The phenotypic and functional characteristics of umbilical cord blood and peripheral blood natural killer cells

British Journal of Haematology

Volumn 147, Issue 2, 2009, Pages 185-191

  Verneris, Michael R ^a,c   Miller, Jeffrey S ^b  

^a CCRB 660 ^*  (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Cytotoxicity; Expansion; Immunotherapy; Natural killer (NK) cells; Umbilical cord blood

Indexed keywords

CD16 ANTIGEN; CD56 ANTIGEN; CD94 ANTIGEN; CELL ADHESION MOLECULE; CYTOKINE; FLT3 LIGAND; HYDROCORTISONE; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 21; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; NATURAL KILLER CELL RECEPTOR NKG2A;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; BLOOD; CELL POPULATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CORD BLOOD STEM CELL TRANSPLANTATION; CYTOTOXICITY; HUMAN; IMMUNOPHENOTYPING; NATURAL KILLER CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; STEM CELL; STIMULATION; UMBILICAL CORD BLOOD;

CYTOKINES; CYTOTOXICITY, IMMUNOLOGIC; FETAL BLOOD; HUMANS; IMMUNOPHENOTYPING; IMMUNOTHERAPY, ADOPTIVE; KILLER CELLS, NATURAL; LEUKEMIA, MYELOID, ACUTE;

EID: 70349687213     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2009.07768.x     Document Type: Review

References (52)

