Effect of pH and ionic strength on the physical stability of adenovirus type 5

Journal of Pharmaceutical Sciences

Volumn 95, Issue 2, 2006, Pages 237-247

  Rexroad, Jason ^a   Evans, Robert K ^b   Middaugh, C Russell ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Absorption spectroscopy; Adenoviral vector; Fluorescence spectroscopy; Gene vectors; Light scattering (dynamic); Physical stability; Spectroscopy; UV Vis spectroscopy; Vaccines; Viral vectors

Indexed keywords

ADENOVIRUS VECTOR; VIRUS DNA; VIRUS VACCINE;

ACIDITY; ADENOVIRUS 5; ARTICLE; BIOPHYSICS; EMPIRICAL PHASE DIAGRAM; FLUORESCENCE; HIGH TEMPERATURE PROCEDURES; IONIC STRENGTH; LIGHT SCATTERING; NONHUMAN; PARTICLE SIZE; PH MEASUREMENT; PROTEIN QUATERNARY STRUCTURE; PROTEIN STABILITY; THERMODYNAMICS; THERMOSTABILITY; ULTRAVIOLET SPECTROSCOPY; VIRUS MORPHOLOGY; VIRUS PARTICLE;

EID: 32644437409     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20496     Document Type: Article

References (36)

1. (GeMCRIS) NFGMCRIS. 2004. NIH Genetic Modification Clinical Research Information System (GeMCRIS). ed.: NIH/FDA Genetic Modification Clinical Research Information System (GeMCRIS).
2. Stewart PL, Fuller SD, Burnett RM. 1993. Difference imaging of adenovirus: Bridging the resolution gap between X-ray crystallography and electron microscopy. Embo J 12:2589-2599.
3. Stewart PL, Burnett RM. 1990. The structure of adenovirus. Semin Virol 1:477-487.
4. Rexroad J, Wiethoff CM, Green AP, Kierstead TD, Scott MO, Middaugh CR. 2003. Structural stability of adenovirus type 5. J Pharm Sci 92:665-678.
5. Maheshwari G, Jannat R, McCormick L, Hsu D. 2004. Thermal inactivation of adenovirus type 5. J Virol Methods 118:141-146.
6. Russell WC, Valentine RC, Pereira HG. 1967. The effect of heat on the anatomy of the adenovirus. J Gen Virol 1:509-522.
7. Galdiero F. 1979. Adenovirus aggregation and preservation in extracellular environment. Arch Virol 59:99-105.
8. Blumenthal R, Seth P, Willingham MC, Pastan I. 1986. pH-dependent lysis of liposomes by adenovirus. Biochemistry 25:2231-2237.
9. Greber UF, Willetts M, Webster P, Helenius A. 1993. Stepwise dismantling of adenovirus 2 during entry into cells. Cell 75:477-486.
10. Evans RK, Nawrocki DK, Isopi LA, Williams DM, Casimiro DR, Chin S, Chen M, Zhu DM, Shiver JW, Volkin DB. 2004. Development of stable liquid formulations for adenovirus-based vaccines. J Pharm Sci 93:2458-2475.
11. Blanche F, Cameron B, Somarriba S, Maton L, Barbot A, Guillemin T. 2001. Stabilization of recombinant adenovirus: Site-directed mutagenesis of key asparagine residues in the hexon protein. Anal Biochem 297:1-9.
12. Croyle MA, Cheng X, Wilson JM. 2001. Development of formulations that enhance physical stability of viral vectors for gene therapy. Gene Ther 8:1281-1290.
13. Croyle MA, Roessler BJ, Davidson BL, Hilfinger JM, Amidon GL. 1998. Factors that influence stability of recombinant adenoviral preparations for human gene therapy. Pharm Dev Technol 3:373-383.
14. Cheng X, Ming X, Croyle MA. 2003. PEGylated adenoviruses for gene delivery to the intestinal epithelium by the oral route. Pharm Res 20:1444-1451.
15. Gloss LM, Simler BR, Matthews CR. 2001. Rough energy landscapes in protein folding: Dimeric E. coli Trp repressor folds through three parallel channels. J Mol Biol 312:1121-1134.
