MTHFR, MTR, and MTHFD1 gene polymorphisms compared to homocysteine and asymmetric dimethylarginine concentrations and their metabolites in epileptic patients treated with antiepileptic drugs

Seizure

Volumn 20, Issue 7, 2011, Pages 533-540

  Sniezawska, Aleksandra ^a   Dorszewska, Jolanta ^a   Rozycka, Agata ^a   Przedpelska Ober, Elzbieta ^a   Lianeri, Margarita ^a   Jagodzinski, Pawel P ^a   Kozubski, Wojciech ^a  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

ADMA; AEDs; Epilepsy; Hcy; MTHFD1; MTHFR; MTR

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ANTICONVULSIVE AGENT; ARGININE; HOMOCYSTEINE; METHIONINE; N(G),N(G) DIMETHYLARGININE;

ADULT; AGED; ANTICONVULSANT THERAPY; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; EPILEPSY; FEMALE; FLUORESCENCE; GENOTYPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYPERHOMOCYSTEINEMIA; MAJOR CLINICAL STUDY; MALE; METABOLITE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ADOLESCENT; ADULT; AGED; ANTICONVULSANTS; ARGININE; EPILEPSY; FEMALE; GENE FREQUENCY; GENOTYPE; HOMOCYSTEINE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NAD+); METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP); METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; POLYMORPHISM, GENETIC;

EID: 79960902722     PISSN: 10591311     EISSN: 15322688     Source Type: Journal    
DOI: 10.1016/j.seizure.2011.04.001     Document Type: Article

References (57)

