Polymorphisms and haplotypes in the bovine neuropeptide Y, growth hormone receptor, ghrelin, insulin-like growth factor 2, and uncoupling proteins 2 and 3 genes and their associations with measures of growth, performance, feed efficiency, and carcass merit in beef cattle

Journal of Animal Science

Volumn 86, Issue 1, 2008, Pages 1-16

  Sherman, E L ^a   Nkrumah, J D ^a,b   Murdoch, B M ^a   Li, C ^a,c   Wang, Z ^a   Fu, A ^a   Moore, S S ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^c LACOMBE RESEARCH CENTRE   (Canada)

Author keywords

Candidate gene; Carcass merit; Cattle; Feed efficiency; Haplotype; Single nucleotide polymorphism

Indexed keywords

GHRELIN; GROWTH HORMONE RECEPTOR; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 2; MITOCHONDRIAL UNCOUPLING PROTEIN 3; NEUROPEPTIDE Y; SOMATOMEDIN; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; BODY COMPOSITION; CATTLE; GENE EXPRESSION REGULATION; GENETICS; GENOTYPE; HAPLOTYPE; MALE; METABOLISM; SINGLE NUCLEOTIDE POLYMORPHISM; WEIGHT GAIN;

ANIMALS; BODY COMPOSITION; CATTLE; GENE EXPRESSION REGULATION; GENOTYPE; GHRELIN; HAPLOTYPES; ION CHANNELS; MALE; MITOCHONDRIAL PROTEINS; NEUROPEPTIDE Y; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, SOMATOTROPIN; SOMATOMEDINS; WEIGHT GAIN;

ANIMALIA; BOS; BOVINAE;

EID: 38149115520     PISSN: 00218812     EISSN: None     Source Type: Journal    
DOI: 10.2527/jas.2006-799     Document Type: Article

References (64)

