The role of the insular cortex in taste function

Neurobiology of Learning and Memory

Volumn 96, Issue 2, 2011, Pages 130-135

  Stehberg, Jimmy ^a   Moraga Amaro, Rodrigo ^a   Simon, Felipe ^a,b  

^a UNIVERSIDAD ANDRÉS BELLO   (Chile)

^b UNIVERSITY OF CHILE   (Chile)

Author keywords

Amnesia; Conditioned taste aversion; CTA; CTA retention; Insular cortex; Lesion; Neophobia; Original taste preference

Indexed keywords

IBOTENIC ACID; SACCHARIN;

AMNESIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX LESION; BRAIN FUNCTION; BRAIN REGION; CONCENTRATION RESPONSE; CONDITIONED TASTE AVERSION; CONTROLLED STUDY; DISCRIMINATION LEARNING; DISEASE SEVERITY; INSULA; LEARNING DISORDER; MALE; MEMORY; MEMORY CONSOLIDATION; NEOPHOBIA; NONHUMAN; RAT; SHAM PROCEDURE; TASTE; TASTE AVERSION; TASTE DISCRIMINATION; TASTE MEMORY; TASTE PREFERENCE;

ANIMALS; CEREBRAL CORTEX; CONDITIONING (PSYCHOLOGY); IBOTENIC ACID; MALE; RATS; RATS, WISTAR; RETENTION (PSYCHOLOGY); TASTE; TASTE PERCEPTION;

EID: 79960830243     PISSN: 10747427     EISSN: 10959564     Source Type: Journal    
DOI: 10.1016/j.nlm.2011.03.005     Document Type: Article

References (42)

