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Volumn 3, Issue 4, 2011, Pages 383-394

Role of natural killer cells in hematopoietic stem cell transplantation: Myth or reality?

Author keywords

Clinical outcome; Graft versus leukemia effect; Hematopoietic transplantation; Natural killer cells

Indexed keywords

KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 2DL1; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 2DL2; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 2DL3; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 3DL1; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 3DL2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NATURAL KILLER CELL RECEPTOR NKG2A;

EID: 79959634359     PISSN: 1662811X     EISSN: 16628128     Source Type: Journal    
DOI: 10.1159/000323935     Document Type: Review
Times cited : (15)

References (57)
  • 1
    • 49249116929 scopus 로고    scopus 로고
    • Human NK cells: From HLA class I-specific killer Iglike receptors to the therapy of acute leuke-mias
    • Moretta A, Locatelli F, Moretta L: Human NK cells: from HLA class I-specific killer Iglike receptors to the therapy of acute leuke-mias. Immunol Rev 2008; 224: 58-69.
    • (2008) Immunol Rev , vol.224 , pp. 58-69
    • Moretta, A.1    Locatelli, F.2    Moretta, L.3
  • 2
    • 49249097006 scopus 로고    scopus 로고
    • Negative signaling by inhibitory receptors: The NK cell paradigm
    • Long EO: Negative signaling by inhibitory receptors: the NK cell paradigm. Immunol Rev 2008; 224:70-84.
    • (2008) Immunol Rev , vol.224 , pp. 70-84
    • Long, E.O.1
  • 5
    • 55249092534 scopus 로고    scopus 로고
    • MHC class I-specific inhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-response
    • Yawata M, Yawata N, Draghi M, Partheniou F, Little AM, Parham P: MHC class I-specific inhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-response. Blood 2008; 112:2369-2380.
    • (2008) Blood , vol.112 , pp. 2369-2380
    • Yawata, M.1    Yawata, N.2    Draghi, M.3    Partheniou, F.4    Little, A.M.5    Parham, P.6
  • 6
    • 63149126181 scopus 로고    scopus 로고
    • NK cell education: Not an on-off switch but a tunable rheostat
    • Brodin P, Kärre K, Höglund P: NK cell education: not an on-off switch but a tunable rheostat. Trends Immunol 2009; 30:143-149.
    • (2009) Trends Immunol , vol.30 , pp. 143-149
    • Brodin, P.1    Kärre, K.2    Höglund, P.3
  • 7
    • 14944355535 scopus 로고    scopus 로고
    • MHC class I molecules and KIRs in human history, health and survival
    • Parham P: MHC class I molecules and KIRs in human history, health and survival. Nat Rev Immunol 2005; 5: 201-214.
    • (2005) Nat Rev Immunol , vol.5 , pp. 201-214
    • Parham, P.1
  • 11
    • 15244346488 scopus 로고    scopus 로고
    • Genotypic inhibitory killer immu-noglobulin-like receptor ligand incompatibility enhances the long-term antileukemic effect of unmodified allogeneic hematopoietic stem cell transplantation in patients with myeloid leukemias
    • Beelen DW, Ottinger HD, Ferencik S, Elmaagacli AH, Peceny R, Trenschel R, Grosse-Wilde H: Genotypic inhibitory killer immu-noglobulin-like receptor ligand incompatibility enhances the long-term antileukemic effect of unmodified allogeneic hematopoietic stem cell transplantation in patients with myeloid leukemias. Blood 2005; 105:2594-2600.
    • (2005) Blood , vol.105 , pp. 2594-2600
    • Beelen, D.W.1    Ottinger, H.D.2    Ferencik, S.3    Elmaagacli, A.H.4    Peceny, R.5    Trenschel, R.6    Grosse-Wilde, H.7
  • 14
    • 1542359024 scopus 로고    scopus 로고
    • The beneficial role of inhibitory KIR genes of HLA class I NK epitopes in haploidentically mismatched stem cell allografts may be masked by residual donor-alloreactive T cells causing GVHD
    • Bishara A, De Santis D, Witt CC, Brautbar C, Christiansen FT, Or R, Nagler A, Slavin S: The beneficial role of inhibitory KIR genes of HLA class I NK epitopes in haploidentically mismatched stem cell allografts may be masked by residual donor-alloreactive T cells causing GVHD. Tissue Antigens 2004; 63:204-211.
