Toll-like receptor 4 and myeloid differentiation factor 88 provide mechanistic insights into the cause and effects of interleukin-6 activation in mouse liver regeneration

Hepatology

Volumn 54, Issue 2, 2011, Pages 597-608

  Vaquero, Javier ^a,b   Campbell, Jean S ^a   Haque, Jamil ^a   Mcmahon, Ryan S ^a   Riehle, Kimberly J ^a   Bauer, Renay L ^a   Fausto, Nelson ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CYCLIN A; CYCLIN E; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA SYNTHESIS; IMMUNOHISTOCHEMISTRY; LIVER CELL; LIVER REGENERATION; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; HEPATECTOMY; INTERLEUKIN-6; LIVER REGENERATION; MICE; MYELOID DIFFERENTIATION FACTOR 88; TOLL-LIKE RECEPTOR 4;

EID: 79960742572     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.24420     Document Type: Review

References (34)

1. Fausto N, Campbell JS, Riehle KJ. Liver regeneration. HEPATOLOGY 2006; 43: S45-S53.
2. Santiago F, Bueno P, Olmedo C, Comino A, Hassan L, Ferron-Celma I, et al. Time course of intraoperative cytokine levels in liver transplant recipients. Transpl Proc 2006; 38: 2492-2494.
3. Yamada Y, Webber EM, Kirillova I, Peschon JJ, Fausto N. Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: requirement for type 1 but not type 2 receptor. HEPATOLOGY 1998; 28: 959-970.
4. Aldeguer X, Debonera F, Shaked A, Krasinkas AM, Gelman AE, Que X, et al. Interleukin-6 from intrahepatic cells of bone marrow origin is required for normal murine liver regeneration. HEPATOLOGY 2002; 35: 40-48.
5. Webber EM, Bruix J, Pierce RH, Fausto N. Tumor necrosis factor primes hepatocytes for DNA replication in the rat. HEPATOLOGY 1998; 28: 1226-1234.
6. Wuestefeld T, Klein C, Streetz KL, Betz U, Lauber J, Buer J, et al. Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration. J Biol Chem 2003; 278: 11281-11288.
7. Cressman DE, Greenbaum LE, DeAngelis RA, Ciliberto G, Furth EE, Poli V, et al. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 1996; 274: 1379-1383.
8. Li W, Liang X, Leu JI, Kovalovich K, Ciliberto G, Taub R. Global changes in interleukin-6-dependent gene expression patterns in mouse livers after partial hepatectomy. HEPATOLOGY 2001; 33: 1377-1386.
9. Sakamoto T, Liu Z, Murase N, Ezure T, Yokomuro S, Poli V, et al. Mitosis and apoptosis in the liver of interleukin-6-deficient mice after partial hepatectomy. HEPATOLOGY 1999; 29: 403-411.
10. Li W, Liang X, Kellendonk C, Poli V, Taub R. STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration. J Biol Chem 2002; 277: 28411-28417.
11. Blindenbacher A, Wang X, Langer I, Savino R, Terracciano L, Heim MH. Interleukin 6 is important for survival after partial hepatectomy in mice. HEPATOLOGY 2003; 38: 674-682.
12. Zimmers TA, McKillop IH, Pierce RH, Yoo JY, Koniaris LG. Massive liver growth in mice induced by systemic interleukin 6 administration. HEPATOLOGY 2003; 38: 326-334.
13. Cornell RP. Restriction of gut-derived endotoxin impairs DNA synthesis for liver regeneration. Am J Physiol 1985; 249: R563-R569.
14. Cornell RP, Liljequist BL, Bartizal KF. Depressed liver regeneration after partial hepatectomy of germ-free, athymic and lipopolysaccharide-resistant mice. HEPATOLOGY 1990; 11: 916-922.
15. Campbell JS, Riehle KJ, Brooling JT, Bauer RL, Mitchell C, Fausto N. Proinflammatory cytokine production in liver regeneration is Myd88-dependent, but independent of Cd14, Tlr2, and Tlr4. J Immunol 2006; 176: 2522-2528.
16. Seki E, Tsutsui H, Iimuro Y, Naka T, Son G, Akira S, et al. Contribution of Toll-like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration. HEPATOLOGY 2005; 41: 443-450.