1. Agriculture Canada. 1992. Livestock carcass grading regulations CAN. Gazette Part II. 126:3821-3828.
2. Arthur, P., G. Renand, and D. Krauss. 2001. Genetic and phenotypic relationships among different measures of growth and feed efficiency in young Charolais bulls. Livest, Prod. Sci. 68:131-139.
3. Barendse, W., D. Vaiman, S. J. Kemp, Y. Sugimoto, S. M. Armitage, J. L. Williams, H. S. Sun, A. Eggen, M. Agaba, S. A. Aleyasin, M. Band, M. D. Bishop, J. Buitkamp, K. Byrne, F. Collins, L. Cooper, W. Coppettiers, B. Denys, R. D. Drinkwater, K. Easterday, C. Elduque, S. Ennis, G. Erhardt, L. Ferretti, N. Flavin, Q. Gao, M. Georges, R. Gurung, B. Harlizius, G. Hawkins, J. Hetzel, T. Hirano, D. Hulme, C. Jorgensen, M. Kessler, B. W. Kirkpatrick, B. Konfortov, S. Kostia, C. Kuhn, J. A. Lenstra, H. Leveziel, H. A. Lewin, B. Leyhe, L. Lil, I. Martin Burriel, R. A. McGraw, J. R. Miller, D. E. Moody, S. S. Moore, S. Nakane, I. J. Nijman, I. Olsaker, D. Pomp, A. Rando, M. Ron, A. Shalom, A. J. Teale, U. Thieven, B. G. D. Urquhart, D.-I. Vage, A. Van de Weghe, S. Varvio, R. Velmala, J. Vilkki, R. Weikard, C. Woodside, and J. E. Womack. 1997. A medium-density genetic linkage map of the bovine genome. Mamm. Genome 8:21-28.
4. Basarab, J. A., M. A. Price, J. L. Aalhus, E. K. Okine, W. M. Snelling, and K. L. Lyle. 2003. Residual feed intake and body composition in young growing cattle. Can. J. Anim. Sci. 83:189-204.
5. Benjamini, Y., and Y. Hochberg. 1995. Controlling the false discovery rate-A practical and powerful approach to multiple testing. J. Royal Stat. Soc. Series B-Methodological. 57:289-300.
6. Boss, O., S. Samec, F. Khne, P. Bjjlenga, F. Assimacopoulos-Jeanneat, J. Seydox, J. P. Giacobino, and P. Muzzin. 1998. Uncoupling protein-3 expression in rodent skeletal muscle is modulated by food intake but not by changes in environmental temperature. J. Biol. Chem. 273:5-8.
7. Bouchard, C.,L. Perusse, Y. C. Chagnon, C. Warden, and D. Ricquier. 1997. Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans. Hum. Mol. Genet. 6:1887-1889.
8. Breier, B. H. 1995. Regulation of growth in ruminants by the somatotropic axis. Pages 451-473 in S. L. -M. W. V. Engelhardt, G. Breves, and D. Giesecke, ed. Ruminant Physiology: Digestion, Metabolism, Growth and Reproduction. Ferdinand Enke Verlag Publishing, Stuttgart, Germany.
9. Brethour, J. 1992. The repeatability and accuracy of ultrasound in measuring backfat of cattle. J. Anim. Sci. 70:1039-1044.
10. Brody, S. 1935. The relation between feeding standards and basal metabolism. Pages 12-13 in Rep. Conf. Energy Metab. Comm. Anim. Nutr. Natl. Acad. Press, Washington, DC.
11. Buchanan, F. C., T. D. Thue, E. D. Elsaesser, and D. C. Winkelman-Som. 2002. A corticotrophin-releasing hormone polymorphism associated with post-natal growth in beef cattle. Pages 11-32 in Proc. 7th World Congr. Genet. Appl. Livest. Prod., Montpellier, France.
12. Buchanan, F. C., T. D. Thue, P. Yu, and D. C. Winkelman-Sim. 2005. Single nucleotide polymorphisms in the corticotrophin-releasing hormone and pro-opiomelancortin genes are associated with growth and carcass yield in beef cattle. Anim. Genet. 36:127-131.
13. Casas, E., J. Keele, S. Shackelford, M. Koohmaraie, and R. Stone. 2004. Identification of quantitative trait loci for growth and carcass composition in cattle. Anim. Genet. 35:2-6.
14. Casas, E., R. T. Stone, J. W. Keele, S. D. Shackelford, S. M. Kappes, and M. Koohmaraie. 2001. A comprehensive search for quantitative trait loci affecting growth and carcass composition of cattle segregating alternative forms of the myostatin gene. J. Anim. Sci. 79:854-860.
15. CCAC. 1993. Guide to the Care and Use of Experimental Animals. Vol. 1. E. D. Olfert, B. M. Cross, A. A. McWilliams, ed. Can. Counc. Anim. Care, Ottawa, Ontario, Canada.
16. Chan, C. B., P. E. MacDonald, M. C. Saleh, D. C. Johns, E. Marban, and M. B. Wheeler. 1999. Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets. Diabetes 48:1482-1486.
17. DeChiara, T. M., A. Efstratiadis, and E. J. Robertson. 1990. A growthdeficiency phenotype in heterozygous mice carrying an insulinlike growth factor II gene disrupted by targeting. Nature 345:78-80.
18. Dickin, J. C., T. D. Thue, and F. C. Buchanan. 2004. An alternative splice site in ghrelin is missing in ruminants. Anim. Genet. 35:411-412.
19. Di Stasio, L., G. Destefanis, A. Brugiapaglia, A. Albera, and A. Rolando. 2005. Polymorphism of the GHR gene in cattle and relationships with meat production and quality. Anim. Genet. 36:138-140.