1. Accolla R., Bathellier B., Petersen C.C., Carleton A. Differential spatial representation of taste modalities in the rat gustatory cortex. Journal of Neuroscience 2007, 27(6):1396-1404.
2. Adolphs R., Tranel D., Koenigs M., Damasio A.R. Preferring one taste over another without recognizing either. Nature Neuroscience 2005, 8(7):860-861.
3. Aguado L., San Antonio A., Perez L., del Valle R., Gomez J. Effects of the NMDA receptor antagonist ketamine on flavor memory: Conditioned aversion, latent inhibition, and habituation of neophobia. Behavioral and Neural Biology 1994, 61:271-281.
4. Bahar A., Dudai Y., Ahissar E. Neural signature of taste familiarity in the gustatory cortex of the freely behaving rat. Journal of Neurophysiology 2004, 92(6):3298-3308.
5. Berman D.E., Hazvi S., Neduva V., Dudai Y. The role of identified neurotransmitter systems in the response of insular cortex to unfamiliar taste: Activation of ERK1-2 and formation of a memory trace. Journal of Neurophysiology 2000, 20(18):7017-7023.
6. Berman D.E., Dudai Y. Memory extinction, learning anew, and learning the new: Dissociations in the molecular machinery of learning in cortex. Science 2001, 291(5512):2417-2419.
7. Berman D.E., Hazvi S., Stehberg J., Bahar A., Dudai Y. Conflicting processes in the extinction of conditioned taste aversion: Behavioral and molecular aspects of latency, apparent stagnation, and spontaneous recovery. Learning and Memory 2003, 10(1):16-25.
8. Bermudez-Rattoni F., McGaugh J.L. Insular cortex and amygdala lesions differentially affect acquisition on inhibitory avoidance and conditioned taste aversion. Brain Research 1991, 549(1):165-170.
9. Braun J.J., Kiefer S.W., Ouellet J.V. Research note psychic ageusia in rats lacking gustatory neocortex. Experimental Neurology 1981, 72(3):711-716.
10. Cechetto D.F., Saper C.B. Evidence for a viscerotopic sensory representation in the cortex and thalamus in the rat. Journal of Comparative Neurology 1987, 262(1):27-45.
11. Desgranges B., Sevelinges Y., Bonnefond M., Lévy F., Ravel N., Ferreira G. Critical role of insular cortex in taste but not odour aversion memory. European Journal of Neuroscience 2009, 29(8):1654-1662.
12. Domjan M., Gillan D. Role of novelty in the aversion for increasingly concentrated saccharin solutions. Physiology and Behavior 1976, 16(5):537-542.
13. Dunn L.T., Everitt B.J. Double dissociations of the effects of amygdala and insular cortex lesions on conditioned taste aversion, passive avoidance, and neophobia in the rat using the excitotoxin ibotenic acid. Behavioral Neuroscience 1988, 102(1):3-23.
14. Escobar M.L., Alcocer I., Chao V. The NMDA receptor antagonist CPP impairs conditioned taste aversion and insular cortex long-term potentiation in vivo. Brain Research 1998, 812(1-2):246-251.
15. Escobar M.L., Alcocer I., Bermudez-Rattoni F. In vivo effects of intracortical administration of NMDA and metabotropic glutamate receptors antagonists on neocortical long-term potentiation and conditioned taste aversion. Behavioural Brain Research 2002, 129(1-2):101-106.
16. Ferreira G., Gutierrez R., De La Cruz V., Bermudez-Rattoni F. Differential involvement of cortical muscarinic and NMDA receptors in short- and long-term taste aversion memory. European Journal of Neuroscience 2002, 16(6):1139-1145.
17. Figueroa-Guzmán Y., Kuo J.S., Reilly S. NMDA receptor antagonist MK-801 infused into the insular cortex prevents the attenuation of gustatory neophobia in rats. Brain Research 2006, 1114(1):183-186.
18. Gutierrez R., Tellez L.A., Bermudez-Rattoni F. Blockade of cortical muscarinic but not NMDA receptors prevents a novel taste from becoming familiar. European Journal of Neuroscience 2003, 17(8):1556-1562.
19. Ivanova S.F., Bures J. Acquisition of conditioned taste aversion in rats is prevented by tetrodotoxin blockade of a small midbrain region centered around the parabrachial nuclei. Physiology and Behavior 1990, 48(4):543-549.
20. Jimenez B., Tapia R. Biochemical modulation of NMDA receptors: Role in conditioned taste aversion. Neurochemical Research 2004, 29(1):161-168.
21. Kiefer S.W., Leach L.R., Braun J.J. Taste agnosia following gustatory neocortex ablation: Dissociation from odor and generality across taste qualities. Behavioral Neuroscience 1984, 98(4):590-608.
22. Kiefer S.W., Orr M.R. Taste avoidance, but not aversion, learning in rats lacking gustatory cortex. Behavioral Neuroscience 1992, 106(1):140-146.
23. Kobayashi M., Fujita S., Takei H., Song L., Chen S., Suzuki I., et al. Functional mapping of gustatory neurons in the insular cortex revealed by pERK-immunohistochemistry and in vivo optical imaging. Synapse 2010, 64(4):323-334.
24. Kosar E., Grill H.J., Norgren R. Gustatory cortex in the rat. I. Physiological properties and cytoarchitecture. Brain Research 1986, 379:329-341.
25. Lin J.Y., Roman C., St.Andre J., Reilly S. Taste, olfactory and trigeminal neophobia in rats with forebrain lesions. Brain Research 2009, 1251:195-203.
26. Naor C., Dudai Y. Transient impairment of cholinergic function in the rat insular cortex disrupts the encoding of taste in conditioned taste aversion. Behavioural Brain Research 1996, 79(1-2):61-67.
27. Núñez-Jaramillo L., Delint-Ramirez I., Bermúdez-Rattoni F. PKC blockade differentially affects aversive but not appetitive gustatory memories. Brain Research 2007, 1148:177-182.
28. Ogawa H., Ito S., Murayama N., Hasegawa K. Taste area in granular and dysgranular insular cortices in the rat identified by stimulation of the entire oral cavity. Neuroscience Research 1990, 9:196-201.
29. Ormsby C.E., Ramírez-Amaya V., Bermúdez-Rattoni F. Long-term memory retrieval deficits of learned taste aversions are ameliorated by cortical fetal brain implants. Behavioral Neuroscience 1998, 112(1):172-182.
30. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 1998, Academic Press, New York. 2nd ed.
31. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 2007, Academic Press, New York. 6th ed.
32. Pedroza-Llinás R., Ramírez-Lugo L., Guzmán-Ramos K., Zavala-Vega S., Bermúdez-Rattoni F. Safe taste memory consolidation is disrupted by a protein synthesis inhibitor in the nucleus accumbens shell. Neurobiology of Learning and Memory 2009, 92(1):45-52.
33. Roman C., Reilly S. Effects of insular cortex lesions on conditioned taste aversion and latent inhibition in the rat. European Journal of Neuroscience 2007, 26(9):2627-2632.
34. Roman C., Lin J.Y., Reilly S. Conditioned taste aversion and latent inhibition following extensive taste preexposure in rats with insular cortex lesions. Brain Research 2009, 1259:68-73.
35. Rosenblum K., Berman D.E., Hazvi S., Lamprecht R., Dudai Y. NMDA receptor and the tyrosine phosphorylation of its 2B subunit in taste learning in the rat insular cortex. Journal of Neuroscience 1997, 17(13):5129-5135.
36. Stone M.E., Grimes B.S., Katz D.B. Hippocampal inactivation enhances taste learning. Learn Memory 2005, 12(6):579-586.
37. Stehberg J., Simon F. Involvement of the insular cortex in retention of conditioned taste aversion is not time dependent. Neurobiology of Learning and Memory 2011, 95(1):14-18.
38. Yamamoto T., Matsuo R., Kawamura Y. Localization of cortical gustatory area in rats and its role in taste discrimination. Journal of Neurophysiology 1980, 44(3):440-455.
39. Yamamoto T., Yuyama N., Kato T., Kawamura Y. A. Gustatory responses of cortical neurons in rats. II. Information processing of taste quality. Journal of Neurophysiology 1985, 53(6):1356-1369.
40. Yamamoto T., Yuyama N., Kato T., Kawamura Y. B. Gustatory responses of cortical neurons in rats. III. Neural and behavioral measures compared. Journal of Neurophysiology 1985, 53(6):1370-1386.
41. Yamamoto T., Shimura T., Sako N., Yasoshima Y., Sakai N. Neural substrates for conditioned taste aversion in the rat. Behavioural Brain Research 1994, 65(2):123-137.
42. Yamamoto T., Fujimoto Y., Shimura T., Sakai N. Conditioned taste aversion in rats with excitotoxic brain lesions. Neuroscience Research 1995, 22(1):31-49.