17. Dean RB, Dixon WJ. Simplified statistics for small number of observations. Anal Chem 1951; 23: 636-638.
18. Mitchell C, Nivison M, Jackson LF, Fox R, Lee DC, Campbell JS, et al. Heparin-binding epidermal growth factor-like growth factor links hepatocyte priming with cell cycle progression during liver regeneration. J Biol Chem 2005; 280: 2562-2568.
19. Dierssen U, Beraza N, Lutz HH, Liedtke C, Ernst M, Wasmuth HE, et al. Molecular dissection of gp130-dependent pathways in hepatocytes during liver regeneration. J Biol Chem 2008; 283: 9886-9895.
20. Fremin C, Bessard A, Ezan F, Gailhouste L, Regeard M, Le Seyec J, et al. Multiple division cycles and long-term survival of hepatocytes are distinctly regulated by extracellular signal-regulated kinases ERK1 and ERK2. HEPATOLOGY 2009; 49: 930-939.
21. Riehle KJ, Campbell JS, McMahan RS, Johnson MM, Beyer RP, Bammler TK, et al. Regulation of liver regeneration and hepatocarcinogenesis by suppressor of cytokine signaling 3. J Exp Med 2008; 205: 91-103.
22. Wustefeld T, Rakemann T, Kubicka S, Manns MP, Trautwein C. Hyperstimulation with interleukin 6 inhibits cell cycle progression after hepatectomy in mice. HEPATOLOGY 2000; 32: 514-522.
23. Kamath AB, Alt J, Debbabi H, Behar SM. Toll-like receptor 4-defective C3H/HeJ mice are not more susceptible than other C3H substrains to infection with Mycobacterium tuberculosis. Infect Immun 2003; 71: 4112-4118.
24. Strey CW, Markiewski M, Mastellos D, Tudoran R, Spruce LA, Greenbaum LE, et al. The proinflammatory mediators C3a and C5a are essential for liver regeneration. J Exp Med 2003; 198: 913-923.
25. Tumanov AV, Koroleva EP, Christiansen PA, Khan MA, Ruddy MJ, Burnette B, et al. T cell-derived lymphotoxin regulates liver regeneration. Gastroenterology 2009; 136: 694-704.e4.
26. Zorde-Khvalevsky E, Abramovitch R, Barash H, Spivak-Pohis I, Rivkin L, Rachmilewitz J, et al. Toll-like receptor 3 signaling attenuates liver regeneration. HEPATOLOGY 2009; 50: 198-206.
27. Selzner N, Selzner M, Odermatt B, Tian Y, Van Rooijen N, Clavien PA. ICAM-1 triggers liver regeneration through leukocyte recruitment and Kupffer cell-dependent release of TNF-alpha/IL-6 in mice. Gastroenterology 2003; 124: 692-700.
28. Sun R, Jaruga B, Kulkarni S, Sun H, Gao B. IL-6 modulates hepatocyte proliferation via induction of HGF/p21cip1: regulation by SOCS3. Biochem Biophys Res Commun 2005; 338: 1943-1949.
29. Campbell JS, Prichard L, Schaper F, Schmitz J, Stephenson-Famy A, Rosenfeld ME, et al. Expression of suppressors of cytokine signaling during liver regeneration. J Clin Invest 2001; 107: 1285-1292.
30. Nicholson SE, De Souza D, Fabri LJ, Corbin J, Willson TA, Zhang JG, et al. Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130. Proc Natl Acad Sci U S A 2000; 97: 6493-6498.
31. Talarmin H, Rescan C, Cariou S, Glaise D, Zanninelli G, Bilodeau M, et al. The mitogen-activated protein kinase kinase/extracellular signal-regulated kinase cascade activation is a key signalling pathway involved in the regulation of G(1) phase progression in proliferating hepatocytes. Mol Cell Biol 1999; 19: 6003-6011.
32. Seki E, Kondo Y, Iimuro Y, Naka T, Son G, Kishimoto T, et al. Demonstration of cooperative contribution of MET- and EGFR-mediated STAT3 phosphorylation to liver regeneration by exogenous suppressor of cytokine signalings. J Hepatol 2008; 48: 237-245.
33. Alexander WS. Suppressors of cytokine signalling (SOCS) in the immune system. Nat Rev Immunol 2002; 2: 410-416.
34. Xia L, Wang L, Chung AS, Ivanov SS, Ling MY, Dragoi AM, et al. Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation. J Biol Chem 2002; 277: 30716-30723.