20. Dyer, C. J., J. M. Simmons, R. L. Matten, and D. H. Keisler. 1997. Effects of an intravenous injection of NPY on leptin and NPY-Y1 receptor MRNA expression in ovine adipose tissue. Domest. Anim. Endocrinol. 14:325-333.
21. Erlanson-Albertsson, C. 2003. The role of uncoupling proteins in the regulation of metabolism. Acta Physiol. Scand. 178:405-412.
22. Falconer, D. S., and T. F. C. Mackay. 1996. Introduction to Quantitative Genetics. 4th ed. Longman Scientific and Technical, New York, NY.
23. Gaunt, T. R., J. A. Cooper, G. J. Miller, I. N. Day, and S. D. O'Dell. 2001. Positive associations between single nucleotide polymorphisms in the IGF2 gene region and body mass index in adult males. Hum. Mol. Genet. 10:1491-1501.
24. Ge, W., M. E. Davis, H. C. Hines, and K. M. Irvin. 1999a. Polymorphism in exon 10 of the bovine GHR gene detected by PCR-DGGE. Anim. Genet. 30:167-168.
25. Ge, W., M. E. Davis, H. C. Hines, and K. M. Irvin. 1999b. Two-allelic DGGE polymorphism detected in the promoter region of the bovine GHR gene. Anim. Genet. 30:71.
26. Ge, W., M. E. Davis, H. C. Hines, K. M. Irvin, and R. C. Simmen. 2003. Association of single nucleotide polymorphisms in the growth hormone and growth hormone receptor genes with blood serum insulin-like growth factor I concentration and growth traits in Angus cattle. J. Anim. Sci. 81:641-648.
27. Goodall, J. J., and S. M. Schmutz. 2003. Linkage mapping of IGF2 on cattle chromosome 29. Anim. Genet. 34:313.
28. Goonewardene, L. A. Z. W., M. A. Price, R. C. Yang, R. T. Berg, and M. Makarechian, 2003. Effect of udder type and calving assistance on weaning traits of beef and dairy x beef calves. Livest. Prod. Sci. 81:47-56.
29. Haegeman, A., J. L. Williams, A. Law, A. Van Zeveren, and L. J. Peelman. 2003. Mapping and SNP analysis of bovine candidate genes for meat and carcass quality. Anim. Genet. 34:349-353.
30. Hayden, J. M., J. E. Williams, and R. J. Collier. 1993. Plasma growth hormone, insulin-like growth factor, insulin, and thyroid hormone association with body protein and fat accretion in steers undergoing compensatory gain after dietary energy restriction. J. Anim. Sci. 71:3327-3338.
31. Istasse, L., C. Van Eenaeme, P. Evrard, A. Gabriel, P. Baldwin, G. Maghuin-Rogister, and J. M. Bienfait. 1990. Animal performance, plasma hormones and metabolites in Holstein and Belgian Blue growing-fattening bulls. J. Anim. Sci. 68:2666-2673.
32. Jarkovska, Z., M. Krsek, M. Rosicka, and J. Marek. 2004. Endocrine and metabolic activities of a recently isolated peptide hormone ghrelin, an endogenous ligand of the growth hormone secretagogue receptor. Endocr. Regul. 38:80-86.
33. Jones, S. D., T. D. Bergess, J. W. Wilton, and C. H. Watson. 1984. Feedlot performance, carcass composition and efficiency of muscle gain in bulls and steers of different mature size slaughtered at different level of fatness. Can. J. Anim. Sci. 64:621-630.
34. Kojima, M., H. Hosoda, Y. Date, M. Nakazato, H. Matso, and K. Kangawa. 1999. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-660.
35. Kontani, Y., Z. Wang, T. Furuyama, Y. Sato, N. Mori, and H. Yamashita. 2002. Effects of aging and denervation on the expression of uncoupling proteins in slow- and fast-twitch muscles of rats. J. Biochem. (Tokyo) 132:309-315.
36. Lucy, M. C., S. D. Hauser, P. J. Eppard, G. G. Krivi, and R. J. Collier. 1991. Genetic polymorphism within the bovine somatotropin (BST) gene detected by polymerase chain reaction and endonuclease digestion. J. Dairy Sci. 74(Suppl. 1):284.
37. MacNeil, M. D., and M. D. Grosz. 2002. Genome-wide scans for QTL affecting carcass traits in Hereford x composite double backcross populations. J. Anim. Sci. 80:2316-2324.
38. Maj, A., J. Oprzadek, E. Dymnicki, and L. Zwierzchowski. 2006a. Association of the polymorphism in the 5′-noncoding region of the bovine growth hormone receptor gene with meat production traits in polish black-and-white cattle. Meat Sci. 72:539-544.
39. Maj, A., J. Oprzadek, A. Oprzadek, E. Dymnicki, and L. Zwierzchowski. 2004. Polymorphism in the 5′-noncoding region of the bovine growth hormone receptor gene and its association with meat production traits in cattle. Anim. Res. 53:503-514.
40. Maj, A., and L. Zwierzchowski. 2006b. Molecular evolution of coding and non-coding sequences of the growth hormone receptor (GHR) gene in the family bovidae. Folia Biol. (Krakow) 54:31-36.
41. Matsuda, J., K. Hosoda, H. Itoh, C. Son, K. Dori, T. Tanaka, Y. Fukunaga, G. Inoue, H. Nishimura, Y. Yoshimasa, Y. Yamori, and K. Nakao. 1997. Cloning of rat uncoupling protein-3 and uncoupling protein-2 cDNAs: Their gene expression in rats fed high-fat diet. FEBS Lett. 418:200-204.
