Antiepileptic drugs and MTHFR polymorphisms influence hyper-homocysteinemia recurrence in epileptic patients

Epilepsia

Volumn 48, Issue 10, 2007, Pages 1990-1994

  Belcastro, Vincenzo ^a   Gaetano, Gorgone ^a   Italiano, Domenico ^a   Oteri, Giancarla ^a   Caccamo, Daniela ^a   Pisani, Laura Rosa ^a   Striano, Pasquale ^b   Striano, Salvatore ^b   Ientile, Riccardo ^a   Pisani, Francesco ^a,c  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF MESSINA   (Italy)

Author keywords

Antiepileptic drugs; Hyper homocysteinemia; MTHFR polymorphisms

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ANTICONVULSIVE AGENT; CARBAMAZEPINE; FOLIC ACID; LAMOTRIGINE; PHENOBARBITAL; PHENYTOIN; PRIMIDONE; TOPIRAMATE;

ADULT; ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; EPILEPSY; FEMALE; GENETIC POLYMORPHISM; HUMAN; HYPERHOMOCYSTEINEMIA; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PLASMA; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECURRENT DISEASE; SUPPLEMENTATION;

ADULT; AGE FACTORS; ANTICONVULSANTS; COMBINED MODALITY THERAPY; EPILEPSY; FEMALE; FOLIC ACID; FOLLOW-UP STUDIES; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; LONGITUDINAL STUDIES; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; POLYMORPHISM, GENETIC; RECURRENCE; SUBSTANCE WITHDRAWAL SYNDROME; TREATMENT OUTCOME;

EID: 35148897283     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2007.01164.x     Document Type: Article

References (12)

1. Apeland T, Mansoor MA, Pentieva K, McNulty H, Seljeflot I, Strandjord RE 2002) The effect of B-vitamins on hyperhomocysteinemia in patients on antiepileptic drugs. Epilepsy Res 51 : 237 247.
2. Bahrami G, Mirzaeei S, Mohammadi B, Kiani A (2005) High performance liquid chromatographic determination of topiramate in human serum using UV detection. J Chromatogr B Analy Technol Biomed Life Sci 822 (1-2 322 325.
3. Caccamo D, Condello S, Gorgone G, Crisafulli G, Belcastro V, Gennaro S, Striano P, Pisani F, Ientile R 2004) Screening for C677T and A1298C MTHFR polymorphisms in patients with epilepsy and risk of hyperhomocysteinemia. Neuromol Med 6 : 117 126.
4. Carmel R, Green R, Rosenblatt TS, Watkins D 2003) Update on cobalamin, folate, and homocysteine. Hematol Am Soc Hematol Educ Program 62 81.
5. Chango A, Boisson F, Barbe F, Quilliot D, Droesch S, Pfister M, Fillon-Emery N, Lambert D, Fremont S, Rosenblatt DS, Nicolas JP 2000) The effect of 677C→T and 1298A→C mutations on plasma homocysteine and 5,10-methylenetetrahydrofolate reductase activity in healthy subjects. Br J Nutr 83 : 593 596.
6. Contin M, Balboni M, Callegati E, Candela C, Albani F, Riva R, Baruzzi A 2005) Simultaneous liquid chromatographic determination of lamotrigine, oxcarbazepine monohydroxy derivative and felbamate in plasma of patients with epilepsy. J Chromatogr B Analyt Technol Biomed Life Sci 828 (1-2 113 117.
7. Herrmann W, Herrmann M, Obeid R 2007) Hyperhomocysteinaemia: a critical review of old and new aspects. Curr Drug Metab 8 (1 17 31.
8. Huemer M, Ausserer B, Graninger G, Hubmann M, Huemer C, Schlachter K, Tscharre A, Ulmer H, Simma B 2005) Hyperhomocysteinemia in children treated with antiepileptic drugs is normalized by folic acid supplementation. Epilepsia 46 : 1677 1683.
9. Lucock M 2000) Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Mol Genet Metab 71 : 121 138.
10. Perucca E 2006) Clinically relevant drug interactions with antiepileptic drugs. Br J Clin Pharmacol 61 : 246 255.
11. Reynolds EH 2006) Vitamin B12, folic acid, and the nervous system. Lancet Neurol 5 : 949 960.
12. Tamura T, Aiso K, Johnston KE, Black L, Faught E 2000) Homocysteine, folate, vitamin B-12(and vitamin B-6 in patients receiving antiepileptic drug monotherapy. Epilepsy Res 40 : 7 15.