Investigating Microtubule Dynamic Instability Using Microtubule-Targeting Agents

Methods in Molecular Biology

Volumn 777, Issue , 2011, Pages 245-260

  Honore, Stéphane ^a   Braguer, Diane ^a  

^a University of the Mediterranean Aix Marseille II   (France)

Author keywords

+TIPs; Drugs; Fluorescence time lapse microscopy; Live cell imaging; Microtubule dynamics; Tubulin

Indexed keywords

TUBULIN;

ARTICLE; CELL CULTURE; CHEMISTRY; FLUORESCENCE MICROSCOPY; HUMAN; METABOLISM; METHODOLOGY; MICROTUBULE;

CELLS, CULTURED; HUMANS; MICROSCOPY, FLUORESCENCE; MICROTUBULES; TUBULIN;

EID: 79960910240     PISSN: 10643745     EISSN: 19406029     Source Type: Book Series    
DOI: 10.1007/978-1-61779-252-6_18     Document Type: Chapter

References (25)

1. Honore S, Pasquier E, Braguer D (2005) Understanding microtubule dynamics for improved cancer therapy. Cell Mol Life Sci 62(24):3039–56.
2. Poulain FE, Sobel A (2010) The microtubule network and neuronal morphogenesis: Dynamic and coordinated orchestration through multiple players. Mol Cell Neurosci 43(1):15–32.
3. Etienne-Manneville S (2010) From signaling pathways to microtubule dynamics: the key players. Curr Opin Cell Biol 22(1):104–11.
4. Jordan MA, Kamath K (2007) How do micro-tubule-targeted drugs work? An overview. Curr Cancer Drug Targets 7(8):730–42.
5. Akhmanova A, Stehbens SJ, Yap AS (2009) Touch, grasp, deliver and control: functional cross-talk between microtubules and cell adhesions. Traffic 10(3):268–74.
6. Zaoui K, Honoré S, Isnardon D, et al (2008) Memo-RhoA-mDia1 signaling controls microtubules, the actin network, and adhesion site formation in migrating cells. J Cell Biol 183(3):401–8.
7. Akhmanova A, Steinmetz MO (2008) Tracking the ends: a dynamic protein network controls the fate of microtubule tips. Nat Rev Mol Cell Biol 9(4):309–22.
8. Toso RJ, Jordan M.A, Farrell KW et al (1993) Kinetic stabilization of microtubule dynamic instability in vitro by vinblastine. Biochemistry 32(5):1285–93.
9. Honore S, Pasquier E, Braguer D (2005) Understanding microtubule dynamics for improved cancer therapy. Cell Mol Life Sci 62(24):3039–56.
10. Calligaris D, Verdier-Pinard P, Devred F et al (2010) Microtubule targeting agents: from biophysics to proteomics. Cell Mol Life Sci 67(7):1089–104.
11. Honore S, Kamath K, Braguer D et al (2004) Synergistic suppression of microtubule dynamics by discodermolide and paclitaxel in non-small cell lung carcinoma cells. Cancer Res 64(14):4957–64.
12. Honore S, Kamath K, Braguer D et al (2003) Suppression of microtubule dynamics by discodermolide by a novel mechanism is associated with mitotic arrest and inhibition of tumor cell proliferation. Mol Cancer Ther 2(12):1303–11.
13. Smith JA, Wilson L, Azarenko O et al (2010) Eribulin binds at microtubule ends to a single site on tubulin to suppress dynamic instability. Biochemistry 49(6):1331–7.
14. Rovini A, Carré M, Bordet T et al (2010) Olesoxime prevents microtubule-targeting drug neurotoxicity: selective preservation of EB comets in differentiated neuronal cells. Biochem Pharmacol in press.
15. Pourroy B, Honoré S, Pasquier E et al (2006) Antiangiogenic concentrations of vinflunine increase the interphase microtubule dynamics and decrease the motility of endothelial cells. Cancer Res 66(6):3256–63.
16. Pasquier E, Honore S, Pourroy B et al (2005) Antiangiogenic concentrations of paclitaxel induce an increase in microtubule dynamics in endothelial cells but not in cancer cells. Cancer Res 65(6):2433–40.
17. Honoré S, Pagano A, Gauthier G et al (2008) Antiangiogenic vinflunine affects EB1 localization and microtubule targeting to adhesion sites. Mol Cancer Ther 7(7):2080–9.
18. Dhamodharan R, Jordan MA, Thrower D, Wilson L, Wadsworth P (1995) Vinblastine suppresses dynamics of individual microtubules in living interphase cells. Mol Biol Cell 6(9):1215–29.
19. Kamath K, Jordan MA (2003) Suppression of microtubule dynamics by epothilone B is associated with mitotic arrest. Cancer Res 63(18):6026–31.
20. Jordan MA, Kamath K, Manna T, Okouneva T, Miller HP, Davis C, Littlefield BA, Wilson L (2005). The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth. Mol Cancer Ther 4(7):1086–95.
21. Pourroy B, Carré M, Honoré S, Bourgarel-Rey V, Kruczynski A, Briand C, Braguer D (2004). Low concentrations of vinflunine induce apoptosis in human SK-N-SH neuro-blastoma cells through a postmitotic G1 arrest and a mitochondrial pathway. Mol Pharmacol 66(3):580–91.
22. Mikhailov A, Gundersen GG. Relationship between microtubule dynamics and lamelli-podium formation revealed by direct imaging of microtubules in cells treated with nocoda-zole or taxol. Cell Motil Cytoskeleton 41(4):325–40.
23. Skube SB, Chaverri JM, Goodson HV (2010) Effect of GFP tags on the localization of EB1 and EB1 fragments in vivo. Cytoskeleton 67(1):1–12.
24. Komarova Y, De Groot CO, Grigoriev I et al (2009) Mammalian end binding proteins control persistent microtubule growth. J Cell Biol 184(5):691–706.
25. Smal I, Grigoriev I, Akhmanova A et al (2009) Accurate estimation of microtubule dynamics using kymographs and variable-rate particle filters. Conf Proc IEEE Eng Med Biol Soc 721–1078:1012–5.