CD4+ T cells defined by their Vβ T cell receptor expression are associated with immunoregulatory profiles and lesion size in human leishmaniasis

Clinical and Experimental Immunology

Volumn 165, Issue 3, 2011, Pages 338-351

  Keesen, T S L ^a,b   Antonelli, L R V ^c   Faria, D R ^a   Guimaraes L H ^d,e   Bacellar, O ^d,e   Carvalho, E M ^d,e   Dutra, W O ^a,e   Gollob, K J ^b,e,f  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b Santa Casa Hospital   (Brazil)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

^d FEDERAL UNIVERSITY OF BAHIA   (Brazil)

^e INCT DT ^*  (Brazil)

^f SRI INTERNATIONAL   (United States)

Author keywords

CD4 T cells; Cytokines; Human leishmaniasis; T cell receptor; Tegumentary lesions

Indexed keywords

CD45RO ANTIGEN; GAMMA INTERFERON; HLA DR ANTIGEN; INTERLEUKIN 10; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; V BETA T LYMPHOCYTE RECEPTOR;

ADOLESCENT; ADULT; ANTIGEN EXPRESSION; ARTICLE; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CELL EXPANSION; CELL HOMING; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HUMAN; IMMUNOREGULATION; IMMUNOSTIMULATION; LEISHMANIA; LESION SIZE; LYMPHOCYTE FUNCTION; MALE; PRIORITY JOURNAL; SKIN LEISHMANIASIS; SKIN ULCER; T LYMPHOCYTE EXPANSION; T LYMPHOCYTE SUBPOPULATION;

ADOLESCENT; ADULT; ANTIGENS, CD45; ANTIGENS, PROTOZOAN; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; CYTOKINES; FEMALE; HLA-DR ANTIGENS; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-10; LEISHMANIA BRAZILIENSIS; LEISHMANIASIS, CUTANEOUS; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SKIN; T-LYMPHOCYTE SUBSETS; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 79960972274     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2011.04430.x     Document Type: Article

References (40)

