CD4+CD25+FoxP3+ regulatory T cells enhance the allogeneic activity of endothelial-specific CD8+/CD28-CTL

International Immunology

Volumn 23, Issue 8, 2011, Pages 485-492

  Eissner, Günther ^a   Hartmann, Isabel ^a   Kesikli, Altug ^b   Holler, Ernst ^b   Haffner, Silvia ^a   Sax, Tanja ^a   Schray, Carolin ^a   Meiser, Bruno ^a   Reichart, Bruno ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

Cytotoxicity; Endothelial cells; Immune effector cells; Transplantation

Indexed keywords

CD28 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSCRIPTION FACTOR FOXP3;

ALLOIMMUNITY; ALLOTRANSPLANTATION; ARTICLE; B LYMPHOCYTE; CD4+CD25+F0XP3+ REGULATORY T LYMPHOCYTE; COCULTURE; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; ENDOTHELIUM CELL; EPSTEIN BARR VIRUS; HLA MATCHING; HUMAN; HUMAN CELL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE;

EID: 79960742431     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxr041     Document Type: Article

References (42)

1. Paris, F., Fuks, Z., Kang, A. et al. 2001. Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science 293:293.
2. Ferrara, J. L., Levine, J. E., Reddy, P. and Holler, E. 2009. Graft-versus-host disease. Lancet. 373:1550.
3. Rothermel, A. L., Wang, Y., Schechner, J. et al. 2004. Endothelial cells present antigens in vivo. BMC Immunol. 5:5.
4. Kreisel, D., Krupnick, A. S., Gelman, A. E. et al. 2002. Non-hematopoietic allograft cells directly activate CD8+ T cells and trigger acute rejection: an alternative mechanism of allorecognition. Nat. Med. 8:233.
5. Biedermann, B. C. and Pober, J. S. 1999. Human vascular endothelial cells favor clonal expansion of unusual alloreactive CTL. J. Immunol. 162:7022.
6. Eissner, G., Multhoff, G. and Holler, E. 1998. Influence of bacterial endotoxin on the allogenicity of human endothelial cells. Bone Marrow Transplant. 21:1286.
7. Eissner, G., Multhoff, G., Gerbitz, A. et al. 2002. Fludarabine induces apoptosis, activation, and allogenicity in human endothelial and epithelial cells: protective effect of defibrotide. Blood 100:334.
8. Kreisel, D., Krupnick, A. S., Balsara, K. R. et al. 2002. Mouse vascular endothelium activates CD8+ T lymphocytes in a B7-dependent fashion. J. Immunol. 169:6154.
9. Krupnick, A. S., Gelman, A. E., Barchet, W. et al. 2005. Cutting edge: murine vascular endothelium activates and induces the generation of allogeneic CD4+25+Foxp3+ regulatory T cells. J. Immunol. 175:6265.
10. Kummer, M., Lev, A., Reiter, Y. and Biedermann, B. C. 2005. Vascular endothelial cells have impaired capacity to present immunodominant, antigenic peptides: a mechanism of cell type-specific immune escape. J. Immunol. 174:1947.
11. Taflin, C., Favier, B., Baudhuin, J. et al. 2011. Human endothelial cells generate Th17 and regulatory T cells under inflammatory conditions. Proc. Natl Acad. Sci. U S A 108:2891.
12. Kruse, N., Neumann, K., Schrage, A. et al. 2009. Priming of CD4+ T cells by liver sinusoidal endothelial cells induces CD25low forkhead box protein 3-regulatory T cells suppressing autoimmune hepatitis. Hepatology 50:1904.
13. Sakaguchi, S., Wing, K., Onishi, Y., Prieto-Martin, P. and Yamaguchi, T. 2009. Regulatory T cells: how do they suppress immune responses? Int. Immunol. 21:1105.
14. Shevach, E. M. 2009. Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity 30:636.
15. Littman, D. R. and Rudensky, A. Y. 2010. Th17 and regulatory T cells in mediating and restraining inflammation. Cell 140:845.
16. Riley, J. L., June, C. H. and Blazar, B. R. 2009. Human T regulatory cell therapy: take a billion or so and call me in the morning. Immunity 30:656.
17. Hoffmann, P., Ermann, J., Edinger, M., Fathman, C. G. and Strober, S. 2002. Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J. Exp. Med. 196:389.
18. Edinger, M., Hoffmann, P., Ermann, J. et al. 2003. CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat. Med. 9:1144.
19. Ades, E. W., Candal, F. J., Swerlick, R. A. et al. 1992. HMEC-1: establishment of an immortalized human microvascular endothelial cell line. J. Invest. Dermatol. 99:683.
