NMDA receptor and the tyrosine phosphorylation of its 2B subunit in taste learning in the rat insular cortex

Journal of Neuroscience

Volumn 17, Issue 13, 1997, Pages 5129-5135

  Rosenblum, Kobi ^a   Berman, Diego E ^a   Hazvi, Shoshi ^a   Lamprecht, Raphael ^a   Dudai, Yadin ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Conditioned taste aversion; Insular cortex; Latent inhibition; NMDA receptor subunit 2B; Taste learning; Tyrosine phosphorylation

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN; RECEPTOR SUBUNIT; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IN SITU HYBRIDIZATION; INSULA; INTERNEURON; LATENT INHIBITION; LEARNING; MALE; NONHUMAN; PHOSPHORYLATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT; TASTE; TASTE AVERSION;

EID: 0030903625     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-13-05129.1997     Document Type: Article

References (38)

1. Abc K, Saito H (1993) Tyrosine kinase inhibitors, herbimycin A and lavendustin A, block formation of long-term potentiation in the dentate gyrus in vivo. Brain Res 621:167-170.
2. Aguado L, Antionio AS, Perez L, del Valle R, Gomez J (1994) Effects of the NMDA receptor antagonist ketamine on flavor memory, conditioned aversion, latent inhibition, and habituation of neophobia. Behav Neural Biol 61:271-281.
3. Aigner TG (1995) Pharmacology of memory: cholinergic-glutamatergic interactions. Curr Opin Neurobiol 5:155-160.
4. Bannerman DM, Good MA, Butcher SP, Ramsay M, Morris RGM (1995) Distinct components of spatial learning revealed by prior training and NMDA receptor blockade. Nature 378:182-186.
5. Bermudez-Rattoni F, McGaugh JL (1991) Insular cortex and amygdala lesions differentially affect acquisition on inhibitory avoidance and conditioned taste aversion. Brain Res 549:165-170.
6. Braun JJ, Slick TB, Lorden JF (1972) Involvement of gustatory neocortex in the learning of taste aversions. Physiol Behav 9:637-641.
7. Braun JJ, Lasiter PS, Kiefer SW (1982) The gustatory neocortex of the rat. Physiol Psychol 10:13-45.
8. Bures J, Buresova O, Krivanek J (1988) Brain and behavior: paradigms for research in neural mechanisms. New York: Wiley.
9. Burnette WW (1981) Western blotting: electrophoretic transfer of proteins from sodium dodecyl sulfate-poryacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal Biochem 112:195-203.
10. Caramanos Z, Shapiro ML (1994) Spatial memory and N-methyl-D-aspartate receptor antagonists APV and MK-801: memory impairments depend on familiarity with the environment, drug dose, and training duration. Behav Neurosci 108:30-43.
11. Chambers KC (1990) A neural model for conditioned taste aversions. Annu Rev Neurosci 13:373-385.
12. Cox CL, Metherate R, Ashe JH (1994) Modulation of cellular excitability in neocortex: muscarinic receptor and second messenger-mediated action. Synapse 16:123-136.
13. Dudai Y (1996) Consolidation: fragility on the road to the engram. Neuron 17:367-370.
14. Dunn LT, Everitt BJ (1988) Double dissociation of the effects of amygdala and insular cortex lesions on conditioned taste aversion, passive avoidance, and neophobia in the rat using the excitotoxin ibotenic acid. Behav Neurosci 102:3-23.
15. Fanslow MS, Kim JJ, Yipp J, De Oca B (1994) Differential effects of the N-methyl-D-aspartate antagonist DL-2-amino-phosphonovalerate on acquisition of fear of auditory and contextual cues. Behav Neurosci 108:235-240.
16. Finger TE (1987) Gustatory nuclei and pathways in the central nervous system. In: Neurobiology of taste and smell (Finger TE, Silver WL, eds), pp. 331-353. New York: Wiley.
17. Gallo M, Roldan G, Bures J (1992) Differential involvement of gustatory insular cortex and amygdala in the acquisition and retrieval of conditioned taste aversion in rats. Behav Brain Res 52:91-97.
18. Gomperts SN (1996) Clustering membrane proteins: it's all coming together with the PSD-95/SAP90 protein family. Cell 84:659-662.
19. Grant SGN, O'Dell TJ, Karl KA, Stein PL, Soriano P, Kandel ER (1992) Impaired long-term potentiation, spatial learning, and hippocampal development in the fyn mutant mice. Science 258:1903-1910.
20. Hebb DO (1949) The organization of behavior: a neuropsychological theory. New York: Wiley.
21. Hettinger TP, Frank ME (1992) Information processing in mammalian gustatory cortex. Curr Opin Neurobiol 2:469-478.
22. Ishii T, Moriyoshi K, Sugihara H, Sakurada K, Kadotani H, Yokoi M, Akazawa R, Mizuno N, Masu M, Nakanishi S (1993) Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. J Biol Chem 268:2836-2843.
23. Kiefer SW, Orr MR (1992) Taste avoidance, but not aversion, learning in rats lacking gustatory cortex. Behav Neurosci 106:140-146.
24. Köhr G, Seeburg PH (1996) Subtype-specific regulation of recombinant NMDA receptor-channels by protein tyrosine kinases of the src family. J Physiol (Lond) 492:445-452.
25. Kornau H-C, Schenker LT, Kennedy MB, Seeburg PH (1995) Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science 269:1737-1740.
26. Kutsuwada T, Sakimura K, Manabe T, Takayama C, Katakura N, Kushiya E, Natsume R, Watanabe M, Inoue Y, Yagi T, Aizawa S, Masaaki A, Takahashi T, Nakamura Y, Mori H, Mishina M (1996) Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor ε2 subunit mutant mice. Neuron 16:333-344.
27. 4. Nature 227:680-685.
28. Muller BM, Kistner U, Kindler S, Chung WJ, Kuhlendhal S, Fenster SD, Lau L-F, Veh RW, Huganir RL, Gundelfinger ED, Garner CC (1996) SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo. Neuron 17:255-265.
29. Naor C, Dudai Y (1996) Transient impairment of cholinergic function in the rat insular cortex disrupts the encoding of taste in conditioned taste aversion. Behav Brain Res 79:61-67.
30. Niethammer M, Kim E, Sheng M (1996) Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases. J Neurosci 16:2157-2163.
31. O'Dell TJ, Kandel ER, Grant SGN (1991) Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors. Nature 353:558-560.
32. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates, 2nd Ed. New York: Academic.
33. Revusky S, Garcia J (1970) Learned associations over long delays. Psychol Learn Motiv 4:3-84.
34. Rosenblum K, Meiri N, Dudai Y (1993) Taste memory: the role of protein synthesis in gustatory cortex. Behav Neural Biol 59:49-56.
35. Schafe GE, Seeley R, Bernstein IL (1995) Forebrain contribution to the induction of a cellular correlate of conditioned taste aversion in the nucleus of the solitary tract. J Neurosci 15:6791-6796.
36. Tong G, Shepherd D, Jahr CE (1995) Synaptic desensitization of NMDA receptors by calcineurin. Science 267:1510-1512.
37. Wang L-Y, Orser BA, Brautigan DL, MacDonald JF (1994) Regulation of NMDA receptors in cultured hippocampal neurons by protein phosphatases 1 and 2A. Nature 369:230-232.
38. Yu X-M, Askalan R, Keil H GJ, Salter MW (1997) NMDA channel regulation by channel-associated protein tyrosine kinase src. Science 275:674-678.