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Volumn 6, Issue 1, 2006, Pages 13-19

Joint inflammation and cytokine inhibition in rheumatoid arthritis

Author keywords

Anti tumour necrosis factor alpha agents; Cytokines; Interleukin 1; Rheumatoid arthritis; Tumour necrosis factor alpha

Indexed keywords

ADALIMUMAB; AMG 714; ATLIZUMAB; ETANERCEPT; INFLIXIMAB; INTERLEUKIN 1; INTERLEUKIN 15; INTERLEUKIN 15 ANTIBODY; INTERLEUKIN 6; METHOTREXATE; MONOCLONAL ANTIBODY; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 33645130483     PISSN: 15918890     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10238-006-0088-5     Document Type: Review
Times cited : (92)

References (60)
  • 1
    • 0033951612 scopus 로고    scopus 로고
    • Economic burden of rheumatoid arthritis: A systematic review
    • Cooper NJ (2000) Economic burden of rheumatoid arthritis: a systematic review. Rheumatology 39:28-33
    • (2000) Rheumatology , vol.39 , pp. 28-33
    • Cooper, N.J.1
  • 2
    • 0033001678 scopus 로고    scopus 로고
    • An assessment of the annual and long-term direct costs of rheumatoid arthritis: The impact of poor function and functional decline
    • Yelin E, Wanke LA (1999) An assessment of the annual and long-term direct costs of rheumatoid arthritis: the impact of poor function and functional decline. Arthritis Rheum 42:1209-1218
    • (1999) Arthritis Rheum , vol.42 , pp. 1209-1218
    • Yelin, E.1    Wanke, L.A.2
  • 3
    • 0021212076 scopus 로고
    • Severe functional declines, work disability, and increased mortality in seventy-five rheumatoid arthritis patients studied over 5 years
    • Pincus T, Callahan LF, Sale WG, Brooks AL, Payne LE, Vaughn WK (1984) Severe functional declines, work disability, and increased mortality in seventy-five rheumatoid arthritis patients studied over 5 years. Arthritis Rheum 27:864-872
    • (1984) Arthritis Rheum , vol.27 , pp. 864-872
    • Pincus, T.1    Callahan, L.F.2    Sale, W.G.3    Brooks, A.L.4    Payne, L.E.5    Vaughn, W.K.6
  • 4
    • 0035119217 scopus 로고    scopus 로고
    • The immunologic homunculus in rheumatoid arthritis. A new viewpoint of immunopathogenesis in rheumatoid arthritis and its therapeutic consequences
    • Blass S, Engel JM, Burmester GR (2001) The immunologic homunculus in rheumatoid arthritis. A new viewpoint of immunopathogenesis in rheumatoid arthritis and its therapeutic consequences. Z Rheumatol 60:1-16
    • (2001) Z Rheumatol , vol.60 , pp. 1-16
    • Blass, S.1    Engel, J.M.2    Burmester, G.R.3
  • 5
    • 0027465503 scopus 로고
    • Cell surface glycoproteins expressed on activated human T cells induce production of interleukin-1 beta by monocytic cells: A possible role of CD69
    • Isler P, Vey E, Zhang JH, Dayer JM (1993) Cell surface glycoproteins expressed on activated human T cells induce production of interleukin-1 beta by monocytic cells: a possible role of CD69. Eur Cytokine Nerve 4:15-23
    • (1993) Eur Cytokine Nerve , vol.4 , pp. 15-23
    • Isler, P.1    Vey, E.2    Zhang, J.H.3    Dayer, J.M.4
  • 6
    • 0029085746 scopus 로고
    • Cytokines in rheumatoid arthritis
    • Houssiau PA (1995) Cytokines in rheumatoid arthritis. Clin Rheumatol 14[Suppl 2]:10-13
    • (1995) Clin Rheumatol , vol.14 , Issue.2 SUPPL. , pp. 10-13
    • Houssiau, P.A.1
  • 7
    • 0027375872 scopus 로고
    • The effects of cytokines on metalloproteinase inhibitors (TIMP) and collagenase production by human chondrocytes and TMIP production by synovial cells and endothelial cells