20. Pilatz, A., Schultheiss, D., Gabouev, A. I. et al. 2005. Isolation of primary endothelial and stromal cell cultures of the corpus cavernosum penis for basic research and tissue engineering. Eur. Urol. 47:710.
21. Edgell, C. J., McDonald, C. C. and Graham, J. B. 1983. Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proc. Natl Acad. Sci. U S A 80:3734.
22. Jaffe, E. A., Nachman, R. L., Becker, C. G. and Minick, C. R. 1973. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J. Clin. Invest. 52:2745.
23. Basu, S., Golovina, T., Mikheeva, T., June, C. H. and Riley, J. L. 2008. Cutting edge: Foxp3-mediated induction of pim 2 allows human T regulatory cells to preferentially expand in rapamycin. J. Immunol. 180:5794.
24. Angulo, R. and Fulcher, D. A. 1998. Measurement of Candida-specific blastogenesis: comparison of carboxyfluorescein succinimidyl ester labelling of T cells, thymidine incorporation, and CD69 expression. Cytometry 34:143.
25. MacDonald, H. R., Engers, H. D., Cerottini, J. C. and Brunner, K. T. 1974. Generation of cytotoxic T lymphocytes in vitro. II. Effect of repeated exposure to alloantigens on the cytotoxic activity of long-term mixed leukocyte cultures. J. Exp. Med. 140:718.
26. Piriou, L., Chilmonczyk, S., Genetet, N. and Albina, E. 2000. Design of a flow cytometric assay for the determination of natural killer and cytotoxic T-lymphocyte activity in human and in different animal species. Cytometry 41:289.
27. Hoffmann, P., Eder, R., Boeld, T. J. et al. 2006. Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homoge-neous regulatory T-cell lines upon in vitro expansion. Blood 108:4260.
28. Schiopu, A. and Wood, K. J. 2008. Regulatory T cells: hypes and limitations. Curr. Opin. Organ Transplant. 13:333.
29. Joosten, S. A., van Meijgaarden, K. E., Savage, N. D. et al. 2007. Identification of a human CD8+ regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4. Proc. Natl Acad. Sci. U S A 104:8029.
30. Myers, L., Croft, M., Kwon, B. S., Mittler, R. S. and Vella, A. T. 2005. Peptide-specific CD8 T regulatory cells use IFN-{gamma} to elaborate TGF-{beta}-based suppression. J. Immunol. 174:7625.
31. Fenoglio, D., Ferrera, F., Fravega, M. et al. 2008. Advancements on phenotypic and functional characterization of non-antigen-specific CD8+CD28-regulatory T cells. Hum. Immunol. 69:745.
32. Manavalan, J. S., Kim-Schulze, S., Scotto, L. et al. 2004. Alloantigen specific CD8+. Int. Immunol. 16:1055.
33. Wang, X. N., Haniffa, M. A., Holtick, U. et al. 2009. Regulatory T-cell suppression of CD8+ T-cell-mediated graft-versus-host reaction requires their presence during priming. Transplantation 88:188.
34. Clarkson, M. R. and Sayegh, M. H. 2005. T-cell costimulatory pathways in allograft rejection and tolerance. Transplantation 80:555.
35. Yamada, A., Kishimoto, K., Dong, V. M. et al. 2001. CD28-independent costimulation of T cells in alloimmune responses. J. Immunol. 167:140.
36. Rose, M. L. 1998. Endothelial cells as antigen-presenting cells: role in human transplant rejection. Cell Mol. Life Sci. 54:965.
37. Dengler, T. J. and Pober, J. S. 2000. Human vascular endothelial cells stimulate memory but not naive CD8+ T cells to differentiate into CTL retaining an early activation phenotype. J. Immunol. 164:5146.
38. Cannons, J. L., Lau, P., Ghumman, B. et al. 2001. 4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy. J. Immunol. 167:1313.
39. Shuford, W. W., Klussman, K., Tritchler, D. D. et al. 1997. 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J. Exp. Med. 186:47.
40. Sakaguchi, S., Miyara, M., Costantino, C. M. and Hafler, D. A. 2010. FOXP3+ regulatory T cells in the human immune system. Nat. Rev. Immunol. 10:490.
41. Bedke, T., Pretsch, L., Karakhanova, S., Enk, A. H. and Mahnke, K. 2010. Endothelial cells augment the suppressive function of CD4+CD25+Foxp3+ regulatory T cells: involvement of programmed death-1 and IL-10. J. Immunol. 184:5562.
42. Croft, M. 2010. Control of immunity by the TNFR-related molecule OX40 (CD134). Annu. Rev. Immunol. 28:57.