    • (2004) Tissue Antigens , vol.63 , pp. 204-211
    • Bishara, A.1    De Santis, D.2    Witt, C.C.3    Brautbar, C.4    Christiansen, F.T.5    Or, R.6    Nagler, A.7    Slavin, S.8
  • 15
    • 20144377362 scopus 로고    scopus 로고
    • Christia nsen FT: Natural killer cell HLA-C epitopes and killer cell immunoglobulin-like receptors both influence outcome of mismatched unrelated donor bone marrow transplants
    • De Santis D, Bishara A, Witt CS, Nagler A, Brautbar C, Slavin S, Christia nsen FT: Natural killer cell HLA-C epitopes and killer cell immunoglobulin-like receptors both influence outcome of mismatched unrelated donor bone marrow transplants. Tissue Antigens 2005; 65: 519-528.
    • (2005) Tissue Antigens , vol.65 , pp. 519-528
    • De Santis, D.1    Bishara, A.2    Witt, C.S.3    Nagler, A.4    Brautbar, C.5    Slavin, S.6
  • 17
    • 1642377663 scopus 로고    scopus 로고
    • Role of KIR ligand incompatibility in hematopoietic stem cell transplantation using unrelated donors
    • Bornhäuser M, Schwerdtfeger R, Martin H, Frank KH, Theuser C, Ehninger G: Role of KIR ligand incompatibility in hematopoietic stem cell transplantation using unrelated donors. Blood 2004; 103:2860-2861.
    • (2004) Blood , vol.103 , pp. 2860-2861
    • Bornhäuser, M.1    Schwerdtfeger, R.2    Martin, H.3    Frank, K.H.4    Theuser, C.5    Ehninger, G.6
  • 18
    • 0037111776 scopus 로고    scopus 로고
    • Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants. Killer immunoglobulin-like receptor
    • Davies SM, Ruggieri L, DeFor T, Wagner JE, Weisdorf DJ, Miller JS, Velardi A, Blazar BR: Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants. Killer immunoglobulin-like receptor. Blood 2002; 100: 3825-3857.
    • (2002) Blood , vol.100 , pp. 3825-3857
    • Davies, S.M.1    Ruggieri, L.2    DeFor, T.3    Wagner, J.E.4    Weisdorf, D.J.5    Miller, J.S.6    Velardi, A.7    Blazar, B.R.8
  • 19
    • 33847612506 scopus 로고    scopus 로고
    • Deleterious effects of KIR ligand incompatibility on clinical outcomes in haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion
    • Huang XJ, Zhao XY, Liu DH, Liu KY, Xu LP: Deleterious effects of KIR ligand incompatibility on clinical outcomes in haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion. Leukemia 2007; 21:848-851.
    • (2007) Leukemia , vol.21 , pp. 848-851
    • Huang, X.J.1    Zhao, X.Y.2    Liu, D.H.3    Liu, K.Y.4    Xu, L.P.5
  • 20
    • 33750312938 scopus 로고    scopus 로고
    • Low number of donor activating killer immunoglobulin-like receptors (KIR) genes but not KIR-ligand mismatch prevents relapse and improves disease-free survival in leukemia patients after in vivo T-cell depleted unrelated stem cell transplantation
    • Kröger N, Binder T, Zabelina T, Wolschke C, Schieder H, Renges H, Ayuk F, Dahlke J, Eiermann T, Zander A: Low number of donor activating killer immunoglobulin-like receptors (KIR) genes but not KIR-ligand mismatch prevents relapse and improves disease-free survival in leukemia patients after in vivo T-cell depleted unrelated stem cell transplantation. Transplantation 2006; 82: 1024-1030.
    • (2006) Transplantation , vol.82 , pp. 1024-1030
    • Kröger, N.1    Binder, T.2    Zabelina, T.3    Wolschke, C.4    Schieder, H.5    Renges, H.6    Ayuk, F.7    Dahlke, J.8    Eiermann, T.9    Zander, A.10
  • 22
    • 6344222785 scopus 로고    scopus 로고
    • Increased infection-related mortality in KIR-ligand-mis-matched unrelated allogeneic hematopoietic stem-cell transplantation
    • Schaffer, M, Malmberg KJ, Ringdén O, Ljunggren HG, Remberger M: Increased infection-related mortality in KIR-ligand-mis-matched unrelated allogeneic hematopoietic stem-cell transplantation. Transplantation 2004; 78:1081-1085.
