies in European Americans. PLoS Genet. 4:e5.
42. Serre, D., A. Montpetit, G. Pare, J. C. Engert, S. Yusuf, B. Keavney, T. J. Hudson, and S. Anand. 2008. Correction of population stratification in large multi-ethnic association study. PLoS ONE 3:e1382.
43. Sherman, E. L., J. D. Nkrumah, B. M. Murdoch, C. Li, Z. Wang, A. Fu, and S. S. Moore. 2008. Polymorphisms and haplotypes in the bovine neuropeptide Y, growth hormone receptor, ghrelin, insulin-like growth factor 2, and uncoupling proteins 2 and 3 genes and their associations with measures of growth, performance, feed efficiency, and carcass merit in beef cattle. J. Anim. Sci. 86:1-16.
44. Shirley, K. L. 2005. Physiological markers and a genomic polymorphism as predictors of reproductive traits in Angus and Brangus heifers. PhD Diss. New Mexico State Univ., Las Cruces.
45. Shirley, K. L., M. G. Thomas, D. H. Keisler, D. M. Hallford, D. M. Montrose, G. A. Silver, and M. D. Garcia. 2006. Case study: A Chihuahuan desert Brangus breeding program: Feed efficiency, metabolic hormones, and puberty in heifers sired by bulls with differing expected progeny differences for growth and scrotal circumference. Prof. Anim. Sci. 22:48-58.
46. Thomas, M. G., R. M. Enns, K. L. Shirley, M. D. Garcia, A. J. Garrett, and G. A. Silver. 2007. Associations of DNA polymorphisms in growth hormone and its transcriptional regulators with growth and carcass traits in two populations of Brangus bulls. Genet. Mol. Res. 6:222-237.
47. Tian, C., P. K. Gregersen, and M. F. Seldin. 2008. Accounting for ancestry: Population substructure and genome-wide association studies. Hum. Mol. Genet. 17:R143-R150.
48. Toosi, A., R. L. Fernando, and J. C. M. Deckers. 2010. Genomic selection in admixed and crossbred populations. J. Anim. Sci. 88:32-46.
49. Walenkamp, M. J. E., and J. M. Wit. 2007. Genetic disorders in the GH-IGF-I axis in mouse and man. Eur. J. Endocrinol. 157(Suppl. 1):S15-S26.
50. Wang, J., Q. Qiu, M. Haider, M. Bell, A. Gruslin, and J. K. Christians. 2009. Expression of pregnancy-associated plasma protein A2 during pregnancy in human and mouse. J. Endocrinol. 202:337-345.
51. Wickramasinghe, S., G. Rincon, and J. F. Medrano. 2011. Pregnancy associated plasma protein-A2 in BTA 16 is associated with daughter calving ease and productive life in Holstein cattle. J. Dairy Sci. 93. doi:10.3168/jds.2010-3237
52. Winn, V. D., M. Gormley, A. C. Paquet, K. Kjaer-Sorensen, A. Kramer, K. K. Rumer, R. Haimov-Kochman, R. F. Yeh, M. T. Overgaard, A. Varki, C. Oxvig, and S. J. Fisher. 2009. Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulinlike lectin-6 and pappalysin-2. Endocrinology 150:452-462.
53. Yan, X., R. C. Baxter, and S. M. Firth. 2010. Involvement of pregnancy-associated plasma protein-A2 in insulin-like growth factor (IGF) binding protein-5 proteolysis during pregnancy: A potential mechanism for increasing IGF bioavailability. J. Clin. Endocrinol. Metab. 95:1412-1420.
54. Zhou, H., A. D. Mitchell, J. P. McMurtry, C. M. Ashwell, and S. J. Lamont. 2005. Insulin-like growth factor-I gene polymorphism associations with growth, body composition, skeleton, integrity, and metabolic traits in chickens. Poult. Sci. 84:212-219.