1. Abu-Ghosh, A., Goldman, S., Slone, V., van de Ven, C., Suen, Y., Murphy, L., Sender, L. Cairo, M. (1999) Immunological reconstitution and correlation of circulating serum inflammatory mediators/cytokines with the incidence of acute graft-versus-host disease during the first 100 days following unrelated umbilical cord blood transplantation. Bone Marrow Transplantation, 24, 535 544.
2. Baessler, T., Krusch, M., Schmiedel, B.J., Kloss, M., Baltz, K.M., Wacker, A., Schmetzer, H.M. Salih, H.R. (2009) Glucocorticoid-induced tumor necrosis factor receptor-related protein ligand subverts immunosurveillance of acute myeloid leukemia in humans. Cancer Research, 69, 1037 1045.
3. Baltz, K.M., Krusch, M., Baessler, T., Schmiedel, B.J., Bringmann, A., Brossart, P. Salih, H.R. (2008) Neutralization of tumor-derived soluble glucocorticoid-induced TNFR-related protein ligand increases NK cell anti-tumor reactivity. Blood, 112, 3735 3743.
4. Barker, J.N. Wagner, J.E. (2003) Umbilical-cord blood transplantation for the treatment of cancer. Nature Reviews. Cancer, 3, 526 532.
5. Barker, J.N., Weisdorf, D.J., DeFor, T.E., Blazar, B.R., McGlave, P.B., Miller, J.S., Verfaillie, C.M. Wagner, J.E. (2005) Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood, 105, 1343 1347.
6. Boissel, L., Tuncer, H.H., Betancur, M., Wolfberg, A. Klingemann, H. (2008) Umbilical cord mesenchymal stem cells increase expansion of cord blood natural killer cells. Biology of Blood and Marrow Transplantation, 14, 1031 1038.
7. Cairo, M.S., Wagner, E.L., Fraser, J., Cohen, G., van de Ven, C., Carter, S.L., Kernan, N.A. Kurtzberg, J. (2005) Characterization of banked umbilical cord blood hematopoietic progenitor cells and lymphocyte subsets and correlation with ethnicity, birth weight, sex, and type of delivery: a Cord Blood Transplantation (COBLT) Study report. Transfusion, 45, 856 866.
8. Choi, S.S., Chhabra, V.S., Nguyen, Q.H., Ank, B.J., Stiehm, E.R. Roberts, R.L. (2004) Interleukin-15 enhances cytotoxicity, receptor expression, and expansion of neonatal natural killer cells in long-term culture. Clinical and Diagnostic Laboratory Immunology, 11, 879 888.
9. Condiotti, R., Zakai, Y.B., Barak, V. Nagler, A. (2001) Ex vivo expansion of CD56+ cytotoxic cells from human umbilical cord blood. Experimental Hematology, 29, 104 113.
10. Cooper, M.A., Fehniger, T.A. Caligiuri, M.A. (2001) The biology of human natural killer-cell subsets. Trends in Immunology, 22, 633 640.
11. Dalle, J.H., Menezes, J., Wagner, E., Blagdon, M., Champagne, J., Champagne, M.A. Duval, M. (2005) Characterization of cord blood natural killer cells: implications for transplantation and neonatal infections. Pediatric Research, 57, 649 655.
12. De Amici, D., Gasparoni, A., Chirico, G., Ceriana, P., Bartoli, A., Ramajoli, I. Moretta, A. (1999) Natural killer cell activity and delivery: possible influence of cortisol and anesthetic agents. A study on newborn cord blood. Biology of the Neonate, 76, 348 354.
13. Eapen, M., Rubinstein, P., Zhang, M.J., Stevens, C., Kurtzberg, J., Scaradavou, A., Loberiza, F.R., Champlin, R.E., Klein, J.P., Horowitz, M.M. Wagner, J.E. (2007) Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study. Lancet, 369, 1947 1954.
14. Fan, Y.Y., Yang, B.Y. Wu, C.Y. (2008) Phenotypic and functional heterogeneity of natural killer cells from umbilical cord blood mononuclear cells. Immunological Investigations, 37, 79 96.
15. Fehniger, T.A., Shah, M.H., Turner, M.J., VanDeusen, J.B., Whitman, S.P., Cooper, M.A., Suzuki, K., Wechser, M., Goodsaid, F. Caligiuri, M.A. (1999) Differential cytokine and chemokine gene expression by human NK cells following activation with IL-18 or IL-15 in combination with IL-12: implications for the innate immune response. Journal of Immunology, 162, 4511 4520.
16. Gaddy, J. Broxmeyer, H.E. (1997) Cord blood CD16+56- cells with low lytic activity are possible precursors of mature natural killer cells. Cellular Immunology, 180, 132 142.
17. Georgeson, G.D., Szony, B.J., Streitman, K., Kovacs, A., Kovacs, L. Laszlo, A. (2001) Natural killer cell cytotoxicity is deficient in newborns with sepsis and recurrent infections. European Journal of Pediatrics, 160, 478 482.
18. Gerosa, F., Baldani-Guerra, B., Nisii, C., Marchesini, V., Carra, G. Trinchieri, G. (2002) Reciprocal activating interaction between natural killer cells and dendritic cells. Journal of Experimental Medicine, 195, 327 333.
19. Godfrey, W.R., Spoden, D.J., Ge, Y.G., Baker, S.R., Liu, B., Levine, B.L., June, C.H., Blazar, B.R. Porter, S.B. (2005) Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. Blood, 105, 750 758.