    • (2004) Transplantation , vol.78 , pp. 1081-1085
    • Schaffer, M.1    Malmberg, K.J.2    Ringdén, O.3    Ljunggren, H.G.4    Remberger, M.5
  • 23
    • 29844437784 scopus 로고    scopus 로고
    • Killer Ig-like receptor (KIR) compatibility plays a role in the prevalence of acute GVHD in unrelated hematopoietic cell transplants for AML
    • Sun JY, Gaidulis L, Dagis A, Palmer J, Rodriguez R, Miller MM, Forman SJ, Senitzer D: Killer Ig-like receptor (KIR) compatibility plays a role in the prevalence of acute GVHD in unrelated hematopoietic cell transplants for AML. Bone Marrow Transplant 2005; 36: 525-530.
    • (2005) Bone Marrow Transplant , vol.36 , pp. 525-530
    • Sun, J.Y.1    Gaidulis, L.2    Dagis, A.3    Palmer, J.4    Rodriguez, R.5    Miller, M.M.6    Forman, S.J.7    Senitzer, D.8
  • 26
    • 0142215546 scopus 로고    scopus 로고
    • T-cell alloreactivity dominates natural killer cell alloreactivity in minimally T-cell-depleted HLA-non-identical paediatric bone marrow transplantation
    • Lowe EJ, Turner V, Handgretinger R, Horwitz EM, Benaim E, Hale GA, Woodard P, Leung W: T-cell alloreactivity dominates natural killer cell alloreactivity in minimally T-cell-depleted HLA-non-identical paediatric bone marrow transplantation. Br J Haematol 2003; 123:323-326.
    • (2003) Br J Haematol , vol.123 , pp. 323-326
    • Lowe, E.J.1    Turner, V.2    Handgretinger, R.3    Horwitz, E.M.4    Benaim, E.5    Hale, G.A.6    Woodard, P.7    Leung, W.8
  • 29
    • 34247853271 scopus 로고    scopus 로고
    • Impact of natural killer cell dose and donor killer-cell immunoglobulin-like receptor (KIR) genotype on outcome following human leucocyte antigen-identical haematopoietic stem cell transplantation
    • Clausen J, Wolf D, Petzer AL, Gunsilius E, Schumacher P, Kircher B, Gastl G, Nachbaur D: Impact of natural killer cell dose and donor killer-cell immunoglobulin-like receptor (KIR) genotype on outcome following human leucocyte antigen-identical haematopoietic stem cell transplantation. Clin Exp Med 2007; 148:520-528.
    • (2007) Clin Exp Med , vol.148 , pp. 520-528
    • Clausen, J.1    Wolf, D.2    Petzer, A.L.3    Gunsilius, E.4    Schumacher, P.5    Kircher, B.6    Gastl, G.7    Nachbaur, D.8
  • 30
    • 20444394742 scopus 로고    scopus 로고
    • Improved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLA genotypes
    • Hsu KC, Keever-Taylor CA, Wilton A, Pinto C, Heller G, Arkun K, O'Reilly RJ, Horowitz MM, Dupont B: Improved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLA genotypes. Blood 2005; 105: 4878-4884.
    • (2005) Blood , vol.105 , pp. 4878-4884
    • Hsu, K.C.1    Keever-Taylor, C.A.2    Wilton, A.3    Pinto, C.4    Heller, G.5    Arkun, K.6    O'Reilly, R.J.7    Horowitz, M.M.8    Dupont, B.9
  • 35
    • 65549133016 scopus 로고    scopus 로고
    • Breaking tolerance to self, circulating natural killer cells expressing inhibitory KIR for non-self HLA exhibit effector function after T cell-depleted allogeneic hematopoietic cell transplantation
    • Yu J, Venstrom JM, Liu XR, Pring J, Hasan RS, O'Reilly RJ, Hsu KC: Breaking tolerance to self, circulating natural killer cells expressing inhibitory KIR for non-self HLA exhibit effector function after T cell-depleted allogeneic hematopoietic cell transplantation. Blood, 2009; 113:3875-3884.
    • (2009) Blood , vol.113 , pp. 3875-3884
    • Yu, J.1    Venstrom, J.M.2    Liu, X.R.3    Pring, J.4    Hasan, R.S.5    O'Reilly, R.J.6    Hsu, K.C.7
  • 37
    • 31544463790 scopus 로고    scopus 로고
    • Donor KIR genotype has a major influence on the rate of cytomegalovirus reactivation following T-cell replete stem cell transplantation
    • Cook M, Briggs D, Craddock C, Mahendra P, Milligan D, Fegan C, Darbyshire P, Lawson S, Boxall E, Moss P: Donor KIR genotype has a major influence on the rate of cytomegalovirus reactivation following T-cell replete stem cell transplantation. Blood 2006; 107: 1230-1232.