    • Shingu M, Nagai Y, Isayama T, Naono T, Nobunaga M, Nagai Y (1993) The effects of cytokines on metalloproteinase inhibitors (TIMP) and collagenase production by human chondrocytes and TMIP production by synovial cells and endothelial cells. Clin Exp Immunol 94:145-149
    • (1993) Clin Exp Immunol , vol.94 , pp. 145-149
    • Shingu, M.1    Nagai, Y.2    Isayama, T.3    Naono, T.4    Nobunaga, M.5    Nagai, Y.6
  • 8
    • 0035932519 scopus 로고    scopus 로고
    • Mechanisms of disease: Cytokine pathways and joint inflammation in rheumatoid arthritis
    • Choy EH, Panayi GS (2001) Mechanisms of disease: cytokine pathways and joint inflammation in rheumatoid arthritis. N Engl J Med 344:907-916
    • (2001) N Engl J Med , vol.344 , pp. 907-916
    • Choy, E.H.1    Panayi, G.S.2
  • 9
    • 0032922359 scopus 로고    scopus 로고
    • The role of tumour necrosis factor in health and disease
    • Beutler BA (1999) The role of tumour necrosis factor in health and disease. J Rheumatol 26[Suppl 57]:16-21
    • (1999) J Rheumatol , vol.26 , Issue.57 SUPPL. , pp. 16-21
    • Beutler, B.A.1
  • 10
    • 0035001641 scopus 로고    scopus 로고
    • Pathogenesis of rheumatoid arthritis. Role of B lymphocytes
    • Zhang Z, Bridges SL Jr (2001) Pathogenesis of rheumatoid arthritis. Role of B lymphocytes. Rheum Dis Clin North Am 27:335-353
    • (2001) Rheum Dis Clin North Am , vol.27 , pp. 335-353
    • Zhang, Z.1    Bridges Jr., S.L.2
  • 12
    • 0032692402 scopus 로고    scopus 로고
    • The role of cytokines in the pathogenesis of rheumatoid arthritis
    • Feldmann M, Maini RN (1999) The role of cytokines in the pathogenesis of rheumatoid arthritis. Rheumatology 38[Suppl 2]:3-7
    • (1999) Rheumatology , vol.38 , Issue.2 SUPPL. , pp. 3-7
    • Feldmann, M.1    Maini, R.N.2
  • 13
    • 0025274640 scopus 로고
    • Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis
    • Arend WP, Dayer JM (1990) Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis. Arthritis Rheum 33:305-315
    • (1990) Arthritis Rheum , vol.33 , pp. 305-315
    • Arend, W.P.1    Dayer, J.M.2
  • 14
    • 0022296893 scopus 로고
    • A cachectin/tumour necrosis factor alpha stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts
    • Dayer JM, Beutler B, Cerami A (1985) A cachectin/tumour necrosis factor alpha stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts. J Exp Med 162:163-168
    • (1985) J Exp Med , vol.162 , pp. 163-168
    • Dayer, J.M.1    Beutler, B.2    Cerami, A.3
  • 15
    • 85047675276 scopus 로고    scopus 로고
    • Prostaglandin E2, Interleukin-1 alpha, and tumour necrosis factor-alpha increase human osteoclast formation and bone resorption in vitro
    • Lader CS, Flanagan AM (1998) Prostaglandin E2, Interleukin-1 alpha, and tumour necrosis factor-alpha increase human osteoclast formation and bone resorption in vitro. Endocrinology 139:3157-3164
    • (1998) Endocrinology , vol.139 , pp. 3157-3164
    • Lader, C.S.1    Flanagan, A.M.2
  • 16
    • 0036083566 scopus 로고    scopus 로고
    • The pathogenesis of rheumatoid arthritis: A guide to therapy
    • Jenkins JK, Hardy KJ, McMurray RW (2002) The pathogenesis of rheumatoid arthritis: a guide to therapy. Am J Med Sci 323:171-180
    • (2002) Am J Med Sci , vol.323 , pp. 171-180
    • Jenkins, J.K.1    Hardy, K.J.2    McMurray, R.W.3
  • 17
    • 0026091413 scopus 로고
    • Localisation of tumour necrosis factor alpha in synovial tissues and at the cartilage-pannus junction in patients with rheumatoid arthritis
    • Chu CQ, Field M, Feldmann M et al (1991) Localisation of tumour necrosis factor alpha in synovial tissues and at the cartilage-pannus junction in patients with rheumatoid arthritis. Arthritis Rheum 34:1125-1132
