Drug-induced pertubation of the aminothiol redox-status in patients with epilepsy: Improvement by B-vitamins

Epilepsy Research

Volumn 82, Issue 1, 2008, Pages 1-6

  Apeland, Terje ^a   Frøyland, Elin S ^a   Kristensen, Ole ^a   Strandjord, Roald E ^a   Mansoor, Mohammad A ^b  

^a STAVANGER UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF AGDER   (Norway)

Author keywords

Aminothiol redox status; Antiepileptic drug; Cysteine; Cysteinylglycine; Homocysteine

Indexed keywords

AMINOTHIOL; ANTICONVULSIVE AGENT; CYSTEINE; CYSTEINYLGLYCINE; HOMOCYSTEINE; VITAMIN B GROUP; CARBAMAZEPINE; DIAGNOSTIC AGENT; DIPEPTIDE; FOLIC ACID; METHIONINE; PHENOBARBITAL; PHENYTOIN; PRIMIDONE; PYRIDOXINE; RIBOFLAVIN; VALPROIC ACID;

ADULT; ARTICLE; CONTROLLED STUDY; EPILEPSY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYPERHOMOCYSTEINEMIA; MAJOR CLINICAL STUDY; MALE; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; VITAMIN SUPPLEMENTATION; BLOOD; CASE CONTROL STUDY; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; DRUG SCREENING; ENZYMOLOGY; INTERVENTION STUDY; LIVER; METABOLISM; OXIDATION REDUCTION REACTION; VITAMIN DEFICIENCY;

ADULT; ANTICONVULSANTS; CARBAMAZEPINE; CASE-CONTROL STUDIES; CYSTEINE; DIPEPTIDES; DRUG EVALUATION; EPILEPSY; FEMALE; FOLIC ACID; HUMANS; HYPERHOMOCYSTEINEMIA; INTERVENTION STUDIES; LIVER; MALE; METHIONINE; OXIDATION-REDUCTION; PHENOBARBITAL; PHENYTOIN; PRIMIDONE; PYRIDOXINE; RIBOFLAVIN; VALPROIC ACID; VITAMIN B DEFICIENCY;

EID: 64149116438     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2008.06.003     Document Type: Article

References (34)