    • (2006) Blood , vol.107 , pp. 1230-1232
    • Cook, M.1    Briggs, D.2    Craddock, C.3    Mahendra, P.4    Milligan, D.5    Fegan, C.6    Darbyshire, P.7    Lawson, S.8    Boxall, E.9    Moss, P.10
  • 40
    • 36249003961 scopus 로고    scopus 로고
    • The activating killer cell immunoglobulin-like receptors as important determinants of acute graft-versus host disease in hematopoietic stem cell transplantation for acute myelogenous leukemia
    • Kim HJ, Choi Y, Min WS, Kim TG, Cho BS, Kim SY, Eom KS, Lee S, Min CK, Cho SG, Kim DW, Lee JW, Kim CC: The activating killer cell immunoglobulin-like receptors as important determinants of acute graft-versus host disease in hematopoietic stem cell transplantation for acute myelogenous leukemia. Transplantation 2007; 84:1082-1091.
    • (2007) Transplantation , vol.84 , pp. 1082-1091
    • Kim, H.J.1    Choi, Y.2    Min, W.S.3    Kim, T.G.4    Cho, B.S.5    Kim, S.Y.6    Eom, K.S.7    Lee, S.8    Min, C.K.9    Cho, S.G.10    Kim, D.W.11    Lee, J.W.12    Kim, C.C.13
  • 42
    • 23744449591 scopus 로고    scopus 로고
    • A defined donor activating natural killer cell receptor genotype protects against leukemic relapse after related HLA-identical hematopoietic stem cell transplantation
    • Verheyden S, Schots R, Duquet W, Demanet C: A defined donor activating natural killer cell receptor genotype protects against leukemic relapse after related HLA-identical hematopoietic stem cell transplantation. Leukemia 2005; 19: 1446-1451.
    • (2005) Leukemia , vol.19 , pp. 1446-1451
    • Verheyden, S.1    Schots, R.2    Duquet, W.3    Demanet, C.4
  • 43
    • 0842285644 scopus 로고    scopus 로고
    • The impact of donor KIR and patient HLA-C genotypes on outcome following HLA-identical sibling hematopoietic stem cell transplantation for myeloid leukemia
    • Cook MA, Milligan DW, Fegan CD, Darbyshire PJ, Mahendra P, Craddock CF, Moss PA, Briggs DC: The impact of donor KIR and patient HLA-C genotypes on outcome following HLA-identical sibling hematopoietic stem cell transplantation for myeloid leukemia. Blood 2004; 103:1521-1526.
    • (2004) Blood , vol.103 , pp. 1521-1526
    • Cook, M.A.1    Milligan, D.W.2    Fegan, C.D.3    Darbyshire, P.J.4    Mahendra, P.5    Craddock, C.F.6    Moss, P.A.7    Briggs, D.C.8
  • 46
    • 34247268450 scopus 로고    scopus 로고
    • Donorrecipient combinations of group A and B KIR haplotypes and HLA class I ligand affect the outcome of HLA-matched, sibling donor hematopoietic cell transplantation
    • McQueen KL, Dorighi KM, Guethlein LA, Wong R, Sanjanwala B, Parham P: Donorrecipient combinations of group A and B KIR haplotypes and HLA class I ligand affect the outcome of HLA-matched, sibling donor hematopoietic cell transplantation. Hum Immunol 2007; 68:309-323.
    • (2007) Hum Immunol , vol.68 , pp. 309-323
    • McQueen, K.L.1    Dorighi, K.M.2    Guethlein, L.A.3    Wong, R.4    Sanjanwala, B.5    Parham, P.6
  • 48
    • 20844438187 scopus 로고    scopus 로고
    • NK-cell reconstitution after haploidentical hematopoietic stem-cell transplantations: Immaturity of NK cells and inhibitory effect of NKG2A override GvL effect
    • Nguyen S, Dhedin N, Vernant JP, Kuentz M, Al Jijakli A, Rouas-Freiss N, Carosella ED, Boudifa A, Debré P, Vieillard V: NK-cell reconstitution after haploidentical hematopoietic stem-cell transplantations: immaturity of NK cells and inhibitory effect of NKG2A override GvL effect. Blood 2005; 105:4135-4142.
    • (2005) Blood , vol.105 , pp. 4135-4142
    • Nguyen, S.1    Dhedin, N.2    Vernant, J.P.3    Kuentz, M.4    Al Jijakli, A.5    Rouas-Freiss, N.6    Carosella, E.D.7    Boudifa, A.8    Debré, P.9    Vieillard, V.10
  • 49
    • 33750686595 scopus 로고    scopus 로고
    • Human natural killer cell development
    • Freud AG, Caligiuri MA: Human natural killer cell development. Immunol Rev 2006; 214: 56-72.
