A method for enhancing the ocular penetration of eye drops using nanoparticles of hydrolyzable dye

Journal of Controlled Release

Volumn 153, Issue 3, 2011, Pages 278-287

  Baba, Koichi ^a,d   Tanaka, Yuji ^a   Kubota, Akira ^a   Kasai, Hitoshi ^b,c   Yokokura, Shunji ^a   Nakanishi, Hachiro ^b   Nishida, Kohji ^a,d  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Confocal laser fluorescence microscopy; Eye drops; Hydrolysis; Nanoparticles; Ocular penetration

Indexed keywords

BARRIER FUNCTIONS; CARRIER-FREE TECHNIQUE; CONFOCAL LASER FLUORESCENCE MICROSCOPY; CORNEAL EPITHELIUM; EYE DROPS; HYDROLYSIS REACTION; IN-VIVO; MICRON-SIZED PARTICLES; OCULAR GLOBE; OCULAR PENETRATION; PENETRATION RATES; PHYSICOCHEMICAL PROPERTY; PRODRUGS; REPRECIPITATION METHODS; TIGHT JUNCTIONS;

DROPS; FLUORESCENCE; FLUORESCENCE MICROSCOPY; HYDROLYSIS; HYDROPHILICITY;

NANOPARTICLES;

DYE; EYE DROPS; NANOPARTICLE;

ANIMAL EXPERIMENT; ARTICLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CORNEA EPITHELIUM; DRUG PENETRATION; HYDROLYSIS; HYDROPHILICITY; IN VIVO STUDY; LIPOPHILICITY; MALE; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRECIPITATION; PRIORITY JOURNAL; RAT; STROMA; TECHNIQUE; TIGHT JUNCTION;

ANIMALS; DRUG COMPOUNDING; EPITHELIUM, CORNEAL; FLUORESCEINS; FLUORESCENT DYES; HYDROLYSIS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MALE; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; NANOPARTICLES; OPHTHALMIC SOLUTIONS; PARTICLE SIZE; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY; SURFACE PROPERTIES;

EID: 79960912803     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.04.019     Document Type: Article

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