1. Andersson A., Hutlberg B., and Lindgren A. Redox status of plasma homocysteine and other plasma thiols in stroke patients. Atherosclerosis 151 2 (2000) 535-539
2. Andersson A., Jonasson T., Ohlin H., Lindgren A., and Hultberg B. Vitamin supplementation normalizes total plasma homocysteine concentration but not plasma homocysteine redox status in patients with acute coronary syndromes and hyperhomocysteinemia. Clin. Chem. Lab. Med. 40 6 (2002) 554-558
3. Apeland T., Mansoor M.A., Strandjord R.E., and Kristensen O. Homocysteine concentrations and methionine loading in patients on antiepileptic drugs. Acta Neurol. Scand. 101 4 (2000) 217-223
4. Apeland T., Mansoor M.A., Strandjord R.E., Vefring H., and Kristensen O. Folate, homocysteine and methionine loading in patients on carbamazepine. Acta Neurol. Scand. 103 5 (2001) 294-299
5. Apeland T., Mansoor M.A., and Strandjord R.E. Antiepileptic drugs as independent predictors of plasma total homocysteine levels. Epilepsy Res. 47 1-2 (2001) 27-35
6. Apeland T., Mansoor M.A., Seljeflot I., Bronstad I., Goransson L., and Strandjord R.E. Homocysteine, malondialdehyde and endothelial markers in dialysis patients during low-dose folinic acid therapy. J. Intern. Med. 252 5 (2002) 456-464
7. Apeland T., Mansoor M.A., Pentieva K., Mcnulty H., Seljeflot I., and Strandjord R.E. The effect of B-vitamins on hyperhomocysteinemia in patients on antiepileptic drugs. Epilepsy Res. 51 3 (2002) 237-247
8. Apeland T., Mansoor M.A., Pentieva K., Mcnulty H., and Strandjord R.E. Fasting and post-methionine loading concentrations of homocysteine, vitamin B2, and vitamin B6 in patients on antiepileptic drugs. Clin. Chem. 49 Part 1 (6) (2003) 1005-1008
9. Caruso R., Campolo J., Sedda V., De Chiara B., Dellanoce C., Baudo F., Tonini A., Parolini M., Cighetti G., and Parodi O. Effect of homocysteine lowering by 5-methyltetrahydrofolate on redox status in hyperhomocysteinemia. J. Cardiovasc. Pharmacol. 47 4 (2006) 549-555
10. Chambers J.C., Ueland P.M., Obeid O.A., Wrigley J., Refsum H., and Kooner J.S. Improved vascular endothelial function after oral B vitamins: an effect mediated through reduced concentrations of free plasma homocysteine. Circulation 102 20 (2000) 2479-2483
11. Chern C.L., Huang R.F., Chen Y.H., Cheng J.T., and Liu T.Z. Folate deficiency-induced oxidative stress and apoptosis are mediated via homocysteine-dependent overproduction of hydrogen peroxide and enhanced activation of NF-kappaB in human Hep G2 cells. Biomed. Pharmacother. 55 8 (2001) 434-442
12. Clarke R., Lewington S., Sherliker P., and Armitage J. Effects of B-vitamins on plasma homocysteine concentrations and on risk of cardiovascular disease and dementia. Curr. Opin. Clin. Nutr. Metab. Care 10 1 (2007) 32-39
13. Di Giuseppe D., Di Simplicio P., Capecchi P.L., Lazzerini P.E., and Pasini F.L. Alteration in the redox state of plasma in heart-transplant patients with moderate hyperhomocysteinemia. J. Lab. Clin. Med. 142 1 (2003) 21-28
14. Graham I.M., Daly L.E., Refsum H.M., Robinson K., Brattstrom L.E., Ueland P.M., Palma-Reis R.J., Boers G.H., Sheahan R.G., Israelsson B., Uiterwaal C.S., Meleady R., Mcmaster D., Verhoef P., Witteman J., Rubba P., Bellet H., Wautrecht J.C., De Valk H.W., Sales Luis A.C., Parrot-Rouland F.M., Tan K.S., Higgins I., Garcon D., Andria G., et al. Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project (see comments). JAMA 277 22 (1997) 1775-1781
15. James G.K., Jones M.W., and Pudek M.R. Homocyst(e)ine levels in patients on phenytoin therapy. Clin. Biochem. 30 8 (1997) 647-649
16. Krause K.H., Bonjour J.P., Berlit P., Kynast G., Schmidt-Gayk H., and Schellenberg B. Effect of long-term treatment with antiepileptic drugs on the vitamin status. Drug Nutr. Interact. 5 4 (1988) 317-343
17. Loscalzo J. The oxidant stress of hyperhomocyst(e)inemia. J. Clin. Invest. 98 1 (1996) 5-7
18. Mansoor M.A., Svardal A.M., Schneede J., and Ueland P.M. Dynamic relation between reduced, oxidized, and protein-bound homocysteine and other thiol components in plasma during methionine loading in healthy men. Clin. Chem. 38 7 (1992) 1316-1321
19. Mansoor M.A., Svardal A.M., and Ueland P.M. Determination of the in vivo redox status of cysteine, cysteinylglycine, homocysteine, and glutathione in human plasma. Anal. Biochem. 200 2 (1992) 218-229
20. Mansoor M.A., Bergmark C., Svardal A.M., Lonning P.E., and Ueland P.M. Redox status and protein binding of plasma homocysteine and other aminothiols in patients with early-onset peripheral vascular disease. Homocysteine and peripheral vascular disease. Arterioscler. Thromb. Vasc. Biol. 15 2 (1995) 232-240
21. Nilsson L., Tomson T., Farahmand B.Y., Diwan V., and Persson P.G. Cause-specific mortality in epilepsy: a cohort study of more than 9000 patients once hospitalized for epilepsy. Epilepsia 38 10 (1997) 1062-1068
22. Reynolds E.H. Chronic antiepileptic toxicity: a review. Epilepsia 16 2 (1975) 319-352
23. SAS Institute Inc. 1998, Cary, NC, USA.
24. Schwaninger M., Ringleb P., Winter R., Kohl B., Fiehn W., Rieser P.A., and Walter-Sack I. Elevated plasma concentrations of homocysteine in antiepileptic drug treatment. Epilepsia 40 3 (1999) 345-350
25. Shirodaria C., Antoniades C., Lee J., Jackson C.E., Robson M.D., Francis J.M., Moat S.J., Ratnatunga C., Pillai R., Refsum H., Neubauer S., and Channon K.M. Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease. Circulation 115 17 (2007) 2262-2270
26. Stabler S.P. Vitamins, homocysteine, and cognition. Am. J. Clin. Nutr. 78 3 (2003) 359-360
27. Tamura T., Aiso K., Johnston K.E., Black L., and Faught E. Homocysteine, folate, vitamin B-12 and vitamin B-6 in patients receiving antiepileptic drug monotherapy. Epilepsy Res. 40 1 (2000) 7-15
28. Ueland P.M. Homocysteine species as components of plasma redox thiol status. Clin. Chem. 41 3 (1995) 340-342
29. Ueland P.M., Mansoor M.A., Guttormsen A.B., Muller F., Aukrust P., Refsum H., and Svardal A.M. Reduced, oxidized and protein-bound forms of homocysteine and other aminothiols in plasma comprise the redox thiol status-a possible element of the extracellular antioxidant defense system. J. Nutr. 126 Suppl. (4) (1996) 1281S-1284S
30. Upchurch Jr. G.R., Welch G.N., Fabian A.J., Freedman J.E., Johnson J.L., Keaney Jr. J.F., and Loscalzo J. Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. J. Biol. Chem. 272 27 (1997) 17012-17017
31. Van Oort F.V., Melse-Boonstra A., Brouwer I.A., Clarke R., West C.E., Katan M.B., and Verhoef P. Folic acid and reduction of plasma homocysteine concentrations in older adults: a dose-response study. Am. J. Clin. Nutr. 77 5 (2003) 1318-1323
32. Vollset S.E., Refsum H., Irgens L.M., Emblem B.M., Tverdal A., Gjessing H.K., Monsen A.L., and Ueland P.M. Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Homocysteine study (see comments). Am. J. Clin. Nutr. 71 4 (2000) 962-968
33. Wald D.S., Law M., and Morris J.K. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ 325 7374 (2002) 1202
34. Zou C.G., and Banerjee R. Homocysteine and redox signaling. Antioxid. Redox Signal 7 5-6 (2005) 547-559