    • (1991) Arthritis Rheum , vol.34 , pp. 1125-1132
    • Chu, C.Q.1    Field, M.2    Feldmann, M.3
  • 18
    • 0029045924 scopus 로고
    • Association between degree of bone-erosion and synovial fluid-levels of tumour necrosis factor alpha in the knee joints of patients with rheumatoid arthritis
    • Neidel J, Schuize M, Lindschau J (1995) Association between degree of bone-erosion and synovial fluid-levels of tumour necrosis factor alpha in the knee joints of patients with rheumatoid arthritis. Inflamm Res 44:217-221
    • (1995) Inflamm Res , vol.44 , pp. 217-221
    • Neidel, J.1    Schuize, M.2    Lindschau, J.3
  • 19
    • 0029617952 scopus 로고
    • Modulation of proinflammatory cytokine release in rheumatoid synovial membrane cell cultures: Comparison of monoclonal anti TNF-alpha antibody with interleukin-1 receptor antagonist
    • Butler DM, Maini RN, Feldmann M, Brennan FM (1995) Modulation of proinflammatory cytokine release in rheumatoid synovial membrane cell cultures: comparison of monoclonal anti TNF-alpha antibody with interleukin-1 receptor antagonist. Eur Cytokine Netw 6:225-230
    • (1995) Eur Cytokine Netw , vol.6 , pp. 225-230
    • Butler, D.M.1    Maini, R.N.2    Feldmann, M.3    Brennan, F.M.4
  • 20
    • 0026039673 scopus 로고
    • Transgenic mice expressing human tumour necrosis factor: A predictive genetic model of arthritis
    • Keffer J, Probert L, Cazlaris H et al (1991) Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J 10:4025-4031
    • (1991) EMBO J , vol.10 , pp. 4025-4031
    • Keffer, J.1    Probert, L.2    Cazlaris, H.3
  • 21
    • 0027422060 scopus 로고
    • Influence of a recombinant human soluble tumour necrosis factor receptor Fc fusion protein on type II collagen-induced arthritis in mice
    • Wooley PH, Dutcher J, Widmer MB, Gillis S (1993) Influence of a recombinant human soluble tumour necrosis factor receptor Fc fusion protein on type II collagen-induced arthritis in mice. J Immunol 151:6602-6607
    • (1993) J Immunol , vol.151 , pp. 6602-6607
    • Wooley, P.H.1    Dutcher, J.2    Widmer, M.B.3    Gillis, S.4
  • 22
    • 0026644298 scopus 로고
    • Anti-tumour necrosis factor ameliorates joint disease in murine collagen-induced arthritis
    • USA
    • Williams RO, Feldmann M, Maini RN (1992) Anti-tumour necrosis factor ameliorates joint disease in murine collagen-induced arthritis. Proc Natl Acad Sci USA 89:9784-9788
    • (1992) Proc Natl Acad Sci , vol.89 , pp. 9784-9788
    • Williams, R.O.1    Feldmann, M.2    Maini, R.N.3
  • 24
    • 0029042275 scopus 로고
    • Periarticular osteopenia in adjuvant induced arthritis: Role of interleukin-1 in decreased osteogenic and increased resorptive potential of bone marrow cells
    • Suzuki Y, Tanihara M, Ichikawa Y, Osanai A, Nakagawa M, Ide M, Mizushima Y (1995) Periarticular osteopenia in adjuvant induced arthritis: role of interleukin-1 in decreased osteogenic and increased resorptive potential of bone marrow cells. Ann Rheum Dis 54:484-490
    • (1995) Ann Rheum Dis , vol.54 , pp. 484-490
    • Suzuki, Y.1    Tanihara, M.2    Ichikawa, Y.3    Osanai, A.4    Nakagawa, M.5    Ide, M.6    Mizushima, Y.7
  • 25
    • 0021069905 scopus 로고
    • An interleukin 1 like factor stimulates bone resorption in vitro
    • Gowen M, Wood DD, Ihrie EJ, McGuire MK, Russel RG (1983) An interleukin 1 like factor stimulates bone resorption in vitro. Nature 306:378-380
    • (1983) Nature , vol.306 , pp. 378-380
    • Gowen, M.1    Wood, D.D.2    Ihrie, E.J.3    McGuire, M.K.4    Russel, R.G.5
