Identification of inhibitors against Mycobacterium tuberculosis Thiamin phosphate synthase, an important target for the development of Anti-TB drugs

PLoS ONE

Volumn 6, Issue 7, 2011, Pages

  Khare, Garima ^a   Kar, Ritika ^a   Tyagi, Anil K ^a  

^a UNIVERSITY OF DELHI   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; SYNTHETASE; THIAMINE PHOSPHATE SYNTHASE; THIAMINE PHOSPHATE SYNTHASE INHIBITOR; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; ENZYME INHIBITOR; THIAMIN PHOSPHATE SYNTHASE; TRANSFERASE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; BINDING SITE; CELL DEATH; CELL LINE; CELL STRAIN HEPG2; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER INTERFACE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; HELA CELL; ISOLATION AND PURIFICATION; MICROBIOLOGICAL EXAMINATION; MOLECULAR CLONING; REPRODUCIBILITY; STRUCTURAL HOMOLOGY; THERMODYNAMICS;

MYCOBACTERIUM TUBERCULOSIS;

ALKYL AND ARYL TRANSFERASES; ANTITUBERCULAR AGENTS; BINDING SITES; CELL DEATH; CELL LINE; CLONING, MOLECULAR; ENZYME INHIBITORS; HELA CELLS; HEP G2 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; REPRODUCIBILITY OF RESULTS; STRUCTURAL HOMOLOGY, PROTEIN; THERMODYNAMICS; USER-COMPUTER INTERFACE;

EID: 79960810267     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022441     Document Type: Article

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