    • (2006) Immunol Rev , vol.214 , pp. 56-72
    • Freud, A.G.1    Caligiuri, M.A.2
  • 51
    • 39149115686 scopus 로고    scopus 로고
    • Involvement of mature donor T cells in the NK cell reconstitution after haploidentical hematopoietic stem-cell transplantation
    • Nguyen S, Kuentz M, Vernant JP, Dhedin N, Bories D, Debré P, Vieillard V: Involvement of mature donor T cells in the NK cell reconstitution after haploidentical hematopoietic stem-cell transplantation. Leukemia 2008; 22: 344-352.
    • (2008) Leukemia , vol.22 , pp. 344-352
    • Nguyen, S.1    Kuentz, M.2    Vernant, J.P.3    Dhedin, N.4    Bories, D.5    Debré, P.6    Vieillard, V.7
  • 52
    • 28844436009 scopus 로고    scopus 로고
    • KIR reconstitution is altered by T cells in the graft and correlates with clinical outcomes after unrelated donor transplantation
    • Cooley S, McCullar V, Wangen R, Bergemann TL, Spellman S, Weisdorf DJ, Miller JS: KIR reconstitution is altered by T cells in the graft and correlates with clinical outcomes after unrelated donor transplantation. Blood 2005; 106:4370-4376.
    • (2005) Blood , vol.106 , pp. 4370-4376
    • Cooley, S.1    McCullar, V.2    Wangen, R.3    Bergemann, T.L.4    Spellman, S.5    Weisdorf, D.J.6    Miller, J.S.7
  • 53
    • 77949423488 scopus 로고    scopus 로고
    • CD3+/CD19+-de-pleted graf ts in HLA-matched allogeneic peripheral blood stem cell transplantation lead to early NK cell cytolytic responses and reduced inhibitory activity of NKG2A
    • Eissens DN, Schaap NP, Preijers FW, Dolstra H, van Cranenbroek B, Schattenberg AV, Joosten I, van der Meer A: CD3+/CD19+-de-pleted graf ts in HLA-matched allogeneic peripheral blood stem cell transplantation lead to early NK cell cytolytic responses and reduced inhibitory activity of NKG2A. Leukemia 2010; 24: 583-591.
    • (2010) Leukemia , vol.24 , pp. 583-591
    • Eissens, D.N.1    Schaap, N.P.2    Preijers, F.W.3    Dolstra, H.4    Van Cranenbroek, B.5    Schattenberg, A.V.6    Joosten, I.7    Van Der Meer, A.8
  • 54
    • 77956021364 scopus 로고    scopus 로고
    • Reconstitution of natural killer cell receptors influences natural killer activity and relapse rate after haploidentical transplantation of T- and B-cell depleted grafts in chi ldren
    • Pfeiffer MM, Feuchtinger T, Teltschik HM, Schumm M, Müller I, Handgretinger R, Lang P: Reconstitution of natural killer cell receptors influences natural killer activity and relapse rate after haploidentical transplantation of T- and B-cell depleted grafts in chi ldren. Haematologica 2010; 95: 1381-1388.
    • (2010) Haematologica , vol.95 , pp. 1381-1388
    • Pfeiffer, M.M.1    Feuchtinger, T.2    Teltschik, H.M.3    Schumm, M.4    Müller, I.5    Handgretinger, R.6    Lang, P.7
  • 55
    • 33947223518 scopus 로고    scopus 로고
    • Relevance of C1 and C2 epitopes for hematopoietic stem cell transplantation: Role for sequential acquisition of HLA-C-specific inhibitory killer Ig-like receptor
    • Fischer JC, Ottinger H, Ferencik S, Sribar M, Punzel M, Beelen DW, Schwan MA, Grosse-Wilde H, Wernet P, Uhrberg M: Relevance of C1 and C2 epitopes for hematopoietic stem cell transplantation: role for sequential acquisition of HLA-C-specific inhibitory killer Ig-like receptor. J Immunol 2007; 178: 3918-3923.
    • (2007) J Immunol , vol.178 , pp. 3918-3923
    • Fischer, J.C.1    Ottinger, H.2    Ferencik, S.3    Sribar, M.4    Punzel, M.5    Beelen, D.W.6    Schwan, M.A.7    Grosse-Wilde, H.8    Wernet, P.9    Uhrberg, M.10


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