  • 26
    • 0025149103 scopus 로고
    • Discoordinate expression of stromelysin, collagenase, and tissue inhibitor of metalloproteinases-1 in rheumatoid human synovial fibroblasts: Synergistic effects of interleukin-1 and tumour necrosis factor-alpha on stromelysin expression
    • MacNaul KL, Chartrain N, Lark M, Tocci MJ, Hutchinson NI (1990) Discoordinate expression of stromelysin, collagenase, and tissue inhibitor of metalloproteinases-1 in rheumatoid human synovial fibroblasts: synergistic effects of interleukin-1 and tumour necrosis factor-alpha on stromelysin expression. J Biol Chem 265:17238-17245
    • (1990) J Biol Chem , vol.265 , pp. 17238-17245
    • MacNaul, K.L.1    Chartrain, N.2    Lark, M.3    Tocci, M.J.4    Hutchinson, N.I.5
  • 27
    • 0000609002 scopus 로고
    • Interleukin I induces leucocyte infiltration and cartilage proteoglycan degradation in the synovial joint
    • U S A
    • Pettipher ER, Higgs GA, Henderson B (1986) Interleukin I induces leucocyte infiltration and cartilage proteoglycan degradation in the synovial joint. Proc Natl Acad Sci U S A 83:8749-8753
    • (1986) Proc Natl Acad Sci , vol.83 , pp. 8749-8753
    • Pettipher, E.R.1    Higgs, G.A.2    Henderson, B.3
  • 28
    • 0029875804 scopus 로고    scopus 로고
    • Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: A comparative study using anti-TNFα, anti-IL-1α/ β, and IL-1Rα
    • Joosten LAB, Helsen MMA, van de Loo FAJ, van den Berg WB (1996) Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: a comparative study using anti-TNFα, anti-IL-1α/β, and IL-1Rα. Arthritis Rheum 39:797-809
    • (1996) Arthritis Rheum , vol.39 , pp. 797-809
    • Joosten, L.A.B.1    Helsen, M.M.A.2    Van De Loo, F.A.J.3    Van Den Berg, W.B.4
  • 29
    • 0023683844 scopus 로고
    • cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily
    • Sims JE, March CJ, Cosman D et al (1988) cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily. Science 241:585-589
    • (1988) Science , vol.241 , pp. 585-589
    • Sims, J.E.1    March, C.J.2    Cosman, D.3
  • 30
    • 0025899561 scopus 로고
    • A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types
    • McMahan CJ, Slack JL, Mosley B et al (1991) A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. EMBO J 10:2821-2832
    • (1991) EMBO J , vol.10 , pp. 2821-2832
    • McMahan, C.J.1    Slack, J.L.2    Mosley, B.3
  • 31
    • 0027287950 scopus 로고
    • Interleukin 1 signalling occurs exclusively via the type I receptor
    • U S A
    • Sims JE, Gayle MA, Slack JL et al (1993) Interleukin 1 signalling occurs exclusively via the type I receptor. Proc Natl Acad Sci U S A 90:6155-6159
    • (1993) Proc Natl Acad Sci , vol.90 , pp. 6155-6159
    • Sims, J.E.1    Gayle, M.A.2    Slack, J.L.3
  • 32
    • 0027181936 scopus 로고
    • Interleukin-1 type II receptor: A decoy target for IL-1 that is regulated by IL-4
    • Colotta F, Re F, Muzio M et al (1993) Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4. Science 261:472-475
    • (1993) Science , vol.261 , pp. 472-475
    • Colotta, F.1    Re, F.2    Muzio, M.3
  • 33
    • 0028675659 scopus 로고
    • The interleukin-1 family: 10 Years of discovery
    • Dinarello CA (1994) The interleukin-1 family: 10 years of discovery. FASEB J 8:1314-1325
    • (1994) FASEB J , vol.8 , pp. 1314-1325
    • Dinarello, C.A.1
  • 34
    • 0025260903 scopus 로고
    • Interleukin-6: An overview
    • Van Snick J (1990) Interleukin-6: an overview. Annu Rev Immunol 8:253-278
    • (1990) Annu Rev Immunol , vol.8 , pp. 253-278
    • Van Snick, J.1
