Conformational change upon product binding to Klebsiella pneumoniae UDP-glucose dehydrogenase: A possible inhibition mechanism for the key enzyme in polymyxin resistance

Journal of Structural Biology

Volumn 175, Issue 3, 2011, Pages 300-310

  Chen, Ying Yin ^a,b   Ko, Tzu Ping ^a   Lin, Chun Hung ^a,b   Chen, Wei Hung ^a   Wang, Andrew H J ^a,b  

^a INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Allosteric inhibition; NAD dependent oxidoreductase; X ray crystallography

Indexed keywords

BACTERIAL ENZYME; KLEBSIELLA PNEUMONIAE URIDINE DIPHOSPHATE GLUCOSE DEHYDROGENASE; POLYMYXIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GLUCOSE; URIDINE DIPHOSPHATE GLUCOSE DEHYDROGENASE; URIDINE DIPHOSPHATE GLUCURONIC ACID;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME INACTIVATION; KLEBSIELLA PNEUMONIAE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING;

ANTI-BACTERIAL AGENTS; CRYSTALLOGRAPHY, X-RAY; KLEBSIELLA PNEUMONIAE; POLYMYXINS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; URIDINE DIPHOSPHATE GLUCOSE DEHYDROGENASE;

BACTERIA (MICROORGANISMS); KLEBSIELLA PNEUMONIAE;

EID: 79960903507     PISSN: 10478477     EISSN: 10958657     Source Type: Journal    
DOI: 10.1016/j.jsb.2011.04.010     Document Type: Article

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