Transient impairment of cholinergic function in the rat insular cortex disrupts the encoding of taste in conditioned taste aversion

Behavioural Brain Research

Volumn 79, Issue 1-2, 1996, Pages 61-67

  Naor, Cathy ^a   Dudai, Yadin ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Acetylcholine; Conditioned taste aversion; Gustatory cortex; Taste

Indexed keywords

ACETYLCHOLINE; OTENZEPAD; PIRENZEPINE; SCOPOLAMINE;

ANIMAL EXPERIMENT; ARTICLE; CHOLINERGIC ACTIVITY; CONTROLLED STUDY; INSULA; INTRACEREBRAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TASTE;

EID: 0030246873     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/0166-4328(95)00262-6     Document Type: Article

References (38)

1. [1] Aigner, T.G. and Mishkin, M., Scopolamine impairs recall of one-trial stimulus reward associations in monkeys, Behav. Brain Res., 54 (1993) 133-136.
2. [2] Bermudez-Rattoni, F., Coburn, K.L., Fernandez, J., Chavez, A.F. and Garcia, J., Potentiation of odor by taste and odor aversions in rats are regulated by cholinergic activity of dorsal hippocampus, Pharmacol. Biochem. Behav., 26 (1987) 553-559.
3. [3] Braun, J.J., Gustatory cortex: definition and function. In: B. Kolb and R.C. Tees (Eds.), The Cerebral Cortex of the Rat, Cambridge University Press, Cambridge, MA, 1990. pp. 407-430.
4. [4] Braun, J.J., Slick, T.B. and Lorden, J.F., Involvement of gustatory neocortex in the learning of taste aversions. Pharmacol. Behav., 9 (1972) 637-641.
5. [5] Bures, J., Buresova, O. and Krivanek. J., Brain and Behaviour. Paradigms for Research in Neural Mechanisms, Academia, Praha, 1988.
6. [6] Cox, C.L., Metherate, R. and Ashe, J.H., Modulation of cellular excitability in neocortex: muscarinic receptor and second messenger-mediated actions of acetylcholine, Synapse, 16 (1994) 123-136.
7. [7] Decker, M.W. and McGaugh, J.L., The role of interaction between the cholinergic system and other neuromodulatory systems in learning and memory. Synapse, 7 (1991) 151-168.
8. [8] Deutch, R., Effects of atropine on conditioned taste aversion, Pharmacol, Biochem. Behav., 8 (1978) 685-694.
9. [9] Doods, H., Entzeroth, M., Ziegler, H., Schiavi, G., Engel, W., Mihm, G. and Rudolf, K., Characterization of BIBN 99: a lipophilic and selective muscarinic M2 receptor antagonist, Eur. J. Pharmacol., 242 (1993) 23-30.
10. [10] Doods, H.N., Willim, K.D., Boddeke, H.W. and Entzeroth, M., Characterization of muscarinic receptors in guinea-pig uterus, Eur. J. Pharmacol., 250 (1993) 223-230.
11. [11] Dudai, Y., Neurogenetic dissection of learning and short-term memory in Drosophila, Annu. Rev. Neurosci,. 11 (1988) 537-563.
12. [12] Fibiger, H.C., Cholinergic mechanisms in learning, memory, and dementia: a review of recent evidence. Trends Neurosci., 14 (1991) 220-223.
13. [13] Frey, K.A. and Howland, M.M., Quantitative autoradiography of muscarinic cholinergic receptor binding in the rat brain: distinction of receptor subtypes in antagonist competition assays, J. Pharmacol. Exp. Ther., 263 (1992) 1391-1400.
14. [14] Gadusek, F.J. and Kalat, J.W., Effects of scopolamine on taste aversion learning in rats, Physiol. Psychol., 3 (1975) 130-132.
15. [15] Gallo, M., Roldan, G. and Bures, J., Differential involvement of gustatory insular cortex and amygdala in the acquisition and retrieval of conditioned taste aversion in rats, Behav. Brain Res., 52 (1992) 91-97.
16. [16] Garcia, J., Kimmeldorf, D.J. and Koelling, R.A., Conditioned aversion to saccharin resulting from exposure to gamma radiation. Science, 122 (1955) 157-158.
17. [17] Gould, M.N. and Yatvin, M.B., Atropine-caused central nervous system interference with radiation-induced learned and unlearned behaviors, Int. J. Radiat. Biol. 24 (1973) 463-468.
