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Volumn 46, Issue 10, 2005, Pages 1677-1683

Hyperhomocysteinemia in children treated with antiepileptic drugs is normalized by folic acid supplementation

Author keywords

Atherosclerosis; Cobalamin; Genetic polymorphisms; Homocysteine metabolism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ANTICONVULSIVE AGENT; CARBAMAZEPINE; COBALAMIN; CYTOCHROME P450; ETHOSUXIMIDE; FOLIC ACID; GENOMIC DNA; HOMOCYSTEINE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PLACEBO; SULTIAME; TOPIRAMATE; VALPROIC ACID; CYANOCOBALAMIN;

EID: 27244443366     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2005.00264.x     Document Type: Article
Times cited : (62)

References (41)
  • 2
    • 0035195248 scopus 로고    scopus 로고
    • Methylation demand and homocysteine metabolism: Effects of dietary provision of creatine and guanidinoacetate
    • Stead LM, Au KP, Jacobs RL, et al. Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate. Am J Physiol Endocrinol Metab 2001;281:E1095-100.
    • (2001) Am J Physiol Endocrinol Metab , vol.281
    • Stead, L.M.1    Au, K.P.2    Jacobs, R.L.3
  • 3
    • 1642586763 scopus 로고    scopus 로고
    • Molecular biology of 5,10-methylenetetrahydrofolate reductase
    • Födinger M, Hörl WH, Sunder-Plassmann G. Molecular biology of 5,10-methylenetetrahydrofolate reductase. J Nephrol 2000;13:20-33.
    • (2000) J Nephrol , vol.13 , pp. 20-33
    • Födinger, M.1    Hörl, W.H.2    Sunder-Plassmann, G.3
  • 4
    • 0033818441 scopus 로고    scopus 로고
    • Pathways and regulation of homocysteine metabolism in mammals
    • Finkelstein JD. Pathways and regulation of homocysteine metabolism in mammals. Semin Thromb Haemost 2000;26:219-25.
    • (2000) Semin Thromb Haemost , vol.26 , pp. 219-225
    • Finkelstein, J.D.1
  • 5
    • 0031971515 scopus 로고    scopus 로고
    • A second common mutation in the methylenetetrahydrofolate reductase gene: An additional risk factor for neural-tube defects?
    • van der Put NMJ, Gabreels F, et al. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? Am J Hum Genet 1998;62:1044-51.
    • (1998) Am J Hum Genet , vol.62 , pp. 1044-1051
    • Van Der Put, N.M.J.1    Gabreels, F.2
  • 6
    • 0035055560 scopus 로고    scopus 로고
    • Homozygous thermolabile variant of the methylenetetrahydrofolate reductase gene: A potential risk factor for hyperhomocysteinaemia, CVD, and stroke in childhood
    • Prengler M, Sturt N, Krywawych S, et al. Homozygous thermolabile variant of the methylenetetrahydrofolate reductase gene: a potential risk factor for hyperhomocysteinaemia, CVD, and stroke in childhood. Dev Med Child Neurol 2001;43:220-5.
    • (2001) Dev Med Child Neurol , vol.43 , pp. 220-225
    • Prengler, M.1    Sturt, N.2    Krywawych, S.3
  • 7
    • 0037079957 scopus 로고    scopus 로고
    • Genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) in ethnic populations in Texas: A report of a novel MTHFR polymorphic site, G1793A
    • Rady PL, Szucs S, Grady J, et al. Genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) in ethnic populations in Texas: a report of a novel MTHFR polymorphic site, G1793A. Am J Med Genet 2002;107:162-8.
    • (2002) Am J Med Genet , vol.107 , pp. 162-168
    • Rady, P.L.1    Szucs, S.2    Grady, J.3
  • 8
    • 0033822422 scopus 로고    scopus 로고
    • Biological and environmental determinants of plasma homocysteine
    • Schneede J, Refsum H, Ueland PM. Biological and environmental determinants of plasma homocysteine. Semin Thromb Haemost 2000;26:263-79.