1. T. Apeland, M.A. Mansoor, K. Pentieva, H. McNulty, I. Seljeflot, and R.E. Standjord The effect of B-vitamins on hyperhomocysteinemia in patients on antiepileptic drugs Epilepsy Research 51 2002 237 247 (Pubitemid 35238047)
2. M. Huemer, B. Ausserer, G. Graninger, M. Hubmann, C. Huemer, and K. Schlachter Hyperhomocysteinemia in children treated with antiepileptic drugs is normalized by folic acid supplementation Epilepsia 46 2005 1677 1683 (Pubitemid 44921945)
3. A. Verrotti, R. Pascarella, D. Trotta, T. Giuva, G. Morgese, and F. Chiarelli Hyperhomocysteinemia in children treated with sodium valproate and carbamazepine Epilepsy Research 41 2000 253 257 (Pubitemid 30658048)
4. H. Karabiber, E. Sonmezgoz, E. Ozerol, C. Yakinci, B. Otlu, and S. Yologlu Effects of valproate and carbamazepine on serum levels of homocysteine, vitamin B12, and folic acid Brain and Development 25 2003 113 115 (Pubitemid 36170307)
5. A. Attilakos, E. Papakonstantinou, K. Schulpis, K. Voudris, E. Katsarou, and S. Mastroyianni Early effect of sodium valproate and carbamazepine monotherapy on homocysteine metabolism in children with epilepsy Epilepsy Research 71 2006 229 232 (Pubitemid 44430143)
6. M. Schwaninger, P. Ringleb, R. Winter, B. Kohl, W. Fiehn, and P.A. Rieser Elevated plasma concentrations of homocysteine in antiepileptic drug treatment Epilepsia 40 1999 345 350 (Pubitemid 29164801)
7. T. Apeland, M.A. Mansoor, and R.E. Strandjord Antiepileptic drugs as independent predictors of plasma total homocysteine levels Epilepsy Research 47 2001 27 35 (Pubitemid 32973645)
8. S.A. Hamed, E.A. Hamed, R. Hamdy, and T. Nabeshima Vascular risk factors and oxidative stress as independent predictors of asymptomatic atherosclerosis in adult patients with epilepsy Epilepsy Research 74 2007 183 192 (Pubitemid 46654751)
9. T. Apeland, E.S. Froyland, O. Kristensen, R.E. Strandjord, and M.A. Mansoor Drug-induced perturbation of the aminothiol redox-status in patients with epilepsy: improvement by B-vitamins Epilepsy Research 82 2008 1 6
10. D. Caccamo, S. Condello, G. Gorgone, G. Crisafulli, V. Belcastro, and S. Gennaro Screening for C677T and A1298C MTHFR polymorphisms in patients with epilepsy and risk of hyperhomocysteinemia Neuromolecular Medicine 6 2004 117 126 (Pubitemid 41265781)
11. V. Belcastro, G. Gaetano, D. Italiano, G. Oteri, D. Caccamo, and L.R. Pisani Antiepileptic drugs and MTHFR polymorphisms influence hyper-homocysteinemia recurrence in epileptic patients Epilepsia 48 2007 1990 1994 (Pubitemid 47537442)
12. S.H. Mudd, F. Skovby, H.L. Levy, K.D. Pettigrew, B. Wilcken, and R.E. Pyeritz The natural history of homocystinuria due to cystathionine beta-synthase deficiency The American Journal of Human Genetics 37 1985 1 31 (Pubitemid 15138674)
13. J.C. Dean, Z. Robertson, V. Reid, Q. Wang, H. Hailey, and S. Moore A high frequency of the MTHFR 677C>T polymorphism in Scottish women with epilepsy: possible role in pathogenesis Seizure 17 2008 269 275 (Pubitemid 351324159)
14. J.H. Yoo, and S.B. Hong A common mutation in the methylenetetrahydrofolate reductase gene is a determinant of hyperhomocysteinemia in epileptic patients receiving anticonvulsants Metabolism 48 1999 1047 1051 (Pubitemid 29374925)
15. H. Ono, A. Sakamoto, N. Mizoguchi, and N. Sakura The C677T mutation in the methylenetetrahydrofolate reductase gene contributes to hyperhomocysteinemia in patients taking anticonvulsants Brain and Development 24 2002 223 226 (Pubitemid 34553341)
16. R.E. Billings Decreased hepatic 5,10-methylenetetrahydrofolate reductase activity in mice after chronic phenytoin treatment Molecular Pharmacology 25 1984 459 466 (Pubitemid 14033969)
17. G.F. Carl, and D.B. Smith The effect of chronic phenytoin treatment on tissue folate concentrations and on the activities of the methyl synthetic enzymes in the rat Journal of Nutrition 113 1983 2368 2374 (Pubitemid 14204957)
18. F.A. Hol, N.M. van der Put, M.P. Geurds, S.G. Heil, F.J. Trijbels, and B.C. Hamel Molecular genetic analysis of the gene encoding the trifunctional enzyme MTHFD (methylenetetrahydrofolate-dehydrogenase, methenyltetrahydrofolate- cyclohydrolase, formyltetrahydrofolate synthetase) in patients with neural tube defects Clinical Genetics 53 1998 119 125 (Pubitemid 28188213)