  • 36
    • 0026537579 scopus 로고
    • Serial estimation of interleukin-6 as a measure of systemic disease in rheumatoid arthritis
    • Dasgupta B, Corkill M, Kirkham B, Gibson T, Panayi G (1992) Serial estimation of interleukin-6 as a measure of systemic disease in rheumatoid arthritis. J Rheumatol 19:22-25
    • (1992) J Rheumatol , vol.19 , pp. 22-25
    • Dasgupta, B.1    Corkill, M.2    Kirkham, B.3    Gibson, T.4    Panayi, G.5
  • 37
    • 13344250490 scopus 로고    scopus 로고
    • Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation
    • Kotake S, Sato K, Kim KJ et al (1996) Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation. J Bone Miner Res 11:88-95
    • (1996) J Bone Miner Res , vol.11 , pp. 88-95
    • Kotake, S.1    Sato, K.2    Kim, K.J.3
  • 38
    • 0026577535 scopus 로고
    • IL-6 and soluble IL-2 receptor in rheumatoid arthritis patients treated with second line drugs
    • Watson J, Crilly A, Madhok R, Capell H, Sturrock R (1992) IL-6 and soluble IL-2 receptor in rheumatoid arthritis patients treated with second line drugs. Biochem Soc Trans 20:138S
    • (1992) Biochem Soc Trans , vol.20
    • Watson, J.1    Crilly, A.2    Madhok, R.3    Capell, H.4    Sturrock, R.5
  • 39
    • 0028179054 scopus 로고
    • Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor
    • Grabstein KH, Eisenman J, Shanebeck K et al (1994) Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. Science 264:965-968
    • (1994) Science , vol.264 , pp. 965-968
    • Grabstein, K.H.1    Eisenman, J.2    Shanebeck, K.3
  • 40
    • 0033046593 scopus 로고    scopus 로고
    • The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens
    • Waldmann TA, Tagaya Y (1999) The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens. Annu Rev Immunol 17:19-49
    • (1999) Annu Rev Immunol , vol.17 , pp. 19-49
    • Waldmann, T.A.1    Tagaya, Y.2
  • 41
    • 0030900454 scopus 로고    scopus 로고
    • In vivo gene expression of type 1 and type 2 cytokines in synovial tissues from patients in early stages of rheumatoid, reactive, and undifferentiated arthritis
    • Kotake S, Schumacher HR Jr, Yarboro CH et al (1997) In vivo gene expression of type 1 and type 2 cytokines in synovial tissues from patients in early stages of rheumatoid, reactive, and undifferentiated arthritis. Proc Assoc Am Physicians 109:286-301
    • (1997) Proc Assoc Am Physicians , vol.109 , pp. 286-301
    • Kotake, S.1    Schumacher Jr., H.R.2    Yarboro, C.H.3
  • 42
    • 0027198002 scopus 로고
    • Soluble tumour necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists
    • Mohler KM, Torrance DS, Smith CA et al (1993) Soluble tumour necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists. J Immunol 151:1548-1561
    • (1993) J Immunol , vol.151 , pp. 1548-1561
    • Mohler, K.M.1    Torrance, D.S.2    Smith, C.A.3
  • 43
    • 0033574147 scopus 로고    scopus 로고
    • Etanercept therapy in rheumatoid arthritis: A randomised controlled trial
    • Moreland LW, Schiff MH, Baumgartner SW et al (1999) Etanercept therapy in rheumatoid arthritis: a randomised controlled trial. Ann Intern Med 130:478-486
    • (1999) Ann Intern Med , vol.130 , pp. 478-486
    • Moreland, L.W.1    Schiff, M.H.2    Baumgartner, S.W.3
  • 44
    • 0013511183 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with a recombinant human tumour necrosis factor receptor (p75)-Fc fusion protein
    • Moreland LW, Baumgartner SW, Schiff MH et al (1997) Treatment of rheumatoid arthritis with a recombinant human tumour necrosis factor receptor (p75)-Fc fusion protein. N Engl J Med 337:141-147