    • (2000) Semin Thromb Haemost , vol.26 , pp. 263-279
    • Schneede, J.1    Refsum, H.2    Ueland, P.M.3
  • 9
    • 0033531649 scopus 로고    scopus 로고
    • Distribution of and factors associated with serum homocysteine levels in children: Child and Adolescent Trial for Cardiovascular Health
    • Osganian S, Stampfer MJ, Spiegelman D, et al. Distribution of and factors associated with serum homocysteine levels in children: Child and Adolescent Trial for Cardiovascular Health. JAMA 1999;281:1189-96.
    • (1999) JAMA , vol.281 , pp. 1189-1196
    • Osganian, S.1    Stampfer, M.J.2    Spiegelman, D.3
  • 10
    • 0032587458 scopus 로고    scopus 로고
    • Plasma homocysteine concentration in a Belgian school-age population
    • De Laet C, Wautrecht JC, Brasseur D, et al. Plasma homocysteine concentration in a Belgian school-age population. Am J Clin Nutr 1999;69:968-72.
    • (1999) Am J Clin Nutr , vol.69 , pp. 968-972
    • De Laet, C.1    Wautrecht, J.C.2    Brasseur, D.3
  • 11
    • 0030900737 scopus 로고    scopus 로고
    • Total homocysteine in pediatric patients
    • Vilaseca MA, Moyano D, Ferrer I, et al. Total homocysteine in pediatric patients. Clin Chem 1997;43:690-2.
    • (1997) Clin Chem , vol.43 , pp. 690-692
    • Vilaseca, M.A.1    Moyano, D.2    Ferrer, I.3
  • 12
    • 0035016214 scopus 로고    scopus 로고
    • Homocysteine concentrations in a German cohort of 500 individuals: Reference ranges and determinants of plasma levels in healthy children and their parents
    • Rauh M, Verwied S, Knerr I, et al. Homocysteine concentrations in a German cohort of 500 individuals: reference ranges and determinants of plasma levels in healthy children and their parents. Amino Acids 2001;20:409-18.
    • (2001) Amino Acids , vol.20 , pp. 409-418
    • Rauh, M.1    Verwied, S.2    Knerr, I.3
  • 13
    • 84860049490 scopus 로고    scopus 로고
    • Total homocysteine, folate, cobalamin and their relation to lifestyle, body mass index and genetic polymorphisms in healthy Austrian children and adolescents
    • (submitted for publication)
    • Huemer M, Vonblon K, Födinger M, et al. Total homocysteine, folate, cobalamin and their relation to lifestyle, body mass index and genetic polymorphisms in healthy Austrian children and adolescents. Pediatr Res (submitted for publication).
    • Pediatr Res
    • Huemer, M.1    Vonblon, K.2    Födinger, M.3
  • 14
    • 0033609098 scopus 로고    scopus 로고
    • Hyperhomocysteinemia: A risk factor for ischemic stroke in children
    • van Beynum IM, Smeitink JA, den Heijer M, et al. Hyperhomocysteinemia: a risk factor for ischemic stroke in children. Circulation 1999;99:2070-2.
    • (1999) Circulation , vol.99 , pp. 2070-2072
    • Van Beynum, I.M.1    Smeitink, J.A.2    Den Heijer, M.3
  • 15
    • 0033679576 scopus 로고    scopus 로고
    • Anti-epileptic drug treatment in children: Hyperhomocysteinaemia, B-vitamins and the 677C→T mutation of the methylenetetrahydrofolate reductase gene
    • Vilaseca MA, Monros E, Artuch R, et al. Anti-epileptic drug treatment in children: hyperhomocysteinaemia, B-vitamins and the 677C→T mutation of the methylenetetrahydrofolate reductase gene. Eur J Pediatr Neurol 2000;4:269-77.
    • (2000) Eur J Pediatr Neurol , vol.4 , pp. 269-277
    • Vilaseca, M.A.1    Monros, E.2    Artuch, R.3
  • 16
    • 0034758336 scopus 로고    scopus 로고
    • Antiepileptic drugs as independent predictors of plasma total homocysteine levels
    • Apeland T, Mansoor MA, Strandjord RE. Antiepileptic drugs as independent predictors of plasma total homocysteine levels. Epilepsy Res 2001;47:27-35.