42. Mizoshita, K., T. Watanabe, H. Hayashi, C. Kubota, H. Yamakuchi, J. Todoroki, and Y. Sugimoto. 2004. Quantitative trait loci analysis for growth and carcass traits in a half-sib family of purebred Japanese Black (Wagyu) cattle. J. Anim. Sci. 82:3415-3420.
43. Moody, D. E., D. Pomp, W. Barendse, and J. E. Womack. 1995. Assignment of the growth hormone receptor gene to bovine chromosome 20 using linkage analysis and somatic cell mapping. Anim. Genet. 26:341-343.
44. Nkrumah, J. D., J. A. Basarab, M. A. Price, E. K. Okine, A. Ammoura, S. Guercio, C. Hansen, C. Li, B. Benkel, B. Murdoch, and S. S. Moore. 2004. Different measures of energetic efficiency and their phenotypic relationships with growth, feed intake, and ultrasound and carcass merit in hybrid cattle. J. Anim. Sci. 82:2451-2459.
45. Nkrumah, J. D., E. K. Okine, G. W. Mathison, K. Schmid, C. Li, J. A. Basarab, M. A. Price, Z. Wang, and S. S. Moore. 2006. Relationships of feedlot feed efficiency, performance, and feeding behavior with metabolic rate, methane production, and energy partitioning in beef cattle. J. Anim. Sci. 84:145-153.
46. NRC. 1996. Nutrient Requirements of Beef Cattle. 7th ed. Natl. Acad. Press, Washington, DC.
47. Oliphant, A., D. L. Barker, J. R. Stuelpnagel, and M. S. Chee. 2002. Beadarray technology: Enabling an accurate, cost-effective approach to high-throughput genotyping. Biotechniques Suppl. 56-58:60-51.
48. Phillips, J. A., III. 1995. Inherited Defects in Growth Hormone Synthesis and Action. 7th ed. McGraw-Hill, New York, NY.
49. Pierroz, D. D., C. Catzeflis, A. C. Aebi, J. E. Rivier, and M. L. Aubert. 1996. Chronic administration of neuropeptide Y into the lateral ventricle inhibits both the pituitary-testicular axis and growth hormone and insulin-like growth factor I secretion in intact adult male rats. Endocrinology 137:3-12.
50. Renaville, R., M. Hammadi, and D. Portetelle. 2002. Role of the somatotropic axis in the mammalian metabolism. Domest. Anim. Endocrinol. 23:351-360.
51. Sandhu, M. S., J. M. Gibson, A. H. Heald, D. B. Dunger, and N. J. Wareham. 2003. Low circulating IGF-II concentrations predict weight gain and obesity in humans. Diabetes 52:1403-1408.
52. Schmutz, S., and J. Goodall. 2005. Improving production characteristics of cattle. European Patent Office WO2005007881.
53. Stone, R., C. Rexroad, and T. Smith. 1999. Bovine UCP2 and UCP3 map to BTA15. Anim. Genet. 30:378-381.
54. Thue, T. D., and F. C. Buchanan. 2004. Linkage mapping of NPY to bovine chromosome 4. Anim. Genet. 35:245-246.
55. Thue, T, D., S. M. Schmutz, and F. C. Buchanan. 2001. A SNP in the cattle MC4R gene is used to map MC4R to BTA 24. Anim. Genet. 32:390-391.
56. Van Laere, A. S., M. Nguyen, M. Brunschweig, C. Nezer, C. Collette, L. Moreau, S. L. Archibald, C. S. Haley, N. Buys, M. Tally, G. Andersson, M. Georges, and L. Andersson. 2003. A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig. Nature 425:832-836.
57. van Rossum, C. T., H. Pyl, R. A. Adan, B. Hoebee, and J. C. Seidell. 2006. Polymorphisms in the NPY and AGRP genes and body fatness in Dutch adults. Int. J. Obes. (Lond.).
58. Vidal-Puig, A. J., D. Grujic, C. Y. Zhang, T. Hagen, O. Boss, Y. Ido, A. Szezepanik, J. Wade, V. Mootha, R. Cortright, D. Muoio, and B. B. Lowell. 2000. Energy metabolism in uncoupling protein 3 gene knockout mice. J. Biol. Chem. 275:16258-16266.
59. Weller, J. I., J. Z. Song, D. W. Heyen, H. A. Lewin, and M. Ron. 1998. A new approach to the problem of multiple comparisons in the genetic dissection of complex traits. Genetics 150:1699-1706.
60. Woods, S. C., R. J. Seeley, D. Porte, Jr., and M. W. Schwartz. 1998. Signals that regulate food intake and energy homeostasis. Science 280:1378-1383.
61. Wortley, K. E., K. D. Anderson, K. Garcia, J. D. Murray, L. Malinova, R. Lui, M. Moncrieffe, K. Thabet, H. J. Cox, G. D. Yancopoulos, S. J. Wiegand, and M. W. Sleeman. 2004. Genetic deletion of ghrelin does not deCLMAse food intake but influences metabolic fuel preference. Proc. Natl. Acad. Sci. USA 101:8227-8232.
62. Wynne, K., S. Stanley, B. McGowan, and S. Bloom. 2005. Appetite control. J. Endocrinol. 184:291-318.
63. Zhang, K., F. Sun, and H. Zhao. 2005. Haplore: A program for haplotype reconstruction in general pedigrees without recombination. Bioinformatics 21:90-103.
64. Zhou, Y., and H. Jiang. 2005. Trait-associated sequence variation in the bovine growth hormone receptor la promoter does not affect promoter activity in vitro. Anim. Genet. 36:156-159.