    • (1997) N Engl J Med , vol.337 , pp. 141-147
    • Moreland, L.W.1    Baumgartner, S.W.2    Schiff, M.H.3
  • 45
    • 0034735827 scopus 로고    scopus 로고
    • A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis
    • Bathon JM, Martin RW, Fleischmann RM et al (2000) A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis. N Engl J Med 343:1586-1593
    • (2000) N Engl J Med , vol.343 , pp. 1586-1593
    • Bathon, J.M.1    Martin, R.W.2    Fleischmann, R.M.3
  • 46
    • 0033611472 scopus 로고    scopus 로고
    • A trial of etanercept, a recombinant tumour necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate
    • Weinblatt ME, Kremer JM, Bankhurst AD et al (1999) A trial of etanercept, a recombinant tumour necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate. N Engl J Med 340:253-259
    • (1999) N Engl J Med , vol.340 , pp. 253-259
    • Weinblatt, M.E.1    Kremer, J.M.2    Bankhurst, A.D.3
  • 47
    • 0028143211 scopus 로고
    • Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis
    • Elliott MJ, Maini RN, Feldmann M et al (1994) Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis. Lancet 344:1105-1110
    • (1994) Lancet , vol.344 , pp. 1105-1110
    • Elliott, M.J.1    Maini, R.N.2    Feldmann, M.3
  • 48
    • 0031660364 scopus 로고    scopus 로고
    • Therapeutic efficacy of multiple intravenous infusions of anti-tumour necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis
    • Maini RN, Breedveld FC, Kalden JR et al (1998) Therapeutic efficacy of multiple intravenous infusions of anti-tumour necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis. Arthritis Rheum 41:1552-1563
    • (1998) Arthritis Rheum , vol.41 , pp. 1552-1563
    • Maini, R.N.1    Breedveld, F.C.2    Kalden, J.R.3
  • 49
    • 0033524159 scopus 로고    scopus 로고
    • Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: A randomised phase III trial
    • Maini R, St Clair EW, Breedveld F et al (1999) Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial. Lancet 354:1932-1939
    • (1999) Lancet , vol.354 , pp. 1932-1939
    • Maini, R.1    St Clair, E.W.2    Breedveld, F.3
  • 50
    • 0034735842 scopus 로고    scopus 로고
    • Infliximab and methotrexate in the treatment of rheumatoid arthritis
    • Lipsky PE, van der Heijde DMFM, St Clair EW et al (2000) Infliximab and methotrexate in the treatment of rheumatoid arthritis. N Engl J Med 343:1594-1602
    • (2000) N Engl J Med , vol.343 , pp. 1594-1602
    • Lipsky, P.E.1    Van Der Heijde, D.M.F.M.2    St Clair, E.W.3
  • 51
    • 0037231533 scopus 로고    scopus 로고
    • Adalimumab, a fully human anti-tumour necrosis factor alpha monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: The ARMADA trial
    • Weinblatt ME, Keystone EC, Frust DE et al (2003) Adalimumab, a fully human anti-tumour necrosis factor alpha monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: the ARMADA trial. Arthritis Rheum 48:35-45
    • (2003) Arthritis Rheum , vol.48 , pp. 35-45
    • Weinblatt, M.E.1    Keystone, E.C.2    Frust, D.E.3
  • 52
    • 0036201985 scopus 로고    scopus 로고
    • Long-term anti-tumour necrosis factor alpha monotherapy in rheumatoid arthritis: Effect on radiological course and prognostic value of markers of cartilage turnover and endothelial activation
    • den Broeder AA, Joosten LA, Saxne T, Heinegard D, Fenner H, Miltenburg AMM (2002) Long-term anti-tumour necrosis factor alpha monotherapy in rheumatoid arthritis: effect on radiological course and prognostic value of markers of cartilage turnover and endothelial activation. Ann Rheum Dis 61:311-318