    • (2001) Epilepsy Res , vol.47 , pp. 27-35
    • Apeland, T.1    Mansoor, M.A.2    Strandjord, R.E.3
  • 17
    • 5144232463 scopus 로고    scopus 로고
    • Phenotypic expression of the methylenetetrahydrofolate reductase 677C→T polymorphism and flavin cofactor availability in thyroid dysfunction
    • Hustad S, Nedebro BG, Ueland PM, et al. Phenotypic expression of the methylenetetrahydrofolate reductase 677C→T polymorphism and flavin cofactor availability in thyroid dysfunction. Am J Clin Nutr 2004;80:1050-7.
    • (2004) Am J Clin Nutr , vol.80 , pp. 1050-1057
    • Hustad, S.1    Nedebro, B.G.2    Ueland, P.M.3
  • 18
    • 0034308118 scopus 로고    scopus 로고
    • Hyperhomocysteinemia in children treated with sodium valproate and carbamazepine
    • Verrotti A, Pascarella R, Trotta D, et al. Hyperhomocysteinemia in children treated with sodium valproate and carbamazepine. Epilepsy Res 2000;41:253-7.
    • (2000) Epilepsy Res , vol.41 , pp. 253-257
    • Verrotti, A.1    Pascarella, R.2    Trotta, D.3
  • 19
    • 0036100083 scopus 로고    scopus 로고
    • The C677T mutation in the methylenetetrahydrofolate reductase gene contributes to hyperhomocysteinemia in patients taking anticonvulsants
    • Ono H, Sakamoto A, Mizoguchi N, et al. The C677T mutation in the methylenetetrahydrofolate reductase gene contributes to hyperhomocysteinemia in patients taking anticonvulsants. Brain Dev 2002;24:223-6.
    • (2002) Brain Dev , vol.24 , pp. 223-226
    • Ono, H.1    Sakamoto, A.2    Mizoguchi, N.3
  • 20
    • 0032910781 scopus 로고    scopus 로고
    • Elevated plasma concentrations of homocysteine in antiepileptic drug treatment
    • Schwaninger M, Ringleb P, Winter R, et al. Elevated plasma concentrations of homocysteine in antiepileptic drug treatment. Epilepsia 1999;40:345-50.
    • (1999) Epilepsia , vol.40 , pp. 345-350
    • Schwaninger, M.1    Ringleb, P.2    Winter, R.3
  • 21
    • 20444445722 scopus 로고    scopus 로고
    • Homocysteine, MTHFR and risk of venous thrombosis: A meta-analysis of published epidemiological studies
    • Den Heijer M, Lewington S, Clarke R. Homocysteine, MTHFR and risk of venous thrombosis: a meta-analysis of published epidemiological studies. J Thromb Haemost 2005;3:292-9.
    • (2005) J Thromb Haemost , vol.3 , pp. 292-299
    • Den Heijer, M.1    Lewington, S.2    Clarke, R.3
  • 22
    • 13844294309 scopus 로고    scopus 로고
    • Relationship between S-adenosylmethionine, S-adenosylhomocysteine, asymmetric dimethylarginine, and endothelial function in healthy human subjects during experimental hyper- and hypohomocysteinemia
    • Doshi S, McDowell I, Goodfellow J, et al. Relationship between S-adenosylmethionine, S-adenosylhomocysteine, asymmetric dimethylarginine, and endothelial function in healthy human subjects during experimental hyper- and hypohomocysteinemia. Metabolism 2005;54:351-60.
    • (2005) Metabolism , vol.54 , pp. 351-360
    • Doshi, S.1    McDowell, I.2    Goodfellow, J.3
  • 23
    • 14044251507 scopus 로고    scopus 로고
    • Asymmetric dimethyl-L-arginine (ADMA): A possible link between homocyst(e)ine and endothelial dysfunction
    • Stühlinger MC, Stanger O. Asymmetric dimethyl-L-arginine (ADMA): a possible link between homocyst(e)ine and endothelial dysfunction. Curr Drug Metab 2005;6:3-14.