20. Gonzalez, V.D., Falconer, K., Michaelsson, J., Moll, M., Reichard, O., Alaeus, A. Sandberg, J.K. (2008) Expansion of CD56- NK cells in chronic HCV/HIV-1 co-infection: reversion by antiviral treatment with pegylated IFNalpha and ribavirin. Clinical Immunology, 128, 46 56.
21. Grzywacz, B., Kataria, N., Sikora, M., Oostendorp, R.A., Dzierzak, E.A., Blazar, B.R., Miller, J.S. Verneris, M.R. (2006) Coordinated acquisition of inhibitory and activating receptors and functional properties by developing human natural killer cells. Blood, 108, 3824 3833.
22. Harada, H., Watanabe, S., Saijo, K., Ishiwata, I. Ohno, T. (2004) A Wilms tumor cell line, HFWT, can greatly stimulate proliferation of CD56+ human natural killer cells and their novel precursors in blood mononuclear cells. Experimental Hematology, 32, 614 621.
23. Hochberg, J., Mar, B., Ayello, J., Day, N., Ven, C.v.d., Ricci, A., Gurnani, L., Cairo, E., Campana, D. Cairo, M.S. (2008) Genetic Engineering and Significant Ex-Vivo Expansion of Cord Blood Natural Killer Cells: Implications for Post-Transplant Adoptive Cellular Immunotherapy. Blood (ASH Annual Meeting Abstracts), 112, 209.
24. Hoshina, T., Kida, K. Ito, M. (1999) Difference in response of NK cell activity in newborns and adult to IL-2, IL-12 and IL-15. Microbiology and Immunology, 43, 161 166.
25. Imai, C., Iwamoto, S. Campana, D. (2005) Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells. Blood, 106, 376 383.
26. Kadereit, S., Mohammad, S.F., Miller, R.E., Woods, K.D., Listrom, C.D., McKinnon, K., Alali, A., Bos, L.S., Iacobucci, M.L., Sramkoski, M.R., Jacobberger, J.W. Laughlin, M.J. (1999) Reduced NFAT1 protein expression in human umbilical cord blood T lymphocytes. Blood, 94, 3101 3107.
27. Kaminski, B.A., Kadereit, S., Miller, R.E., Leahy, P., Stein, K.R., Topa, D.A., Radivoyevitch, T., Veigl, M.L. Laughlin, M.J. (2003) Reduced expression of NFAT-associated genes in UCB versus adult CD4+ T lymphocytes during primary stimulation. Blood, 102, 4608 4617.
28. Krampera, M., Tavecchia, L., Benedetti, F., Nadali, G. Pizzolo, G. (2000) Intracellular cytokine profile of cord blood T-, and NK- cells and monocytes. Haematologica, 85, 675 679.
29. Lin, S.J. Yan, D.C. (2000) ICAM-1 (CD54) expression on T lymphocytes and natural killer cells from umbilical cord blood: regulation with interleukin-12 and interleukin-15. Cytokines, Cellular and Molecular Therapy, 6, 161 164.
30. Lopez, M.C., Palmer, B.E. Lawrence, D.A. (2008) Phenotypic differences between cord blood and adult peripheral blood. Cytometry. Part B, Clinical Cytometry, 76B, 37 46.
31. Lu, X., Kondo, Y., Takamatsu, H., Ohata, K., Yamazaki, H., Takami, A., Akatsuka, Y. Nakao, S. (2008) CD16+ CD56- NK cells in the peripheral blood of cord blood transplant recipients: a unique subset of NK cells possibly associated with graft-versus-leukemia effect. European Journal of Haematology, 81, 18 25.
32. Mavilio, D., Lombardo, G., Benjamin, J., Kim, D., Follman, D., Marcenaro, E., O'Shea, M.A., Kinter, A., Kovacs, C., Moretta, A. Fauci, A.S. (2005) Characterization of CD56-/CD16+ natural killer (NK) cells: a highly dysfunctional NK subset expanded in HIV-infected viremic individuals. Proceedings of the National Academy of Sciences of the United States of America, 102, 2886 2891.
33. McCullar, V., Oostendorp, R., Panoskaltsis-Mortari, A., Yun, G., Lutz, C.T., Wagner, J.E. Miller, J.S. (2008) Mouse fetal and embryonic liver cells differentiate human umbilical cord blood progenitors into CD56-negative natural killer cell precursors in the absence of interleukin-15. Experimental Hematology, 36, 598 608.
34. McDonald, T., Sneed, J., Valenski, W.R., Dockter, M., Cooke, R. Herrod, H.G. (1992) Natural killer cell activity in very low birth weight infants. Pediatric Research, 31, 376 380.
35. Miller, J.S. McCullar, V. (2001) Human natural killer cells with polyclonal lectin and immunoglobulinlike receptors develop from single hematopoietic stem cells with preferential expression of NKG2A and KIR2DL2/L3/S2. Blood, 98, 705 713.
36. Miller, J.S., Soignier, Y., Panoskaltsis-Mortari, A., McNearney, S.A., Yun, G.H., Fautsch, S.K., McKenna, D., Le, C., Defor, T.E., Burns, L.J., Orchard, P.J., Blazar, B.R., Wagner, J.E., Slungaard, A., Weisdorf, D.J., Okazaki, I.J. McGlave, P.B. (2005) Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer. Blood, 105, 3051 3057.