19. J. Dorszewska, J. Florczak, A. Rozycka, B. Kempisty, J. Jaroszewska-Kolecka, and K. Chojnacka Oxidative DNA damage and level of thiols as related to polymorphisms of MTHFR, MTR, MTHFD1 in Alzheimer's and Parkinson's diseases Acta Neurobiologiae Experimentalis 67 2007 113 129 (Pubitemid 47066464)
20. R.H. Boger, S.M. Bode-Boger, K. Sydow, D.D. Heistad, and S.R. Lentz Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase is elevated in monkey with hyperhomocysteinemia or hypercholesterolemia Arteriosclerosis, Thrombosis, and Vascular Biology 20 2000 1557 1564 (Pubitemid 30353888)
21. M.C. Stuhlinger, P.S. Tsao, J.H. Her, M. Kimoto, R.F. Balint, and J.P. Cooke Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine Circulation 104 2001 2569 2575 (Pubitemid 33104795)
22. J.H. Yoo, and S.C. Lee Elevated levels of plasma homocyst(e)ine and asymmetric dimethylarginine in elderly patients with stroke Atherosclerosis 158 2001 425 430
23. M.C. Stuhlinger, R.K. Oka, E.E. Graf, I. Schmolzer, B.M. Upson, and O. Kapoor Endothelial dysfunction induced by hyperhomocyst(e)inemia: role of asymmetric dimethylarginine Circulation 108 2003 933 938 (Pubitemid 37048221)
24. B. Schmitt, M. Wolters, G. Kressel, O. Hulsmann, A. Strohle, and W.N. Kuhn-Velten Effects of combined supplementation with B vitamins and antioxidants on plasma levels of asymmetric dimethylarginine (ADMA) in subjects with elevated risk for cardiovascular disease Atherosclerosis 193 2007 168 176 (Pubitemid 46779119)
25. T.F. Jonasson, T. Hedner, B. Hultberg, and H. Ohlin Hyperhomocysteinaemia is not associated with increased levels of asymmetric dimethylarginine in patients with ischaemic heart disease European Journal of Clinical Investigation 33 2003 543 549 (Pubitemid 36789780)
26. P. Wanby, L. Brattstrom, L. Brudin, B. Hultberg, and T. Teerlink Asymmetric dimethylarginine and total homocysteine in plasma after oral methionine loading Scandinavian Journal of Clinical and Laboratory Investigation 63 2003 347 353 (Pubitemid 37297077)
27. J.R. Chan, R.H. Boger, S.M. Bode-Boger, O. Tangphao, P.S. Tsao, and T.F. Blaschke Asymmetric dimethylarginine increases mononuclear cell adhesiveness in hypercholesterolemic humans Arteriosclerosis, Thrombosis, and Vascular Biology 20 2000 1040 1046 (Pubitemid 30207579)
28. J.P. Cooke, and R.K. Oka Atherogenesis and the arginine hypothesis Current Atherosclerosis Reports 3 2001 252 259
29. Commision on Classification and Terminology of The International League Against Epilepsy Proposal for revised classification of epilepsies and epileptic syndromem Epilepsia 30 1989 389 399
30. R. Accinni, S. Bartesaghi, G. De Leo, C.F. Cursano, G. Achilli, and A. Loaldi Screening of homocysteine from newborn blood spots by high-performance liquid chromatography with coulometric array detection Journal of Chromatography A 896 2000 186 189
31. J. Pi, Y. Kumagai, G. Sun, and N. Shimojo Improved method for simultaneous determination of l-arginine and its mono- and dimethylated metabolites in biological samples by high-performance liquid chromatography Journal of Chromatography B: Biomedical Sciences and Applications 742 2000 199 203 (Pubitemid 30330938)
32. J.L. Moore The significance of folic acid for epilepsy patients Epilepsy and Behavior 7 2005 172 181 (Pubitemid 41149519)
33. A. Siniscalchi, F. Mancuso, L. Gallelli, G. Ferreri Ibbadu, N. Biagio Mercuri, and G. De Sarro Increase in plasma homocysteine levels induced by drug treatments in neurologic patients Pharmacological Research 52 2005 367 375 (Pubitemid 41531156)
34. H. Ono, A. Sakamoto, T. Eguchi, N. Fujita, S. Nomura, and H. Ueda Plasma total homocysteine concentrations in epileptic patients taking anticonvulsants Metabolism 46 1997 959 962 (Pubitemid 27339924)
35. J.I. Toohey Possible involvement of sulfane sulfur in homocysteine-induced atherosclerosis Medical Hypotheses 56 2001 259 261 (Pubitemid 32202640)
36. A.M. Engbersen, D.G. Franken, G.H. Boers, E.M. Stevens, F.J. Trijbels, and H.J. Blom Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia The American Journal of Human Genetics 56 1995 142 150