    • (2005) Curr Drug Metab , vol.6 , pp. 3-14
    • Stühlinger, M.C.1    Stanger, O.2
  • 24
    • 8444221172 scopus 로고    scopus 로고
    • Coping with endothelial superoxide: Potential complementarity of arginine and high-dose folate
    • McCarty MF. Coping with endothelial superoxide: potential complementarity of arginine and high-dose folate. Med Hypotheses 2004;63:709-18.
    • (2004) Med Hypotheses , vol.63 , pp. 709-718
    • McCarty, M.F.1
  • 25
    • 11144356870 scopus 로고    scopus 로고
    • Folic acid improves endothelial function in children and adolescents with type 1 diabetes
    • Pena AS, Wiltshire E, Gent R, et al. Folic acid improves endothelial function in children and adolescents with type 1 diabetes. J Pediatr 2004;144:500-4.
    • (2004) J Pediatr , vol.144 , pp. 500-504
    • Pena, A.S.1    Wiltshire, E.2    Gent, R.3
  • 26
    • 0030744636 scopus 로고    scopus 로고
    • Plasma total homocysteine concentrations in epileptic patients taking anticonvulsants
    • Ono H, Sakamoto A, Eguchi T, et al. Plasma total homocysteine concentrations in epileptic patients taking anticonvulsants. Metabolism 1997;46:959-62.
    • (1997) Metabolism , vol.46 , pp. 959-962
    • Ono, H.1    Sakamoto, A.2    Eguchi, T.3
  • 27
    • 0025352013 scopus 로고
    • Adenosinergic modulation of homocysteine-induced seizures in mice
    • Marangos PJ, Loftus T, Wiesner J, et al. Adenosinergic modulation of homocysteine-induced seizures in mice. Epilepsia 1990;31:239-46.
    • (1990) Epilepsia , vol.31 , pp. 239-246
    • Marangos, P.J.1    Loftus, T.2    Wiesner, J.3
  • 28
    • 0041833480 scopus 로고    scopus 로고
    • Folate deprivation induces neurodegeneration: Roles of oxidative stress and increased homocysteine
    • Ho PI, Ashline D, Dhitavat S, et al. Folate deprivation induces neurodegeneration: roles of oxidative stress and increased homocysteine. Neurobiol Dis 2003;14:32-42.
    • (2003) Neurobiol Dis , vol.14 , pp. 32-42
    • Ho, P.I.1    Ashline, D.2    Dhitavat, S.3
  • 29
    • 15744380517 scopus 로고    scopus 로고
    • Dietary vitamin B-6 restriction does not alter rates of homocysteine remethylation or synthesis in healthy young women and men
    • Davis SR, Scheer JB, Quinlivan EP, et al. Dietary vitamin B-6 restriction does not alter rates of homocysteine remethylation or synthesis in healthy young women and men. Am J Clin Nutr 2005;81:648-55.
    • (2005) Am J Clin Nutr , vol.81 , pp. 648-655
    • Davis, S.R.1    Scheer, J.B.2    Quinlivan, E.P.3
  • 30
    • 0038359296 scopus 로고    scopus 로고
    • Fasting and postmethionine loading concentrations of homocysteine, vitamin B2, and vitamin B6 in patients on antiepileptic drugs
    • Apeland T, Mansoor MA, Pentieva K, et al. Fasting and postmethionine loading concentrations of homocysteine, vitamin B2, and vitamin B6 in patients on antiepileptic drugs. Clin Chem 2003;49:1005-8.
    • (2003) Clin Chem , vol.49 , pp. 1005-1008
    • Apeland, T.1    Mansoor, M.A.2    Pentieva, K.3
  • 31
    • 0037360131 scopus 로고    scopus 로고
    • Effects of valproate and carbamazepine on serum levels of homocysteine, vitamin B12, and folic acid
    • Karabiber H, Sonmezgoz E, Ozerol E, et al. Effects of valproate and carbamazepine on serum levels of homocysteine, vitamin B12, and folic acid. Brain Dev 2003;25:113-5.
    • (2003) Brain Dev , vol.25 , pp. 113-115
    • Karabiber, H.1    Sonmezgoz, E.2    Ozerol, E.3
  • 32
    • 0031405742 scopus 로고    scopus 로고
    • Homocyst(e)ine levels in patients on phenytoin therapy
    • James GK, Jones MW, Pudek MR. Homocyst(e)ine levels in patients on phenytoin therapy. Clin Biochem 1997;30:647-9.