37. Miller, J.S., Brunstein, C.G., Cooley, S., Verneris, M.R., Panoskaltsis-Mortari, A., Burns, L.J., McKenna, D., Dusenbery, K., Stevens, C., Rubensten, P., Tomblyn, M., Arora, M., MacMillan, M.L., DeFor, T., Le, C., McGlave, P.B., Blazar, B.R. Weisdorf, D.J. (2006) A novel triple umbilical cord blood transplant (UCBT) strategy to promote NK cell immunotherapy (unit 1) with a fully ablative preparative regimen followed by a double UCBT in patients with refractory AML. Blood (ASH Annual Meeting Abstracts), 108, 3111.
38. Nagamura-Inoue, T., Mori, Y., Yizhou, Z., Watanabe, N. Takahashi, T.A. (2004) Differential expansion of umbilical cord blood mononuclear cell-derived natural killer cells dependent on the dose of interleukin-15 with Flt3L. Experimental Hematology, 32, 202 209.
39. Nomura, A., Takada, H., Jin, C.H., Tanaka, T., Ohga, S. Hara, T. (2001) Functional analyses of cord blood natural killer cells and T cells: a distinctive interleukin-18 response. Experimental Hematology, 29, 1169 1176.
40. Perez, S.A., Sotiropoulou, P.A., Gkika, D.G., Mahaira, L.G., Niarchos, D.K., Gritzapis, A.D., Kavalakis, Y.G., Antsaklis, A.I., Baxevanis, C.N. Papamichail, M. (2003) A novel myeloid-like NK cell progenitor in human umbilical cord blood. Blood, 101, 3444 3450.
41. Perez, S.A., Mahaira, L.G., Sotiropoulou, P.A., Gritzapis, A.D., Iliopoulou, E.G., Niarchos, D.K., Cacoullos, N.T., Kavalakis, Y.G., Antsaklis, A.I., Sotiriadou, N.N., Baxevanis, C.N. Papamichail, M. (2006) Effect of IL-21 on NK cells derived from different umbilical cord blood populations. International Immunology, 18, 49 58.
42. Rocha, V., Labopin, M., Sanz, G., Arcese, W., Schwerdtfeger, R., Bosi, A., Jacobsen, N., Ruutu, T., de Lima, M., Finke, J., Frassoni, F. Gluckman, E. (2004) Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. New England Journal of Medicine, 351, 2276 2285.
43. Rutella, S., Bonanno, G., Marone, M., De Ritis, D., Mariotti, A., Voso, M.T., Scambia, G., Mancuso, S., Leone, G. Pierelli, L. (2003) Identification of a novel subpopulation of human cord blood CD34-CD133-CD7-CD45+lineage- cells capable of lymphoid/NK cell differentiation after in vitro exposure to IL-15. Journal of Immunology, 171, 2977 2988.
44. Sancho, L., de la Hera, A., Casas, J., Vaquer, S., Martinez, C. Alvarez-Mon, M. (1991) Two different maturational stages of natural killer lymphocytes in human newborn infants. Journal of Pediatrics, 119, 446 454.
45. Satwani, P., Ayello, J., Ven, C., O'Neill, A.F., Simpson, L.L., Baxi, L. Cairo, M.S. (2005) Immaturity of IL-18 gene expression and protein production in cord blood (CB) versus peripheral blood (PB) mononuclear cells and differential effects in natural killer (NK) cell development and function. British Journal of Haematology, 130, 284 292.
46. Suen, Y., Lee, S.M., Qian, J., van de Ven, C. Cairo, M.S. (1998) Dysregulation of lymphokine production in the neonate and its impact on neonatal cell mediated immunity. Vaccine, 16, 1369 1377.
47. Tanaka, H., Kai, S., Yamaguchi, M., Misawa, M., Fujimori, Y., Yamamoto, M. Hara, H. (2003) Analysis of natural killer (NK) cell activity and adhesion molecules on NK cells from umbilical cord blood. European Journal of Haematology, 71, 29 38.
48. Theilgaard-Monch, K., Raaschou-Jensen, K., Palm, H., Schjodt, K., Heilmann, C., Vindelov, L., Jacobsen, N. Dickmeiss, E. (2001) Flow cytometric assessment of lymphocyte subsets, lymphoid progenitors, and hematopoietic stem cells in allogeneic stem cell grafts. Bone Marrow Transplantation, 28, 1073 1082.
49. Vitale, M., Della Chiesa, M., Carlomagno, S., Romagnani, C., Thiel, A., Moretta, L. Moretta, A. (2004) The small subset of CD56brightCD16- natural killer cells is selectively responsible for both cell proliferation and interferon-gamma production upon interaction with dendritic cells. European Journal of Immunology, 34, 1715 1722.
50. Wagner, J.E., Barker, J.N., DeFor, T.E., Baker, K.S., Blazar, B.R., Eide, C., Goldman, A., Kersey, J., Krivit, W., MacMillan, M.L., Orchard, P.J., Peters, C., Weisdorf, D.J., Ramsay, N.K. Davies, S.M. (2002) Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood, 100, 1611 1618.
51. Wang, Y., Xu, H., Zheng, X., Wei, H., Sun, R. Tian, Z. (2007) High expression of NKG2A/CD94 and low expression of granzyme B are associated with reduced cord blood NK cell activity. Cellular & Molecular Immunology, 4, 377 382.
52. Zarife, M.A., Reis, E.A., Carmo, T.M., Lopes, G.B., Brandao, E.C., Silva, H.R., Santana, N., Martins-Filho, O.A. Reis, M.G. (2009) Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV. Journal of Medical Virology, 81, 49 59.