37. S. Vurucu, E. Demirkaya, M. Kul, B. Unay, D. Gul, and R. Akin Evaluation of the relationship between C677T variants of methylenetetrahydrofolate reductase gene and hyperhomocysteinemia in children receiving antiepileptic drug therapy Progress Neuropsychopharmacology and Biology Psychiatry 32 2008 844 848 (Pubitemid 351312385)
38. S.S. Kang, J. Zhou, P.W. Wong, J. Kowalisyn, and G. Strokosch Intermediate Homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase The American Journal of Human Genetics 43 1988 414 421
39. P. Frosst, H.J. Blom, R. Milos, P. Goyette, C.A. Sheppard, and R.G. Matthews A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase Nature Genetics 10 1995 111 113
40. J. Selhub, P.F. Jacques, A.G. Bostom, R.B. D'Agostino, P.W. Wilson, and A.J. Belanger Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis The New England Journal of Medicine 332 1995 286 291
41. A. Verrotti, S. Domizio, B. Angelozzi, G. Sabatino, G. Morgese, and F. Chiarelli Changes in serum lipids and lipoproteins in epileptic children treated with anticonvulsants Journal of Paediatrics and Child Health 33 1997 242 245 (Pubitemid 27295020)
42. T.Y. Tan, C.H. Lu, H.Y. Chuang, T.K. Lin, C.W. Liou, and W.N. Chang Long-term antiepileptic drug therapy contributes to the acceleration of atherosclerosis Epilepsia 50 2009 1579 1586
43. H. Kubova, J. Folbergrova, and P. Mares Seizures induced by homocysteine in rats during ontogenesis Epilepsia 36 1995 750 756
44. M.B. Landim, A. Casella Filho, and A.C. Chagas Asymmetric dimethylarginine (ADMA) and endothelial dysfunction: implications for atherogenesis Clinics 64 2009 417 478
45. K.B. Holven, T.S. Haugstad, T. Holm, P. Aukrust, L. Ose, and M.S. Nenseter Folic acid treatment reduced elevated plasma levels of asymmetric dimethylarginine in hyperhomocysteinaemic subjects British Journal of Nutrition 89 2003 359 363 (Pubitemid 36422777)
46. K. Sydow, E. Schwedhelm, N. Arakawa, S.M. Bode-Boger, D. Tsikas, and B. Hornig ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of l-arginine and B vitamins Cardiovascular Research 57 2003 244 252 (Pubitemid 36009457)
47. R.H. Boger, K. Sydow, J. Borlak, T. Thum, H. Lenzen, and B. Schubert LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S-adenosylmethionine-dependent methyltransferases Circulation Research 87 2000 99 105 (Pubitemid 30616904)
48. P. Vallance The asymmetrical dimethylarginine/dimethylarginine dimethylaminohydrolase pathway in the regulation of nitric oxide generation Clinical Science 100 2001 159 160 (Pubitemid 32165359)
49. J.T. Kielstein, S.M. Bode-Boger, J.C. Frolich, E. Ritz, H. Haller, and D. Fliser Asymmetric dimethylarginine, blood pressure, and renal perfusion in elderly subjects Circulation 107 2003 1891 1895 (Pubitemid 36444130)
50. H. Miyazaki, H. Matsuoka, J.P. Cooke, M. Usui, S. Ueda, and S. Okuda Endogenous nitric oxide synthase inhibitor: a novel marker of atherosclerosis Circulation 99 1999 1141 1146 (Pubitemid 29120084)
51. J.T. Kielstein, S.M. Bode-Boger, J.C. Frolich, H. Haller, and R.H. Boger Relationship of asymmetric dimethylarginine to dialysis treatment and atherosclerotic disease Kidney International Supplement 78 2001 9 13
52. G. Wu, and S.M. Morris Arginine metabolism: nitric oxide and beyond Biochemical Journal 336 1998 1 17 (Pubitemid 28532555)
53. M.P. Mattson Glutamate and neurotrophic factors in neuronal plasticity and disease Annals of the New York Academy of Sciences 1144 2008 97 112
54. S. Dayal, and S.R. Lentz ADMA and hyperhomocysteinemia Vascular Medicine 10 2005 27 33
55. R. Maas Pharmacotherapies and their influence on asymmetric dimethylarginine (ADMA) Vascular Medicine 10 2005 49 57
56. H. Matsuoka, S. Itoh, M. Kimoto, K. Kohno, O. Tamai, and Y. Wada Asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in experimental hypertension Hypertension 29 1997 242 247 (Pubitemid 27074050)
57. Y. Koga, Y. Akita, J. Nishioka, S. Yatsuga, N. Povalko, and Y. Tanabe l-Arginine improves the symptoms of strokelike episodes in Melas Neurology 64 2005 710 712 (Pubitemid 40261903)