16. HuCQ, Sturtevant JM, Thomson JA, Erickson RE, Pace CN. 1992. Thermodynamics of ribonuclease T1 denaturation. Biochemistry 31:4876-4882.
17. Nishimura C, Uversky VN, Fink AL. 2001. Effect of salts on the stability and folding of staphylococcal nuclease. Biochemistry 40(7):2113-2128.
18. Pace CN, Grimsley GR. 1988. Ribonuclease T1 is stabilized by cation and anion binding. Biochemistry 27:3242-3246.
19. Kueltzo LA, Ersoy B, Ralston JP, Middaugh CR. 2003. Derivative absorbance spectroscopy and protein phase diagrams as tools for comprehensive protein characterization: A bGCSF case study. J Pharm Sci 92:1805-1820.
20. Sweeney JA, Hennessey JP, Jr. 2002. Evaluation of accuracy and precision of adenovirus absorptivity at 260 nm under conditions of complete DNA disruption. Virology 295:284-288.
21. Oliver CJ, Shortridge KF, Belyavin G. 1976. Diffusion coefficient and molecular weight of type 5 adenovirus by photon-correlation spectroscopy. Biochim Biophys Acta 437:589-598.
22. Meyer JD, Ho B, Manning MC. 2002. Effects of conformation on the chemical stability of pharmaceutically relevant polypeptides. Pharm Biotechnol 13:85-107.
23. Teschke CM, McGough A, Thuman-Commike PA. 2003. Penton release from P22 heat-expanded capsids suggests importance of stabilizing pentonhexon interactions during capsid maturation. Biophys J 84:2585-2592.
24. Martin-Fernandez M, Longshaw SV, Kirby I, Santis G, Tobin MJ, Clarke DT, Jones GR. 2004. Adenovirus type-5 entry and disassembly followed in living cells by FRET, fluorescence anisotropy, and FLIM. Biophys J 87:1316-1327.
25. Van Dyke RW. 1996. Acidification of lysosomes and endosomes. Subcell Biochem 27:331-360.
26. Laver WG, Wrigley NG, Pereira HG. 1969. Removal of pentons from particles of adenovirus type 2. Virology 39:599-604.
27. van Oostrum J, Burnett RM. 1985. Molecular composition of the adenovirus type 2 virion. J Virol 56:439-448.
28. Wiethoff CM, Wodrich H, Gerace L, Nemerow GR. 2005. Adenovirus protein VI mediates membrane disruption following capsid disassembly. J Virol 79:1992-2000.
29. Wallis C, Yang CS, Melnick JL. 1962. Effect of cations on thermal inactivation of vaccinia, herpes simplex, and adenoviruses. J Immunol 89:41-46.
30. Yang CS, Tai FH, Wallis C, Melnick JL. 1963. Adenovirus Vaccine Prepared By Thermal Inactivation Of The Infective Moiety Of The Virus In Magnesium Ions. J Immunol 91:283-286.
31. Canada PHAo. 2001. Adenovirus types 1, 2, 3, 4, 5 and 7-Material Safety Data Sheet, ed.: Public Health Agency of Canada.
32. Arakawa T, Timasheff SN. 1982. Preferential interactions of proteins with salts in concentrated solutions. Biochemistry 21:6545-6552.
33. Sweeney JA, Hennessey JP, Jr. 2002. Evaluation of accuracy and precision of adenovirus absorptivity at 260 nm under conditions of complete DNA disruption. Virology 295:284-288.
34. Stock RS, Ray WH. 1985. Interpretation of photon correlation spectroscopy data: A comparison of analysis methods. J Poly Sci: Poly Phys Ed 23:1393-1447.
35. Mach H, Middaugh CR. 1994. Simultaneous monitoring of the environment of tryptophan, tyrosine, and phenylalanine residues in proteins by near-ultraviolet second-derivative spectroscopy. Anal Biochem 222:323-331.
36. Mach H, Volkin DB, Burke CJ, Middaugh CR. 1995. Ultraviolet absorption spectroscopy. In: Shirley BA, editor. Methods in molecular biology. Vol 40: Totowa, NJ: Humana Press, pp 91-113.