18. [18] Hasselmo, M.E. and Bower, J.M., Acetylcholine and memory, Trends Neurosci., 16 (1993) 218-222.
19. [19] Kral, P.A., Effects of scopolamine injection during CS-US interval on conditioning, Psychol. Rep., 28 (1971) 690.
20. [20] Lasiter, P.S., Gastrointestinal reactivity in rats lacking anterior insular neocortex, Behav. Neural Biol., 39 (1983) 149-154.
21. [21] Lopez-Garcia, J.C., Bermudez-Rattoni, F. and Tapia, R., Release of acetylcholme, γ-aminobutyrate, dopamine and glutamate, and activity of some related enzymes, in rat gustatory neocortex, Brain Res., 523 (1990) 100-104.
22. [22] Lopez-Garcia, J.C., Fernandez-Ruiz, J., Bermudez-Rattoni, F. and Tapia, R., Correlation between acetylcholine release and recovery of conditioned taste aversion induces by fetal neocortex grafts, Brain Res., 523 (1990) 105-110.
23. [23] Lopez-Garcia, J.C., Fernandez-Ruiz, J., Escobar, M.L., Bermudez-Rattoni, F. and Tapia, R., Effects of excitotoxic lesions of the nucleus basalis magnocellularis on conditioned taste aversion and inhibitory avoidance in the rat, Pharmacol. Biochem. Behav., 45 (1993) 147-152.
24. [24] Lubow, R.E., Latent Inhibition and Conditioned Attention Theory, Cambridge University Press, Cambridge, 1989.
25. [25] Markram, H. and Segal, M., The inositol 1,4,5-triphosphate pathway mediates cholinergic potentiation of rat hippocampal neuronal responses to NMDA, J. Physiol. (Lond.), 447 (1992) 513-533.
26. [26] Mishkin, M. and Murray, E.A., Stimulus recognition, Curr. Opin. Neurobiol., 4 (1994) 200-206.
27. [27] Moon, I.S., Apperson, M.L. and Kennedy, M.B., The major tyrosine-phosphorylated protein in the postsynaptic density fraction is N-methyl-D-aspartate receptor subunit 2B, Proc. Natl. Acad. Sci. USA, 91 (1994) 3954-3958.
28. [28] Muir, J.L., Page, K.J., Sirinathsinghji, D.J.S., Robbins, T.W. and Eventt, B.J., Excitoxic lesions of basal forebrain cholinergic neurons: effects on learning, memory and behavior, Behav. Brain Res., 57 (1993) 123-131.
29. [29] Overton, D.A., State-dependent or 'dissociated' learning produced with pentobarbital. J. Comp. Physiol. Psychol., 57 (1964) 3-12.
30. [30] Paxinos, G. and Watson, C., The Rat Brain in Stereotaxic Coordinates. 1986, Academic Press, New York.
31. [31] Rosenblum, K., Hazvi, S., Berman, D.E., Naor, C. and Dudai, Y., The tyrosine phosphorylation of a set of proteins in the rat gustatory cortex, that is modulated by gustatory experience, is also modulated by in vivo administration of carbamylcholine, Soc. Neurosci. Abstr., 20 (1994) 1763.
32. [32] Rosenblum, K., Meiri, N. and Dudai, Y., Taste memory: the role of protein synthesis in gustatory cortex, Behav. Neural Biol., 59 (1993) 49-56.
33. [33] Rosenblum, K., Schul, R., Hadari, Y.R., Zick, Y. and Dudai, Y., Modulation of protein tyrosine phosphorylation in rat insular cortex after conditioned taste aversion training, Proc. Natl. Acad. Sci. USA, 92 (1995) 1157-1161.
34. [34] Segal, M., Acetylcholine enhances NMDA-evoked calcium rise in hippocampal neurons. Brain Res., 587 (1992) 83-87.
35. [35] Stivers, J.A., Skirboll, L.R., Long, R. and Crawley, J.N., Anatomical analysis of frontal cortex sites at which carbachol induces motor seizures in the rat, Pharmacol. Biochem. Behav., 30 (1988) 129-136.
36. [36] Waelbroeck, M., Tastenoy, M., Camus, J. and Christophe, J., Binding of selective antagonists to four muscarinic receptors (M1 to M4) in rat forebrain. Mol. Pharmacol., 38 (1990) 267-273.
37. [37] Wang, Y. and Salter, M.W., Regulation of NMDA receptors by tyrosine kinase and phosphatases, Nature, 369 (1994) 233-235.
38. [38] Yamamoto, T., Shimura, T., Sako, N., Yasoshima, Y. and Sakai, N., Neural substrates for conditioned taste aversion in the rat, Behav. Brain Res., 65 (1994) 123-137.