    • (2002) Ann Rheum Dis , vol.61 , pp. 311-318
    • Den Broeder, A.A.1    Joosten, L.A.2    Saxne, T.3    Heinegard, D.4    Fenner, H.5    Miltenburg, A.M.M.6
  • 53
    • 17444394445 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist
    • Bresnihan B, Alvaro-Gracia JM, Cobby M et al (1998) Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist. Arthritis Rheum 41:2196-2204
    • (1998) Arthritis Rheum , vol.41 , pp. 2196-2204
    • Bresnihan, B.1    Alvaro-Gracia, J.M.2    Cobby, M.3
  • 54
    • 0036190776 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist (IL-1Ra) in combination with methotrexate
    • Cohen S, Hurd E, Cush J et al (2002) Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist (IL-1Ra) in combination with methotrexate. Arthritis Rheum 46:614-624
    • (2002) Arthritis Rheum , vol.46 , pp. 614-624
    • Cohen, S.1    Hurd, E.2    Cush, J.3
  • 55
    • 0029943271 scopus 로고    scopus 로고
    • Dose-range and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis
    • Campion GV, Lebsack ME, Lookabaugh J, Gordon G, Catalano M, IL-1Ra Arthritis Study Group (1996) Dose-range and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis. Arthritis Rheum 39:1092-1101
    • (1996) Arthritis Rheum , vol.39 , pp. 1092-1101
    • Campion, G.V.1    Lebsack, M.E.2    Lookabaugh, J.3    Gordon, G.4    Catalano, M.5
  • 56
    • 0026056197 scopus 로고
    • Blocking IL-1: Interleukin 1 receptor antagonist in vivo and in vitro
    • Dinarello CA, Thompson RC (1991) Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro. Immunol Today 12:404-410
    • (1991) Immunol Today , vol.12 , pp. 404-410
    • Dinarello, C.A.1    Thompson, R.C.2
  • 57
    • 2642558925 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: A multicenter, double-blind, placebo-controlled trial
    • Nishimoto N, Yoshizaki K, Miyasaka N et al (2004) Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial. Arthritis Rheum 50:1761-1769
    • (2004) Arthritis Rheum , vol.50 , pp. 1761-1769
    • Nishimoto, N.1    Yoshizaki, K.2    Miyasaka, N.3
  • 58
    • 8344243130 scopus 로고    scopus 로고
    • Anti-IL6 receptor therapy: Rationale and early results in rheumatoid arthritis
    • Abstract
    • Maini RN (2004) Anti-IL6 receptor therapy: rationale and early results in rheumatoid arthritis. Ann Rheum Dis 63[Suppl 1]:25-26, Abstract
    • (2004) Ann Rheum Dis , vol.63 , Issue.1 SUPPL. , pp. 25-26
    • Maini, R.N.1
  • 59
    • 25444519432 scopus 로고    scopus 로고
    • Targeting interleukin-15 in patients with rheumatoid arthritis: A proof-of-concept study
    • Baslund B, Tvede N, Danneskiold-Samsoe B et al (2005) Targeting interleukin-15 in patients with rheumatoid arthritis: a proof-of-concept study. Arthritis Rheum 52:2686-2692
    • (2005) Arthritis Rheum , vol.52 , pp. 2686-2692
    • Baslund, B.1    Tvede, N.2    Danneskiold-Samsoe, B.3
  • 60
    • 14844289358 scopus 로고    scopus 로고
    • Safety and efficacy of a human monoclonal antibody to IL-15 (AMG 714) in patients with rheumatoid arthritis (RA): Results from a multicenter, randomised, double-blind, placebo-controlled trial
    • McInnes I, Martin R, Zimmerman-Gorska I et al (2004) Safety and efficacy of a human monoclonal antibody to IL-15 (AMG 714) in patients with rheumatoid arthritis (RA): Results from a multicenter, randomised, double-blind, placebo-controlled trial. Arthritis Rheum 50[Suppl 9]:S241
    • (2004) Arthritis Rheum , vol.50 , Issue.9 SUPPL.
    • McInnes, I.1    Martin, R.2    Zimmerman-Gorska, I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.