1. Murray HW, Berman JD, Davies CR, Saravia NG. Advances in leishmaniasis. Lancet 2005; 366:1561-77.
2. Desjeux P. Leishmaniasis: current situation and new perspectives. Comp Immunol Microbiol Infect Dis 2004; 27:305-423.
3. Goto H, Lindoso JA. Current diagnosis and treatment of cutaneous and mucocutaneous leishmaniasis. Exp Rev Anti Infect Ther 2010; 8:419-33.
4. Carvalho EM, Barral A, Costa JM, Bittencourt A, Marsden P. Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis. Acta Trop 1994; 56:315-25.
5. Barral A, Barral-Netto M, Almeida R etal. Lymphadenopathy associated with Leishmania braziliensis cutaneous infection. Am J Trop 1992; 47:587-92.
6. Reiner SL, Locksley RM. The regulation of immunity to Leishmania major. Annu Rev Immunol 1995; 13:151-77.
7. Sacks D, Noben-Trauth N. The immunology of susceptibility and resistance to Leishmania major in mice. Nat Rev Immunol 2002; 2:845-58.
8. Harty JT, Tvinnereim AR, White DW. CD8+ T cell effector mechanisms in resistance to infection. Annu Rev Immunol 2000; 18:275-308.
9. Mendonca SC, De Luca PM, Mayrink W etal. Characterization of human T lymphocyte-mediated immune responses induced by a vaccine against American tegumentary leishmaniasis. Am J Trop Med Hyg 1995; 53:195-201.
10. Antonelli LR, Dutra WO, Almeida RP, Bacellar O, Gollob KJ. Antigen-specific correlations of cellular immune responses in human leishmaniasis suggests mechanisms for immunoregulation. Clin Exp Immunol 2004; 136:341-8.
11. Bottrel RL, Dutra WO, Martins FA etal. Flow cytometric determination of cellular sources and frequencies of key cytokine-producing lymphocytes directed against recombinant LACK and soluble Leishmania antigen in human cutaneous leishmaniasis. Infect Immun 2001; 69:3232-9.
12. Faria DR, Gollob KJ, Barbosa J, Jr etal. Decreased in situ expression of interleukin-10 receptor is correlated with the exacerbated inflammatory and cytotoxic responses observed in mucosal leishmaniasis. Infect Immun 2005; 73:7853-9.
13. Gaze ST, Dutra WO, Lessa M etal. Mucosal leishmaniasis patients display an activated inflammatory T-cell phenotype associated with a nonbalanced monocyte population. Scand J Immunol 2006; 63:70-8.
14. Gomes-Silva A, de Cassia BR, Dos Santos NR etal. Can interferon-gamma and interleukin-10 balance be associated with severity of human Leishmania (Viannia) braziliensis infection? Clin Exp Immunol 2007; 149:440-4.
15. Antonelli LR, Dutra WO, Almeida RP, Bacellar O, Carvalho EM, Gollob KJ. Activated inflammatory T cells correlate with lesion size in human cutaneous leishmaniasis. Immunol Lett 2005; 101:226-30.
16. Meuer SC, Cooper DA, Hodgdon JC etal. Identification of the receptor for antigen and major histocompatibility complex on human inducer T lymphocytes. Science 1983; 222:1239-42.
17. Lennon GP, Sillibourne JE, Furrie E, Doherty MJ, Kay RA. Antigen triggering selectively increases TCRBV gene transcription. J Immunol 2000; 165:2020-7.
18. Brenner MB, Trowbridge IS, Strominger JL. Cross-linking of human T cell receptor proteins: association between the T cell idiotype beta subunit and the T3 glycoprotein heavy subunit. Cell 1985; 40:183-90.
19. Herman A, Kappler JW, Marrack P, Pullen AM. Superantigens: mechanism of T-cell stimulation and role in immune responses. Annu Rev Immunol 1991; 9:745-72.
20. Costa RP, Gollob KJ, Fonseca LL etal. T-cell repertoire analysis in acute and chronic human Chagas' disease: differential frequencies of Vbeta5 expressing T cells. Scand J Immunol 2000; 51:511-19.
21. Fontenot AP, Kotzin BL, Comment CE, Newman LS. Expansions of T-cell subsets expressing particular T-cell receptor variable regions in chronic beryllium disease. Am J Respir Cell Mol Biol 1998; 18:581-9.
22. Giacoia-Gripp CB, Neves I, Jr, Galhardo MC, Morgado MG. Flow cytometry evaluation of the T-cell receptor Vbeta repertoire among HIV-1 infected individuals before and after antiretroviral therapy. J Clin Immunol 2005; 25:116-26.
23. Mancia L, Wahlstrom J, Schiller B etal. Characterization of the T-cell receptor V-beta repertoire in Kawasaki disease. Scand J Immunol 1998; 48:443-9.
24. McCormick JK, Yarwood JM, Schlievert PM. Toxic shock syndrome and bacterial superantigens: an update. Annu Rev Microbiol 2001; 55:77-104.
25. Gollob KJ, Palmer E. Divergent viral superantigens delete V beta 5+ T lymphocytes. Proc Natl Acad Sci USA 1992; 89:5138-41.
26. Modlin RL, Tapia FJ, Bloom BR etal. In situ characterization of the cellular immune response in American cutaneous leishmaniasis. Clin Exp Immunol 1985; 60:241-8.
27. Pirmez C, Cooper C, Paes-Oliveira M, Schubach A, Torigian VK, Modlin RL. Immunologic responsiveness in American cutaneous leishmaniasis lesions. J Immunol 1990; 145:3100-4.
28. Uyemura K, Pirmez C, Sieling PA, Kiene K, Paes-Oliveira M, Modlin RL. CD4+ type 1 and CD8+ type 2 T cell subsets in human leishmaniasis have distinct T cell receptor repertoires. J Immunol 1993; 151:7095-104.
29. Clarencio J, de Oliveira CI, Bomfim G etal. Characterization of the T-cell receptor Vbeta repertoire in the human immune response against Leishmania parasites. Infect Immun 2006; 74:4757-65.
30. Mayrink W, Schettini AP, Williams P etal. Histological observations on Montenegro's reaction in man. Rev Inst Med Trop Sao Paulo 1989; 31:256-61.
31. Follador I, Araujo C, Bacellar O etal. Epidemiologic and immunologic findings for the subclinical form of Leishmania braziliensis infection. Clin Infect Dis 2002; 34:E54-E58.
32. Jose FF, da Silva IM, Araujo MI, Almeida RP, Bacellar O, Carvalho EM. [Evaluation of the sensitization power of Montenegro skin test]. Rev Soc Bras Med Trop 2001; 34:537-42.
33. Gazzinelli G, Katz N, Rocha RS, Colley DG. Immune responses during human Schistosomiasis mansoni. X. Production and standardization of an antigen-induced mitogenic activity by peripheral blood mononuclear cells from treated, but not active cases of schistosomiasis. J Immunol 1983; 130:2891-5.
34. Bacellar O, Lessa H, Schriefer A etal. Up-regulation of Th1-type responses in mucosal leishmaniasis patients. Infect Immun 2002; 70:6734-40.
35. Reiner SL, Wang ZE, Hatam F, Scott P, Locksley RM. TH1 and TH2 cell antigen receptors in experimental leishmaniasis. Science 1993; 259:1457-60.
36. Rogers KA, DeKrey GK, Mbow ML, Gillespie RD, Brodskyn CI, Titus RG. Type 1 and type 2 responses to Leishmania major. FEMS Microbiol Lett 2002; 209:1-7.
37. Da-Cruz AM, Conceicao-Silva F, Bertho AL, Coutinho SG. Leishmania-reactive CD4+ and CD8+ T cells associated with cure of human cutaneous leishmaniasis. Infect Immun 1994; 62:2614-18.
38. Coutinho SG, Oliveira MP, Da-Cruz AM etal. T-cell responsiveness of American cutaneous leishmaniasis patients to purified Leishmania pifanoi amastigote antigens and Leishmania braziliensis promastigote antigens: immunologic patterns associated with cure. Exp Parasitol 1996; 84:144-55.
39. Castes M, Trujillo D, Rojas ME etal. Serum levels of tumor necrosis factor in patients with American cutaneous leishmaniasis. Biol Res 1993; 26:233-8.
40. - cells from chagasic patients: distinct repertoire and cytokine expression. Clin Exp Immunol 2004; 137:129-38.