    • (1997) Clin Biochem , vol.30 , pp. 647-649
    • James, G.K.1    Jones, M.W.2    Pudek, M.R.3
  • 33
    • 0030891977 scopus 로고    scopus 로고
    • Mechanism for reduction of serum folate by antiepileptic drugs during prolonged therapy
    • Kishi T, Fujita N, Eguchi T, et al. Mechanism for reduction of serum folate by antiepileptic drugs during prolonged therapy. J Neurol Sci 1997;145:109-12.
    • (1997) J Neurol Sci , vol.145 , pp. 109-112
    • Kishi, T.1    Fujita, N.2    Eguchi, T.3
  • 34
    • 0033541022 scopus 로고    scopus 로고
    • Impaired methionine synthesis and hypomethylation in rats exposed to valproate during gestation
    • Alonso-Aperte E, Ubeda N, Achon M, et al. Impaired methionine synthesis and hypomethylation in rats exposed to valproate during gestation. Neurology 1999;52:750-6.
    • (1999) Neurology , vol.52 , pp. 750-756
    • Alonso-Aperte, E.1    Ubeda, N.2    Achon, M.3
  • 35
    • 13044250452 scopus 로고    scopus 로고
    • A common mutation in the methylenetetrahydrofolate reductase gene is a determinant of hyperhomocysteinemia in epileptic patients receiving anticonvulsants
    • Yoo JH, Hong SB. A common mutation in the methylenetetrahydrofolate reductase gene is a determinant of hyperhomocysteinemia in epileptic patients receiving anticonvulsants. Metabolism 1999;48:1047-51.
    • (1999) Metabolism , vol.48 , pp. 1047-1051
    • Yoo, J.H.1    Hong, S.B.2
  • 36
    • 0345169186 scopus 로고    scopus 로고
    • The role of genetic factors in the development of hyperhomocysteinemia
    • Geisel J, Hubner U, Bodis M, et al. The role of genetic factors in the development of hyperhomocysteinemia. Clin Chem Lab Med 2003;41:1427-34.
    • (2003) Clin Chem Lab Med , vol.41 , pp. 1427-1434
    • Geisel, J.1    Hubner, U.2    Bodis, M.3
  • 37
    • 0031749452 scopus 로고    scopus 로고
    • Genetic defects of folate and cobalamin metabolism
    • Fowler B. Genetic defects of folate and cobalamin metabolism. Eur J Pediatr 1998;157:S60-6.
    • (1998) Eur J Pediatr , vol.157
    • Fowler, B.1
  • 38
    • 0037164104 scopus 로고    scopus 로고
    • Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis
    • Homocysteine Studies Collaboration
    • Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA 2002;288:2015-22.
    • (2002) JAMA , vol.288 , pp. 2015-2022
  • 39
    • 0036738023 scopus 로고    scopus 로고
    • Effect of riboflavin supplementation on plasma homocysteine in elderly people with low riboflavin status
    • McKinley MC, McNulty H, McPartlin J, et al. Effect of riboflavin supplementation on plasma homocysteine in elderly people with low riboflavin status. Eur J Clin Nutr 2002;56:850-6.
    • (2002) Eur J Clin Nutr , vol.56 , pp. 850-856
    • McKinley, M.C.1    McNulty, H.2    McPartlin, J.3
  • 40
    • 0037953208 scopus 로고    scopus 로고
    • Folic acid and epilepsy
    • Morrell MJ. Folic acid and epilepsy. Epilepsy Curr 2002;2:31-4.
    • (2002) Epilepsy Curr , vol.2 , pp. 31-34
    • Morrell, M.J.1
  • 41
    • 16544370325 scopus 로고    scopus 로고
    • Will mandatory folic acid fortification prevent or promote cancer?
    • Kim YI. Will mandatory folic acid fortification prevent or promote cancer? Am J Clin Nutr 2004;80:1123-8.
    • (2004) Am J Clin Nutr , vol.80 , pp. 1123-1128
    • Kim, Y.I.1


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